A directory of where to buy chemicals in the UK including: distributors, industrial manufacturers, wholesalers, raw ingredients, bulk supplies and finished goods for sale.
PD-0325901 is a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. Uses: Reprogramming, self-renewal. Group: Pharmaceutical. CAS No. 391210-10-9. Pack Sizes: 100 mg. Product ID: B0084-091588. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
PD123319
PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. Uses: Vasoconstrictor agents. Group: Pharmaceutical. CAS No. 130663-39-7. Pack Sizes: 25 mg. Product ID: B2693-163469. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
PD173074
PD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell proliferation remarkably in two cell lines, namely, UM-UC-14 and MGHU3, which expressed mutated FGFR3 protein. Cell cycle analysis revealed the growth inhibitory effect of PD173074 was associated with arrest at G(1)-S transition in a dose-depending manner. In the mouse xenograft models using subcutaneously transplanted UM-UC-14 and MGHU3, orally administered PD173074 suppressed tumor growth and induced apoptotic changes comparable with the results of our in vitro assay. These findings elucidated the effectiveness of molecular targeted approach for bladder UC harboring FGFR3 mutations and the potential utility to decrease the intravesical recurrence of nonmuscle invasive bladder UC after transurethral surgical resection. Uses: Differentiation, self-renewal. Group: Pharmaceutical. CAS No. 219580-11-7. Pack Sizes: 50 mg. Product ID: B2693-263525. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
PD-173955
PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth. Group: Pharmaceutical. CAS No. 260415-63-2. Pack Sizes: 10 mg. Product ID: B0084-088782. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
PD-1-IN-17
PD-1-IN-17 is a programmed cell death-1 (PD-1) inhibitor. PD-1-IN-17 was first reported in patent WO2015033301A1, (Compound 12), inhibits 92% splenocyte proliferation at 100 nM. Group: Pharmaceutical. CAS No. 1673560-66-1. Pack Sizes: 25 mg. Product ID: B1370-382917. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
PD98059
PD98059 is a potent, selective and cell-permeant inhibitor of MAP kinase kinase. It enhances human embryonic stem cell self-renewal. Group: Pharmaceutical. CAS No. 167869-21-8. Pack Sizes: 250 mg. Product ID: B2693-286170. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
PDV Salt 25kg
Salt - Pure Dried Vacuum - per 25kg. NOTE: THIS PRODUCT CAN ONLY BE DELIVERED TO COMMERCIAL PREMISES.
PEACH - Our signature range of liquid botanical extracts
England, Scotland
PEACH JUICE
PEACH JUICE - Our signature range of liquid botanical extracts
England, Scotland
PEACH KERNEL OIL
PEACH KERNEL OIL - Our range of Vegetable Oils is constantly expanding and includes many interesting and unusual ingredients for use in cosmetics and toiletries.
PEANUT - Our signature range of liquid botanical extracts
England, Scotland
PEAR
PEAR - Our signature range of liquid botanical extracts
England, Scotland
Pearl Chemicals provide an extensive range of Toll manufacturing and formulating services
Pearl Chemicals goes beyond the offerings of traditional UK chemical distributors, providing a wide array of specialised services. These include: Manufacturing chemicals, decanting liquids from road tankers into IBCs and smaller packs, Chemical blending, blending solids and liquids, dispersing powders into liquids, packing and repacking liquid and powder chemicals, and reprocessing powders through crushing, milling, grinding, sieving, and micronizing. We also handle reprocessing of waste streams. Contact us for toll manufacturing, custom product formulations, tailored pack sizes, and more.
Pectolinarin
Pectolinarin, which can be found in the herbs of Cirsium japonicum DC, possesses anti-inflammatory activity and may inhibit eicosanoid formation in inflammatory lesions. It exerted a better analgesic effect than linarin. Pectolinarin also increased activity levels of GSH, GR, GCS, and GST, as well as SOD. Uses: Anti-inflammatory / analgesic / hepatoprotective. Group: Pharmaceutical. CAS No. 28978-02-1. Pack Sizes: 50 mg. Product ID: NP2528. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Pedatisectine F
Pedatisectine F is an alkaloid isolated from the tubers of Pinellia pedatisecta Schott. Group: Pharmaceutical. CAS No. 206757-32-6. Pack Sizes: 5 mg. Product ID: NP0125. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Peficitinib
Peficitinib is a potent JAK inhibitor with IC50 values of 3.9, 5.0, 0.71 and 4.8 nM for JAK1, JAK2, JAK3 and TYK2 enzyme activities, respectively. It inhibits the IL-2-induced proliferation of human T cells with IC50 value of 18 nM. Moreover, peficitinib is 14-fold more potent against JAK1/3 than JAK2/2 on the basis of EPO-induced proliferation of human leukemia cells. Peficitinib has been used for the treatment of psoriasis and rheumatoid arthritis. Uses: Inhibited jak1, jak2, jak3 and tyk2 enzyme activities with ic50 values of 3.9, 5.0, 0.71 and 4.8 nm, respectively; inhibited the il-2-induced proliferation of human t cells with an ic50 value of 18 nm. Group: Pharmaceutical. CAS No. 944118-01-8. Pack Sizes: 25 mg. Product ID: B0084-462759. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Pefloxacin-[d5]
Pefloxacin-[d5] is the labelled analogue of Pefloxacin, which is a quinolone antibiotic used to treat bacterial infections. Group: Pharmaceutical. CAS No. 1228182-51-1. Pack Sizes: 10 mg. Product ID: BLP-011740. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Pefloxacin Impurities
Pefloxacin Impurities, essential in the biomedical field, are used for analytical purposes to understand the profile of pefloxacin, a fluoroquinolone antibiotic. Analyzing these impurities helps ensure drug safety and efficacy in the treatment of bacterial infections, including urinary tract infections and respiratory diseases. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Pefloxacin mesylate
25g Pack Size. Group: Antibiotics, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C17H20FN3O3 ·CH3SO3H. CAS No. 70458-95-6. Prepack ID : 54165700-25g. Molecular Weight : 429.46.
Pefloxacin mesylate
5g Pack Size. Group: Antibiotics, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C17H20FN3O3 ·CH3SO3H. CAS No. 70458-95-6. Prepack ID : 54165700-5g. Molecular Weight : 429.46.
PEG-12 DIMETHICONE - Our range of Silicone Compounds is constantly expanding and includes many interesting and functional ingredients for use in personal care formulations.