UK Chemical Suppliers

A directory of where to buy chemicals in the UK including: distributors, industrial manufacturers, wholesalers, raw ingredients, bulk supplies and finished goods for sale.

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Product
K03861 K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. Group: Pharmaceutical. CAS No. 853299-07-7. Pack Sizes: 50 mg. Product ID: B0084-459880. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
K252A K252a, an analog of staurosporine, has been found to be a protein kinase inhibitor and exhibit antitumor activity at some extent. Group: Pharmaceutical. CAS No. 99533-80-9. Pack Sizes: 50 mg. Product ID: BBF-04182. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
K-7174 dihydrochloride K-7174, one of proteasome inhibitory homopiperazine derivatives, exhibits a therapeutic effect, which is stronger when administered orally than intravenously, without obvious side effects in a murine myeloma model. Moreover, K-7174 kills bortezomib-resistant myeloma cells carrying a β5-subunit mutation in vivo and primary cells from a patient resistant to bortezomib. Group: Pharmaceutical. CAS No. 191089-60-8. Pack Sizes: 100 mg. Product ID: B2693-463577. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferitrin Kaempferitrin isolated from the root of Kaempferia galangal L. It stimulates glucose-metabolizing enzymes and promotes glucose homeostasis. Uses: Cytotoxic and antitumor effects; antidepressant-like effect; immunostimulatory effects. Group: Pharmaceutical. CAS No. 482-38-2. Pack Sizes: 20 mg. Product ID: NP1860. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from plant sources. It has many functions such as anti-cancer, diuretic, anti-inflammatory, antioxidant, anti-bacterial, and anti-virus. Kaempferol can be used in food additive. Uses: Anti-inflammatory; diuretic; antioxidant; inhibitor of topoisomerase-ii. Group: Pharmaceutical. CAS No. 520-18-3. Pack Sizes: 250 mg. Product ID: NP1821. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol 25mg Pack Size. Group: Bioactive Small Molecules, Aroma Chemicals, Biochemicals, Organics, Research Organics & Inorganics. Formula: C15H10O6. CAS No. 520-18-3. Prepack ID : 35856397-25mg. Molecular Weight : 286.24. Molekula
Kaempferol 3-a-L-arabinopyranoside Kaempferol 3-a-L-arabinopyranoside comes from the roots of Ligusticum jeholense Nakai et Kitag. Group: Pharmaceutical. CAS No. 99882-10-7. Pack Sizes: 5 mg. Product ID: NP1830. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol-3-Glucuronide Kaempferol-3-beta-O-glucuronide is a flavonoid glucuronide, which can be found in vegetables and deconjugated by microsomal β-glucuronidase from various human cells. Uses: Antioxidant. Group: Pharmaceutical. CAS No. 22688-78-4. Pack Sizes: 10 mg. Product ID: B2703-001600. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol 3-O-(2''-O-glucosyl)rutinoside Kaempferol-3-O-(2"-O-β-D- glucopyl)-β-D-rutinoside is a compound of the flavonoid class. Group: Pharmaceutical. CAS No. 55696-58-7. Pack Sizes: 5 mg. Product ID: NP2093. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol-3-O-α-L-rhamnopyranosyl-(1?6)-β-D-glucopyranosyl-(1?2)-β-D-glucopyranoside Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside is found in Hosta plantaginea, it shows antioxidant activity. Group: Pharmaceutical. CAS No. 476617-49-9. Pack Sizes: 5 mg. Product ID: B1370-334820. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol 3-O-beta-(6''-p-coumaroyl) glucopyranosyl (1?2)-alpha-L-rhamnopyranoside Kaempferol 3-O-beta-(6''-p-coumaroyl)glucopyranosyl(1→2)-alpha-L-rhamnopyranoside is a flavonoid and a natural antioxidant. Group: Pharmaceutical. CAS No. 111957-48-3. Pack Sizes: 5 mg. Product ID: B1370-334434. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol 3-O-sophoroside Kaempferol 3-β-Sophoroside is a derivative of Kaempferol with antibacterial and antiviral activities. Group: Pharmaceutical. CAS No. 19895-95-5. Pack Sizes: 5 mg. Product ID: NP2493. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol 3-O-sophoroside-7-O-glucoside Kaempferol 3-sophoroside-7-glucoside is a compound of the flavonoid class found in the stems of Equisetum hyemale L. Group: Pharmaceutical. CAS No. 55136-76-0. Pack Sizes: 5 mg. Product ID: NP2035. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol 3-sophoroside-7-rhamnoside Kaempferol 3-sophoroside-7-rhamnoside is a compound of the flavonoid class found in the herbs of Elaeagnus multiflora Thunb. Group: Pharmaceutical. CAS No. 93098-79-4. Pack Sizes: 5 mg. Product ID: B0005-053545. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol 7,4'-dimethyl ether 3,5-Dihydroxy-4',7-dimethoxyflavone is a natural flavonoid found in the herb of Andrographis paniculata (Burm. f.) Nees. Group: Pharmaceutical. CAS No. 15486-33-6. Pack Sizes: 5 mg. Product ID: NP2039. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol-7-O-glucoside Kaempferol-7-O-β-D-glucopyranoside is extracted from the herbs of Hosta plantaginea. Group: Pharmaceutical. CAS No. 16290-07-6. Pack Sizes: 10 mg. Product ID: B0005-224057. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol 7-O-rhamnoside Kaempferol 7-O-rhamnoside is isolated from the herbs of Maytenus hookeri. Group: Pharmaceutical. CAS No. 20196-89-8. Pack Sizes: 5 mg. Product ID: NP2003. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaempferol Impurities Kaempferol Impurities are instrumental in the biomedical sector, functioning as reference benchmarks for the scrutiny and quality assurance of kaempferol-related pharmaceutical products. These impurities facilitate the assessment of kaempferol's purity, which is under exploration for therapeutic potential in addressing diverse inflammatory ailments and oncological conditions. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaerophyllin Kaerophyllin isolated from the roots of Bupleurum chinense DC. Group: Pharmaceutical. CAS No. 75590-33-9. Pack Sizes: 1 mg. Product ID: NP3941. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kainic acid 50mg Pack Size. Group: Amino Acids, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C10H15NO4. CAS No. 487-79-6. Prepack ID : 58606205-50mg. Molecular Weight : 213.23. Molekula
Kainic acid 10mg Pack Size. Group: Amino Acids, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C10H15NO4. CAS No. 487-79-6. Prepack ID : 58606205-10mg. Molecular Weight : 213.23. Molekula
Kajiichigoside F1 Kajiichigoside F1 is a triterpenoid compound found in the roots of Rosa rugosa. Kajiichigoside F1 exhibits anti-inflammatory and hepatoprotective activities in vivo and antiviral activity in vitro. Group: Pharmaceutical. CAS No. 95298-47-8. Pack Sizes: 2 mg. Product ID: NP7062. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kallikrein Inhibitor Kallikrein Inhibitor, a synthetic peptide, is a serine protease inhibitor that inhibits kallikrein and plasmin, and can attenuate breast cancer cell invasion. Group: Pharmaceutical. CAS No. 97145-43-2. Pack Sizes: 10 mg. Product ID: BAT-006188. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kalopanaxsaponin H Kalopanaxsaponin H is extracted from the herbs of Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. It has antidiabetic activity. Group: Pharmaceutical. CAS No. 128730-82-5. Pack Sizes: 5 mg. Product ID: B0005-465767. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kanamycin acid sulfate 5g Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C18H40N4O19S2. CAS No. 64013-70-3. Prepack ID : 24757506-5g. Molecular Weight : 680.65. Molekula
Kanamycin A Sulfate 100g Pack Size. Group: Antibiotics, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C18H36N4O11 · H2O4S. CAS No. 25389-94-0. Prepack ID : 12914940-100g. Molecular Weight : 582.58. Molekula
Kanamycin base 5g Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C ‚ ‚ˆH ‚ƒ ‚†N ‚„O ‚ ‚. CAS No. 8063-7-8. Prepack ID : 56564516-5g. Molecular Weight : 484.4986. Molekula
Kanamycin Impurities Kanamycin Impurities, integral to the biomedical sector, play a crucial role in quality control and assurance processes within kanamycin antibiotic production. These impurities are vital for evaluating the purity and safety of kanamycin formulations, ensuring effective treatment of bacterial infections, especially in tackling multidrug-resistant tuberculosis and other severe bacterial maladies. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kanamycin sulfate 100g Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C18H38N4O15S. CAS No. 70560-51-9. Prepack ID : 15202460-100g. Molecular Weight : 582.57. Molekula
Kanamycin sulfate 25g Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C18H38N4O15S. CAS No. 70560-51-9. Prepack ID : 15202460-25g. Molecular Weight : 582.57. Molekula
Kanamycin sulfate 5g Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C18H38N4O15S. CAS No. 70560-51-9. Prepack ID : 15202460-5g. Molecular Weight : 582.57. Molekula
Kanshone H Kanshone H can be isolated from the rhizomes and roots of Nardostachys chinensis. Group: Pharmaceutical. CAS No. 1445952-33-9. Pack Sizes: 1 mg. Product ID: NP5870. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kansuinine A Kansuinine A is extracted from the roots of Euphorbia kansui. It shows analgesic props and NGF inducing activity. Group: Pharmaceutical. CAS No. 57701-86-7. Pack Sizes: 1 mg. Product ID: NP1381. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaolin Kaolin - China Clay, Powders. Mistral Industrial Chemicals our speciality is supplying Technical grade & Industrial grade chemicals in sizes from: 1Kg to 25Kg.  We can also supply products in barrels & multiple bags / pallets.   Mistral Lab Supplies
Northern Ireland
Kaolin 1kg Pack Size. Group: Inorganic Chemicals. CAS No. 1332-58-7. Prepack ID : 12687158-1kg. Molekula
Karakoline Alkaloid , from plants of the Ranunculaceae family. Ganglioblocker; nicotinic receptor antagonist; hypotensive; presents micromolar affinity at brain a Bungarotoxin-sensitive nAChR. (See attached sheet.). Group: Pharmaceutical. CAS No. 39089-30-0. Pack Sizes: 20 mg. Product ID: B0005-115266. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Karl-Fischer Reagent (Titraquant 2) 2.5lt Pack Size. Group: Analytical Reagents. Prepack ID : 24055880-2.5lt. Molekula
Karl-Fischer Reagent (Titraquant 2) 1lt Pack Size. Group: Analytical Reagents. Prepack ID : 24055880-1lt. Molekula
Karl-Fischer Reagent (Uniquant 5) 1lt Pack Size. Group: Analytical Reagents. Prepack ID : 90005253-1lt. Molekula
Karl-Fischer Reagent (Uniquant 5) 2.5lt Pack Size. Group: Analytical Reagents. Prepack ID : 90005253-2.5lt. Molekula
Karl-Fischer working medium K solvent 1lt Pack Size. Group: Analytical Reagents, Diagnostic Raw Materials, Stains & Indicators, Water Analysis. Prepack ID : 34496486-1lt. Molekula
Kartogenin Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBF&beta. Group: Pharmaceutical. CAS No. 4727-31-5. Pack Sizes: 250 mg. Product ID: B0085-462283. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kaurenoic acid Kaurenoic acid is a natural diterpenoid found in the herbs of Croton antisyphiliticus. Kaurenoic acid has anti-inflammatory activity, and also exhibits cytotoxic and embryotoxic effects. It acts through inhibition of iNOS and COX-2 expression. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 6730-83-2. Pack Sizes: 25 mg. Product ID: NP1523. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
KAVA KAVA KAVA KAVA - Our signature range of liquid botanical extracts Suppliers Needed
England, Scotland
Kazinol B Kazinol B is a natural flavonoid found in the barks of Broussonetia papyrife. It has inhibition of nitric oxide production on LPS-activated macrophages and has inhibiion of SOCE. Group: Pharmaceutical. CAS No. 99624-27-8. Pack Sizes: 1 mg. Product ID: NP2014. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kazinol U Kazinol U is one estrogenic found in Broussonetia kazinoki. Kazinoki may be useful in the treatment of menopausal symptoms and may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes. Group: Pharmaceutical. CAS No. 1238116-48-7. Pack Sizes: 1 mg. Product ID: NP2369. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
KB-R7943 mesylate KB-R7943 is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 μM). Group: Pharmaceutical. CAS No. 182004-65-5. Pack Sizes: 100 mg. Product ID: B1370-207121. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
KD025 KD025 is an orally available and selective ROCK2 inhibitor with IC50 value of 60 nM and Ki value of 41 nm, respectively. It was shown to suppress adipogenesis in human adipose-derived stem cells. Uses: Protein kinase inhibitors. Group: Pharmaceutical. CAS No. 911417-87-3. Pack Sizes: 100 mg. Product ID: B0084-460389. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
KDM5-inhibitor KDM5-inhibitor is an analog of CPI-455, a selective KDM5 inhibitor. CPI-455 increases levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell lines treated with standard chemotherapy or targeted agents. It reduces survival of drug-tolerant cancer cells. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B0084-284866. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
KE604 ROSIN KE604 ROSIN. Industry Served: Soldering fluxes Suppliers Wanted
England
Kenpaullone Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC50 = 400 nM), CDK2/cyclin A (IC50 = 680 nM), CDK2/cyclin E (IC50 = 7.5 uM) and CDK5/p25 (IC50 = 850 nM). Kenpaullone inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC50 values are 0.68, 7.5 and 0.85 μM respectively). Uses: Reprogramming. Group: Pharmaceutical. CAS No. 142273-20-9. Pack Sizes: 100 mg. Product ID: B2693-350677. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kerantinocyte Growth Factor Recombinant Human KGF is an 18.9 kDa protein containing 163 amino residues. Group: Pharmaceutical. CAS No. 148348-15-6. Pack Sizes: 50 mg. Product ID: B1370-167006. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Kerosene (Odourless) Kerosene (Odourless). At Tan International we supply a wide range of products covering all industry sectors Tan International
Scotland
Ketoconazole 25g Pack Size. Group: Bioactive Small Molecules, Building Blocks, Research Organics & Inorganics. Formula: C26H28Cl2N4O4. CAS No. 65277-42-1. Prepack ID : 21106075-25g. Molecular Weight : 531.43. Molekula
Ketoconazole 5g Pack Size. Group: Bioactive Small Molecules, Building Blocks, Research Organics & Inorganics. Formula: C26H28Cl2N4O4. CAS No. 65277-42-1. Prepack ID : 21106075-5g. Molecular Weight : 531.43. Molekula
Ketoconazole EP Impurity C Ketoconazole EP Impurity C is an impurity of Ketoconazole, which is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. Group: Pharmaceutical. CAS No. 83374-59-8. Pack Sizes: 5 mg. Product ID: B1270-120523. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Ketoconazole Impurities Ketoconazole Impurities, intricately examined within pharmaceutical domains, unveil essential data regarding drug safety and efficacy. Their critical presence is paramount in the meticulous scrutiny of ketoconazole-based formulations, ensuring regulatory adherence and therapeutic optimization, thereby enhancing treatment efficacies for fungal maladies such as candidiasis and dermatophytosis. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Ketoprofen 5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C16H14O3. CAS No. 22071-15-4. Prepack ID : 41476439-5g. Molecular Weight : 254.28. Molekula
Ketoprofen Impurities Ketoprofen Impurities are vital in the biomedical industry for research and development of non-steroidal anti-inflammatory drugs (NSAIDs). These impurities help in understanding the pharmacokinetics, stability, and efficacy of ketoprofen, benefiting treatments for conditions like arthritis, pain, and inflammation-related disorders. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Ketorolac Impurities Ketorolac Impurities, observed in the synthesis of ketorolac, play a crucial role in quality control and enhancement of anti-inflammatory and analgesic drug formulations. These impurities help researchers understand pharmacokinetics and ensure the efficacy and safety of ketorolac, widely used for treating postoperative pain and inflammation. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Ketorolac tromethamine salt 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C19H24N2O6. CAS No. 74103-07-4. Prepack ID : 21205730-1g. Molecular Weight : 376.4. Molekula
Ketotifen fumarate 5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C23H23NO5S. CAS No. 34580-14-8. Prepack ID : 51433384-5g. Molecular Weight : 425.5. Molekula
Ketotifen fumarate 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C23H23NO5S. CAS No. 34580-14-8. Prepack ID : 51433384-1g. Molecular Weight : 425.5. Molekula
Ketotifen Fumarate Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks. Uses: Antipruritics. Group: Pharmaceutical. CAS No. 34580-14-8. Pack Sizes: 5 g. Product ID: B0046-463927. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Ketotifen Impurities Ketotifen Impurities are crucial in the biomedical industry for evaluating the purity and quality of Ketotifen, an antihistamine used to treat asthma and allergic conditions. Understanding these impurities aids in ensuring the efficacy and safety of the drug while facilitating research into improved formulations and therapeutic outcomes. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
Ketotifen Impurity B Ketotifen impurity, used in separation of enantiomers of Ketotifen and its polar intermediate by isotachophoresis. Group: Pharmaceutical. CAS No. 59743-88-3. Pack Sizes: 50 mg. Product ID: B1271-261956. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
KGA2727 KGA2727 is a selective and potent SGLT1 inhibitor for the treatment of diabete. Its inhibition constant (Ki) values of 97 and 13,600 nM for human (h) SGLT1 and hSGLT2 respectively. It inhibited the absorption of glucose but not that of fructose. Uses: Kga2727 is used for the treatment of diabete. Group: Pharmaceutical. CAS No. 666842-36-0. Pack Sizes: 50 mg. Product ID: B2693-476095. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
KGL360 1 Anderson Product KGL360 1 Anderson Chemicals Description Anderson Chemicals
KGL360 1 Eliana Product KGL360 1 Eliana Chemicals Description Eliana Chemicals
KGL360 1 Makayla Product KGL360 1 Makayla Chemicals Description Makayla Chemicals