BOC Sciences - Products
London
BOC Sciences provides various research (bio)chemicals: inhibitors, building blocks, carbohydrates, nucleosides, nucleotides, GMP Products, impurities, metabolites, APIs, natural compounds, ADCs, and chiral compounds.
| Product | Description | |
|---|---|---|
| Bafilomycin A1 | It is produced by the strain of Streptomyces griseus ssp. sulphurus TU 1022 and Str. griseus TU 2437. Bafilomycin A1 is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM. It can inhibit the growth of gram-positive bacteria, negative bacteria, fungi, yeast and protozoa, and has the effects of insect killing, nematode killing and immunosuppression. Group: Pharmaceutical. Alternative Names: NSC 381866; NSC-381866; NSC381866; Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-; (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one; Hygrolidin, 21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-; (-)-Bafilomycin A1; Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[2-hydroxy-1-methyl-3-[tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-, [7R-[3Z,5E,7R*,8S*,9S*,11E,13E,15S*,16R*[1S*,2R*,3S*(2R*,4R*,5S*,6R*)]]]-. CAS No. 88899-55-2. Pack Sizes: 5 mg. Product ID: BBF-00625. Molecular formula: C35H58O9. Mole weight: 622.83. Custom synthesis is available. Send your inquirie |  London |
| Baicalein | Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor. Baicalein is a natural compound and can be used in cosmestics material. Uses: Neuroprotective; anticancer. Group: Pharmaceutical. Alternative Names: 5,6,7-Trihydroxyflavone; 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one; NSC 661431; Noroxylin; 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one. CAS No. 491-67-8. Pack Sizes: 5 g. Product ID: NP1936. Molecular formula: C15H10O5. Mole weight: 270.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Baicalin | Baicalin is a flavone found in several species in the genus Scutellaria, including Scutellaria baicalensis and Scutellaria lateriflora. Baicalin is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABA receptor. Baicalin can also absorb ultraviolet rays, scavenge oxygen free radicals, and inhibit the production of melanin. Therefore, it can be used in medicine and cosmetics. It is a good functional cosmetic raw material. Group: Pharmaceutical. Alternative Names: Baicalin;21967-41-9;Baicalein 7-O-glucuronide;7-D-Glucuronic acid-5,6-dihydroxyflavone;Baicalein 7-glucuronide;CHEBI:2981;MFCD00134418;347Q89U4M5;5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid;7-D-glucuronic acid-5,6-dihydroxy-flavone;CHEMBL485818;UNII-347Q89U4M5;5,6,7-trihydroxyflavone 7-O-beta-D-glucuronide;Baicalein 7-O-.beta.-D-glucuronide;beta-D-Glucopyranosidur. CAS No. 21967-41-9. Pack Sizes: 50 g. Product ID: BBF-03753. Molecular formula: C17H17ClN4. Mole weight: 320.8. Custom synthesis is available. Send your inquiries for more information. | London |
| Bakkenolide B | Bakkenolide B is isolated from the leaves of Petasites japonicus and exhibits anti-allergic and anti-inflammatory effects. Group: Pharmaceutical. Alternative Names: Fukinolide; (-)-Bakkenolide B. CAS No. 18455-98-6. Pack Sizes: 1 mg. Product ID: NP5640. Molecular formula: C22H30O6. Mole weight: 390.48. Custom synthesis is available. Send your inquiries for more information. | London |
| Bakuchiol | Bakuchiol is a phytoestrogen isolated from the seeds of Psoralea corylifolia L with anti-tumor, antioxidant, and antibacterial effects. Bakuchiol has a retinol-like effect on skin gene expression and properties. Bakuchiol inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 μM). Bakuchiol has hypoglycemic, hypolipidemic, anti-inflammatory, anti-wrinkle, soothing and liver protective, anticancer, antidepressant, and estrogen-like effects. Uses: Antioxidant. Group: Pharmaceutical. Alternative Names: Drupanol; Chiba; NSC-671195; NSC671195; NSC 671195; UP-256; UP256; UP 256; W1975; W 1975; W-1975; 4-[(1E,3S)-3-Ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol; Phenol, 4-(3-ethenyl-3,7-dimethyl-1,6-octadienyl)-, [S-(E)]-; Phenol, 4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadienyl]-; (+)-Bakuchiol; (S)-(+)-Bakuchiol; (S)-Bakuchiol; Bakutrol; Neuvachiol; Sytenol A. CAS No. 10309-37-2. Pack Sizes: 100 mg. Product ID: NP4619. Molecular formula: C18H24O. Mole weight: 256.38. Custom synthesis is available. Send your inquiries for more information. | London |
| Balanol | It is produced by the strain of Streptomyces sp. Tu 4128. Balanol, a fungal metabolite, is a potent ATP-competitive inhibitor of Protein Kinase C (PKC) and Protein Kinase A (PKA). It is an important target in oncology. Group: Pharmaceutical. Alternative Names: 4-(2-Carboxy-6-hydroxybenzoyl)-3,5-dihydroxybenzoic Acid (3R,4R)-Hexahydro-3-[(4-hydroxybenzoyl)amino]-1H-azepin-4-yl Ester; (3R-trans)-Balanol; (-)-Balanol; Azepinostatin; Ophiocordin. CAS No. 63590-19-2. Pack Sizes: 1mg;1g;10g. Product ID: BBF-00627. Molecular formula: C28H26N2O10. Mole weight: 550.53. Custom synthesis is available. Send your inquiries for more information. | London |
| (+)-Balanophonin | (+)-Balanophonin is a lignan isolated from the barks of Gmelina arborea and the seeds of Crataegus pinnatifida. Study indicates that (+)-Balanophonin inhibits the proliferation of OPM2 and RPMI-8226 cells. Group: Pharmaceutical. Alternative Names: (2E)-3-[(2S,3R)-2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-5-benzofuranyl]-2-propenal. CAS No. 215319-47-4. Pack Sizes: 5 mg. Product ID: B0005-053978. Molecular formula: C20H20O6. Mole weight: 356.37. Custom synthesis is available. Send your inquiries for more information. | London |
| Balofloxacin dihydrate | Balofloxacin is a fluoroquinolone antibiotic. Balofloxacin is used to treat a variety of bacterial infections of the urinary tract and lungs. It is sold under the brand name Q-Roxin in Korea. It is not approved by the FDA for use in the United States. Group: Pharmaceutical. Alternative Names: Neuroquinoron; (+/-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)-1-piperidinyl]-4-oxo-3-quinolinecarboxylic Acid Dihydrate. CAS No. 151060-21-8. Pack Sizes: 1mg;1g;10g. Product ID: 151060-21-8. Molecular formula: C20H28FN3O6. Mole weight: 425.45. Custom synthesis is available. Send your inquiries for more information. | London |
| Baloxavir | Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Group: Pharmaceutical. Alternative Names: Baloxavir acid; BXA; Xofluza; S-033447. CAS No. 1985605-59-1. Pack Sizes: 50 mg. Product ID: B2692-008721. Molecular formula: C24H19F2N3O4S. Mole weight: 483.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Baloxavir-[d4] | Baloxavir-[d4] is an isotope compound of Baloxavir. Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Group: Pharmaceutical. CAS No. 2415027-80-2. Pack Sizes: 2 mg. Product ID: BLP-003387. Molecular formula: C24H15D4F2N3O4S. Mole weight: 487.51. Custom synthesis is available. Send your inquiries for more information. | London |
| Baloxavir marboxil | Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Group: Pharmaceutical. Alternative Names: S-033188; HY-109025. CAS No. 1985606-14-1. Pack Sizes: 50 mg. Product ID: B2692-291710. Molecular formula: C27H23F2N3O7S. Mole weight: 571.55. Custom synthesis is available. Send your inquiries for more information. | London |
| Balsalazide disodium | Balsalazide disodium is the disodium salt form of balsalazide which is a sulfasalazine analogue and can be synthesized from 4-aminobenzoyl-β-alanine (ABA). Balsalazide was approved for the treatment of mild-to-moderate active UC and as an anti-inflammatory drug. Group: Pharmaceutical. Alternative Names: Balsalazide sodium; disodium (3Z)-3-[[4-(2-carboxylatoethylcarbamoyl)phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylate. CAS No. 82101-18-6. Pack Sizes: 1mg;1g;10g. Product ID: 82101-18-6. Molecular formula: C17H13N3O6.2Na. Mole weight: 401.286. Custom synthesis is available. Send your inquiries for more information. | London |
| Balsalazide disodium dihydrate | Balsalazide disodium dihydrate is the disodium salt form of balsalazide which is a sulfasalazine analogue and can be synthesized from 4-aminobenzoyl-β-alanine (ABA). Balsalazide was approved for the treatment of mild-to-moderate active UC and as an anti-inflammatory drug. Group: Pharmaceutical. Alternative Names: Balsalazide disodium salt dihydrate; disodium (3E)-3-[[4-(2-carboxylatoethylcarbamoyl)phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylate;dihydrate. CAS No. 150399-21-6. Pack Sizes: 1mg;1g;10g. Product ID: 150399-21-6. Molecular formula: C17H13N3O6.2Na.2H2O. Mole weight: 437.316. Custom synthesis is available. Send your inquiries for more information. | London |
| BAM 15 | BAM 15 is a novel mitochondrial protonophore uncoupler that uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). BAM 15 cannot depolarize the plasma membrane, and protects mice from acute renal ischemic-reperfusion injury. BAM 15 has the potential to treat obesity, Parkinson's disease, and aging. Group: Pharmaceutical. Alternative Names: BAM15; BAM-15; N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine; N-[6-(2-Fluoroanilino)[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl]-N-(2-fluorophenyl)amine. CAS No. 210302-17-3. Pack Sizes: 100 mg. Product ID: B1370-119162. Molecular formula: C16H10F2N6O. Mole weight: 340.29. Custom synthesis is available. Send your inquiries for more information. | London |
| Baohuoside II | IKarisoside A is a natural compound isolated from Epimedium koreanum, which has anti-inflammatory properties. Uses: Cardioprotective effect. Group: Pharmaceutical. Alternative Names: Icarisoside A. CAS No. 55395-07-8. Pack Sizes: 5 mg. Product ID: NP1956. Molecular formula: C26H28O10. Mole weight: 500.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Baohuoside V | Baohuoside V is extracted from the herbs of Epimedium brevicornum Maxim. Group: Pharmaceutical. Alternative Names: 3-[[6-Deoxy-2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-mannopyranosyl]oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; Diphylloside B. CAS No. 118544-18-6. Pack Sizes: 5 mg. Product ID: B0005-465723. Molecular formula: C38H48O19. Mole weight: 808.8. Custom synthesis is available. Send your inquiries for more information. | London |
| Baohuoside VII | Baohuoside VII is a compound of the flavonoid class found in the herbs of Epimedium brevicornum Maxim. Group: Pharmaceutical. Alternative Names: 3-[(2S,3R,4S,5R,6S)-3,4-dihydroxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one. CAS No. 119730-89-1. Pack Sizes: 5 mg. Product ID: B0005-053790. Molecular formula: C33H40O15. Mole weight: 676.668. Custom synthesis is available. Send your inquiries for more information. | London |
| Baquiloprim | Baquiloprim is an antifolate that can be used as an antibacterial. Group: Pharmaceutical. Alternative Names: 5-(8-Dimethylamino-7-methylquinolin-5-ylmethyl)-pyrimidine-2,4-diamine. CAS No. 102280-35-3. Pack Sizes: 1mg;1g;10g. Product ID: 102280-35-3. Molecular formula: C17H20N6. Mole weight: 308.389. Custom synthesis is available. Send your inquiries for more information. | London |
| BAR-501 | BAR-501, a UDCA derivative, is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR-501 effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with a EC50 of 1 μM. Besides, it protects against development of portal hypertension in rodent models of liver injury and endothelial dysfunction. Group: Pharmaceutical. Alternative Names: 3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol; BAR-501; BAR 501; BAR501. CAS No. 1632118-69-4. Pack Sizes: 10 mg. Product ID: B0084-482211. Molecular formula: C26H46O3. Mole weight: 406.651. Custom synthesis is available. Send your inquiries for more information. | London |
| BAR502 | BAR502 is a dual FXR and GPBAR1 agonist (IC50= 2 μM and 0.4 μM for FXR and GPBAR1, respectively). Group: Pharmaceutical. Alternative Names: BAR-502; BAR 502; BAR502; (5S,8S,9R,10S,13R,14S,17R)-6-ethyl-17-(4-hydroxybutan-2-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol. CAS No. 1612191-86-2. Pack Sizes: 5 mg. Product ID: B0084-007371. Molecular formula: C25H44O3. Mole weight: 392.62. Custom synthesis is available. Send your inquiries for more information. | London |
| Bardoxolone | Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events. Group: Pharmaceutical. Alternative Names: CDDO; RTA 401; RTA401; RTA-401. CAS No. 218600-44-3. Pack Sizes: 25 mg. Product ID: B0084-427947. Molecular formula: C31H41NO4. Mole weight: 491.66. Custom synthesis is available. Send your inquiries for more information. | London |
| Bardoxolone methyl | Bardoxolone methyl (also known as "RTA 402" and "CDDO-methyl ester") is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class. It is the most potent known inducer of the Nrf2 pathway to enter clinical development and works to suppress both oxidative stress and inflammation. Uses: Bardoxolone methyl, also known as rta 402, is a semisynthetic derivative of oleanolic acid that has attracted much attention in the medical community for its potential to treat a variety of chronic diseases, especially chronic kidney disease (ckd). as a member of the antioxidant inflammatory modulator (aim) class of drugs, bardoxolone methyl exerts its therapeutic effects by targeting inflammation. Group: Pharmaceutical. Alternative Names: CDDO Methyl ester; CDDOMe; RTA 402; RTA-402; RTA402; TP-155; TP155; TP 155; 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid methyl ester; bardoxolone methyl; CDDO-Me; methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate; (4aS,6aR,6bS,8aR,12aS,14bS)-Methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate. CAS No. 218600-53-4. Pack Sizes: 250 mg. Product ID: BAT-008967. Molecular formula: C32H43NO4. Mole weight: 505.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Baricitinib | Baricitinib is a selective and orally bioactive inhibitor of JAK1 and JAK2. It has been approved by FDA for the treatment of rheumatoid arthritis (RA). Uses: The treatment of rheumatoid arthritis (ra). Group: Pharmaceutical. Alternative Names: LY3009104; 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile; Olumiant. CAS No. 1187594-09-7. Pack Sizes: 1 g. Product ID: B0084-457382. Molecular formula: C16H17N7O2S. Mole weight: 371.419. Custom synthesis is available. Send your inquiries for more information. | London |
| Baricitinib phosphate | Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM). Baricitinib has been approved by FDA for the treatment of rheumatoid arthritis (RA). Group: Pharmaceutical. Alternative Names: INCB 028050; LY 3009104; INCB028050; LY3009104; LY-3009104; INCB-028050. CAS No. 1187595-84-1. Pack Sizes: 25 g. Product ID: B1370-463116. Molecular formula: C16H20N7O6PS. Mole weight: 469.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Barnidipine-[d5] | Barnidipine-[d5] is a stable isotope form of Barnidipine which is a calcium channel blocker. Group: Pharmaceutical. Alternative Names: 3-(3S)-1-[(D5)benzyl]pyrrolidin-3-yl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (S)-3-((S)-1-Benzylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate-d5. Pack Sizes: 5 mg. Product ID: BLP-003392. Molecular formula: C27H24D5N3O6. Mole weight: 496.57. Custom synthesis is available. Send your inquiries for more information. | London |
| Basmisanil | Basmisanil is a highly selective inverse agonist/negative allosteric modulator GABAAα5 receptors. It was developed by Roche to treat cognitive impairment associated with Down syndrome. In Apr 2016, Roche completed the phase II in Down syndrome (In adolescents, In adults) in USA, Argentina, Canada, France, Italy, Mexico, New Zealand, Singapore, Spain and the UK. In Sep 2016, Phase-II clinical trials in Neurological disorders (In adults, In the elderly) in Spain was on going. Uses: Down syndrome; neurological disorders. Group: Pharmaceutical. Alternative Names: (1,1-dioxidothiomorpholino)(6-((3-(4-fluorophenyl)-5-methylisoxazol-4-yl)methoxy)pyridin-3-yl)methanone; RG 1662; RG-1662; RG1662; RO5186582; RO-5186582; RO 5186582. CAS No. 1159600-41-5. Pack Sizes: 100 mg. Product ID: B2693-475111. Molecular formula: C21H20FN3O5S. Mole weight: 445.47. Custom synthesis is available. Send your inquiries for more information. | London |
| Batabulin sodium | Batabulin sodium is a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity. T138067 covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton. Group: Pharmaceutical. Alternative Names: T138067 sodium; T138067-sodium; T 138067 sodium; T 67; D03059; D 03059; D-03059; T-138067 sodium. CAS No. 195533-53-0. Pack Sizes: 50 mg. Product ID: B2693-305409. Molecular formula: C13H7F6NO3S. Mole weight: 371.253. Custom synthesis is available. Send your inquiries for more information. | London |
| Batefenterol | Batefenterol is a Beta 2 adrenergic receptor agonist and also a Muscarinic receptor antagonist. It shows high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic receptors (Ki = 1.3 nM) and hβ2-adrenoceptors (Ki = 3.7 nM). Batefenterol is a hβ2-adrenoceptor agonist with EC50 value of 0.29 nM for stimulation of cAMP levels. This is 440- and 320-fold functional selectivity over hβ1- and hβ3-adrenoceptors. In Jul 2016, GlaxoSmithKline completed a phase II trial for Chronic obstructive pulmonary disease in USA, Germany and South Africa. Uses: Chronic obstructive pulmonary disease. Group: Pharmaceutical. Alternative Names: GSK-961081; TD-5959; GSK 961081; TD 5959; GSK961081; TD5959; (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate. CAS No. 743461-65-6. Pack Sizes: 25 mg. Product ID: B0084-476591. Molecular formula: C40H42ClN5O7. Mole weight: 740.25. Custom synthesis is available. Send your inquiries for more information. | London |
| Batefenterol Succinate | Batefenterol is a beta 2 adrenergic receptor agonist and also a muscarinic receptor antagonist. It shows high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic receptors (Ki = 1.3 nM) and hβ2-adrenoceptors (Ki = 3.7 nM). Batefenterol is a hβ2-adrenoceptor agonist with EC50 value of 0.29 nM for stimulation of cAMP levels. This is 440- and 320-fold functional selectivity over hβ1- and hβ3-adrenoceptors. Group: Pharmaceutical. Alternative Names: Batefenterol Succinate; 945905-37-3; UNII-552KVF22JT; Batefenterol succinate [USAN]552KVF22JT. CAS No. 945905-37-3. Pack Sizes: 25 mg. Product ID: B2693-383251. Molecular formula: C44H48ClN5O11. Mole weight: 858.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Batimastat | Batimastat (also known as BB-94) is a synthetic matrix metalloproteinase inhibitor that has shown antineoplastic and antiangiogenic activity in various tumor models. Batimastat acts as an inhibitor of metalloproteinase activity by binding the zinc ion in the active site of MMPs. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: (2S,3R)-N-Hydroxy-N'-[(2S)-1-methylamino-1-oxo-3-phenylpropan-2-yl]-3-(2-methylpropyl)-2-(thiophen-2-ylsulfanylmethyl)butanediamide; BB94; BB-94; BB 94. CAS No. 130370-60-4. Pack Sizes: 10 mg. Product ID: B2693-082981. Molecular formula: C23H31N3O4S2. Mole weight: 477.638. Custom synthesis is available. Send your inquiries for more information. | London |
| Baumycin C1 | Baumycin C1, an impurity of Daunorubicin and Doxorubicin, is an anthracycline antibiotic isolated from Streptomyces coeruleorubidus. Baumycin C1 shows antitumor activity. Group: Pharmaceutical. Alternative Names: N-((2S,3S,4S,6R)-6-(((1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)-3-hydroxy-2-methyltetrahydro-2H-pyran-4-yl)formamide; N-Formyldaunorubicin; NSC 227012; 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-((2,3,6-trideoxy-3-(formylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-, (8S-cis)-; (8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[(3-(formylamino)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-5,12-naphthacenedione. CAS No. 63084-42-4. Pack Sizes: 1mg;1g;10g. Product ID: BBF-00272. Molecular formula: C28H29NO11. Mole weight: 555.53. Custom synthesis is available. Send your inquiries for more information. | London |
| Bavachin | Bavachin, a natural phytoestrogen found in the fruits of Psoralea corylifolia L, potentially protects cartilage from inflammation-mediated damage in joints of osteoarthritis patients through decreasing IL-1β-induced activation of IKK-IκBα-NF-κB signaling pathway. Bavachin also exhibits the activities of antioxidant, antimutagenic and weak phytoestrogen by binding and activating the estrogen receptor. Group: Pharmaceutical. Alternative Names: 4H-1-benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten -1-yl)-;7-Hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-chromen -4-one. CAS No. 19879-32-4. Pack Sizes: 50 mg. Product ID: NP1866. Molecular formula: C20H20O4. Mole weight: 324.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Bavachinin | Bavachinin is a natural compound isolated from the Chinese herb Fructus Psoraleae. Bavachinin has potent anti-angiogenic activity in vitro and in vivo. Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α. It significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model. Uses: Antiinflammatory; antipyretic; analgesic. Group: Pharmaceutical. Alternative Names: 7-O-Methylbavachin; Bavachinin A. CAS No. 19879-30-2. Pack Sizes: 100 mg. Product ID: NP1951. Molecular formula: C21H22O4. Mole weight: 338.4. Custom synthesis is available. Send your inquiries for more information. | London |
| BAY-1895344 | BAY-1895344 is a selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor that inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). BAY-1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas, and it is undergoing a phase I clinical trial of safety and tolerability for cancer patients. Uses: A selective atr (ataxia-telangiectasia and rad3 related protein) inhibitor used for the treatment of advanced solid tumors and lymphomas. Group: Pharmaceutical. Alternative Names: BAY-1895344; BAY 1895344; BAY1895344; (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine. CAS No. 1876467-74-1. Pack Sizes: 10 mg. Product ID: B0084-484682. Molecular formula: C20H21N7O. Mole weight: 375.181. Custom synthesis is available. Send your inquiries for more information. | London |
| BAY-218 | BAY-218, which is known as BAY-2335218, is a potent and selective small-molecule AhR inhibitor with an IC50 of 39.9 nM in human cell line. It is a new modality to counteract tumor immunosuppression. Group: Pharmaceutical. Alternative Names: BAY 218; BAY218; BAY-2335218; BAY 2335218; BAY2335218; (S)-6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide; AHR antagonist 1. CAS No. 2162982-11-6. Pack Sizes: 100 mg. Product ID: B1370-291455. Molecular formula: C20H17ClFN3O3. Mole weight: 401.82. Custom synthesis is available. Send your inquiries for more information. | London |
| BAY 2416964 | BAY 2416964 is a potent, orally active, aromatic hydrocarbon receptor (AHR) antagonist, which has the potential to treat solid tumors. Group: Pharmaceutical. Alternative Names: BAY2416964; (S)-6-(4-Chlorophenyl)-N-(1-Hydroxypropan-2-Yl)-2-(1-Methyl-1H-Pyrazol-4-Yl)-3-Oxo-2,3-Dihydropyridazine-4-Carboxamide. CAS No. 2242464-44-2. Pack Sizes: 100 mg. Product ID: B1370-373127. Molecular formula: C18H18ClN5O3. Mole weight: 387.82. Custom synthesis is available. Send your inquiries for more information. | London |
| BAY 299 | BAY 299 is a potent and selective inhibitor of BRD1 and TAF1 (IC50 = 6-67 and 8-13 nM, respectively) with selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). BAY 299 suppresses binding of BRD1 and TAF1 to histone H4 (IC50 = 575 nM and 0.9 μM, respectively) and histone H3.3 (IC50 = 825 nM and 1.4 μM, respectively). Group: Pharmaceutical. Alternative Names: BAY-299; BAY 299; BAY299. 6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione. CAS No. 2080306-23-4. Pack Sizes: 25 mg. Product ID: B0084-119159. Molecular formula: C25H23N3O4. Mole weight: 429.47. Custom synthesis is available. Send your inquiries for more information. | London |
| BAY 41-4109 | BAY 41-4109 is a novel drug inhibiting hepatitis B virus capsid formation and replication. Group: Pharmaceutical. Alternative Names: BAY-41-4109; BAY41-4109; BAY 41-4109; BAY-414109; BAY414109; BAY 414109. methyl (4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate. CAS No. 298708-81-3. Pack Sizes: 2 mg. Product ID: B0084-475623. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.766. Custom synthesis is available. Send your inquiries for more information. | London |
| BAY-57-1293 | BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex. Potent helicase-primase inhibitor (HPI) effective against herpes simplex virus (HSV) infections with IC50 value of 20 nM for inhibition of the replication of both HSV-1 and HSV-2 in Vero cells, and ED50 value of 0.5 mg/kg for both HSV-1 and HSV-2 in the murine lethal challenge model of disseminated herpes. Uses: For research used only. Group: Pharmaceutical. Alternative Names: Pritelivir; BAY-57-1293; BAY 57-1293; BAY-57 1293; BAY 57 1293; BAY571293; AIC316; AIC 316; AIC-316. CAS No. 348086-71-5. Pack Sizes: 100 mg. Product ID: B0084-459053. Molecular formula: C18H18N4O3S2. Mole weight: 402.49. Custom synthesis is available. Send your inquiries for more information. | London |
| BAY-876 | BAY-876 is a potent and selective inhibitor of GLUT1, which is overexpressed in multiple cancers. Uses: Anticancer agent. Group: Pharmaceutical. Alternative Names: BAY-876; BAY 876; BAY876. 4-N-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide. CAS No. 1799753-84-6. Pack Sizes: 100 mg. Product ID: B0084-053992. Molecular formula: C24H16F4N6O2. Mole weight: 496.426. Custom synthesis is available. Send your inquiries for more information. | London |
| BAY-985 | BAY-985 is a highly effective, orally active and selective TANK-binding kinase 1 (TBK1) and IκB kinase ε dual inhibitor, with anti-tumor activity. Group: Pharmaceutical. Alternative Names: BAY985; GTPL10597; EX-A3294. CAS No. 2409479-29-2. Pack Sizes: 100 mg. Product ID: B1370-373113. Molecular formula: C27H30F3N9O. Mole weight: 553.6. Custom synthesis is available. Send your inquiries for more information. | London |
| (±)-Bay K 8644 | (±)-Bay K 8644 is a L-type Ca2+ channel activator. It exhibits positive inotropic, vasoconstrictive and behavioral effects in vivo. Uses: Reprogramming. Group: Pharmaceutical. Alternative Names: Bay K 8644; (+/-)-BAY K 8644; BAY-K-8644; methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate. CAS No. 71145-03-4. Pack Sizes: 25 mg. Product ID: B2693-462890. Molecular formula: C16H15F3N2O4. Mole weight: 356.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Bayogenin 3-O-β-D-glucopyranoside | Bayogenin 3-O-β-D-glucopyranoside is a triterpenoid saponin isolated from the aerial parts of Polygala japonica Houtt. Group: Pharmaceutical. Alternative Names: 2beta,23-Dihydroxy-3beta-(beta-D-glucopyranosyloxy)oleana-12-ene-28-oic acid. CAS No. 104513-86-2. Pack Sizes: 5 mg. Product ID: B0005-053787. Molecular formula: C36H58O10. Mole weight: 650.85. Custom synthesis is available. Send your inquiries for more information. | London |
| Bazedoxifene acetate | Bazedoxifene acetate, also called as TSE424 or WAY-140424, is a selective nonsteroidal estrogen receptor modulator (SERM) with antiosteoporotic activity (ERα: IC50= 26 nM; ERβ= 99 nM). Uses: Bone density conservation agents. Group: Pharmaceutical. Alternative Names: TSE 424; TSE-424; TSE424; WAY-140424; WAY 140424; WAY140424. CAS No. 198481-33-3. Pack Sizes: 1 g. Product ID: B2693-206133. Molecular formula: C32H38N2O5. Mole weight: 530.66. Custom synthesis is available. Send your inquiries for more information. | London |
| BCN-OH | BCN-OH is an alcohol functionalized cyclooctyne derivative. Group: Pharmaceutical. Alternative Names: (1alpha,8alpha,9beta)-Bicyclo[6.1.0]non-4-yn-9-ylmethanol; Rel-((1R,8S,9r)-bicyclo[6.1.0]non-4-yn-9-yl)methanol. CAS No. 1263166-90-0. Pack Sizes: 1 g. Product ID: BB054510. Molecular formula: C10H14O. Mole weight: 150.22. Custom synthesis is available. Send your inquiries for more information. | London |
| BCN-PEG4-NHS ester | BCN-endo-PEG4-NHS is an ADC Linker containing 4 PEG units. Group: Pharmaceutical. Alternative Names: BCN-endo-PEG4-NHS; BCN-endo-PEG4-SPA; BCN-exo-PEG4-NHS; rel-2,5-Dioxopyrrolidin-1-yl 1-((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oate. CAS No. 1702356-19-1. Pack Sizes: 50 mg. Product ID: BADC-00415. Molecular formula: C26H38N2O10. Mole weight: 538.59. Custom synthesis is available. Send your inquiries for more information. | London |
| BD 1047 dihydrobromide | The dihydrobromide salt form of BD-1047, a selective σ1 receptor antagonist, has been found to have antipsychotic effect and could be probably used against schizophrenia and neuropathic pain. Uses: Bd 1047 dihydrobromide is a selective antagonist of σ receptors. Group: Pharmaceutical. Alternative Names: BD-1047 (dihydrobromide); BD-1047 dihydrobromide; N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide. CAS No. 138356-21-5. Pack Sizes: 1 g. Product ID: B1370-361794. Molecular formula: C13H22Br2Cl2N2. Mole weight: 437.04. Custom synthesis is available. Send your inquiries for more information. | London |
| BD140 [for Albumin binding assay] | BD140 [for Albumin binding assay]. Group: Pharmaceutical. Alternative Names: 2,2-difluoro-6-methyl-4-[(E)-2-(4-propoxyphenyl)ethenyl]-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaene; 4,4-Difluoro-1-methyl-3-(4-propoxystyryl)-4-bora-3a,4a-diaza-s-indacene; (E)-5,5-Difluoro-1-methyl-3-(4-propoxystyryl)-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine. CAS No. 1201643-08-4. Pack Sizes: 100 mg. Product ID: F01-0255. Molecular formula: C21H21BF2N2O. Mole weight: 366.22. Custom synthesis is available. Send your inquiries for more information. | London |
| BDA-366 | BDA-366 is a small-molecule antagonist of Bcl2-BH4 domain with high affinity and selectivity for Bcl2-BH4. BDA-366 induces apoptosis in multiple myeloma cells via Bcl2 conformational change. Group: Pharmaceutical. Alternative Names: BDA-366; BDA 366; BDA366; 1-[[(2S)-3-(diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-oxiran-2-yl]methylamino]anthracene-9,10-dione. CAS No. 1909226-00-1. Pack Sizes: 300 mg. Product ID: B0084-053991. Molecular formula: C24H29N3O4. Mole weight: 423.513. Custom synthesis is available. Send your inquiries for more information. | London |
| BDY FL, SE | BODIPY dyes are used to generate fluorescent conjugates of proteins, nucleotides, oligonucleotides and dextrans, as well as to prepare fluorescent enzyme substrates, fatty acids, phospholipids, lipopolysaccharides, receptor ligands and polystyrene microspheres. Group: Pharmaceutical. Alternative Names: 3-(3-((2,5-dioxopyrrolidin-1-yl)oxy)-3-oxopropyl)-5,5-difluoro-7,9-dimethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide; 7-(3-((2,5-Dioxopyrrolidin-1-yl)oxy)-3-oxopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide; 4,4-Difluoro-5,7-Dimethyl-4-Bora-3a,4a-Diaza-s-Indacene-3-Propionic Acid, Succinimidyl Ester; BDP FL NHS ester. CAS No. 146616-66-2. Pack Sizes: 50 mg. Product ID: B0245-118888. Molecular formula: C18H18BF2N3O4. Mole weight: 389.166. Custom synthesis is available. Send your inquiries for more information. | London |
| Beauveriolide I | Beauveriolide I is produced by the strain of Beauveria sp. FO-6979. The effect of I and III can inhibit the formation of Lipid droplet. 10μmol/L can reduce the number and size of the cytolipid droplet in the macrophage but it is not cytotoxic to the macrophages. Group: Pharmaceutical. Alternative Names: CHEMBL516093; SCHEMBL15474166. CAS No. 154491-55-1. Pack Sizes: 1mg;1g;10g. Product ID: BBF-00273. Molecular formula: C27H41N3O5. Mole weight: 487.63. Custom synthesis is available. Send your inquiries for more information. | London |
| Beauveriolide III | Beauveriolide III is produced by the strain of Beauveria sp. FO-6979. The effect of I and III can inhibit the formation of Lipid droplet. 10μmol/L can reduce the number and size of the cytolipid droplet in the macrophage but it is not cytotoxic to the macrophages. Group: Pharmaceutical. Alternative Names: CHEMBL409855; SCHEMBL16174055. CAS No. 221111-70-2. Pack Sizes: 1mg;1g;10g. Product ID: BBF-00274. Molecular formula: C27H41N3O5. Mole weight: 487.63. Custom synthesis is available. Send your inquiries for more information. | London |
| BEC HCl | BEC HCl is an Arginase II inhibitor(Ki=0.31μM).In vitro,BEC HCl enhances NO-dependent smooth muscle relaxation by binding to arginase as a transition state analogue.In vivo,BEC HCl enhances peribronchiolar and perivascular inflammation in mice. Group: Pharmaceutical. Alternative Names: (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid hydrochloride. CAS No. 222638-67-7. Pack Sizes: 25 mg. Product ID: B0084-245384. Molecular formula: C5H13BClNO4S. Mole weight: 229.482. Custom synthesis is available. Send your inquiries for more information. | London |
| Bedaquiline | TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB. Group: Pharmaceutical. Alternative Names: Sirturo; TMC207; TMC-207; TMC 207; R207910; R-207910; R 207910. CAS No. 843663-66-1. Pack Sizes: 100 mg. Product ID: B0084-152490. Molecular formula: C32H31BrN2O2. Mole weight: 555.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Bedaquiline fumarate | Bedaquiline fumarate is an anti-tuberculosis drug which selectively inhibits the mycobacterial energy metabolism and found to be effective against all states of Mycobacterium tuberculosis. It possesses a unique mechanism of action that disrupts the activity of the mycobacterial adenosine triphosphate synthase. It has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis, however, its side effect profile limits its use against MDR-TB when no other effective regimen can be provided. Uses: Antitubercular agents. Group: Pharmaceutical. Alternative Names: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol fumarate. CAS No. 845533-86-0. Pack Sizes: 200 mg. Product ID: B0084-463644. Molecular formula: C36H35BrN2O6. Mole weight: 671.58. Custom synthesis is available. Send your inquiries for more information. | London |
| Belinostat | Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor. Belinostat targets HDAC enzymes to inhibit tumor cell proliferation and angiogenesis, induce apoptosis and promote cellular differentiation. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: Belinostat; PXD 101; Beleodaq; PDX101; PX 105684; PXD-101; PXD101; (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide. CAS No. 414864-00-9. Pack Sizes: 100 mg. Product ID: B0084-141764. Molecular formula: C15H14N2O4S. Mole weight: 318.347. Custom synthesis is available. Send your inquiries for more information. | London |
| Bellidifolin | Bellidifolin is a xanthone that can be isolated from the plants of Gentiana species. Study shows that bellidifolin is a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Bellidifolin may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms related to inhibition of cell apoptosis independent of the ERK pathway, but may involve blockade of p38MAPK signaling pathway activation and downstream caspase-3 expression. Group: Pharmaceutical. Alternative Names: 1,5,8-Trihydroxy-3-methoxy-9H-xanthen-9-one. CAS No. 2798-25-6. Pack Sizes: 5 mg. Product ID: NP7359. Molecular formula: C14H10O6. Mole weight: 274.228. Custom synthesis is available. Send your inquiries for more information. | London |
| Belnacasan | Belnacasan is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. Belnacasan inhibits interlukin-1β biosynthesis. Group: Pharmaceutical. Alternative Names: VX 765, VX765, VX-765, Belnacasan; (2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide. CAS No. 273404-37-8. Pack Sizes: 50 mg. Product ID: B0084-307700. Molecular formula: C24H33ClN4O6. Mole weight: 509. Custom synthesis is available. Send your inquiries for more information. | London |
| Belotecan hydrochloride | Belotecan hydrochloride is a topoisomerase I inhibitor. It is a synthetic and water-soluble camptothecin derivative which forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. CKD-602 has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group. Group: Pharmaceutical. Alternative Names: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-, hydrochloride (1:1), (4S)-; (S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride; CKD 602; Belotecan monohydrochloride; (4S)-4-Ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride; 7-[2-(N-Isopropylamino)ethyl]-(20S)-camptothecin hydrochloride; Camtobell hydrochloride. CAS No. 213819-48-8. Pack Sizes: 20 mg. Product ID: B0084-087456. Molecular formula: C25H27N3O4.HCl. Mole weight: 469.96. Custom synthesis is available. Send your inquiries for more information. | London |
| Bemcentinib | Bemcentinib is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metast | London |
| Benalaxyl | Benalaxyl is an internal fungicide, used to control grape downy mildew, potato, strawberry, and other phytophthora disease. Uses: An acylamino acid fungicide. Group: Pharmaceutical. Alternative Names: Alanine, N-(2,6-dimethylphenyl)-N-(2-phenylacetyl)-, methyl ester; DL-Alanine, N-(2,6-dimethylphenyl)-N-(phenylacetyl)-, methyl ester; Alanine, N-(2,6-dimethylphenyl)-N-(phenylacetyl)-, methyl ester; (±)-Benalaxyl; Galben; Galben R 4-33 Blu; M 9834; methyl N-(2,6-dimethylphenyl)-N-(2-phenylacetyl)alaninate. CAS No. 71626-11-4. Pack Sizes: 1mg;1g;10g. Product ID: 71626-11-4. Molecular formula: C20H23NO3. Mole weight: 325.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Benalaxyl-M | Benalaxyl-M is an isomer of Benalaxyl, which is a fungicide. Group: Pharmaceutical. Alternative Names: N-(2,6-Dimethylphenyl)-N-(phenylacetyl)-Dalanine methyl ester. CAS No. 98243-83-5. Pack Sizes: 1mg;1g;10g. Product ID: 98243-83-5. Molecular formula: C20H23NO3. Mole weight: 325.408. Custom synthesis is available. Send your inquiries for more information. | London |
| Benazeprilat | Benazeprilat is the active metabolite of benazepril, formed after cleavage of the ester group. It is a potent inhibitor of angiotensin-converting enzyme (ACE). Group: Pharmaceutical. Alternative Names: Benazepril Related Compound C; Benazepril USP Related Compound C; Benazepril Diacid; (3S)-3-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid. CAS No. 86541-78-8. Pack Sizes: 50 mg. Product ID: B1370-148959. Molecular formula: C22H24N2O5. Mole weight: 396.45. Custom synthesis is available. Send your inquiries for more information. | London |
| Benazepril EP Impurity G | Benazepril EP Impurity G is an ethyl ester derivative of Benazepril, which is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Group: Pharmaceutical. Alternative Names: Benazepril Related Compound G; Benazepril USP Related Compound G; Benazepril ethyl ester; (S)-Ethyl 2-(((S)-1-(2-ethoxy-2-oxoethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)amino)-4-phenylbutanoate; (3-(1-Ethoxycarbonyl-3-phenyl-(1S)-propyl)amino-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine)-1-acetic Acid ethyl Ester. CAS No. 103129-58-4. Pack Sizes: 25 mg. Product ID: B1370-151604. Molecular formula: C26H32N2O5. Mole weight: 452.54. Custom synthesis is available. Send your inquiries for more information. | London |
| Benazepril hydrochloride | Benazepril is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Group: Pharmaceutical. Alternative Names: 2-((S)-3-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid hydrochloride; 1H-1-Benzazepine-1-acetic acid, 3-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, hydrochloride (1:1), (3S)-; 1H-1-Benzazepine-1-acetic acid, 3-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, monohydrochloride, (3S)-; 1H-1-Benzazepine-1-acetic acid, 3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, monohydrochloride, [S-(R*,R*)]-; CGS 14824A; CGS 14824A HCl; Lotensin; Lotension. CAS No. 86541-74-4. Pack Sizes: 1mg;1g;10g. Product ID: NP3422. Molecular formula: C24H28N2O5.HCl. Mole weight: 460.95. Custom synthesis is available. Send your inquiries for more information. | London |
| Bendamustine Chloro Dimer Impurity | Bendamustine Chloro Dimer Impurity is an impurity of Bendamustine, a chemotherapy medication indicated for the treatment of chronic lymphocytic leukemia, multiple myeloma, and non-Hodgkin's lymphoma. Group: Pharmaceutical. Alternative Names: Bendamustine Dimer Impurity; 5-[bis(2-Chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid 2-[[2-(3-Carboxypropyl)-1-methyl-1H-benzimidazol-5-yl](2-chloroethyl)amino]ethyl Ester. CAS No. 1228551-91-4. Pack Sizes: 10 mg. Product ID: B2694-467289. Molecular formula: C32H41Cl3N6O4. Mole weight: 680.08. Custom synthesis is available. Send your inquiries for more information. | London |
| Bendamustine hydrochloride | Bendamustine hydrochloride is the hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Group: Pharmaceutical. Alternative Names: SDX-105 (Cytostasane) HCl; SDX 105 (Cytostasane) HCl; SDX105 (Cytostasane) HCl. CAS No. 3543-75-7. Pack Sizes: 500 mg. Product ID: NP3323. Molecular formula: C16H21Cl2N3O2.HCl. Mole weight: 394.72. Custom synthesis is available. Send your inquiries for more information. | London |
| Bendamustine Related Compound C | Bendamustine Related Compound C is an impurity of Bendamustine. Bendamustine is a DNA alkylating agent used for the treatment of chronic lymphocytic leukemia (CLL). Group: Pharmaceutical. Alternative Names: Bendamustine USP RC C; Bendamustine USP Related Compound C; 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester; 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acidethylester; 1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester. CAS No. 3543-74-6. Pack Sizes: 1mg;1g;10g. Product ID: NP3325. Molecular formula: C18H27N3O4. Mole weight: 349.43. Custom synthesis is available. Send your inquiries for more information. | London |
| Bendroflumethiazide-[d5] | Bendroflumethiazide-[d5] is a labelled Bendroflumethiazide. Bendroflumethiazide is a diuretic used to treat hypertension. Group: Pharmaceutical. Alternative Names: rac Bendroflumethiazide-d5; 3,4-Dihydro-3-(phenylmethyl-d5)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide; 3-(Benzyl-d5)-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4- benzothiadiazine-7-sulfonamide 1,1-Dioxide; Aprinox-d5; Be 724A-d5. CAS No. 1330183-13-5. Pack Sizes: 10 mg. Product ID: BLP-013872. Molecular formula: C15H9F3N3O4S2D5. Mole weight: 426.45. Custom synthesis is available. Send your inquiries for more information. | London |
| Benfotiamine | Benfotiamine is an amphiphilic S-acyl thiamine derivative used as a lipid soluble alternative source of bioavailable thiamine. Benfotiamine is being investigated in a variety of therapeutic applications. Uses: Adjuvants, immunologic. Group: Pharmaceutical. Alternative Names: Benzenecarbothioic acid, S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester; Benzoylthiamine monophosphate; Berdi; Betivina; Bietamine; Biotamin; Milgamma; Nitanevril; S-Benzoylthiamine O-monophosphate; Tabiomyl; Vitanevril; BTMP; Benzenecarbothioic acid, S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester; Benzoic acid, thio-, S-ester with N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide dihydrogen phosphate (ester); Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)-, S-benzoate O-(dihydrogen phosphate); 8088CB; Benfothiamine; Benzoylthiamine O-monophosphate; N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide S-benzoate O-phosphate; Neurostop; S-Benzoylthiamine monophosphate. CAS No. 22457-89-2. Pack Sizes: 500 g. Product ID: B1370-063311. Molecular formula: C19H23N4O6PS. Mole weight: 466.45. Custom synthesis is available. Send your inquiries for more information. | London |
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