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| Product | Description | |
|---|---|---|
| Vemurafenib | Vemurafenib is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity than wild-type B-Raf. Group: Pharmaceutical. Alternative Names: PLX4032; PLX 4032; PLX-4032; RG7204 ; RG7204 ; RG 7204 ; RO5185426; RO 5185426 RO5185426 Vemurafenib; Brand name: Zelboraf. CAS No. 918504-65-1. Pack Sizes: 100 mg. Product ID: B0084-307764. Molecular formula: C23H18ClF2N3O3S. Mole weight: 489.92. Custom synthesis is available. Send your inquiries for more information. |  London |
| SCH772984 | SCH772984 is a potent and selective ERK inhibitor with potential anticancer activity. SCH722984 showed activity against BRAF mutant, NRAS mutant and wild-type melanoma. Combining vemurafenib and SCH722984 in BRAF mutant melanoma was synergistic in a majority of cell lines and significantly delayed the onset of acquired resistance in long term in vitro assays. Therefore, SCH772984 may be clinically applicable as a treatment for non-BRAF mutant melanoma or in BRAF-mutant melanoma with innate or acquired resistance, alone or in combination with BRAF inhibitors. Group: Pharmaceutical. Alternative Names: SCH-772984; SCH 772984; (R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide. CAS No. 942183-80-4. Pack Sizes: 25 mg. Product ID: B2693-429803. Molecular formula: C33H33N9O2. Mole weight: 587.688. Custom synthesis is available. Send your inquiries for more information. | London |
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