tyrphostin Suppliers UK

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Product
Tyrphostin 9 Tyrphostin 9 is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM. Group: Pharmaceutical. Alternative Names: Malonoben; SF 6847; SF6847; SF-6847; RG 50872; RG50872; RG-50872; 2,6-Di-tert-butyl-4-(2,2-dicyanovinyl)phenol. CAS No. 10537-47-0. Pack Sizes: 1 g. Product ID: B1370-358320. Molecular formula: C18H22N2O. Mole weight: 282.38. Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
AG 126 Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Group: Pharmaceutical. Alternative Names: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. CAS No. 118409-62-4. Pack Sizes: 100 mg. Product ID: B1370-195904. Molecular formula: C10H5N3O3. Mole weight: 215.16. Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
AG-490 Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: Tyrphostin AG 490; AG-490; AG490. CAS No. 133550-30-8. Pack Sizes: 25 mg. Product ID: B0084-164022. Molecular formula: C17H14N2O3. Mole weight: 294.31. Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London
AG-879 AG-879, a tyrphostin compound, is a dual EGFR/HER2 inhibitor that was administered together with androgen withdrawal therapy. It inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM). Group: Pharmaceutical. Alternative Names: α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide. CAS No. 148741-30-4. Pack Sizes: 20 mg. Product ID: B0084-195953. Molecular formula: C18H24N2OS. Mole weight: 316.5. Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London

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