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| Product | Description | |
|---|---|---|
| Tyrosine Impurities | Tyrosine Impurities, often evaluated in the biomedical industry, are crucial for ensuring the purity and safety of pharmaceutical formulations containing tyrosine. These impurities are meticulously studied to prevent adverse effects, ensuring efficacy in the treatment of conditions like phenylketonuria and thyroid disorders. Detecting these impurities contributes to developing safer tyrosine-based therapies. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 3,5-DIIODO-L-TYROSINE DI HYDRATE | 3,5-DIIODO-L-TYROSINE DI HYDRATE Uses: Pharmaceutical R&D. Group: Iodides. CAS No. 18835-59-1. Pack Sizes: Enquire for MOQ. Categories: NORDMANN Key intermediates and specialty chemicals suppliers. |  UK / EU / USA / Japan |
| Acetyl-D-tyrosine | Acetyl-D-tyrosine. Group: Pharmaceutical. CAS No. 19764-32-0. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003467. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-D-tyrosine methyl ester | Acetyl-D-tyrosine methyl ester. Group: Pharmaceutical. CAS No. 65160-71-6. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-000391. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-L-tyrosine amide | Acetyl-L-tyrosine amide. Group: Pharmaceutical. CAS No. 1948-71-6. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003906. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-L-tyrosine ethyl ester hydrate | A substrate for chymotrypsin and carboxypeptidase Y. Group: Pharmaceutical. CAS No. 36546-50-6. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003907. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-L-tyrosine hydrazide | Acetyl-L-tyrosine hydrazide. Group: Pharmaceutical. CAS No. 2381-7-9. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003908. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-L-tyrosine methyl amide | Acetyl-L-tyrosine methyl amide. Group: Pharmaceutical. CAS No. 6367-14-2. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003909. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-L-tyrosine methyl ester | Acetyl-L-tyrosine methyl ester. Group: Pharmaceutical. CAS No. 2440-79-1. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003880. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-O-methyl-L-tyrosine | Acetyl-O-methyl-L-tyrosine. Group: Pharmaceutical. CAS No. 28047-05-4. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003882. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-O-methyl-L-tyrosine methyl ester | Acetyl-O-methyl-L-tyrosine methyl ester. Group: Pharmaceutical. CAS No. 17355-24-7. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003883. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-O-tert-butyl-L-tyrosine | Acetyl-O-tert-butyl-L-tyrosine. Group: Pharmaceutical. CAS No. 201292-99-1. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003886. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BOC-L-Tyrosine-OH | 25g Pack Size. Group: Amino Acids. Formula: C14H19NO5. CAS No. 3978-80-1. Prepack ID : 31623559-25g. Molecular Weight : 281.3. |  |
| D-Tyrosine | 1g Pack Size. Group: Amino Acids, Biochemicals. Formula: 4-(HO)C6H4CH2CH(NH2)CO2H. CAS No. 556-02-5. Prepack ID : 24156427-1g. Molecular Weight : 181.19. | |
| D-Tyrosine | 5g Pack Size. Group: Amino Acids, Biochemicals. Formula: 4-(HO)C6H4CH2CH(NH2)CO2H. CAS No. 556-02-5. Prepack ID : 24156427-5g. Molecular Weight : 181.19. | |
| Fmoc-2,6-dimethyl-L-tyrosine | Fmoc-2,6-dimethyl-L-tyrosine, a derivative of tyrosine, is extensively utilized in peptide composite processes. In a myriad of studies, the peptide is known to be an effective building block in the assembly of bioactive peptides or proteins. Its application has been discovered in the realm of therapeutics too, working as a primary ingredient in drugs aiming to cure serious diseases such as cancer and neurological disorders. Group: Pharmaceutical. CAS No. 206060-54-0. Pack Sizes: 250 mg. Product ID: BAT-006161. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Hexa-L-Tyrosine | Hexa-L-Tyrosine, a molecule frequently employed in the creation of peptide-based therapeutic treatments for afflictions such as cancer and neurodegenerative conditions, possesses potent antioxidant capabilities. It may also serve as a fundamental unit in the assembly of peptides displaying enhanced pharmacologically relevant traits. Group: Pharmaceutical. CAS No. 6934-38-9. Pack Sizes: 50 mg. Product ID: BAT-015250. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| L-α-Methyltyrosine | L-α-Methyltyrosine is a tyrosine hydroxylase inhibitor. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. It reduces the elevated levels of catecholamines associated with pheochromocytoma, thus preventing hypertension. It significantly inhibits COX-2 activity and has anti-inflammatory and anti-ulcer effects. Uses: L-α-methyltyrosine is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. Group: Pharmaceutical. CAS No. 672-87-7. Pack Sizes: 5 g. Product ID: BAT-008124. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| L-Tyrosine | 100g Pack Size. Group: Amino Acids, Biochemicals, Peptide Reagents. Formula: C9H11NO3. CAS No. 60-18-4. Prepack ID : 12097155-100g. Molecular Weight : 181.19. | |
| L-Tyrosine | 1kg Pack Size. Group: Amino Acids, Biochemicals, Peptide Reagents. Formula: C9H11NO3. CAS No. 60-18-4. Prepack ID : 12097155-1kg. Molecular Weight : 181.19. | |
| L-Tyrosine-diethylamide hydrochloride | L-Tyrosine-diethylamide hydrochloride. Group: Pharmaceutical. Pack Sizes: 100 mg. Product ID: BAT-014381. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| L-Tyrosine disodium salt dihydrate | 100g Pack Size. Group: Amino Acids, Biochemicals, Building Blocks, Diagnostic Raw Materials. Formula: C9H9NO3 ·2Na ·2H2O. CAS No. 122666-87-9. Prepack ID : 90025336-100g. Molecular Weight : 261.18. | |
| L-Tyrosine disodium salt dihydrate | 25g Pack Size. Group: Amino Acids, Biochemicals, Building Blocks, Diagnostic Raw Materials. Formula: C9H9NO3 ·2Na ·2H2O. CAS No. 122666-87-9. Prepack ID : 90025336-25g. Molecular Weight : 261.18. | |
| L-Tyrosine disodium salt hydrate | 100g Pack Size. Group: Amino Acids, Biochemicals, Chiral Compounds, Diagnostic Raw Materials. Formula: C9H9NNa2O3 x nH2O. CAS No. 69847-45-6. Prepack ID : 26504155-100g. Molecular Weight : 225.1522. | |
| L-Tyrosine disodium salt hydrate | 25g Pack Size. Group: Amino Acids, Biochemicals, Chiral Compounds, Diagnostic Raw Materials. Formula: C9H9NNa2O3 x nH2O. CAS No. 69847-45-6. Prepack ID : 26504155-25g. Molecular Weight : 225.1522. | |
| L-Tyrosine ethyl ester hydrochloride | 25g Pack Size. Group: Amino Acids, Biochemicals, Building Blocks, Peptide Reagents. Formula: C11H16ClNO3. CAS No. 4089-07-0. Prepack ID : 35021613-25g. Molecular Weight : 245.70264. | |
| N-Acetyl-3-iodo-L-tyrosine hemihydrate | N-Acetyl-3-iodo-L-tyrosine hemihydrate, a chemical reagent with notable significance in studying enzyme inhibitors and protein synthesis, is widely utilized in the medical research community to develop promising drug therapies for thyroid disorders and cancers. Such compounds may also be used to synthesize radioiodinated compounds, essential in the realm of medical imaging and diagnostics. Uses: Thyronine analog. Group: Pharmaceutical. CAS No. 23277-49-8. Pack Sizes: 100 mg. Product ID: B2699-115435. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-Acetyl-L-tyrosine | 25g Pack Size. Group: Amino Acids, Biochemicals, Building Blocks, Research Organics & Inorganics. Formula: 4- (HO)C6H4CH2CH (NHCOCH3)CO2H. CAS No. 537-55-3. Prepack ID : 18176221-25g. Molecular Weight : 223.23. | |
| N-Acetyl-L-tyrosine | N-Acetyl-L-tyrosine. Group: Pharmaceutical. CAS No. 537-55-3. Pack Sizes: 1 kg. Product ID: BAT-003879. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-Acetyl-L-tyrosine ethyl ester monohydrate (ATEE) | 5g Pack Size. Group: Amino Acids, Biochemicals, Building Blocks. Formula: C13H17NO4 ·H2O. CAS No. 36546-50-6. Prepack ID : 26518563-5g. Molecular Weight : 269.29. | |
| N-Fmoc-2-fluoro-L-tyrosine | N-Fmoc-2-fluoro-L-tyrosine. Group: Pharmaceutical. CAS No. 1196146-72-1. Pack Sizes: 100 mg. Product ID: BAT-008609. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-Fmoc-3-fluoro-L-tyrosine | N-Fmoc-3-fluoro-L-tyrosine. Group: Pharmaceutical. CAS No. 1270290-56-6. Pack Sizes: 100 mg. Product ID: BAT-016100. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-L-γ-glutamyl-L-tyrosine | N-L-γ-glutamyl-L-tyrosine is a dipeptide produced by the catabolism of proteins. Group: Pharmaceutical. CAS No. 7432-23-7. Pack Sizes: 1 g. Product ID: BAT-015508. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N,N-Dimethyl-L-Tyrosine | N,N-Dimethyl-L-Tyrosine, a derivative of the amino acid tyrosine, has been a subject of interest in the research field due to its key role in elucidating amino acid metabolism. Additionally, it has been extensively studied for its precursor role in the synthesis of well-known neurotransmitters like dopamine and norepinephrine, thereby finding novel therapeutic applications in the treatment of neurodegenerative disorders such as Parkinson's disease and depression. The significance of this chemical compound could not be overstated in the realm of medicinal research. Group: Pharmaceutical. CAS No. 17350-74-2. Pack Sizes: 50 mg. Product ID: B2699-052153. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| O-Sulfonato-L-tyrosine sodium salt | O-Sulfonato-L-tyrosine sodium salt, an amino acid derivative utilized in biomedical research, presents itself as a valuable asset. Its application as a protein tyrosine phosphatase and kinase specificity substrate highlights its pertinence in the industry. Excitingly, it has been researched extensively for its anti-inflammatory attributes and could potentially offer new remedies for autoimmune diseases. Group: Pharmaceutical. CAS No. 98930-06-4. Pack Sizes: 100 mg. Product ID: BAT-006967. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 1-NA-PP1 | 1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. Group: Pharmaceutical. CAS No. 221243-82-9. Pack Sizes: 25 mg. Product ID: B2693-102805. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2-((3-Iodo-1H-indazol-6-yl)thio)-N-methylbenzamide | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Group: Pharmaceutical. CAS No. 885126-34-1. Pack Sizes: 100 mg. Product ID: B2694-467100. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5,7-Dihydrox -4'-methoxyisoflavone | Biochanin A, an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM. Uses: Anti-tumorigenesis, anti-oxidation, and anti-inflammatory. Group: Pharmaceutical. CAS No. 491-80-5. Pack Sizes: 5 g. Product ID: NP1827. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Abl Cytosolic Substrate | Abl Cytosolic Substrate is a substrate for Abelson tyrosine kinase (Abl). Group: Pharmaceutical. CAS No. 168202-46-8. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-016269. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Abl Cytosolic Substrate acetate | Abl Cytosolic Substrate acetate is a substrate for Abelson tyrosine kinase (Abl). Group: Pharmaceutical. CAS No. 2918768-10-0. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-016268. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Abyssinone V | Abyssinone V is extracted from the root bark of Erythrina mildbraedii. It is a protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 values ranging from 14.8 to 39.7 microM. Group: Pharmaceutical. CAS No. 77263-11-7. Pack Sizes: 1mg; 1g; 10g. Product ID: NP2310. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acalabrutinib | Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Group: Pharmaceutical. CAS No. 1420477-60-6. Pack Sizes: 250 mg. Product ID: B0084-470855. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acalabrutinib-[d4] | Acalabrutinib-[d4] is a labelled version of Acalabrutinib. Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Group: Pharmaceutical. Pack Sizes: 5 mg. Product ID: BLP-003188. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ac-Tyr(3,5-NO2)-OH | N-Acetyl-3,5-dinitro-L-tyrosine is a pepsin inhibitor and have been used to study the hydrolysis actions of the substrate-binding region of the active center of the enzyme. Group: Pharmaceutical. CAS No. 20767-00-4. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003858. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AEE-788 | AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. Group: Pharmaceutical. CAS No. 497839-62-0. Pack Sizes: 10 mg. Product ID: B0084-258485. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Afatinib Impurities | Afatinib Impurities are critical for assessing the quality and safety of afatinib, a tyrosine kinase inhibitor used in treating non-small cell lung cancer. These impurities provide insights into the drug's stability and degradation pathways, ensuring therapeutic efficacy and compliance with rigorous pharmaceutical standards. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Group: Pharmaceutical. CAS No. 118409-62-4. Pack Sizes: 100 mg. Product ID: B1370-195904. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AG 1406 | AG 1406 is an inhibitor of tyrosine phosphorylation. Group: Pharmaceutical. CAS No. 71308-34-4. Pack Sizes: 25 mg. Product ID: B0084-284859. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AG-1557 | AG-1557 is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Group: Pharmaceutical. CAS No. 189290-58-2. Pack Sizes: 50 mg. Product ID: B0084-284805. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AG-879 | AG-879, a tyrphostin compound, is a dual EGFR/HER2 inhibitor that was administered together with androgen withdrawal therapy. It inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM). Group: Pharmaceutical. CAS No. 148741-30-4. Pack Sizes: 20 mg. Product ID: B0084-195953. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Apatinib mesylate | Apatinib mesylate is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 1218779-75-9. Pack Sizes: 250 mg. Product ID: B2693-457664. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Asciminib | Asciminib, also known as ABL-001, is a potent and selective allosteric Bcr-Abl inhibitor. Asciminib inhibits Ba/F3 cell growth with an IC50 of 0.25 nM. Uses: Tyrosine kinase inhibitors. Group: Pharmaceutical. CAS No. 1492952-76-7. Pack Sizes: 10 mg. Product ID: B0084-007699. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AT9283 | AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50= 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. Group: Pharmaceutical. CAS No. 896466-04-9. Pack Sizes: 10 mg. Product ID: B0084-100114. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AV-412 | AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Group: Pharmaceutical. CAS No. 451492-95-8. Pack Sizes: 20 mg. Product ID: B0084-324573. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AVL-292 | AVL-292, also known as CC-292, is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, AVL-292 targets and covalently binds to BTK, thereby preventing its activity. Uses: Protein kinase inhibitors. Group: Pharmaceutical. CAS No. 1202757-89-8. Pack Sizes: 1 g. Product ID: B2693-462475. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Axitinib | Axitinib (AG013736) is a tyrosine kinase inhibitor developed by Pfizer. Axitinib is a tyrosine kinase inhibitor that blocks the activation of VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ (IC50 = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively). It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models. Uses: Protein kinase inhibitors. Group: Pharmaceutical. CAS No. 319460-85-0. Pack Sizes: 5 g. Product ID: NP3631. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Axitinib Impurities | Axitinib Impurities hold paramount significance in pharmaceutical scrutiny, profoundly enhancing comprehension of axitinib, an essential tyrosine kinase inhibitor utilized in renal carcinoma treatment. These nuanced elements reveal drug stability, ensuring safety and therapeutic exactitude, thereby advancing cancer agent refinement and potentially elevating oncology treatment paradigms. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Axitinib Impurity 2 | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Group: Pharmaceutical. CAS No. 1428728-83-9. Pack Sizes: 5 mg. Product ID: B2694-467092. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Axitinib sulfoxide | A major metabolite of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Group: Pharmaceutical. CAS No. 1347304-18-0. Pack Sizes: 10 mg. Product ID: B2694-467095. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AZD-8931 | Sapitinib, also known as AZD-8931, is an erbB receptor tyrosine kinase inhibitor with potential antineoplastic activity. AZD8931 binds to and inhibits erbB tyrosine receptor kinases, which may result in the inhibition of cellular proliferation and angiogenesis in tumors expressing erbB. Group: Pharmaceutical. CAS No. 848942-61-0. Pack Sizes: 100 mg. Product ID: B0084-286313. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bemcentinib | Bemcentinib is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metast | London |
| BLZ945 | BLZ945 is an orally active, potent and selective CSF-1R inhibitor, which inhibits CSF-1R activity with an IC50 of 1nM and is more than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and Platelet-derived Growth Factor Receptor beta (PDGFRb). Group: Pharmaceutical. CAS No. 953769-46-5. Pack Sizes: 50 mg. Product ID: B0084-463485. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BMS-986195 | BMS-986195 is a Bruton's tyrosine kinase (BTK) inhibitor with IC50 of 0.1 nM. Group: Pharmaceutical. CAS No. 1912445-55-6. Pack Sizes: 200 mg. Product ID: B1370-057810. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Brivanib | Brivanib is the hydrolyzed form of Brivanib alaninate, which is a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. CAS No. 649735-46-6. Pack Sizes: 20 mg. Product ID: B0084-146707. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Brivanib alaninate | Brivanib alaninate is the alaninate ester of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. CAS No. 649735-63-7. Pack Sizes: 10 mg. Product ID: B2693-146708. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (-)-Catechin gallate | (-)-Catechin gallate, a minor polyphenolic constituent in green tea, is used to study its cytotoxicity. It enhances Fe(2+)-induced, lipid peroxidation. It also inhibits aromatase activity, an enzyme that converts androgens to estrogen and is thought to play a role in the etiology of breast cancer. Uses: (-)-catechin gallate has been found to be probably effective in restraining tyrosine phosphorylation caused by vegf and have potential activity in the study of breast cancer. Group: Pharmaceutical. CAS No. 130405-40-2. Pack Sizes: 25 mg. Product ID: B2703-464825. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cediranib dihydrochloride | Cediranib (AZD-2171; tentative trade name Recentin) is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.The drug is being developed by AstraZeneca as a possible anti-cancer chemotherapeutic agent for oral administration. Group: Pharmaceutical. CAS No. 288383-20-0. Pack Sizes: 50 mg. Product ID: B2693-065171. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cobimetinib | Cobimetinib (GDC-0973, RG7420) is a potent, orally available and highly selective MEK1 inhibitor with IC50 of 4.2 nM. It shows more than 100-fold selectively for MEK1 over MEK2 when tested against a panel of more than 100 serine-threonine and tyrosine kinases and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Group: Pharmaceutical. CAS No. 934660-93-2. Pack Sizes: 25 mg. Product ID: B0084-460683. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cosmosiin | Cosmosiin also called Apigenin 7-O-glucoside, is a natural flavonoid found in the flowers of Cosmos bipinnatus. Cosmosiin exhibits the activities of anti-HIV, anti-proliferative and antioxidant, the compound may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation. Uses: Anti-proliferative; antioxidant; anti-hiv. Group: Pharmaceutical. CAS No. 578-74-5. Pack Sizes: 20 mg. Product ID: NP1892. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Dacomitinib | Dacomitinib, aslo known as PF-299 and PF-00299804; or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types. Group: Pharmaceutical. CAS No. 1110813-31-4. Pack Sizes: 250 mg. Product ID: B0084-452473. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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