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| Product | Description | |
|---|---|---|
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) | 1,2-dioleoyloxy-3-(trimethylammonium)propane (DOTAP) chloride has been used for the preparation of cationic liposome and liposome-DNA complex. It has also been used to assess tumor necrosis factor α (TNF-α) production. Group: Pharmaceutical. CAS No. 132172-61-3. Pack Sizes: 5 g. Product ID: B2697-071954. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp | Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp is an intramolecularly quenched fluorescent substrate with the ortho-aminobenzoyl (Abz)/N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor/acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence, which is targeted by β-secretase BACE (β-site APP-cleaving activity). It is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2). Group: Pharmaceutical. CAS No. 1007306-20-8. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-014531. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AcetaMide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl) | 3-Acetylaminophthalic Anhydride is used in the synthesis of Apremilast, a potent phosphodiesterase 4 and tumor necrosis Factor-α inhibitor used in the treatment of psoriatic arthritis. Also a reagent in the preparation of Tillivalline. Group: Pharmaceutical. CAS No. 6296-53-3. Pack Sizes: 1mg; 1g; 10g. Product ID: 6296-53-3. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Group: Pharmaceutical. CAS No. 118409-62-4. Pack Sizes: 100 mg. Product ID: B1370-195904. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Boc-D-FMK | BOC-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα). It has been found to reduce the activation of nuclear factor kappa light chain enhancer of activated B cells (NF-kB), suppress the phosphorylation of subunit nuclear factor kappa light polypeptide gene enhancer in B cells inhibitor α (IkBα) and inhibit TNF-induced expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1). Moreover, it has also effectively attenuated the hepatocyte apoptosis in bile duct-ligated rats potentially improving the survival rates. Uses: Caspase inhibitors. Group: Pharmaceutical. CAS No. 187389-53-3. Pack Sizes: 100 mg. Product ID: BAT-010386. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bonducellin | Bonducellin is isolated from the herbs of Caesalpinia spinosa. Bonducellin shows weak antiproliferative against A2780 human ovarian cancer cell line with the IC50 value of 10.6 uM. Bonducellin has anti-inflammatory activities that can significantly and dose-dependently inhibit the inflammatory mediators: nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. Bonducellin shows modulation in the MIC of EtBr by eight fold at a concentration of 62.5 mg/L and also shows significant efflux pump inhibitory activity. Group: Pharmaceutical. CAS No. 83162-84-9. Pack Sizes: 2 mg. Product ID: NP2129. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cepharanthine | Cepharanthine (CEP) is a biscoclaurine alkaloid isolated from Stephania cepharantha. It has anticancer, antiinflammatory, antiallergic, immunomo- dulatory, and many other interesting biological activities. Cepharanthine has been widely used in Japan for more than 40 years to treat a wide variety of acute and chronic diseases. CEP inhibits tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppresses cytokine production. It has also been shown to scavenge free radicals and to have a protective effect against some of the responses mediated by pro-inflammatory cytokines such as TNF-α, interleukin (IL)-1β and IL6. CEP has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported. Uses: Anti-tumor/anti-inflammatory. Group: Pharmaceutical. CAS No. 481-49-2. Pack Sizes: 10 g. Product ID: NP0541. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Clenbuterol Impurity E | Clenbuterol Impurity E is an impurity of Clenbuterol and is used as a reagent in the synthesis of pyrazolopyridine derivatives as inhibitors of phosphodiesterase-4 (PDE-IV) and production of tumor necrosis factor-α (TNF-α). Group: Pharmaceutical. CAS No. 37148-47-3. Pack Sizes: 1 g. Product ID: B2694-469119. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| crisaborole | Crisaborole is a novel PDE-4 inhibitor used as a nonsteroidal topical medication for the treatment of mild-to-moderate atopic dermatitis (eczema). Crisaborole selectively inhibits PDE-4B which mainly leads to inflammation. Tumor necrosis factor alpha (TNFα), interleukin-12 (IL-12), IL-23 and other cytokines are also suppressed while crisaborole functioning. Uses: The treatment of mild-to-moderate atopic dermatitis (eczema). Group: Pharmaceutical. CAS No. 906673-24-3. Pack Sizes: 250 mg. Product ID: B0084-426762. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Crocin | Crocin is a water-soluble carotenoid pigment in saffron (Crocus sativus L.) with anti-inflammatory, antioxidant, anti-apoptosis, anti-asthma, anti-cancer, anti-allergy, relaxation of smooth muscle and hypolipidemic effects. Crocin inhibits tumor necrosis factor (TNF) α-induced pheochromocytoma (PC12) apoptosis by regulating the mRNA expression of Bcl-2 family proteins, which trigger downstream signals that ultimately lead to caspase-3 activation and subsequent cell death. Uses: Antioxidant, anticancer. Group: Pharmaceutical. CAS No. 42553-65-1. Pack Sizes: 100 mg. Product ID: B2703-002922. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Fosbretabulin disodium | Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue. Group: Pharmaceutical. CAS No. 168555-66-6. Pack Sizes: 100 mg. Product ID: B0084-085514. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GYY-4137 Morpholine salt | GYY-4137 Morpholine salt is a novel water-soluble and slow releasing Hydrogen sulfide(H2S) donor. It protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats. It inhibits the inflammatory response by suppressing the activation of nuclear factor-kappa B and mitogen-activated protein kinases in Coxsackie virus B3-infected rat cardiomyocytes. It exhibits potent anti-cancer activity. It exhibits vasodilator and antihypertensive activity in rats, in either the acute or chronic hypertension models. It does not influence vascular smooth muscle cell viability in culture. It also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation. Uses: Gyy-4137 morpholine salt inhibits the inflammatory response. it exhibits potent anti-cancer activity. it exhibits vasodilator and antihypertensive activity. Group: Pharmaceutical. CAS No. 106740-09-4. Pack Sizes: 100 mg. Product ID: B2693-272139. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Hydroxysafflor yellow A | Hydroxysafflor yellow A has been demonstrated to prevent steroid-induced avascular necrosis of femoral head by inhibiting primary bone marrow-derived mesenchymal stromal cells adipogenic differentiation induced by steroid. Uses: Anti-tumor. Group: Pharmaceutical. CAS No. 78281-02-4. Pack Sizes: 100 mg. Product ID: NP0993. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| OXi-4503 | OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated levels in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production. CA1 binds to tubulin at the same site as colchicine but with higher affinity. Group: Pharmaceutical. CAS No. 288847-35-8. Pack Sizes: 100 mg. Product ID: B0084-353235. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PNC-27 | PNC-27 is an anti-cancer peptide that induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line depending on expression of HDM-2 in the plasma membrane of these cells. Group: Pharmaceutical. Pack Sizes: 5 mg. Product ID: BAT-006241. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ruscogenin | Ruscogenin is a saponin found in the root of Ophiopogon japonicus. It inhibits the expressions of TF, iNOS, and NF-kappaB p65 and is therefore a potential target for acute lung injury or sepsis. It remarkably inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner. Group: Pharmaceutical. CAS No. 472-11-7. Pack Sizes: 10 mg. Product ID: B2703-464341. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SB239063 | SB239063 is a potent p38MAPK inhibitor. SB 239063 had an IC(50) of 44 nM for inhibition of recombinant purified human p38alpha. In lipopolysaccharide-stimulated human peripheral blood monocytes, SB 239063 inhibited interleukin-1 and tumor necrosis factor-alpha production. SB 239063 may be useful for the treatment of asthma and other inflammatory disorders. Uses: Protein kinase inhibitors. Group: Pharmaceutical. CAS No. 193551-21-2. Pack Sizes: 100 mg. Product ID: B2693-196670. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Solamargine | Solamargine, a steroidal alkaloid glycoside, is isolated from the fruits of a traditional Chinese medicinal herb called Solanum incanum L., triggered gene expression of human tumor necrosis factor receptor (TNFR) I which might lead to cell apoptosis. Uses: Anti-trypanosomal. Group: Pharmaceutical. CAS No. 20311-51-7. Pack Sizes: 25 mg. Product ID: NP0028. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Theaflavin | Theaflavin is an antioxidant polyphenol which is formed from the condensation of flavan-3-ols in tea leaves during the enzymatic oxidation (fermentation) of black?tea. It can inhibit HIV-1 replication with multiple mechanisms of action, and tumor necrosis factor-alpha mediated Interleukin-8 gene expression. It exhibits differential inhibitory effects on cancer cell lines and has the potential to be used individually for functional food applications and for therapy targeting specific cancer treatment. Nutritional supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 4670-5-7. Pack Sizes: 20 mg. Product ID: B0005-464630. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| TNF-α (46-65), human | TNF-α (46-65), human is a compound accomplishing its efficacy by specifically targeting a fragment of Tumor Necrosis Factor-alpha (TNF-α), finding purpose in the studyof diverse conditions, encompassing rheumatoid arthritis, psoriasis, Crohn's disease and ulcerative colitis. Group: Pharmaceutical. CAS No. 144796-72-5. Pack Sizes: 5 mg. Product ID: BAT-006197. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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