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| Product | Description | |
|---|---|---|
| 5(6)-Carboxyfluorescein N-hydroxysuccinimide ester | 5(6)-Carboxyfluorescein N-hydroxysuccinimide ester is an amine-reactive fluorescent probe useful for preparation of tubulin derivatives. Group: Pharmaceutical. CAS No. 117548-22-8. Pack Sizes: 100 mg. Product ID: B2708-359684. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Acetylene-linker-Val-Cit-PABC-MMAE | Acetylene-linker-Val-Cit-PABC-MMAE consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE), Acetylene-linker-Val-Cit-PABC-MMAE is an antibody drug conjugate. Group: Pharmaceutical. CAS No. 1411977-95-1. Pack Sizes: 1mg; 1g; 10g. Product ID: BADC-00849. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Auristatin E | Auristatin E is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent.Auristatin E inhibits tubulin polymerization. Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. Uses: Adcs cytotoxin. Group: Pharmaceutical. CAS No. 160800-57-7. Pack Sizes: 5 mg. Product ID: BADC-00188. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Auristatin F | Auristatin F, a synthetic analog of dolastatin 10, is a cytotoxic tubulin modifier with potent and selective antitumor activity. It is an MMAF analog and cytotoxin in Antibody-drug conjugates. Uses: Adcs cytotoxin. Group: Pharmaceutical. CAS No. 163768-50-1. Pack Sizes: 25 mg. Product ID: BBF-05829. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Batabulin sodium | Batabulin sodium is a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity. T138067 covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton. Group: Pharmaceutical. CAS No. 195533-53-0. Pack Sizes: 50 mg. Product ID: B2693-305409. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Combretastatin A4 | Combretastatin A4 is a stilbenoid isolated from Combretum caffrum. Combretastatin A4 was shown to inhibit tubulin polymerization (IC50 = 2.2 μM). It has demonstrable antineoplastic activity. Uses: Antineoplastic agents, phytogenic. Group: Pharmaceutical. CAS No. 117048-59-6. Pack Sizes: 1 g. Product ID: BADC-00361. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| DBCO-PEG4-vc-PAB-MMAF | DBCO-PEG4-vc-PAB-MMAF is a drug-linker conjugate for ADC by using Monomethylauristatin F (MMAF, a potent tubulin polymerization inhibitor), linked via DBCO-PEG4-vc-PAB. Group: Pharmaceutical. Pack Sizes: 5 mg. Product ID: BADC-00756. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| DM4 | DM4 is an anti-tubulin agent that inhibits cell division. DM4 can be used to prepare antibody-drug conjugates. DM4 binds to tubulin at the maytansine-binding site, disrupting microtubule assembly/disassembly dynamics and inhibiting mitosis. Group: Pharmaceutical. CAS No. 796073-69-3. Pack Sizes: 5 mg. Product ID: BBF-05778. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| DM4-SPDB | DM4 with a reactive linker SPDB, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site. Group: Pharmaceutical. CAS No. 1626359-62-3. Pack Sizes: 1 mg. Product ID: BADC-00012. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| DM4-SPDP | DM4 with a reactive linker SPDP, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site. Group: Pharmaceutical. CAS No. 2245698-48-8. Pack Sizes: 1 mg. Product ID: BADC-00011. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Erastin | Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces non-apoptotic tumor cell death by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. Reversal of tubulin-VDAC interaction by erastin antagonizes Warburg metabolism and restores oxidative mitochondrial metabolism. Group: Pharmaceutical. CAS No. 571203-78-6. Pack Sizes: 100 mg. Product ID: B0084-300990. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Eribulin Mesylate | Eribulin Mesylate is an antitumor drug that can be used to treat patients with metastatic breast cancer. It inhibits the proliferation of cancer cells by binding tubulin and microtubules. Eribulin Mesylate can inhibit experimental metastasis of breast cancer cells by reversing phenotype from epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET) states. Uses: The treatmnet of breast cancer. Group: Pharmaceutical. CAS No. 441045-17-6. Pack Sizes: 1 mg. Product ID: BADC-01399. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Fosbretabulin disodium | Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue. Group: Pharmaceutical. CAS No. 168555-66-6. Pack Sizes: 100 mg. Product ID: B0084-085514. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Gly3-VC-PAB-MMAE | Gly3-VC-PAB-MMAE is a drug-linker conjugate for ADC consisting of a cleavable ADC linker (Gly3-VC-PAB) and a potent tubulin inhibitor (MMAE). Group: Pharmaceutical. CAS No. 2684216-48-4. Pack Sizes: 2 mg. Product ID: BADC-01340. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ispinesib | Ispinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. Group: Pharmaceutical. CAS No. 336113-53-2. Pack Sizes: 50 mg. Product ID: B0084-066412. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ixabepilone | Ixabepilone (also known as azaepothilone B, or BMS-247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Ixabepilone was approved in 2007. Group: Pharmaceutical. CAS No. 219989-84-1. Pack Sizes: 5 mg. Product ID: B0084-063099. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Larotaxel | Larotaxel is a semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier. Group: Pharmaceutical. CAS No. 156294-36-9. Pack Sizes: 50 mg. Product ID: B2693-244933. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Maytansine | Maitansine, a cytotoxic agent, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. Group: Pharmaceutical. CAS No. 35846-53-8. Pack Sizes: 5 mg. Product ID: BADC-00346. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mc-MMAE | Mc-MMAE is a protective group conjugated MMAE, MMAE inhibits tubulin polymerization so that it inhibits cell division. Group: Pharmaceutical. CAS No. 863971-24-8. Pack Sizes: 1 mg. Product ID: BADC-00025. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mc-MMAF | Mc-MMAF is a protective group-conjugated MMAF, MMAF is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin and it has lower cytotoxic activity than MMAE. Uses: Sgd 1269 is a potent tubulin inhibitor and is a toxin payload in antibody drug conjugate. it is a useful agent for make antibody drug conjugate (adc) for targeted drug delivery. Group: Pharmaceutical. CAS No. 863971-19-1. Pack Sizes: 1 mg. Product ID: BADC-00014. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MC-Val-Cit-PAB-MMAE | MC-Val-Cit-PAB-MMAE is a potent tubulin inhibitor (MMAE), Val-Cit-PAB-MMAE is an antibody drug conjugate. Group: Pharmaceutical. CAS No. 646502-53-6. Pack Sizes: 1 mg. Product ID: BBF-05783. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MC-Val-Cit-PAB-MMAF | MC-Val-Cit-PAB-MMAF is a potent tubulin inhibitor (MMAF), Val-Cit-PAB-MMAF is an antibody drug conjugate. Group: Pharmaceutical. CAS No. 863971-17-9. Pack Sizes: 1 mg. Product ID: BADC-00013. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MMAD | Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate. Uses: Adcs cytotoxin. Group: Pharmaceutical. CAS No. 203849-91-6. Pack Sizes: 10 mg. Product ID: BADC-00309. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MMAE | Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity. Uses: Adcs cytotoxin. Group: Pharmaceutical. CAS No. 474645-27-7. Pack Sizes: 25 mg. Product ID: BBF-05782. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MMAE-[d8] | MMAE-[d8] is a labelled analogue of MMAE, which is a potent mitotic inhibitor and a tubulin inhibitor. Group: Pharmaceutical. CAS No. 2070009-72-0. Pack Sizes: 10 mg. Product ID: BLP-012288. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| OXi-4503 | OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated levels in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production. CA1 binds to tubulin at the same site as colchicine but with higher affinity. Group: Pharmaceutical. CAS No. 288847-35-8. Pack Sizes: 100 mg. Product ID: B0084-353235. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sabizabulin | Sabizabulin is a tubulin polymerization inhibitor with anti-tumor activity. Group: Pharmaceutical. CAS No. 1332881-26-1. Pack Sizes: 25 mg. Product ID: B2693-372930. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Taxcultine | Taxol D is an impurity of Paclitaxel, an antineoplastic. It is used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. Group: Pharmaceutical. CAS No. 153415-46-4. Pack Sizes: 2.5 mg. Product ID: NP1480. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Trastuzumab emtansine | Trastuzumab emtansine is an antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surface surfaces. Upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers. Group: Pharmaceutical. CAS No. 1018448-65-1. Pack Sizes: 5 mg. Product ID: BADC-00023. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Val-Cit-PAB-MMAE | Val-Cit-PAB-MMAE, a tubulin polymerase inhibitor, is a drug-linker conjugate for ADC. It contains an ADC linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE. Group: Pharmaceutical. CAS No. 644981-35-1. Pack Sizes: 100 mg. Product ID: BBF-05881. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Vinblastine sulfate | Vinblastine sulfate, also called cellblastin, derived from C. roseus, as a microtubule disrupter and antineoplastic agent, it binds tubulin and disrupts microtubule assembly and proper formation of the mitotic spindle, which leads to the assembly of microtubules and causing M phase-specific cell cycle arrest. Uses: Anticancer. Group: Pharmaceutical. CAS No. 143-67-9. Pack Sizes: 500 mg. Product ID: B0084-058749. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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