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Triazole lactic acid. Group: Pharmaceutical. Alternative Names: 2-Hydroxy-3-(1H-1,2,4-triazol-1-yl)propanoic acid; 1H-1,2,4-Triazole-1-propanoic acid, alpha-hydroxy-. CAS No. 1450828-63-3. Pack Sizes: 10 mg. Product ID: B2699-383252. Molecular formula: C5H7N3O3. Mole weight: 157.13. Custom synthesis is available. Send your inquiries for more information.
London
1,1'-Carbonyl-di(1,2,4-triazole)
1,1'-Carbonyl-di(1,2,4-triazole) Uses: Pharmaceutical Research and Development. Group: Imidazoles. CAS No. 41864-22-6. Pack Sizes: Enquire for MOQ. Categories: Nordmann UK Fine Chemicals (Formerly Melrob-Eurolabs).
UK / EU / USA / Japan
1,2,3-1H-Triazole
1,2,3-1H-Triazole Uses: Pharmaceutical R&D. Group: Chemicals & Intermediates. CAS No. 288-36-8. Pack Sizes: Enquire for MOQ. Categories: NORDMANN UK Fine Chemicals Suppliers.
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1H-1,2,3-Triazole
1H-1,2,3-Triazole. CAS No. 288-36-8. Cenik is your partner of choice for specialised chemicals. We don't just provide products - we supply solutions to your technical and regulatory specifications.
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1-H,1,2,4 Triazole
1-H,1,2,4 Triazole Uses: Pharmaceutical R&D. Group: Intermediates. CAS No. 288-88-0. Pack Sizes: Enquire for MOQ. Categories: Nordmann UK Fine Chemicals suppliers (Formerly Melrob-Eurolabs).
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1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,-triazole
1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,-triazole Uses: Pharmaceutical R&D. Group: Coupling Reagents. Alternative Names: MSNT. CAS No. 74257-00-4. Pack Sizes: Enquire for MOQ. Categories: NORDMANN Key intermediates and specialty chemicals suppliers.
Posaconazole Diastereoisomer Related Compound 6 is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. Uses: Intermediate in the preparation of posaconazole. Group: Pharmaceutical. Alternative Names: Posaconazole Impurity 63; 2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one. CAS No. 184177-83-1. Pack Sizes: 1mg;1g;10g. Product ID: NP3092. Molecular formula: C30H35N5O3. Mole weight: 513.63. Custom synthesis is available. Send your inquiries for more information.
2,4-Difluoro-2-(1h-1,2,4-Triazole-1Yl)Acetophenone Uses: Pharmaceutical Research and Development. Group: Intermediates. CAS No. 86404-63-9. Pack Sizes: Enquire for MOQ. Categories: NORDMANN UK Fine Chemicals: innovative sourcing and supply.
(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide is a linker widely used in antibody-drug conjugates (ADCs). Group: Pharmaceutical. Alternative Names: (2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide. CAS No. 1797406-69-9. Pack Sizes: 10 mg. Product ID: BADC-01565. Molecular formula: C49H60ClN9O8S2. Mole weight: 1002.64. Custom synthesis is available. Send your inquiries for more information.
London
3,5-dipyridyl-1,2,4-triazole
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Group: Pharmaceutical. Alternative Names: 4,4'-(1H-1,2,4-triazole-3,5-diyl)dipyridine; 3,5-Di(4-pyridyl)-1,2,4-triazole. CAS No. 4329-78-6. Pack Sizes: 500 mg. Product ID: B2694-484333. Molecular formula: C12H9N5. Mole weight: 223.24. Custom synthesis is available. Send your inquiries for more information.
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3-Amino-1,2,4-triazole
100g Pack Size. Group: Biochemicals. Formula: C2H4N4. CAS No. 1004-40-6. Prepack ID : 69030032-100g. Molecular Weight : 84.08.
3-Amino-1,2,4-triazole-5-carboxylic acid
100g Pack Size. Group: Building Blocks, Organics. Formula: C3H4N4O2. CAS No. 3641-13-2. Prepack ID : 22677851-100g. Molecular Weight : 128.09.
3-Amino-1,2,4-triazole-5-carboxylic acid
25g Pack Size. Group: Building Blocks, Organics. Formula: C3H4N4O2. CAS No. 3641-13-2. Prepack ID : 22677851-25g. Molecular Weight : 128.09.
(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1- pyrrolidinylphosphonium hexafluorophosphate Uses: Pharmaceutical Research and Development. Group: Coupling Reagents. Alternative Names: PyAOP. CAS No. 156311-83-0. Pack Sizes: Enquire for MOQ. Categories: NORDMANN UK Fine Chemicals: innovative sourcing and supply.
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3-Mercapto-1,2,4-triazole
100g Pack Size. Group: Building Blocks, Organics. Formula: C2H3N3S. CAS No. 3179-31-5. Prepack ID : 10821503-100g. Molecular Weight : 101.13.
3-Mercapto-1,2,4-triazole
25g Pack Size. Group: Building Blocks, Organics. Formula: C2H3N3S. CAS No. 3179-31-5. Prepack ID : 10821503-25g. Molecular Weight : 101.13.
4-(1H-1,2,4-Triazol-1-ylmethyl)aniline
4-(1H-1,2,4-Triazol-1-ylmethyl)aniline Uses: Pharmaceutical R&D. Group: Chemicals & Intermediates. CAS No. 119192-10-8. Pack Sizes: Enquire for MOQ. Categories: NORDMANN UK Fine Chemicals Suppliers.
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4,5-Dibromo-1H-1,2,3-triazole
1g Pack Size. Group: Building Blocks. Formula: C2HBr2N3. CAS No. 15294-81-2. Prepack ID : 23114418-1g. Molecular Weight : 226.9.
4,8-Dibromo-6-(2-ethylhexyl)-[1,2,5]thiadiazolo[3,4f]benzotriazole (CAS# 1307899-44-0 ) is a useful research chemical. Group: Pharmaceutical. Alternative Names: 4,8-Dibromo-6-(2-ethylhexyl)-6H-2λ4δ2-[1,2,3]triazolo[4,5-f]-2,1,3-benzothiadiazole; 6H-2λ4δ2-[1,2,3]Triazolo[4,5-f]-2,1,3-benzothiadiazole, 4,8-dibromo-6-(2-ethylhexyl)-. CAS No. 1307899-44-0. Pack Sizes: 25 mg. Product ID: B2699-334045. Molecular formula: C14H17Br2N5S. Mole weight: 447.19. Custom synthesis is available. Send your inquiries for more information.
London
4-cyclohexyl-5-phenyl-4H-1,2,4-triazole-3-thiol
4-cyclohexyl-5-phenyl-4H-1,2,4-triazole-3-thiol. Group: Pharmaceutical. Alternative Names: 4-cyclohexyl-5-phenyl-1,2,4-triazole-3-thiol; 4-cyclohexyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione. CAS No. 38942-57-3. Pack Sizes: 50 mg. Product ID: B1370-017256. Molecular formula: C14H17N3S. Mole weight: 259.37. Custom synthesis is available. Send your inquiries for more information.
A metabolite of Aprepitant. Group: Pharmaceutical. Alternative Names: Monobenzyl Fosaprepitant. CAS No. 889852-02-2. Pack Sizes: 1mg;1g;10g. Product ID: NP3713. Molecular formula: C30H28F7N4O6P. Mole weight: 704.54. Custom synthesis is available. Send your inquiries for more information.
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(1R,2R,3R)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Group: Pharmaceutical. Alternative Names: (R,R,R)-Aprepitant; USP Aprepitant Related Compound A; Aprepitant Related Compound A; Aprepitant USP Related Compound A; Aprepitant R,R,R-Diastereomer; 3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one; 5-[[(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Aprepitant USP RC A (R,R,R-Diasteromer). CAS No. 1148113-53-4. Pack Sizes: 50 mg. Product ID: B2694-466699. Molecular formula: C23H21F7N4O3. Mole weight: 534.44. Custom synthesis is available. Send your inquiries for more information.
London
(1R,2S,3R)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Group: Pharmaceutical. Alternative Names: 5-(((2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one. CAS No. 1185502-97-9. Pack Sizes: 50 mg. Product ID: B2694-466697. Molecular formula: C23H21F7N4O3. Mole weight: 534.44. Custom synthesis is available. Send your inquiries for more information.
London
(1R,2S,3S)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Group: Pharmaceutical. Alternative Names: 5-(((2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one. CAS No. 172822-28-5. Pack Sizes: 50 mg. Product ID: B2694-466702. Molecular formula: C23H21F7N4O3. Mole weight: 534.44. Custom synthesis is available. Send your inquiries for more information.
((1R,3R)-3-Amino-cyclopentyl)-carbamic Acid tert-Butyl Ester is used in the preparation of quinoline-3-carboxoamides as H-PGDS inhibitors as well as novel triazolo-pyrrolopyridines as Janus kinase 1 inhibitors. Group: Pharmaceutical. Alternative Names: tert-Butyl ((1R,3R)-3-aminocyclopentyl)carbamate; tert-butyl n-[(1r,3r)-3-aminocyclopentyl]carbamate; tert-Butyl rac-[(1R,3R)-3-aminocyclopentyl] carbamate; tert-Butyl ((1R,3R)-rel-3-aminocyclopentyl)carbamate; tert-Butyl N-[trans-3-aminocyclopentyl]carbamate; tert-Butyl [trans-3-aminocyclopentyl]carbamate. CAS No. 1009075-44-8. Pack Sizes: 1 g. Product ID: BB074488. Molecular formula: C10H20N2O2. Mole weight: 200.28. Custom synthesis is available. Send your inquiries for more information.
London
(1S,2R,3R)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Group: Pharmaceutical. Alternative Names: 5-(((2R,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one. CAS No. 1242175-34-3. Pack Sizes: 50 mg. Product ID: B2694-466696. Molecular formula: C23H21F7N4O3. Mole weight: 534.44. Custom synthesis is available. Send your inquiries for more information.
London
(1S,2S,3S)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Group: Pharmaceutical. Alternative Names: 5-(((2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one. CAS No. 1242175-40-1. Pack Sizes: 100 mg. Product ID: B2694-466704. Molecular formula: C23H21F7N4O3. Mole weight: 534.44. Custom synthesis is available. Send your inquiries for more information.
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5-(Bromomethyl)undecane
5-(Bromomethyl)undecane (CAS# 85531-02-8) is used as a reagent in the synthesis of alkyl triazole glycosides (ATGs) which is a new class of bio-related surfactants. Group: Pharmaceutical. Alternative Names: 5-(bromomethyl)undecane; 5-(bromomethyl)undecane. CAS No. 85531-02-8. Pack Sizes: 25 g. Product ID: BB037646. Molecular formula: C12H25Br. Mole weight: 249.23. Custom synthesis is available. Send your inquiries for more information.
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8-Azaguanine
It is produced by the strain of Str. albus var. pathocidicus. It is a nitrogen-containing heterocyclic antifungal antibiotic. 8-azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth. Group: Pharmaceutical. Alternative Names: Pathocidin; 5-Amino-1H-vic-triazolo[d]pyrimidin-7-ol; 5-Amino-7-hydroxy-1H-v-triazolo[d]pyrimidine; 5-Amino-3,6-dihydro-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one; 8-AG; Azaguanine; Azan; Guanazol; Guanazolo; NSC 151069; NSC 223526; NSC 749; Pathocidine. CAS No. 134-58-7. Pack Sizes: 20 g. Product ID: BBF-02371. Molecular formula: C4H4N6O. Mole weight: 152.11. Custom synthesis is available. Send your inquiries for more information.
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A1874
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. A1874 (A-1874) is a nutlin-based and BRD4-degrading PROTAC with DC50 of 32 nM (induce BRD4 degradation in cells); A1874 is more effective in inhibiting proliferation of many cancer cell lines with wild type p53 than was a corresponding VHL-utilizing PROTAC with similar potency and efficacy to degrade BRD4; demonstrates synergistic antiproliferative effect via simultaneous degradation of BRD4 and stabilization of p53. Group: Pharmaceutical. Alternative Names: A1874; A 1874; A-1874; (2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-N-(4-((1-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)carbamoyl)-2-methoxyphenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamide. CAS No. 2064292-12-0. Pack Sizes: 1mg;1g;10g. Product ID: 2064292-12-0. Molecular formula: C58H62Cl3F2N9O7S. Mole weight: 1173.59. Custom synthesis is available. Send your inquiries for more information.
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A2ti-1
A2ti-1 is a selective and high-affinity inhibitor of annexin A2/S100A10 heterotetramer (A2t) with an IC50 of 24 μM. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. It protects against human papillomavirus type 16 (HPV16) infection. Group: Pharmaceutical. Alternative Names: Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-; 2-({4-(2-Ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide. CAS No. 570390-00-0. Pack Sizes: 10 mg. Product ID: B1370-060255. Molecular formula: C20H22N4O2S. Mole weight: 382.48. Custom synthesis is available. Send your inquiries for more information.
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A2ti-2
A2ti-2 is a selective and low-affinity inhibitor of annexin A2/S100A10 heterotetramer (A2t) with an IC50 of 230 μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. It protects against human papillomavirus type 16 (HPV16) infection. Group: Pharmaceutical. Alternative Names: 2-{5-[(2-methylphenoxy)methyl]-4-phenyl-1,2,4-triazol-3-ylthio}acetamide; Acetamide, 2-[[5-[(2-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]-; 2-({5-[(2-Methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide. CAS No. 482646-13-9. Pack Sizes: 100 mg. Product ID: B1370-382474. Molecular formula: C18H18N4O2S. Mole weight: 354.43. Custom synthesis is available. Send your inquiries for more information.
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AA26-9
AA26-9, synthesized based on a piperazine scaffold, is a potent and broad spectrum serine hydrolase inhibitor. Group: Pharmaceutical. Alternative Names: AA 26-9; AA-26-9; AA26-9; AA 269; AA-269; AA269; pyrrolidin-1-yl(triazol-1-yl)methanone; Pyrrolidin-1-yl(1H-1,2,3-triazol-1-yl)methanone. CAS No. 1312782-34-5. Pack Sizes: 1mg;1g;10g. Product ID: 1312782-34-5. Molecular formula: C7H10N4O. Mole weight: 166.18. Custom synthesis is available. Send your inquiries for more information.
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AB928
AB928 is a dual antagonist of the A2aR and A2bR adenosine receptors with Kb of 1.5 and 2.0 nM, respectively. It potently blocks the immunosuppressive effects of high adenosine concentrations in the tumor microenvironment. Group: Pharmaceutical. Alternative Names: A2Ar/A2bR antagonist-1; 3-(2-Amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile. CAS No. 2239273-34-6. Pack Sizes: 50 mg. Product ID: B2693-334167. Molecular formula: C23H22N8O. Mole weight: 426.5. Custom synthesis is available. Send your inquiries for more information.
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Aprepitant
Aprepitant is a specific NK-1R antagonist, used as an antiemetic agent. Group: Pharmaceutical. Alternative Names: 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend; L 754030; MK 0869; MK 869; ONO 7436. CAS No. 170729-80-3. Pack Sizes: 1 g. Product ID: B2692-461949. Molecular formula: C23H21F7N4O3. Mole weight: 534.43. Custom synthesis is available. Send your inquiries for more information.
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ARV-771
ARV-771 is a potent BET bromodomain PROTAC® Degrader based on von Hippel-Lindau (VHL) E3 ligase, consisting of a BRD4-binding moiety bound to a VHL ligand via a linker. Group: Pharmaceutical. Alternative Names: ARV 771; ARV771; (2S,4R)-1-((S)-2-(tert-butyl)-15-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide; L-Prolinamide, N-[2-[3-[2-[[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetyl]amino]ethoxy]propoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-; N-({3-[2-({[(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetyl}amino)ethoxy]propoxy}acetyl)-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide. CAS No. 1949837-12-0. Pack Sizes: 5 mg. Product ID: B2693-007297. Molecular formula: C49H60ClN9O7S2. Mole weight: 986.64. Custom synthesis is available. Send your inquiries for more information.
London
ARV-825
ARV-825 is a BRD4 inhibitor based on PROTAC technology. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4. In post-myeloproliferative neoplasm secondary (s) AML cell lines, treatment with ARV-825 induces apoptosis and inhibits cell proliferation. Group: Pharmaceutical. Alternative Names: 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide. CAS No. 1818885-28-7. Pack Sizes: 100 mg. Product ID: B1370-474664. Molecular formula: C46H47ClN8O9S. Mole weight: 923.44. Custom synthesis is available. Send your inquiries for more information.
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AZD 5153
AZD5153 is a potent, selective, and orally available inhibitor of the bromodomain and extraterminal (BET). It can simultaneously bind two bromodomains in BRD4 with the IC50 value of 5 nM, which has been shown to increase antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma. AZD5153 also shows enhanced potency as a result of bivalent binding and a clear correlation between BRD4 activity and cellular potency. Group: Pharmaceutical. Alternative Names: AZD-5153; AZD5153; (R)-4-(2-(4-(1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)-1,3-dimethylpiperazin-2-one. CAS No. 1869912-39-9. Pack Sizes: 25 mg. Product ID: B1370-291088. Molecular formula: C25H33N7O3. Mole weight: 479.57. Custom synthesis is available. Send your inquiries for more information.
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Azido-PEG3-acetic acid
N3-PEG3-CH2COOH is a PROTAC linker, which refers to the alkyl/ether composition. N3-PEG3-CH2COOH can be used in the synthesis of a series of PROTACs. N3-PEG3-CH2COOH is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. Group: Pharmaceutical. Alternative Names: Azido-PEG3-CH2CO2H;11-Azido-3,6,9-trioxaundecanoic Acid; N3-PEG3-CH2COOH; {2-[2-(2-Azidoethoxy)ethoxy]ethoxy}acetic acid; Acetic acid, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-; Azido-PEG3-CH2COOH. CAS No. 172531-37-2. Pack Sizes: 5 g. Product ID: B1370-291925. Molecular formula: C8H15N3O5. Mole weight: 233.22. Custom synthesis is available. Send your inquiries for more information.
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Bitertanol
Bitertanol is a broad-spectrum agricultural fungicide with dual functions of prevention and treatment, which is used to prevent and control a variety of plant rust, powdery mildew, leaf spot, black star disease and so on. Group: Pharmaceutical. Alternative Names: 1H-1,2,4-Triazole-1-ethanol, β-([1,1'-biphenyl]-4-yloxy)-α-(1,1-dimethylethyl)-; β-([1,1'-Biphenyl]-4-yloxy)-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol; Baycor; Baycor 25WP; Baycor DC 300; Biloxazol; KWG 0599. CAS No. 55179-31-2. Pack Sizes: 1mg;1g;10g. Product ID: 55179-31-2. Molecular formula: C20H23N3O2. Mole weight: 337.42. Custom synthesis is available. Send your inquiries for more information.
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Calcitriol EP Impurity C
Calcitriol EP Impurity C is an impurity of Calcitriol, which is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Group: Pharmaceutical. Alternative Names: Triazoline Adduct of pre-Calcitriol; pre-Calcitriol PTAD Adduct (Mixture of Diastereomers); Impurity C of Calcitriol (6aR,7R,9aR)-11-[(3S,5R)-3,5-dihydroxy-2-methylcyclohex-1-enyl]-7-[(1R)-5-hydroxy-1,5-dimethylhexyl]-6a-methyl-2-phenyl-5,6,6a,7,8,9,9a,11-octahydro-1H,4aH-cyclopenta[f][1,2,4]triazolo[1,2-a]cinnoline-1,3(2H)-dione. CAS No. 86307-44-0. Pack Sizes: 1 mg. Product ID: B0504-485045. Molecular formula: C35H49N3O5. Mole weight: 591.78. Custom synthesis is available. Send your inquiries for more information.
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CGS 15943
CGS 15943 is a potent and orally bioactive adenosine receptor antagonist (Ki = 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors, respectively). Group: Pharmaceutical. Alternative Names: CGS 15943; CGS15943; CGS-15943; 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine. CAS No. 104615-18-1. Pack Sizes: 100 mg. Product ID: B2693-159610. Molecular formula: C13H8ClN5O. Mole weight: 285.69. Custom synthesis is available. Send your inquiries for more information.
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CPI-203
CPI-203 is a BET bromodomain inhibitor. It inhibits BRD4 in vitro and in cells, and causes G1 cell cycle arrest. It also arrests the growth of T cell acute lymphoblastic leukemia cells in vitro (EC50 = 91.2 nM). Group: Pharmaceutical. Alternative Names: CPI203; CPI-203; CPI 203; TEN010; TEN 010; TEN010; JQ-2; JQ 2; JQ2; RG-6146; RG 6146; RG-6146; RO6870810; RO-6870810; RO 6870810. (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide. CAS No. 1446144-04-2. Pack Sizes: 25 mg. Product ID: B0084-463432. Molecular formula: C19H18ClN5OS. Mole weight: 399.9. Custom synthesis is available. Send your inquiries for more information.
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CPI-444
CPI-444 is a potent, orally available, selective antagonist of the adenosine A2A receptor that has been well tolerated in Ph 1/1b studies in non-oncology indications. Group: Pharmaceutical. Alternative Names: (S)-7-(5-methylfuran-2-yl)-3-((6-(((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine; CPI-444; CPI 444; CPI444; V81444; V-81444; V 81444. CAS No. 1202402-40-1. Pack Sizes: 20 mg. Product ID: B0084-007707. Molecular formula: C20H21N7O3. Mole weight: 407.17. Custom synthesis is available. Send your inquiries for more information.
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Dapiprazole Hydrochloride
Dapiprazole Hydrochloride is a salt form of Dapiprazole, an alpha-1-adrenergic antagonist. Dapiprazole inhibits alpha-adrenergic receptors in the smooth muscle of blood vessels (arteries, arterioles and veins), gastrointestinal tract, and radial smooth muscle of the iris, resulting in vasodilatation. Group: Pharmaceutical. Alternative Names: Dapiprazole HCl; Rev-Eyes; 3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine hydrochloride. CAS No. 72822-13-0. Pack Sizes: 250 mg. Product ID: B0084-013400. Molecular formula: C19H28ClN5. Mole weight: 361.918. Custom synthesis is available. Send your inquiries for more information.
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dBET1
dBET1 is a potent BRD4 protein degrader composed of a BET bromodomain inhibitor (+)-JQ1 and a sedative drug thalidomide. The (+)-JQ1 portion binds to the BET bromodomains, and the thalidomide binds to cereblon to form a cereblon E3 ubiquitin ligase complex, inducing cereblon-dependent BET protein degradation. Group: Pharmaceutical. Alternative Names: (6S)-4-(4-chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide. CAS No. 1799711-21-9. Pack Sizes: 50 mg. Product ID: B1370-285214. Molecular formula: C38H37ClN8O7S. Mole weight: 785.27. Custom synthesis is available. Send your inquiries for more information.
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Deferasirox
Deferasirox is an oral iron chelator used to treat chronic iron overload in patients receiving long term blood transfusions. Group: Pharmaceutical. Alternative Names: 4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic Acid; Exjade; ICL-670; ICL-670A; CGP-72670. CAS No. 201530-41-8. Pack Sizes: 250 mg. Product ID: NP3629. Molecular formula: C21H15N3O4. Mole weight: 373.36. Custom synthesis is available. Send your inquiries for more information.
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Defluoro Aprepitant
A metabolite of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Group: Pharmaceutical. Alternative Names: Desfluoro aprepitant; Aprepitant Impurity A; 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]-ethoxy]-3-phenylmorpholin-4-yl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Aprepitant EP Impurity A; 5-([(2R,3S)-2-((R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy)-3-phenylmorpholino]methyl)-1H-1,2,4-triazol-3(2H)-one; Aprepitant desfluoro; 5-[[(2R,3S)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-phenylmorpholino]methyl]-2H-1,2,4-triazol-3(4H)-one. CAS No. 170729-76-7. Pack Sizes: 100 mg. Product ID: B2694-466701. Molecular formula: C23H22F6N4O3. Mole weight: 516.45. Custom synthesis is available. Send your inquiries for more information.
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Denifanstat
Denifanstat is an orally bioavailable fatty acid synthase (FASN) inhibitor, with potential antineoplastic activity. Group: Pharmaceutical. Alternative Names: FASN-IN-2; TVB-2640; 4-(1-(4-Cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile; TVB2640; TVB 2640; FASN inhibitor 2; Benzonitrile, 4-[1-[4-cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl]-4-piperidinyl]-. CAS No. 1399177-37-7. Pack Sizes: 50 mg. Product ID: B1370-372974. Molecular formula: C27H29N5O. Mole weight: 439.55. Custom synthesis is available. Send your inquiries for more information.
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Doravirine
Doravirine is a non-nucleoside reverse transcriptase inhibitor under development of Merck & Co. IC 50 value is 12 nM against the wild type, 21nM against K103N, 31 nM against Y181C, 33nM against K103N/Y181C mutant viruses in vitro. MK-1439 exhibited similar antiviral activities against 10 different HIV-1 subtype viruses. Phase III for the treatment of HIV-1 infections is on-going. Uses: Hiv-1 infections. Group: Pharmaceutical. Alternative Names: MK-1439; MK 1439; MK1439; MK-1439-019;3-Chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile. CAS No. 1338225-97-0. Pack Sizes: 100 mg. Product ID: B2693-475314. Molecular formula: C17H11ClF3N5O3. Mole weight: 425.75. Custom synthesis is available. Send your inquiries for more information.
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Doravirine-[13C6]
Labelled Doravirine. Doravirine is a non-nucleoside reverse transcriptase inhibitor under development of Merck & Co. IC 50 value is 12 nM against the wild type, 21nM against K103N, 31 nM against Y181C, 33nM against K103N/Y181C mutant viruses in vitro. MK-1439 exhibited similar antiviral activities against 10 different HIV-1 subtype viruses. Phase III for the treatment of HIV-1 infections is on-going. Group: Pharmaceutical. Alternative Names: 3-Chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]benzonitrile-13C6. Pack Sizes: 1 mg. Product ID: BLP-001304. Molecular formula: C11[13C]6H11ClF3N5O3. Mole weight: 431.71. Custom synthesis is available. Send your inquiries for more information.
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EED-226
EED-226 is a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor (IC50 = 23.4 nM when the substrate is H3K27me0 peptide and IC50 = 53.5 nM when the substrate is mononucleosom). EED-226 induces a conformational change via binding EED which invalidates PRC2 activity. PRC2 plays pivotal roles in transcriptional regulation. EED-226 has the potential to treat PRC2-dependent cancers, such as human lymphoma xenograft tumors. Group: Pharmaceutical. Alternative Names: EED226; EED-226; EED 226. N-(2-furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine. CAS No. 2083627-02-3. Pack Sizes: 10 mg. Product ID: B0084-484681. Molecular formula: C17H15N5O3S. Mole weight: 369.4. Custom synthesis is available. Send your inquiries for more information.
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Efinaconazole
Efinaconazole is a triazole antifungal. It is approved for use in Canada and the USA as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nail). Efinaconazole acts as a 14α-demethylase inhibitor. Efinaconazole inhibits fungal lanosterol 14α-demethylase involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes. Efinaconazole has been shown to be active against isolates of the following microorganisms, both in vitro and in clinical infections. Efinaconazole exhibits in vitro minimum inhibitory concentrations (MICs) of 0.06 μg/mL or less against most ( ≥ 90%) isolates of the following microorganisms: Trichophyton rubrum; Trichophyton mentagrophytes. Group: Pharmaceutical. Alternative Names: KP103; KP-103; KP 103; CTK5J2975; AGJ95634; KB145948; AGJ 95634; KB 145948; AGJ-95634; KB-145948; Efinaconazole; trade name: Jublia. CAS No. 164650-44-6. Pack Sizes: 50 mg. Product ID: B0084-463563. Molecular formula: C18H22F2N4O. Mole weight: 348.39. Custom synthesis is available. Send your inquiries for more information.
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Efinaconazole Related Impurity 3
The S,S-enantiomer of Efinaconazole, a medication used to treat toenail infection caused by fungus. Group: Pharmaceutical. Alternative Names: ent-Efinaconazole; (2S,3S)-Efinaconazole; (αS,βS)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidine ethanol; [S-(R*,R*)]-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidine ethanol. CAS No. 164650-45-7. Pack Sizes: 100 mg. Product ID: B2694-470719. Molecular formula: C18H22F2N4O. Mole weight: 348.39. Custom synthesis is available. Send your inquiries for more information.
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Efinaconazole Related Impurity 4
An enantiomer of Efinaconazole, a triazole antifungal approved to treat fungal infections of the toenails as a topical solution. Group: Pharmaceutical. Alternative Names: Efinaconazole 2S,3R Epoxy triazole; 1-(((2S,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole; 1-{[(2S,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl]methyl}-1H-1,2,4-triazole; (2S,3R)-2-(2,4-difluorophenyl)-3-methyl-2-(1H-1,2,4-triazol-1-yl)methyloxirane. CAS No. 135270-07-4. Pack Sizes: 5 mg. Product ID: B0821-470720. Molecular formula: C12H11F2N3O. Mole weight: 251.24. Custom synthesis is available. Send your inquiries for more information.
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(E)-KPT330
(E)-Kpt-330 is an E-isomer of Kpt-330, also known as Selinexor, which is an orally available inhibitor of CRM1 with potential antineoplastic activity. Group: Pharmaceutical. Alternative Names: (E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide; Selinexor trans-isomer; KPT-330, (E)-; UNII-MVY2AE6R24; MVY2AE6R24; KPT330,(E)-; 2-Propenoic acid, 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-, 2-(2-pyrazinyl)hydrazide, (2E)-; 1421923-86-5 (E-isomer); KPT330Selinexor; O=C(NNC1=NC=CN=C1)/C=C/N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2; 2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2E)-; (E)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide. CAS No. 1421923-86-5. Pack Sizes: 25 mg. Product ID: B0084-284796. Molecular formula: C17H11F6N7O. Mole weight: 443.3. Custom synthesis is available. Send your inquiries for more information.
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EW-7197
EW-7197 is a potent and selective ALK5 inhibitor, displaying antimetastatic and anticancer effects. It inhibits TGF-β/Smad signaling, and abrogates TGF-β1-induced tumor cell migration and invasion. EW-7197 inhibits breast cancer metastasis to the lung. EW-7197 prolongs the life span of BALB/c 4T1 mice via inhibition of EMT. EW-7197 inhibits metastasis and enhances the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotopic grafted mice. Group: Pharmaceutical. Alternative Names: Vactosertib; N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine. CAS No. 1352608-82-2. Pack Sizes: 50 mg. Product ID: B0084-462343. Molecular formula: C22H18FN7. Mole weight: 399.433. Custom synthesis is available. Send your inquiries for more information.
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Fluconazole
Fluconazole is a triazole antifungal agent that is effective against most Candida strains. Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor used in the treatment and prevention of superficial and systemic fungal infections. Group: Pharmaceutical. Alternative Names: UK 49858; UK49858; UK-49858; α-(2,4-Difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazol-1-ethanol; 1-(2,4-Difluorophenyl)-1,1-bis[(1H-1,2,4-triazol-1-yl)methyl]methanol; Biozolene; Diflucan; Difluconazole; Elazor; Fluconal; Flucostat; Flumycon; Flusol; Fluzon; Triflucan; Zoltec. CAS No. 86386-73-4. Pack Sizes: 10 g. Product ID: BBF-04628. Molecular formula: C13H12F2N6O. Mole weight: 306.27. Custom synthesis is available. Send your inquiries for more information.
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Fluconazole EP Impurity H
Fluconazole EP Impurity H is an impurity of Fluconazole, which is a triazole antifungal agent used in the treatment and prevention of superficial and systemic fungal infections. Group: Pharmaceutical. Alternative Names: (2RS)-1-bromo-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol; 1H-1,2,4-Triazole-1-ethanol, α-(bromomethyl)-α-(2,4-difluorophenyl)-; α-(Bromomethyl)-α-(2,4-difluorophenyl)-1H-1,2,4-triazole-1-ethanol; 2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-bromopropan-2-ol; Fluconazole impurity H. CAS No. 150194-52-8. Pack Sizes: 50 mg. Product ID: B2694-471658. Molecular formula: C11H10BrF2N3O. Mole weight: 318.12. Custom synthesis is available. Send your inquiries for more information.
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Fluconazole Impurity A
A stereoisomer of Fluconazole. Fluconazole is a triazole antifungal agent that is effective against most Candida strains. Group: Pharmaceutical. Alternative Names: Iso Fluconazole; (2RS)-(2,4-Difluorophenyl)-α-(4H-1,2,4-triazol-4-ylmethyl)-1H-1,2,4-triazole-1-ethanol. CAS No. 89429-59-4. Pack Sizes: 10 mg. Product ID: B0061-154408. Molecular formula: C13H12F2N6O. Mole weight: 306.28. Custom synthesis is available. Send your inquiries for more information.
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Fluconazole Impurity C
An impurity of the antifungal agent Fluconazole. Fluconazole is a triazole antifungal agent that is effective against most Candida strains. Group: Pharmaceutical. Alternative Names: 1,1'-(1,3-Phenylene)bis-1H-1,2,4-triazole; 1,1'-(1,3-Phenylene)di-1H-1,2,4-triazole. CAS No. 514222-44-7. Pack Sizes: 10 mg. Product ID: B2694-263597. Molecular formula: C10H8N6. Mole weight: 212.22. Custom synthesis is available. Send your inquiries for more information.
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Fluconazole Impurity I
An impurity of the antifungal agent Fluconazole. Fluconazole is a triazole antifungal agent that is effective against most Candida strains. Group: Pharmaceutical. Alternative Names: Fluconazole Amino Impurity ; 4-Amino-1-[(2RS)-2-(2,4-difluorophenyl)-2-hydroxy-3(1H-1,2,4-triazol-1-yl)propyl]-4H-1,2,4-triazolium bromide. CAS No. 150168-54-0. Pack Sizes: 100 mg. Product ID: B2694-471657. Molecular formula: C13H14F2N7O. Br. Mole weight: 402.2. Custom synthesis is available. Send your inquiries for more information.
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Flumetsulam
Flumetsulam is a triazolopyrimidine herbicide that is used for post-emergence control for undersown wheat and certain legume crops and pastures. Group: Pharmaceutical. Alternative Names: [1,2,4]Triazolo[1,5-a]pyrimidine-2-sulfonamide, N-(2,6-difluorophenyl)-5-methyl-; Broadstrike; DE 498; Python; Python (pesticide); Scorpion; Scorpion (pesticide); XRD 498. CAS No. 98967-40-9. Pack Sizes: 1mg;1g;10g. Product ID: 98967-40-9. Molecular formula: C12H9F2N5O2S. Mole weight: 325.29. Custom synthesis is available. Send your inquiries for more information.
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Fosaprepitant-[d4] Dimeglumine
Fosaprepitant-[d4] Dimeglumine is a labelled form of Fosaprepitant Dimeglumine, which has been found to be a selective neurokinin-1 (NK-1) receptor antagonist. Group: Pharmaceutical. Alternative Names: [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl-d4)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate 1-Deoxy-1-(methylamino)-D-glucitol; Fosaprepitant D4 Dimeglumine; MK-0517-d4; L785298-d4. Pack Sizes: 25 mg. Product ID: BLP-005503. Molecular formula: C37H52D4F7N6O16P. Mole weight: 1008.86. Custom synthesis is available. Send your inquiries for more information.
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Fosfluconazole
Fluconazole, a water-soluble phosphate prodrug of fluconazole, is a triazole antifungal agent that is effective against most Candida strains. Uses: 14-alpha demethylase inhibitors. Group: Pharmaceutical. Alternative Names: Procif; UK 292663; UK-292,663. CAS No. 194798-83-9. Pack Sizes: 100 mg. Product ID: B2692-062094. Molecular formula: C13H13F2N6O4P. Mole weight: 386.26. Custom synthesis is available. Send your inquiries for more information.
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GSK2982772
GSK2982772, with potential effect to treat inflammatory diseases, potently binds to RIP1 with exquisite kinase specificity. In phase 2a clinical studies for psoriasis, rheumatoid arthritis, and ulcerative colitis. Group: Pharmaceutical. Alternative Names: GSK2982772; GSK 2982772; GSK-2982772; 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide. CAS No. 1622848-92-3. Pack Sizes: 100 mg. Product ID: B0084-007719. Molecular formula: C20H19N5O3. Mole weight: 377.4. Custom synthesis is available. Send your inquiries for more information.
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