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| Product | Description | |
|---|---|---|
| All-trans-4-oxoretinoic acid | All-trans-4-oxoretinoic acid is a metabolite of all-trans-Retinoic Acid that binds to both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). Group: Pharmaceutical. CAS No. 38030-57-8. Pack Sizes: 100 mg. Product ID: B1370-114262. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| all trans-Retinal | All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. It can promote collagen and hyaluronic acid synthesis, increase skin thickness and elasticity, remove wrinkles and tighten skin, also can inhibit melanin synthesis, reduce pigmentation, whitening and freckle removal. It has the function of anti-oxidation, anti-aging skin, updating cutin and rejuvenating skin. It can kill propionibacterium acnes and streptococcus, etc., treat acne, reduce acne marks and treat skin photoaging. Group: Pharmaceutical. CAS No. 116-31-4. Pack Sizes: 1 g. Product ID: B2694-186375. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Peretinoin | Peretinoin, also known as NIK-333, orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells. Group: Pharmaceutical. CAS No. 81485-25-8. Pack Sizes: 10 mg. Product ID: B0084-305467. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SR1001 | Retinoic-acid-receptor-related orphan receptors (ROR) α and γ play a key role in the development of T-helper cells that produce interleukin-17 (TH17 cells), a subset of CD4+ T-cells that contribute to the inflammatory process and have been implicated in the pathology of autoimmune diseases. SR 1001 is a synthetic ligand specific for RORα and RORγ (Kis = 172 and 111 nM, respectively) that functions as an inverse agonist at these receptors. SR 1001 has been shown to suppress IL-17 promoter driven transcriptional activity by inhibiting the interaction of co-activators such as TRAP220 nuclear receptor box 2 peptide (IC50 = 117 nM) and SRC2 with RORα and RORγ as well as by increasing the recruitment of corepressors such as NCoR. At 5 μM, SR 1001 inhibits TH17 cell differentiation and IL-17A secretion in cultured splenocytes and human PBMCs. A 25 mg/kg dose of SR 1001 twice/day delays the onset and the severity of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. Group: Pharmaceutical. CAS No. 1335106-03-0. Pack Sizes: 100 mg. Product ID: B1370-463179. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SR3335 | The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM). It has no effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor &alpha. SR 3335 evokes RORα-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis. Group: Pharmaceutical. CAS No. 293753-05-6. Pack Sizes: 50 mg. Product ID: B2693-458981. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tamibarotene | Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute promyelocytic leukemia in vivo. It is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. It may show sustained plasma levels compared to ATRA. It may exhibit a lower toxicity profile than ATRA, in part, due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor in the dermal epithelium. Group: Pharmaceutical. CAS No. 94497-51-5. Pack Sizes: 1 g. Product ID: B2693-079954. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| All-trans Retinol | Vitamin A1 is a group of unsaturated nutritional organic compounds, which includes retinol, retinal, retinoic acid, several provitamin A carotenoids, and beta-carotene. Vitamin A1 is important for growth and development, the maintenance of the immune system, and good vision. Vitamin A1 is needed by the retina of the eye in the form of retinal, which combines with protein opsin to form rhodopsin, the light-absorbing molecule necessary for both low-light (scotopic vision) and color vision. Vitamin A1 also functions in a very different role as retinoic acid (an irreversibly oxidized form of retinol), which is an important hormone-like growth factor for epithelial and other cells. It has the functions of removing wrinkles, whitening and removing freckles, anti-aging, skin rejuvenation, acne removal, anti-oxidation, anti-ultraviolet, sunblock injury, anti-inflammatory and antibacterial, soothing and repairing, treating skin photoaging and rosacea. Uses: Vitamin a is indicated only for prevention or treatment of vitamin a deficiency states. Group: Pharmaceutical. CAS No. 68-26-8. Pack Sizes: 5 g. Product ID: B1370-464873. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Retinoic Acid 3,3-Dimethyl-2-oxobutyl Ester | Hydroxypinacolone Retinoate (HPR) is a revolutionary new retinoid. Compared with other vitamin A products, it can directly work through the excitatory receptor without metabolic transformation (generally retinoids need to be transformed in the skin in two steps). It is less irritating, highly potent, more stable, and less likely to be oxidized. It is a safe and effective anti-aging (effective in reducing fine lines and wrinkles, fading color spots) and anti-acne ingredient. Hydroxypinacolone retinoate, a derivative of retinol, regulates the metabolism of the epidermis and stratum corneum. It can be anti-aging, reduce sebum overflow, desalinate epidermal pigment, and play a role in preventing skin aging, preventing acne, whitening and lightening spots. It can be used to treat skin diseases. Group: Pharmaceutical. CAS No. 893412-73-2. Pack Sizes: 1 g. Product ID: B2694-154375. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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