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| Product | Description | |
|---|---|---|
| 6,7-Dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione | 6,7-Dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione, an organic compound of petite stature, finds widespread employment as a fundamental constituent in the production of diverse healing agents. Its competence as an anticonvulsant is well-documented and it serves as a propitious precursor in the construction of topoisomerase inhibitors and neuroprotective remedies. Group: Pharmaceutical. Alternative Names: Aldisin; 6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione; Pyrrolo[2,3-c]azepine-4,8(1H,5H)-dione, 6,7-dihydro-; 1H,4H,5H,6H,7H,8H-pyrrolo[2,3-c]azepine-4,8-dione. CAS No. 72908-87-3. Pack Sizes: 250 mg. Product ID: B0001-042431. Molecular formula: C8H8N2O2. Mole weight: 164.16. Custom synthesis is available. Send your inquiries for more information. |  London |
| 9-Aminocamptothecin | 9-Aminocamptothecin is a water-insoluble camptothecin derivative and an inhibitor of the nuclear enzyme topoisomerase I, disrupting the repair of single-strand DNA breakages. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: 9-amino-camptothecin; 9-amino-CPT; 9-AC; 9-amino-20(S)-camptothecin; 9-amino-20-camptothecin; Aminocamptothecin. CAS No. 91421-43-1. Pack Sizes: 100 mg. Product ID: NP0052. Molecular formula: C20H17N3O4. Mole weight: 363.37. Custom synthesis is available. Send your inquiries for more information. | London |
| ABT-719 | ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies. Group: Pharmaceutical. Alternative Names: ABT-719; ABT719; ABT 719; ABT-719; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid. CAS No. 162829-90-5. Pack Sizes: 1mg;1g;10g. Product ID: 162829-90-5. Molecular formula: C18H20FN3O3. Mole weight: 345.23. Custom synthesis is available. Send your inquiries for more information. | London |
| ABT-719 HCl | The hydrochloride salt form of ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies. Group: Pharmaceutical. Alternative Names: ABT-719 HCl; ABT719 HCl; ABT 719 HCl; ABT-719 hydrochloride; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride. CAS No. 162763-53-3. Pack Sizes: 1mg;1g;10g. Product ID: 162763-53-3. Molecular formula: C18H21ClFN3O3. Mole weight: 381.83. Custom synthesis is available. Send your inquiries for more information. | London |
| Aclarubicin hydrochloride | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting replication and repair of DNA and RNA, and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin. Uses: Antibiotics, antineoplastic. Group: Pharmaceutical. Alternative Names: Aclacinon; Aclaplastin; Aclacinomycin A Hydrochloride; Aclarubicin HCl; Aclarubicina Clorhidrato [Spanish]. CAS No. 75443-99-1. Pack Sizes: 5 mg. Product ID: BBF-04081. Molecular formula: C42H54ClNO15. Mole weight: 848.33. Custom synthesis is available. Send your inquiries for more information. | London |
| Ametantrone | Ametantrone (AM) is a topoisomerase II inhibitor leading to covalent cross-links in DNA of tumor cells. It is a synthetic 9,10-anthracenedione containing two (hydroxyethylamino)ethylamino residues at positions 1 and 4. Along with other anthraquinones and anthracyclines, it shares a polycyclic intercalating moiety and charged side chains that stabilize DNA binding. Group: Pharmaceutical. Alternative Names: CI881; CI 881; CI-881; NSC196473; NSC 287513; NSC-196473; NSC 287513; 1,4-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione. CAS No. 64862-96-0. Pack Sizes: 5 mg. Product ID: B0084-146674. Molecular formula: C22H28N4O4. Mole weight: 412.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Amonafide | Amonafide is an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: Nafidimide; Quinamed; Xanafide. CAS No. 69408-81-7. Pack Sizes: 50 mg. Product ID: B0084-097145. Molecular formula: C16H17N3O2. Mole weight: 283.33. Custom synthesis is available. Send your inquiries for more information. | London |
| Belotecan hydrochloride | Belotecan hydrochloride is a topoisomerase I inhibitor. It is a synthetic and water-soluble camptothecin derivative which forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. CKD-602 has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group. Group: Pharmaceutical. Alternative Names: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-, hydrochloride (1:1), (4S)-; (S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride; CKD 602; Belotecan monohydrochloride; (4S)-4-Ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride; 7-[2-(N-Isopropylamino)ethyl]-(20S)-camptothecin hydrochloride; Camtobell hydrochloride. CAS No. 213819-48-8. Pack Sizes: 20 mg. Product ID: B0084-087456. Molecular formula: C25H27N3O4.HCl. Mole weight: 469.96. Custom synthesis is available. Send your inquiries for more information. | London |
| Berubicin | Berubicin has potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis. Group: Pharmaceutical. Alternative Names: Daunorubicin Impurity 9; RTA 744; RTA-744; RTA744; WP 769; WP769; WP-769; 5,12-Naphthacenedione, 10-[[3-amino-2,3,6-trideoxy-4-O-(phenylmethyl)-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-. CAS No. 677017-23-1. Pack Sizes: 1mg;1g;10g. Product ID: BBF-04653. Molecular formula: C34H35NO11. Mole weight: 633.65. Custom synthesis is available. Send your inquiries for more information. | London |
| Berubicin Hydrochloride | Berubicin hydrochloride is the hydrochloride of berubicin, which is an anthracycline derivative used as a topoisomerase II inhibitor with activity in ependymoma. Berubicin hydrochloride has potential antineoplastic activity. Uses: A topoisomerase ii inhibitor with activity in ependymoma. Group: Pharmaceutical. Alternative Names: Daunorubicin Impurity 9 hydrochloride; WP 769 hydrochloride; 5,12-Naphthacenedione, 10-[[3-amino-2,3,6-trideoxy-4-O-(phenylmethyl)-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-, hydrochloride (1:1); Berubicin monohydrochloride; RTA 744; WP 744. CAS No. 293736-67-1. Pack Sizes: 1mg;1g;10g. Product ID: BBF-05864. Molecular formula: C34H35NO11.HCl. Mole weight: 670.1. Custom synthesis is available. Send your inquiries for more information. | London |
| Carminomycin I | It is produced by the strain of Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair, and RNA and protein synthesis. Group: Pharmaceutical. Alternative Names: Karminomitsin; NSC180024; NSC-180024; CMM; Karminomycin; (8S-cis)-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-5,12-naphthacenedione; Antibiotic R 588A; Demethyldaunomycin; (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-5,12-naphthacenedione; 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S-cis)-; Caminomycin; Carminomicin I; Carubicin. CAS No. 50935-04-1. Pack Sizes: 10 mg. Product ID: BBF-00703. Molecular formula: C26H27NO10. Mole weight: 513.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Chebulagic acid | Chebulagic acid is a polyphenol and tannin that has been found in T. chebula and has diverse biological activities. It is an inhibitor of COX-1, COX-2, and 5-lipoxygenase (5-LO; IC50s = 15, 0.92, and 2.1 μM, respectively) as well as α-glucosidase and 15-LO (IC50s = 0.05 and 24.9 μM, respectively). Chebulagic acid inhibit the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. And it can also inhibit the production of NO, prostaglandin E2 (PGE2), and reactive oxygen species (ROS), and nuclear translocation of NF-κB in RAW 264.7 macrophages in a concentration-dependent manner. Chebulagic acid also show a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Uses: Topoisomerase i inhibitors. Group: Pharmaceutical. Alternative Names: β-D-glucopyranose; Cyclic 3,6-[(1R)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1-(3,4,5-trihydroxybenzoate); Cyclic 2→2:4→1-ester with (2S)-2-[(3S,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid. CAS No. 23094-71-5. Pack Sizes: 50 mg. Product ID: B1370-300064. Molecular formula: C41H30O27. Mole weight: 954.66. Custom synthesis is available. Send your inquiries for more information. | London |
| Chimmitecan | Chimmitecan is a potent topoisomerase I inhibitor. Chimmitecan is also an active metabolite of simmitecan. Chimmitecan displays outstanding activity in vitro and in vivo. The substitution at the 9-position benefits chimmitecan a salient anti-MDR activity, stability in human serum albumin, improved solubility, and oral availability, which might favorably promise its therapeutic potential in clinical settings. Group: Pharmaceutical. Alternative Names: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-10-(2-propen-1-yl)-, (4S)-; (4S)-4-Ethyl-4,9-dihydroxy-10-(2-propen-1-yl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-10-(2-propenyl)-, (4S)-; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-10-(2-propenyl)-, (S)-; (S)-9-Allyl-10-Hydroxycamptothecin; (S)-10-allyl-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. CAS No. 185425-25-6. Pack Sizes: 5 mg. Product ID: BADC-01397. Molecular formula: C23H20N2O5. Mole weight: 404.42. Custom synthesis is available. Send your inquiries for more information. | London |
| CL2A-SN 38 | CL2A-SN 38 is a drug-linker conjugate for ADC by using SN 38 (a DNA Topoisomerase I inhibitor), linked via CL2A. Group: Pharmaceutical. Alternative Names: CL2A-SN-38. CAS No. 1279680-68-0. Pack Sizes: 5 mg. Product ID: BADC-00742. Molecular formula: C73H97N11O22. Mole weight: 1480.63. Custom synthesis is available. Send your inquiries for more information. | London |
| Clinafloxacin | Clinafloxacin is a fluoroquinolone antibiotic with a broad-range of antibacterial activity. It inhibits both DNA gyrase and topoisomerase IV. Group: Pharmaceutical. Alternative Names: 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. CAS No. 105956-97-6. Pack Sizes: 100 mg. Product ID: B0084-053762. Molecular formula: C17H17ClFN3O3. Mole weight: 365.79. Custom synthesis is available. Send your inquiries for more information. | London |
| Deruxtecan | Deruxtecan analog is a drug-linker conjugate for antibody-drug conjugate (ADC). Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan (DS-8201a), which is a HER2-targeting antibody-drug conjugate. DS-8201a significantly suppressed tumor growth in an immunocompetent mouse model with human HER2-expressing CT26.WT (CT26.WThHER2) cells. DS-8201a is currently in clinical trials. Group: Pharmaceutical. Alternative Names: Deruxtecan Analog; Deruxtecan, Trastuzumab deruxtecan; DS-8201a; DS8201a; DS 8201a; Exatecan derivative; DX-8951 derivative; DX 8951; DX8951; N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]glycylglycyl-L-phenylalanyl-N-[(2-{[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino}-2-oxoethoxy)methyl]glycinamide. CAS No. 1599440-13-7. Pack Sizes: 5 mg. Product ID: BBF-05879. Molecular formula: C52H56FN9O13. Mole weight: 1034.05. Custom synthesis is available. Send your inquiries for more information. | London |
| Doxorubicin | Doxorubicin is an anthracycline antibiotic produced in Str. peucetius var. caesinus. Doxorubicin has anti-Gram-positive bacteria activity and has a broad anti-tumor spectrum. Doxorubicin is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. Uses: Adcs cytotoxin. Group: Pharmaceutical. Alternative Names: Daunorubicin Impurity D; Daunorubicin EP Impurity D; (8S,10S)-10-[(3-Aamino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione; Adriamycin; Doxil; Adriablastin; Doxorubicine; Adriblastina; 14-Hydroxydaunomycin; 14-Hydroxydaunorubicine; Caelyx; Hydroxydaunorubicin; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; NSC 123127; (1S,3S)-3,5,12-Trihydroxy-3-(hydroxyacetyl)-10-(methyloxy)-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside; Epirubicin EP Impurity C. CAS No. 23214-92-8. Pack Sizes: 1mg;1g;10g. Product ID: BBF-00550. Molecular formula: C27H29NO11. Mole weight: 543.52. Custom synthesis is available. Send your inquiries for more information. | London |
| Doxorubicin hydrochloride | Doxorubicin is an anthracycline antibiotic with antineoplastic activity produced by the bacterium Streptomyces peucetius var. Doxorubicin is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. Uses: Adcs cytotoxin. Group: Pharmaceutical. Alternative Names: Daunorubicin EP Impurity D hydrochloride; (8S,10S)-10-[(3-Aamino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride; Doxorubicine hydrochloride; Adriblastina hydrochloride; 14-Hydroxydaunomycin hydrochloride; 14-Hydroxydaunorubicine hydrochloride; Hydroxydaunorubicin hydrochloride; (1S,3S)-3,5,12-Trihydroxy-3-(hydroxyacetyl)-10-(methyloxy)-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside hydrochloride; Epirubicin EP Impurity C hydrochloride. CAS No. 25316-40-9. Pack Sizes: 1 g. Product ID: BBF-03859. Molecular formula: C27H30ClNO11. Mole weight: 579.98. Custom synthesis is available. Send your inquiries for more information. | London |
| Doxorubicinol hydrochloride | Doxorubicinol is the major metabolite of doxorubicin, which inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. Group: Pharmaceutical. Alternative Names: (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-[(1S)-1,2-dihydroxyethyl]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride; Adriamycinol Hydrochloride; 13-Dihydrodoxorubicin Hydrochloride; (1S,3S)-3-[(1S)-1,2-Dihydroxyethyl]-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside hydrochloride (1:1); 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-[(1S)-1,2-dihydroxyethyl]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-, hydrochloride (1:1). CAS No. 63950-05-0. Pack Sizes: 1mg;1g;10g. Product ID: BBF-04065. Molecular formula: C27H32ClNO11. Mole weight: 582. Custom synthesis is available. Send your inquiries for more information. | London |
| DXD | DXD, an Exatecan derivative for ADC, is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 μM. It can be used as a payload for antibody-conjugated drug ADCs targeting HER2. Group: Pharmaceutical. Alternative Names: N-((1S,9S)-9-Ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinolin-1-yl)-2-hydroxyacetamide. CAS No. 1599440-33-1. Pack Sizes: 25 mg. Product ID: BADC-01394. Molecular formula: C26H24FN3O6. Mole weight: 493.48. Custom synthesis is available. Send your inquiries for more information. | London |
| Enrofloxacin | Enrofloxacin is a fluoroquinolone antibiotic that prevents DNA superhelix and DNA synthesis by inhibiting bacterial DNA gyrase (a type II topoisomerase). It can be used for bacterial diseases caused by sensitive bacteria in livestock and small animals. Group: Pharmaceutical. Alternative Names: Baytril; Enrofloxacine; CFPQ; Enrofloxacino; Bay Vp 2674. CAS No. 93106-60-6. Pack Sizes: 100 g. Product ID: BBF-04643. Molecular formula: C19H22FN3O3. Mole weight: 359.39. Custom synthesis is available. Send your inquiries for more information. | London |
| Epidaunorubicin | An impurity of Epirubicin, which is an anthracycline topoisomerase inhibitor used as an antineoplastic agent. Group: Pharmaceutical. Alternative Names: 4'-epidaunorubicin; Epirubicin EP Impurity F; 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-; (1S,3S)-3-Acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranoside; (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; (8S-cis)-4'-Epidaunorubicin; 4'-epi-Daunomycin; NSC 249333; 4'-Epi-daunorubicin; epi-Daunorubicin. CAS No. 57918-24-8. Pack Sizes: 0.5 mg. Product ID: BBF-05859. Molecular formula: C27H29NO10. Mole weight: 527.52. Custom synthesis is available. Send your inquiries for more information. | London |
| Epirubicin | Epirubicin, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. It is clinically active against a broad range of tumor types, including breast cancer, malignant lymphomas, soft tissue sarcomas, lung cancer, pleural mesothelioma, gastrointestinal cancer, head and neck cancer, ovarian cancer, prostatic carcinoma, transitional bladder carcinoma and so on. Group: Pharmaceutical. Alternative Names: Pharmorubicin; Ellence; Epiadriamycin; Epidoxorubicin; 4'-Epiadriamycin; Epirubicine; Pidorubicine; NSC 256942; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; (8S-cis)-4'-Epidoxorubicin; (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranoside. CAS No. 56420-45-2. Pack Sizes: 1mg;1g;10g. Product ID: BBF-05862. Molecular formula: C27H29NO11. Mole weight: 543.52. Custom synthesis is available. Send your inquiries for more information. | London |
| Epirubicin Hydrochloride | Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. Uses: Antibiotics, antineoplastic. Group: Pharmaceutical. Alternative Names: epi-Doxorubicin HCl; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione Hydrochloride; (8S-cis)-4'-Epidoxorubicin Hydrochloride; 4'-epi-Adriamycin Hydrochloride; Ellence; Epidoxorubicin Hydrochloride; Farmorubicin; Pharmorubicin; NSC-759195; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-. CAS No. 56390-09-1. Pack Sizes: 500 mg. Product ID: BBF-04657. Molecular formula: C27H29NO11.HCl. Mole weight: 579.98. Custom synthesis is available. Send your inquiries for more information. | London |
| Etoposide | Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. Group: Pharmaceutical. Alternative Names: 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-b-D-glucopyranoside). CAS No. 33419-42-0. Pack Sizes: 25 g. Product ID: NP4193. Molecular formula: C29H32O13. Mole weight: 588.55. Custom synthesis is available. Send your inquiries for more information. | London |
| Etoposide-[13C,d3] | One of the isotope labelled form of Etoposide, which is a cytotoxic anticancer drug which belongs to the topoisomerase inhibitor drug class and could be used in form of its salt etoposide phosphate. Group: Pharmaceutical. Alternative Names: (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one-13C-d3. Pack Sizes: 5 mg. Product ID: B1370-175035. Molecular formula: C28[13C]H29D3O13. Mole weight: 592.58. Custom synthesis is available. Send your inquiries for more information. | London |
| Exatecan Mesylate | Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting the religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogs. Group: Pharmaceutical. Alternative Names: DX 8951 mesylate; (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione mesylate; 10H,13H-Benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S-trans)-, mesylate (1:1); NSC-829066 mesylate. CAS No. 169869-90-3. Pack Sizes: 500 mg. Product ID: BBF-04655. Molecular formula: C25H26FN3O7S. Mole weight: 531.56. Custom synthesis is available. Send your inquiries for more information. | London |
| Flumequine | Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM. It is a first-generation fluoroquinolone antibacterial that has been removed from clinical use and is no longer marketed. Uses: Anti-infective agents, urinary; topoisomerase ii inhibitors. Group: Pharmaceutical. Alternative Names: 9-Fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid; Fluoromethylquinoline; Fluoromethyl; Apurone; Fantacin; R 802. CAS No. 42835-25-6. Pack Sizes: 1mg;1g;10g. Product ID: BBF-03879. Molecular formula: C14H12FNO3. Mole weight: 261.25. Custom synthesis is available. Send your inquiries for more information. | London |
| Fostriecin sodium salt | Fostriecin sodium salt is a protein phosphatase types 2A (PP2A) and 4 (PP4) inhibitor (IC50 = 1.5 nM and 3 nM, respectively). It also has an inhibitory effect on topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM). Fostriecin is found in Streptomyces pulveraceous. Uses: Enzyme inhibitors. Group: Pharmaceutical. Alternative Names: Fostriecin Sodium; Antibiotic CI 920 sodium salt; (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt. CAS No. 87860-39-7. Pack Sizes: 1 mg. Product ID: B1370-381555. Molecular formula: C19H26O9PNa. Mole weight: 452.37. Custom synthesis is available. Send your inquiries for more information. | London |
| Guajadial F | Guajadial F is a sesquiterpenoid-based meroterpenoid isolated from the leaves of Psidium guajava. Guajadial F has potential anticancer effects. Biochemical topoisomerase I (Top1) assay revealed that guajadial F acted as a Top1 catalytic inhibitor and delayed Top1 poison-mediated DNA damage. Group: Pharmaceutical. Alternative Names: (5aS,7S,10R,10aR,11aR,12R)-1,3-dihydroxy-5a,10-dimethyl-12-phenyl-7-propan-2-yl-7,8,9,10,10a,11,11a,12-octahydrobenzo[b]xanthene-2,4-dicarbaldehyde. CAS No. 1529775-08-3. Pack Sizes: 1 mg. Product ID: NP5861. Molecular formula: C30H34O5. Mole weight: 474.597. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan | Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. It is used for the treatment of colon and rectum cancers. It binds to topoisomerase I-DNA complex, preventing religation of the DNA strand and leading to double-strand DNA breakage and cell death. Uses: Anticancer drug. Group: Pharmaceutical. Alternative Names: Irinophore C; Irinotecan lactone; Irinotecan mylan; Onivyde; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.; (S)-[1,4'-Bipiperidine]-1'-carboxylic Acid 4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl Ester; Camptosar; Irinotecanum; CPT-11; CPT 11; CPT11; (+)-Irinotecan. CAS No. 97682-44-5. Pack Sizes: 1mg;1g;10g. Product ID: BBF-05861. Molecular formula: C33H38N4O6. Mole weight: 586.68. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan-[d10] Hydrochloride | Irinotecan-[d10] Hydrochloride is the labelled analogue of Irinotecan, which is a DNA topoisomerase inhibitor. Group: Pharmaceutical. Alternative Names: Irinotecan D10 Hydrochloride. CAS No. 718612-62-5. Pack Sizes: 10 mg. Product ID: BLP-012397. Molecular formula: C33H29D10ClN4O6. Mole weight: 633.2. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan EP Impurity A | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Group: Pharmaceutical. Alternative Names: (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-9-yl (1,4'-bipiperidine)-1'-carboxylate; 11-Desethyl Irinotecan. CAS No. 103816-16-6. Pack Sizes: 5 mg. Product ID: B1370-473338. Molecular formula: C31H34N4O6. Mole weight: 558.64. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan EP Impurity B | 10-Hydroxycamptothecin inhibits the growth of BT-20 and MDA-231 cell with IC50 of 34.3 nM and 7.27 nM, respectively, more potently than camptothecin (CPT) with IC50 of >500 nM. 10-Hydroxycamptothecin is also an impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Uses: Anti-cancer. Group: Pharmaceutical. Alternative Names: 10-Hydroxycamptothecin; Irinotecan Related Compound A; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-; (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (S)-; Camptothecine, 10-hydroxy-; (+)-10-Hydroxycamptothecin; (S)-10-Hydroxycamptothecin; 10-HCPT; 10-Hydroxycamptothecin; 10-Hydroxycamptothecine; Hydroxycamptothecin; NSC 107124; USP Irinotecan Related Compound A; Irinotecan USP Related Compound A. CAS No. 19685-09-7. Pack Sizes: 5 g. Product ID: B2703-086753. Molecular formula: C20H16N2O5. Mole weight: 364.35. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan EP Impurity C | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Group: Pharmaceutical. Alternative Names: 8-ethyl irinotecan; (S)-4,8,11-Triethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-9-yl (1,4'-bipiperidine)-1'-carboxylate. CAS No. 947687-02-7. Pack Sizes: 10 mg. Product ID: B1370-186673. Molecular formula: C35H42N4O6. Mole weight: 614.75. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan EP Impurity E (SN-38) | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. It inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. Uses: The treatment of colorectal cancer. Group: Pharmaceutical. Alternative Names: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione; 10-Hydroxy-7-ethylcamptothecin; SN 38 Lactone; Irinotecan EP Impurity E; SN-38; USP Irinotecan Related Compound B; Irinotecan Related Compound B; Irinotecan EP Impurity E; NSC-673596. CAS No. 86639-52-3. Pack Sizes: 1 g. Product ID: BADC-01393. Molecular formula: C22H20N2O5. Mole weight: 392.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan EP Impurity G | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Group: Pharmaceutical. Alternative Names: (4S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 7,11-Diethyl-10-hydroxycamptothecin. CAS No. 947687-01-6. Pack Sizes: 2.5 mg. Product ID: B2694-468001. Molecular formula: C24H24N2O5. Mole weight: 420.47. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan hydrochloride | Irinotecan Hcl(CPT-11 Hcl) prevents DNA from unwinding by inhibition of topoisomerase 1. Uses: Topoisomerase i inhibitors. Group: Pharmaceutical. Alternative Names: CPT-11 hydrochloride; CPT 11 hydrochloride; CPT11 hydrochloride; Camptothecin 11 hydrochloride. CAS No. 100286-90-6. Pack Sizes: 1mg;1g;10g. Product ID: NP3346. Molecular formula: C33H39ClN4O6. Mole weight: 623.14. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan Hydrochloride Trihydrate | The hydrochloride salt of Irinotecan. Irinotecan is a prodrug that can be activated to 7-ethyl-10-hydroxy-camptothecin (SN-38) by the carboxylesterase-converting enzyme. SN-38 inhibits topoisomerase I to suppress DNA replication and promote cell death. Group: Pharmaceutical. Alternative Names: CPT-11 HCl Trihydrate; CPT 11 HCl Trihydrate; CPT11 HCl Trihydrate; Irinotecan Hcl Trihydrate; UNII-042LAQ1IIS. CAS No. 136572-09-3. Pack Sizes: 1 g. Product ID: B0084-057943. Molecular formula: C33H38N4O6.HCl.3H2O. Mole weight: 677.18. Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan Hydroxyl Acid Disodium Salt | The active metabolite of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Group: Pharmaceutical. Alternative Names: SN-38 Hydroxy Acid Disodium Salt; SN-38 Carboxylate Disodium Salt; (S)-2-(12-ethyl-2-hydroxy-8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoic acid, sodium salt (1:2). Pack Sizes: 10 mg. Product ID: B1370-186667. Molecular formula: C22H20N2Na2O6. Mole weight: 454.38. Custom synthesis is available. Send your inquiries for more information. | London |
| Kaempferol | Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from plant sources. It has many functions such as anti-cancer, diuretic, anti-inflammatory, antioxidant, anti-bacterial, and anti-virus. Kaempferol can be used in food additive. Uses: Anti-inflammatory; diuretic; antioxidant; inhibitor of topoisomerase-ii. Group: Pharmaceutical. Alternative Names: Robigenin; Kaempherol; Kempferol; Populnetin; Rhamnolutein. CAS No. 520-18-3. Pack Sizes: 250 mg. Product ID: NP1821. Molecular formula: C15H10O6. Mole weight: 286.23. Custom synthesis is available. Send your inquiries for more information. | London |
| LMP744 hydrochloride | LMP744, also known as NSC706744, is a novel indenoisoquinoline topoisomerase I inhibitor. Uses: Topoisomerase i inhibitors. Group: Pharmaceutical. Alternative Names: LMP744; LMP 744; LMP-744; 6-(3-(2-hydroxyethyl)amino-1-propyl)-5,6-dihydro-2,3-dimethoxy-8,9-methylenedioxy-5,11-dioxo-11H-indeno(1,2-)isoquinoline; MJ-III-65; NSC 706744; NSC-706744; NSC706744; uglysy8 cpd. CAS No. 308246-57-3. Pack Sizes: 5 mg. Product ID: B2693-007629. Molecular formula: C24H24N2O7. Mole weight: 452.46. Custom synthesis is available. Send your inquiries for more information. | London |
| Mauritianin | Mauritianin is a compound of the flavonoid class found in the herbs of Hypericum japonicum Thunb. Mauritianin is a topoisomerase I inhibitor. Group: Pharmaceutical. Alternative Names: 5,7-dihydroxy-3-[(2R,3R,4S,5S,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy]oxan-2-yl]oxy-2-(4-hydroxyphenyl)chromen-4-one. CAS No. 109008-28-8. Pack Sizes: 5 mg. Product ID: NP2040. Molecular formula: C33H40O19. Mole weight: 740.664. Custom synthesis is available. Send your inquiries for more information. | London |
| Mitoxantrone | Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoma. Uses: Analgesics. Group: Pharmaceutical. Alternative Names: mitoxantrone; 65271-80-9; Mitoxanthrone; Mitozantrone; DHAQ. CAS No. 65271-80-9. Pack Sizes: 2.5 g. Product ID: B2693-074515. Molecular formula: C22H28N4O6. Mole weight: 444.48. Custom synthesis is available. Send your inquiries for more information. | London |
| Moxifloxacin-[d3] | Moxifloxacin-[d3] is a labelled form of Moxifloxacin. Moxifloxacin exerts its effects by trapping a DNA drug enzyme complex and specfically inhibiting ATP-dependent enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. Group: Pharmaceutical. Alternative Names: 1-Cyclopropyl-6-fluoro-8-methoxy-D3-7-[(4aS,7aS)-octahydro-pyrrolo [3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin-D3. CAS No. 1092356-42-7. Pack Sizes: 10 mg. Product ID: BLP-013398. Molecular formula: C21H21D3FN3O4. Mole weight: 404.44. Custom synthesis is available. Send your inquiries for more information. | London |
| Moxifloxacin Hydrochloride | Moxifloxacin exerts its effects by trapping a DNA drug enzyme complex and specifically inhibiting ATP-dependent enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. It is a fluoroquinolone antibiotic with broad-spectrum bactericidal activity against gram-positive and gram-negative strains. Group: Pharmaceutical. Alternative Names: BAY12-8039 HCl; BAY12 8039 HCl; BAY128039 HCl; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic Acid Hydrochloride (1:1); Actira; Avalox; Lapinix; Moxifloxacine Hydrochloride; Octegra. CAS No. 186826-86-8. Pack Sizes: 100 g. Product ID: BBF-04614. Molecular formula: C21H24FN3O4.HCl. Mole weight: 437.89. Custom synthesis is available. Send your inquiries for more information. | London |
| Nemorubicin | Nemorubicin, is a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. Uses: Adcs cytotoxin. Group: Pharmaceutical. Alternative Names: Methoxymorpholinyldoxorubicin; PNU152243A; PNU-152243A; PNU 152243A; (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2,3,6-trideoxy-3-[(2S)-2-methoxymorpholin-4-yl]-α-L-lyxo-hexopyranoside; 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-; 3'-Deamino-3'-(2(S)-methoxy-4-morpholinyl)doxorubicin; Methoxymorpholino-doxorubicin. CAS No. 108852-90-0. Pack Sizes: 10 mg. Product ID: BADC-00088. Molecular formula: C32H37NO13. Mole weight: 643.23. Custom synthesis is available. Send your inquiries for more information. | London |
| Pirarubicin | Pirarubicin is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into DNA and interacts with topoisomerase II, used as an antineoplastic agent. Group: Pharmaceutical. Alternative Names: Theprubicin; CGH-869; CGH 869; CGH869. CAS No. 72496-41-4. Pack Sizes: 25 mg. Product ID: BBF-03937. Molecular formula: C32H37NO12. Mole weight: 627.64. Custom synthesis is available. Send your inquiries for more information. | London |
| PNU-159682 | PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes. It is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity, and shows >3,000-fold cytotoxic than its parent compound (MMDX and doxorubicin). It is a more potent and well tolerated ADC cytotoxin than doxorubicin. Uses: Adcs cytotoxin. Group: Pharmaceutical. Alternative Names: (8S,10S)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-(((1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano(4',3':4,5)oxazolo(2,3-c)(1,4)oxazin-3-yl)oxy)-5,12-naphthacenedione; 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-(((1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano(4',3':4,5)oxazolo(2,3-c)(1,4)oxazin-3-yl)oxy)-, (8S,10S)-; PNU159682; PNU 159682. CAS No. 202350-68-3. Pack Sizes: 5 mg. Product ID: BBF-05916. Molecular formula: C32H35NO13. Mole weight: 641.62. Custom synthesis is available. Send your inquiries for more information. | London |
| PNU159682-EDA | PNU159682-EDA is a drug-linker conjugate for ADC by using PNU159682 (a potent DNA topoisomerase II inhibitor), linked via EDA. Group: Pharmaceutical. Alternative Names: EDA-PNU-159682; PNU-EDA. CAS No. 2255344-14-8. Pack Sizes: 5 mg. Product ID: BADC-01404. Molecular formula: C33H39N3O12. Mole weight: 669.68. Custom synthesis is available. Send your inquiries for more information. | London |
| Rubitecan | Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells. This agent also prevents repair of reversible single-strand DNA breaks. Group: Pharmaceutical. Alternative Names: RFS 2000; 9-Nitrocamptothecin; (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizinol[1,2-b]quinoline-3,14(4H,12H)-dione; 9-NC; Orathecin; 9-nitro-20(S)-camptothecin; Camptogen; (S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 9-nitro-CPT; Nitrocamptothecin. CAS No. 91421-42-0. Pack Sizes: 100 mg. Product ID: B2692-079493. Molecular formula: C20H15N3O6. Mole weight: 393.35. Custom synthesis is available. Send your inquiries for more information. | London |
| Sarafloxacin | Sarafloxacin is a quinolone antibiotic that inhibits bacterial DNA-topoisomerase II. It has been used in veterinary medicine. Group: Pharmaceutical. Alternative Names: 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid. CAS No. 98105-99-8. Pack Sizes: 1mg;1g;10g. Product ID: 98105-99-8. Molecular formula: C20H17F2N3O3. Mole weight: 385.36. Custom synthesis is available. Send your inquiries for more information. | London |
| Sarafloxacin-[d8] Hydrochloride | Sarafloxacin-[d8] Hydrochloride is the labelled hydrochloride form of Sarafloxacin. Sarafloxacin is a quinolone antibiotic drug, inhibiting the topoisomerase II ligase domain. Group: Pharmaceutical. Alternative Names: 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl-d8)-3-quinolinecarboxylic Acid Hydrochloride; A 56620-d8; PD 121960-d8; Sarafin-d8. CAS No. 1352879-52-7. Pack Sizes: 10 mg. Product ID: BLP-004197. Molecular formula: C20H10D8ClF2N3O3. Mole weight: 429.87. Custom synthesis is available. Send your inquiries for more information. | London |
| Sarafloxacin-[d8] hydrochloride hydrate | Sarafloxacin-[d8] hydrochloride hydrate is a labelled analogue of Sarafloxacin. Sarafloxacin is a topoisomerase II ligase inhibitor used as a quinolone antibiotic drug. Group: Pharmaceutical. Alternative Names: Sarafloxacin-D8 hydrochloride hydrate; Difloxacino-d8 hydrochloride hydrate; Difloxacinum-d8 hydrochloride hydrate; Sarafloxacino-d8 hydrochloride hydrate; Sarafloxacinum-d8 hydrochloride hydrate; 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazine-D8-1-yl-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate. Pack Sizes: 10 mg. Product ID: BLP-009155. Molecular formula: C20H9D8F2N3O3.HCl.H2O. Mole weight: 447.87. Custom synthesis is available. Send your inquiries for more information. | London |
| Sarafloxacin hydrochloride | Sarafloxacin is a quinolone antibiotic drug, inhibiting the topoisomerase II ligase domain. It inhibits bacterial Topo II α (DNA gyrase, topoisomerase) and is effective against Mycobacterium tuberculosis. Group: Pharmaceutical. Alternative Names: Sarafloxacin HCl; A-56620; A 56620; A56620. CAS No. 91296-87-6. Pack Sizes: 1mg;1g;10g. Product ID: BBF-03959. Molecular formula: C20H17F2N3O3.HCl. Mole weight: 421.83. Custom synthesis is available. Send your inquiries for more information. | London |
| Scabioside C | Scabioside C is extracted from Pulsatilla chinensis (Bunge) Regel. Uses: Topoisomerase i inhibitors. Group: Pharmaceutical. Alternative Names: Scabioside C; 17233-22-6; (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid; Leontoside B; CHEMBL466974; AKOS040760693; HY-107309; CS-0027942. CAS No. 17233-22-6. Pack Sizes: 5 mg. Product ID: B0005-465777. Molecular formula: C41H66O13. Mole weight: 767. Custom synthesis is available. Send your inquiries for more information. | London |
| Tirapazamine | Tirapazamine is a benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. Alternative Names: US brand name: Tirazone. Code names: SR 4233. WIN 59075. SR-259075, NSC-130181, Win-59075, SR-4233. CAS No. 27314-97-2. Pack Sizes: 1 g. Product ID: B2693-350792. Molecular formula: C7H6N4O2. Mole weight: 178.15. Custom synthesis is available. Send your inquiries for more information. | London |
| Topotecan hydrochloride | Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Uses: Topoisomerase i inhibitors. Group: Pharmaceutical. Alternative Names: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, hydrochloride (1:1), (4S)-; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (4S)-; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (S)-; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[l,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride; Hycamtin; Nogitecan hydrochloride; NSC 609669; SKF 104864A; SKFS 104864A; Topotecan chlorohydrate; Xinze. CAS No. 119413-54-6. Pack Sizes: 1 g. Product ID: NP0530. Molecular formula: C23H24ClN3O5. Mole weight: 457.91. Custom synthesis is available. Send your inquiries for more information | London |
| Zoliflodacin | Zoliflodacin, an oxazolidinone derivative, has been found to be a DNA gyrase inhibitor that could be used as an antibacterial agent. It is still under Phase II trial in Gonorrhea. Uses: Topoisomerase ii inhibitors. Group: Pharmaceutical. Alternative Names: UNII-FWL2263R77; AZD-0914; AZD0914; AZD 0914; FWL2263R77; FWL 2263R77; FWL-2263R77; Zoliflodacin; AZD0914; CHEMBL3544978; (2R,4S,4aS)-11-fluoro-2,4-dimethyl-8-((S)-4-methyl-2-oxooxazolidin-3-yl)-1,2,4,4a-tetrahydro-2'H,6H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5'-pyrimidine]-2',4',6'(1. CAS No. 1620458-09-4. Pack Sizes: 1 mg. Product ID: B0084-475910. Molecular formula: C22H22FN5O7. Mole weight: 487.4. Custom synthesis is available. Send your inquiries for more information. | London |
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