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| Product | Description | |
|---|---|---|
| 3,3,5-Triiodo-L-thyronine | 3,3,5-Triiodo-L-thyronine is a metabolite of thyroxine that binds to both thyroid hormone receptors TRα and TRβ so that might help maintain the metabolic homeostasis. It promotes chondrogenesis of human mesenchymal stem cells. Uses: 3,3,5-triiodo-l-thyronine(t3) is an active metabolite of thyroxine and could be effective in agonizing both thyroid hormone receptors trα and trβ. Group: Pharmaceutical. Alternative Names: Levothyroxine EP Impurity A; Liothyronine; Triiodothyronine; T3; (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid. CAS No. 6893-2-3. Pack Sizes: 1 g. Product ID: B0084-357278. Molecular formula: C15H12I3NO4. Mole weight: 650.97. Custom synthesis is available. Send your inquiries for more information. |  London |
| 3,3',5-Triiodo Thyropropionic Acid | 3,3',5-Triiodo Thyropropionic Acid is a thyroid hormone analog that can be used as an antilipemic. Group: Pharmaceutical. Alternative Names: Thyropropic Acid; 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid. CAS No. 51-26-3. Pack Sizes: 20 mg. Product ID: B0136-120818. Molecular formula: C15H11I3O4. Mole weight: 635.962. Custom synthesis is available. Send your inquiries for more information. | London |
| 3,5-Diiodo-L-tyrosine dihydrate | 3,5-Diiodo-L-tyrosine dihydrate is a widely employed compound assuming a pivotal function in the synthesand regulation of thyroid hormones. Its application extends to studying diverse thyroid disorders, including hyperthyroidism and goiter. Group: Pharmaceutical. Alternative Names: (S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate. CAS No. 18835-59-1. Pack Sizes: 1mg;1g;10g. Product ID: BAT-008065. Molecular formula: C9H13I2NO5. Mole weight: 469.01. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide | [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide is an intermediate of Sorafenib, which is a kinase inhibitor drug used for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), FLT3-ITD positive AML and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: 4-(4-Aminophenoxy)-N-methylpicolinamide; 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]aniline; 4-[(4-aminomethyl)phenoxy]-2-pyridine carbonic acid methylamide; Sorafenib Imp -1; Sorafenib Related Compound 23. CAS No. 284462-37-9. Pack Sizes: 1mg;1g;10g. Product ID: NP2695. Molecular formula: C13H13N3O2. Mole weight: 243.26. Custom synthesis is available. Send your inquiries for more information. | London |
| Agouti-related Protein (AGRP) (25-82), human | Agouti-related protein (AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. It acts as a melanocortin receptor antagonist that exerts a central inhibitory action on the Hypothalamic-Pituitary-Thyroid (HPT) Axis. Group: Pharmaceutical. Pack Sizes: 1 mg. Product ID: BAT-006143. Molecular formula: C279H468N80O90S1. Mole weight: 6415.39. Custom synthesis is available. Send your inquiries for more information. | London |
| Calcitonin eel | Calcitonin eel is a peptide hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Group: Pharmaceutical. Alternative Names: Eel calcitonin; Calcitonin (eel); Calcitonin, Eel; Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-NH2 [Disulfide bridge: 1-7]; Thyrocalcitonin Eel; L-Cysteinyl-L-seryl-L-asparaginyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-α-aspartyl-L-valylglycyl-L-alanylglycyl-L-threonyl-L-prolinamide cyclic (1→7)-disulfide; Eel thyrocalcitonin; HC 58; 26-L-Aspartic acid-27-L-valine-29-L-alanine-calcitonin (salmon). CAS No. 57014-02-5. Pack Sizes: 2.5 mg. Product ID: BAT-006141. Molecular formula: C146H241N43O47S2. Mole weight: 3414.86. Custom synthesis is available. Send your inquiries for more information. | London |
| Ethyl (4-((2-(Methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: PAPE-ethyl Carbamate; Sorafenib related compound 7. CAS No. 2206827-12-3. Pack Sizes: 100 mg. Product ID: B2694-479756. Molecular formula: C16H17N3O4. Mole weight: 315.32. Custom synthesis is available. Send your inquiries for more information. | London |
| Levothyroxine EP Impurity F | An impurity of Thyroxine which is one of the two major hormones secreted by the thyroid gland and used to stimulate the consumption of oxygen and thus the metabolism of all cells and tissues in the body. Group: Pharmaceutical. Alternative Names: O-(4-Hydroxy-3,5-diiodophenyl)thyroxine; O-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-3,5-diiodo-L-tyrosine; T6. CAS No. 911661-90-0. Pack Sizes: 5 mg. Product ID: B2694-413570. Molecular formula: C21H13I6NO5. Mole weight: 1120.77. Custom synthesis is available. Send your inquiries for more information. | London |
| Levothyroxine sodium | Levothyroxine sodium is the hormone derived from thyroid gland. Group: Pharmaceutical. Alternative Names: L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1); Thyroxine, monosodium salt, L-; L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt; Dathroid; Eltroxin; Laevoxin; Levoroxine; Sodium levothyroxine; Sodium thyroxin; Sodium L-thyroxine; Sodium thyroxine; Thyroxine sodium; L-Thyroxine sodium; L-Thyroxine monosodium salt; L-Thyroxine sodium salt; Monosodium thyroxine; Sodium thyroxinate; Thyroxine sodium salt. CAS No. 55-03-8. Pack Sizes: 1 g. Product ID: B0084-069975. Molecular formula: C15H10I4NNaO4. Mole weight: 798.856. Custom synthesis is available. Send your inquiries for more information. | London |
| Liothyronine Sodium | Liothyronine Sodium is the most potent form of thyroid hormone acting on the body to increase the basal metabolic rate, affect protein synthesis. Group: Pharmaceutical. Alternative Names: Cytomel; Triostat; 3,3',5-Triiodo-L-Thyronine Sodium Salt. CAS No. 55-06-1. Pack Sizes: 1 g. Product ID: BAT-008129. Molecular formula: C15H11I3NO4.Na. Mole weight: 672.96. Custom synthesis is available. Send your inquiries for more information. | London |
| MGL-3196 | MGL-3196 is a first-in-class, orally available, once-daily and liver-directed thyroid hormone receptor (THR) beta-selective agonist. Studies suggest that MGL-3196 has an attractive, differentiated profile as a potential treatment for non-alcoholic steatohepatitis (NASH) and dyslipidemias. Uses: Potential treatment for non-alcoholic steatohepatitis (nash) and dyslipidemias. Group: Pharmaceutical. Alternative Names: CHEMBL3261331; UNII-RE0V0T1ES0; MGL-3196; MGL 3196; MGL3196; VIA 3196; VIA3196; VIA-3196; Resmetirom.RE0V0T1ES0; 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1H-pyridazin-3-yl)oxy]phenyl]-3,5-dioxo-1,2,4-triazine-6-carbonitrile. CAS No. 920509-32-6. Pack Sizes: 1 g. Product ID: B0084-008623. Molecular formula: C17H12Cl2N6O4. Mole weight: 435.211. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Acetyl-3-iodo-L-tyrosine hemihydrate | N-Acetyl-3-iodo-L-tyrosine hemihydrate, a chemical reagent with notable significance in studying enzyme inhibitors and protein synthesis, is widely utilized in the medical research community to develop promising drug therapies for thyroid disorders and cancers. Such compounds may also be used to synthesize radioiodinated compounds, essential in the realm of medical imaging and diagnostics. Uses: Thyronine analog. Group: Pharmaceutical. Alternative Names: L-Tyrosine, N-acetyl-3-iodo-, hydrate (2:1). CAS No. 23277-49-8. Pack Sizes: 100 mg. Product ID: B2699-115435. Molecular formula: C22H26I2N2O9. Mole weight: 716.3. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Desmethyl Vandetanib | N-Desmethyl Vandetanib is a metabolite of Vandetanib. Vandetanib is an antitumor drug used for the treatment of medullary thyroid cancer. Vandetanib effects through inhibiting vascular endothelial growth factor receptor-2 (VEGFR), epidermal growth factor receptor (EGFR) and the RET-tyrosine kinase activity. Group: Pharmaceutical. Alternative Names: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(4-piperidinylmethoxy)-4-quinazolinamine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(piperidin-4-yl)methoxy]quinazoline. CAS No. 338992-12-4. Pack Sizes: 5 mg. Product ID: B1926-260255. Molecular formula: C21H22BrFN4O2. Mole weight: 461.34. Custom synthesis is available. Send your inquiries for more information. | London |
| Oleuropein | Oleuropein is isolated from the herb of Olea europaea L. It inhibits cell proliferation and induces apoptosis in breast cancer, colorectal cancer and thyroid cancer. Oleuropein also has other functions such as anti-ischemic, antioxidative, anti-inflammatory. It can be used in cosmetics material. Uses: Antioxidant activity; anti-inflammatory agent. Group: Pharmaceutical. Alternative Names: 2H-Pyran-4-acetic acid, 3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-, 2-(3,4-dihydroxyphenyl)ethyl ester, [2S-(2α,3E,4β)]-; 2H-Pyran-4-acetic acid, 5-carboxy-3-ethylidene-2-(β-D-glucosyloxy)-3,4-dihydro-, 3,4-dihydroxyphenethyl 5-methyl ester; 2H-Pyran-4-acetic acid, 3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-, 2-(3,4-dihydroxyphenyl)ethyl ester, (2S,3E,4S)-; Oleoeuropein; Oleoeuropeine; Oleuropeine; Opiace. CAS No. 32619-42-4. Pack Sizes: 500 mg. Product ID: NP3908. Molecular formula: C25H32O13. Mole weight: 540.51. Custom synthesis is available. Send your inquiries for more information. | London |
| PF-1355 | PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MPO without disrupting a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. PF-1355 was used to test the hypothesis that MPO activity is a critical mediator of disease activity in immune complex vasculitis mouse models, and to support the confidence in rationale for this mechanism as a therapeutic approach to treat related human condition such as alleviating tissue injury caused by Goodpasture syndrome and pulmonary vasculitis induced by immune complexes. Group: Pharmaceutical. Alternative Names: 2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide;PF-06281355; PF 06281355; PF06281355; PF-1355; PF 1355; PF1355. CAS No. 1435467-38-1. Pack Sizes: 50 mg. Product ID: B0084-474818. Molecular formula: C14H15N3O4S. Mole weight: 321.35. Custom synthesis is available. Send your inquiries for more information. | London |
| Potassium Iodide | Classed as a metal halide, potassium iodide is a chemical compound that's made from metal (potassium) and halogen (iodine). It has the chemical formula KI and can either appear as a liquid solution, crystals or a white powder. Potassium iodide is commonly used in the medical sector to protect the thyroid during nuclear medicine scintigraphy. It's also used as a dietary supplement to help prevent iodine deficiency. The substance has a neutral or slightly alkaline pH. Uses: Radiation protection. Group: Laboratory Chemicals. Alternative Names: KI. CAS No. 7681-11-0. Pack Sizes: 500G, 1KGs. | Chemicals.co.uk |
| Selpercatinib | Selpercatinib is a selective RET inhibitor with antineoplastic activity. It inhibits proliferation of cancer cells containing RET mutations or gene fusions. It is indicated for the treatment of non-small cell lung cancer (NSCLC), medullary thyroid cancer (MTC) and other thyroid cancer tumors. Group: Pharmaceutical. Alternative Names: LOXO-292; LOXO292; LOXO 292; ARRY-192; ARRY192; ARRY 192. CAS No. 2152628-33-4. Pack Sizes: 1 g. Product ID: B2692-009515. Molecular formula: C29H31N7O3. Mole weight: 525.6. Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib related compound 10 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxylic Acid; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinic Acid; Sorafenib Hydroxydemethylamine. CAS No. 1012058-78-4. Pack Sizes: 10 mg. Product ID: B1630-479761. Molecular formula: C20H13ClF3N3O4. Mole weight: 451.79. Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib Related Compound 15 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: 4,4'-[Carbonylbis(imino-4,1-phenyleneoxy)]bis[N-methyl-2-pyridinecarboxamide]; PAPE-urea; N,N'-Bis[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea. CAS No. 284670-98-0. Pack Sizes: 250 mg. Product ID: B2694-479766. Molecular formula: C27H24N6O5. Mole weight: 512.53. Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib related compound 2 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: N-[4-Chloro-3-(trifluoromethyl)phenyl]carbamic Acid Ethyl Ester; [4-Chloro-3-(trifluoromethyl)phenyl]carbamic Acid Ethyl Ester; 4-Chloro-3-(trifluoromethyl)carbanilic Acid Ethyl Ester; Ethyl (4-Chloro-3-(trifluoromethyl)phenyl)carbamate. CAS No. 18585-06-3. Pack Sizes: 2 g. Product ID: B2694-233982. Molecular formula: C10H9ClF3NO2. Mole weight: 267.64. Custom synthesis is available. Send your inquiries for more information. | London |
| Trametinib | A MEK inhibitor that suppresses MEK1 and MEK2 with IC50 of 0.92 and 1.8 nM and no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. It has been approved by FDA, in combination with Tafilnar, for the treatment of metastatic anaplastic thyroid cancer (ATC) with BRAF V600E mutation. Group: Pharmaceutical. Alternative Names: GSK-1120212; GSK 1120212; GSK1120212; JTP74057; JTP 74057; JTP-74057; Mekinist. CAS No. 871700-17-3. Pack Sizes: 500 mg. Product ID: B0084-307744. Molecular formula: C26H23FIN5O4. Mole weight: 615.39. Custom synthesis is available. Send your inquiries for more information. | London |
| VER-155008 | VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 μM) that is selective over Hsp90. It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 μM) and glucose-regulated protein 78 (Grp78; KD = 80 nM). VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death. It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors. VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells. Group: Pharmaceutical. Alternative Names: 8-(3,4-Dichlorobenzyl)amino-5'-O-(4-cyanobenzyl)adenosine; C07; VER 155008; VER155008; 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-Adenosine; 4-((((2R,3S,4R,5R)-5-(6-amino-8-(3,4-dichlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)methyl)benzonitrile. CAS No. 1134156-31-2. Pack Sizes: 100 mg. Product ID: B1370-272446. Molecular formula: C25H23Cl2N7O4. Mole weight: 556.4. Custom synthesis is available. Send your inquiries for more information. | London |
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