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| Product | Description | |
|---|---|---|
| Tazemetostat hydrobromide | Tazemetostat hydrobromide is a potent, selective and orally bioavailable EZH2 inhibitor with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. It inhibits EZH1 and rat EZH2 with IC50s of 392 nM and 4 nM, respectively. It inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki of 2.5 nM. Group: Pharmaceutical. Alternative Names: EPZ-6438 hydrobromide; E-7438 hydrobromide; (1,1'-Biphenyl)-3-carboxamide, N-((1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(4-morpholinylmethyl)-, hydrobromide (1:1); N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide hydrobromide. CAS No. 1467052-75-0. Pack Sizes: 100 mg. Product ID: B1370-382050. Molecular formula: C34H45BrN4O4. Mole weight: 653.65. Custom synthesis is available. Send your inquiries for more information. |  London |
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