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| Product | Description | |
|---|---|---|
| Tafamidis | Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. It is a drug for the amelioration of transthyretin-related hereditary amyloidosis. It functions by kinetic stabilization of the correctly folded tetrameric form of the transthyretin (TTR) protein and binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR. Group: Pharmaceutical. Alternative Names: Fx-1006A; Vyndaqel. CAS No. 594839-88-0. Pack Sizes: 1 g. Product ID: B2693-463292. Molecular formula: C14H7Cl2NO3. Mole weight: 308.12. Custom synthesis is available. Send your inquiries for more information. |  London |
| Tafamidis-[d3] | Tafamidis-[d3] is deuterium labelled Tafamidis. Tafamidis is a potent and selective transthyretin (TTR) stabilizer, showing comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis. Group: Pharmaceutical. Alternative Names: Tafamidis-d3; d3-Tafamidis. Pack Sizes: 10 mg. Product ID: BLP-014826. Molecular formula: C14H4D3Cl2NO3. Mole weight: 311.13. Custom synthesis is available. Send your inquiries for more information. | London |
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