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| Product | Description | |
|---|---|---|
| 2',3'-cGAMP | 2',3'-cGAMP was considered to be the metazoan second messenger which is produced by cGAMP synthase (cGAS), the mammalian intrinsic immune DNA sensor. It can activate innate immunity by directly binding the endoplasmic reticulum-resident receptor STING (stimulator of interferon genes). Group: Pharmaceutical. CAS No. 1441190-66-4. Pack Sizes: 1 mg. Product ID: B1370-006099. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid | 2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid, a promising antifungal agent, possesses potent activity against Candidiasis and Aspergillosis. The compound targets 3-ketoacyl-ACP synthase III (FabH), a key enzyme in the biosynthesis of fungal fatty acids, and reduces fungal growth by inducing cellular membrane disruption through inhibition of FabH activity. With its unique mode of action, 2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid stands as a notably effective potential antifungal therapeutic candidate. Group: Pharmaceutical. CAS No. 955373-67-8. Pack Sizes: 1 mg. Product ID: B0001-382957. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5'-Deoxy-5'-isobutylthioadenosine | 5'-Deoxy-5'-isobutylthioadenosine selectively inhibits spermine synthase. Uses: Antimalarials. Group: Pharmaceutical. CAS No. 35899-54-8. Pack Sizes: 20 mg. Product ID: B2000-112201. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Aza-2-thiothymine | 6-Aza-2-thiothymine, a nucleoside analog widely utilized in cancer research, is profoundly effective in inhibiting thymidylate synthase; hence, it's active against several cancer cell lines. Furthermore, the compound's promising potential as a radiosensitizer renders it an excellent option for the management of solid tumors. This ground-breaking analog with unparalleled efficacy and versatility is a definitive focal point of modern-day cancer research. Group: Pharmaceutical. CAS No. 615-76-9. Pack Sizes: 25 g. Product ID: B2699-030048. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 9-Bromononanoic acid | 9-Bromononanoic acid, an instrumental biochemical reagent, finds ubiquitous use in several industrial processes including the synthesis of pharmaceutical drugs. Known for its inhibitory properties against fatty acid synthase, its prowess extends to manufacturing surfactants, detergents while also being extensively used as a building block in organic synthesis. This acid's multifunctional attributes coupled with its incomparable industrial benefits are a testament to its quintessential role in modern chemistry. Group: Pharmaceutical. CAS No. 41059-02-3. Pack Sizes: 25 g. Product ID: B2699-149193. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 9-Hydroxy-α-lapachone | 9-Hydroxy-α-lapachone isolated from the herbs of Catalpa ovata. It exhibits potent inhibitory activity against H. pylori Cystathionine gamma-synthase. Uses: Potent inhibitory activity. Group: Pharmaceutical. CAS No. 22333-58-0. Pack Sizes: 1 mg. Product ID: NP4466. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetophenone-[13C6] | Acetophenone-[13C6] is an intermediate in synthesizing Ibuprofen-[13C]6, a labelled Ibuprofen. It is a selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. Group: Pharmaceutical. CAS No. 125770-94-7. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-000007. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acivicin | Acivicin is an isoxazole antibiotic isolated from Streptomyces. sviceus. Acivicin is a glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase, respectively) as a potent antitumor antibiotic that induces apoptosis in human lymphoblastoid cells. Acivicin is an inhibitor of GGT used for solid tumor research. Uses: Protease inhibitor. Group: Pharmaceutical. CAS No. 42228-92-2. Pack Sizes: 1mg; 1g; 10g. Product ID: BBF-00541. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Agmatine sulfate salt | Agmatine sulfate, the sulfate preparation of Agmatine, is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. Agmatine displaces clonidine at α2-adrenergic and at imidazoline receptors and produces blockade of the NMDA-receptor associated cation channels. Nutritional supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 2482-00-0. Pack Sizes: 1 kg. Product ID: BAT-008149. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| α-Viniferin | α-Viniferin isolated from the herb of Carex humilis Leyss. It inhibits AChE activity is specific, reversible and noncompetitive,down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages. Uses: Anti-inflammatory activity; antifungal; inhibits protein kinase c; inhibits prostaglandin h2 synthase carex humilis. Group: Pharmaceutical. CAS No. 62218-13-7. Pack Sizes: 1 mg. Product ID: NP4646. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Alsterpaullone | Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Group: Pharmaceutical. CAS No. 237430-03-4. Pack Sizes: 50 mg. Product ID: B2693-103248. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Anidulafungin | Anidulafungin, is a semisynthetic echinocandin that inhibits glucan synthase, an enzyme important in the formation of (1→3)-β-D-glucan, a major fungal cell wall component, and thus is used as an antifungal drug. Group: Pharmaceutical. CAS No. 166663-25-8. Pack Sizes: 100 mg. Product ID: BBF-03844. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AR-A014418 | AR-A014418 is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β), a serine/threonine protein kinase involved in multiple diseases including Alzheimer's disease and type 2 diabetes. Group: Pharmaceutical. CAS No. 487021-52-3. Pack Sizes: 25 mg. Product ID: B0084-258809. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AR-AO 14418-[d3] | AR-AO 14418-[d3] is a labelled analogue of AR-AO 14418, a Glycogen Synthase Kinase 3β (GSK-3β) inhibitor. Group: Pharmaceutical. CAS No. 1216908-63-2. Pack Sizes: 5 mg. Product ID: BLP-014119. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Aureobasidin A | Aureobasidin A is a cyclic depsipeptide antibiotic isolated from the filamentous fungus Aureobasidium pullulans R106. It is an antifungal agent that inhibits phosphorylceramide synthase. Group: Pharmaceutical. CAS No. 127785-64-2. Pack Sizes: 1 mg. Product ID: BBF-04146. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Avicularin | Avicularin, a natural plant flavonoid isolated from the herbs of Polygonum aviculare, exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. By decreasing C/EBPα-activated GLUT4-mediated glucose uptake in adipocytes and potently inhibiting fatty acid synthase, avicularin can inhibit the accumulation of the intracellular lipids. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 572-30-5. Pack Sizes: 10 mg. Product ID: NP1949. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bedaquiline | TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB. Group: Pharmaceutical. CAS No. 843663-66-1. Pack Sizes: 100 mg. Product ID: B0084-152490. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bedaquiline fumarate | Bedaquiline fumarate is an anti-tuberculosis drug which selectively inhibits the mycobacterial energy metabolism and found to be effective against all states of Mycobacterium tuberculosis. It possesses a unique mechanism of action that disrupts the activity of the mycobacterial adenosine triphosphate synthase. It has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis, however, its side effect profile limits its use against MDR-TB when no other effective regimen can be provided. Uses: Antitubercular agents. Group: Pharmaceutical. CAS No. 845533-86-0. Pack Sizes: 200 mg. Product ID: B0084-463644. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| β-Nicotinamide Adenine Dinucleotide | NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It plays a role in the activity of several enzymes, such as poly(ADP)-ribose polymerases and cADP-ribose synthases. NAD+ is commonly used as an oxidizing agent. Nutritional supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 53-84-9. Pack Sizes: 10 g. Product ID: B0084-094034. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| β-pseudoUridine | An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that Beta-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes. Group: Pharmaceutical. CAS No. 1445-07-4. Pack Sizes: 5 g. Product ID: BBF-04654. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bismuth Subsalicylate | Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2. Uses: Antidiarrheals. Group: Pharmaceutical. CAS No. 14882-18-9. Pack Sizes: 1 kg. Product ID: B1370-059261. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| C16 Ceramide | C16 ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling. It has also been found to activate NF-κB and PKCζ3. Uses: A predominant, rather hydrophobic natural ceramide. activates a cytosolic serine/threonine protein phosphatase in t9 cells; induces egf receptor phosphorylation in a-431 cells; stimulates ceramide-activated protein kinase. Group: Pharmaceutical. CAS No. 24696-26-2. Pack Sizes: 100 mg. Product ID: B1370-059982. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CHIR-99021 | CHIR-99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. It enhances reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs in combination with tranylcypromine. It also induces cardiomyocyte differentiation from human embryonic stem (ES). Uses: Potential antineoplastic agent. Group: Pharmaceutical. CAS No. 252917-06-9. Pack Sizes: 100 mg. Product ID: B0084-462893. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Chrysoeriol | Chrysoeriol is a natural compound isolated from the herbs of Medicago sativa. Chrysoeriol can potently inhibit the induction of nitric oxide synthase by blocking activator protein 1 (AP-1) activation and its anti-inflammatory effects. Chrysoeriol can induce nod genes in rhizobium meliloti. Chrysoeriol can inhibit the downstream signal transduction pathways of platelet-derived growth factor (PDGF)-Rbeta, including ERK1/2, p38, and Akt phosphorylation, which suggests that chrysoeriol may be used for the prevention and treatment of vascular diseases during restenosis after coronary angioplasty. Group: Pharmaceutical. CAS No. 491-71-4. Pack Sizes: 25 mg. Product ID: NP2023. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Eliglustat hemitartrate | Eliglustat hemitartrate is a specific inhibitor of glucosylceramide synthase. It is under development as an oral substrate reduction therapy for Gaucher disease type 1 (GD1). It was developed by Genzyme Corp and has been listed by the FDA August 2014. Group: Pharmaceutical. CAS No. 928659-70-5. Pack Sizes: 1 g. Product ID: B2693-474918. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Givosiran sodium | Givosiran sodium is a small interfering RNA (siRNA) directed towards delta-aminolevulinate synthase 1 (ALAS1). Givosiran sodium has been indicated for the treatment of adults with acute hepatic porphyria (AHP). Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B1370-212888. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Irigenin | Irigenin is a natural compound isolated from the rhizomes of Belamcanda chinensis (L.) DC. Irigenin prevents metastatic capacity of lung cancer cells by selectively blocking Extra Domain A. Irigenin has anti-inflammatory effects that can inhibit the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins and mRNAs without an appreciable cytotoxic effect. Group: Pharmaceutical. CAS No. 548-76-5. Pack Sizes: 20 mg. Product ID: NP2498. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Isovitexin | Isovitexin, a food phytochemical contained in dietary rice products, or as a natural plant flavonoid isolated from the seeds of Vitex trifolia L, suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages. Isovitexin exhibits anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting MAPK and NF-κB and activating HO-1/Nrf2 pathways. Isovitexin can inhibit xanthine oxidase with an IC50 value of 15.2 microM, and it may protect cells from oxidative stress. Group: Pharmaceutical. CAS No. 29702-25-8. Pack Sizes: 100 mg. Product ID: NP1807. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Manzamine A | Manzamine A is an alkaloid in the class of β-carboline isolated from the marine sponges. It acts as an inhibitor of glycogen synthase kinase 3β (GSK3β). It exhibits inhibitory effects against growth of the rodent malaria parasite Plasmodium berghei in vivo. Group: Pharmaceutical. CAS No. 104196-68-1. Pack Sizes: 5 mg. Product ID: B2703-196790. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| methyl 3-guanidino-4-methylbenzoate mononitrate | Methyl 3-guanidino-4-methylbenzoate mononitrate, a highly versatile pharmaceutical intermediate, is utilized for the synthesis of nitric oxide synthase isoform-specific drugs that exhibit therapeutic potential against a variety of cardiovascular and inflammatory maladies associated with NOS isoform dysregulation. Its wide scope of therapeutic applications underscores its immense potential as a drug precursor. Group: Pharmaceutical. CAS No. 1025716-99-7. Pack Sizes: 5 g. Product ID: B2699-046503. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Miglustat HCl | Miglustat HCl is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1). It also inhibits glucosidase I and II, as well as HIV-1 and HIV-2 infection of peripheral blood mononuclear cells (PBMCs). Group: Pharmaceutical. CAS No. 210110-90-0. Pack Sizes: 10 mg. Product ID: B0084-101894. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mussaenoside | Mussaenoside is a natural iridoid found in the herbs of Melampyrum roseum Maxim, it can inhibit the release of pro-inflammatory cytokines induced by LPS, the production of nitric oxide (NO) and prostaglandin E2, and the expression of inducible NO synthase and cyclooxygenase-2 induced by lipopolysaccharide (LPS) in the RAW264.7 murine macrophage cell line. Mussaenoside also exhibits the activity of anti-inflammatory. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 64421-27-8. Pack Sizes: 1 mg. Product ID: NP3859. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Nolatrexed dihydrochloride | Nolatrexed, also known as AG337, is a thymidylate synthase inhibitor with potential anticancer activity. A phase II study of nolatrexed in 2007 in advanced HCC patients demonstrated minimal activity and significant stomatitis. Group: Pharmaceutical. CAS No. 152946-68-4. Pack Sizes: 50 mg. Product ID: B0084-059576. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Oligomycin A | Oligomycin A, an ATP synthase inhibitor and a macrolide antibiotic with fungicidal activity isolated from Streptomyces species, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria. Group: Pharmaceutical. CAS No. 579-13-5. Pack Sizes: 10 mg. Product ID: BBF-02618. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Raltitrexed | Raltitrexed is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth. Raltitrexed is used as an antimetabolite drug used in the treatment of colorectal cancer, and may be beneficial for malignant mesothelioma treatment. Uses: The treatment of colorectal cancer. Group: Pharmaceutical. CAS No. 112887-68-0. Pack Sizes: 100 mg. Product ID: B0084-054820. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SDMA | An endogenous inhibitor of nitric oxide (NO) synthase activity. Group: Pharmaceutical. CAS No. 30344-00-4. Pack Sizes: 50 mg. Product ID: B0084-105642. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SKF-86002 | SKF-86002 is a p38 MAP kinase inhibitor, the IC50 is 0.1 - 1 μM. It potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes, the IC50 is1 μM. It also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO). In vitro: SKF-86002 inhibited prostaglandin H2 synthase activity, the IC50 is 120 mM as well as prostanoid production by rat basophilic leukemia cells, the IC50 is mM and its sonicate ( the IC50 is 100 mM and human monocytes (the IC50 is 1 mM. It inhibited the generation of dihydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid by a high speed supernatant fraction of RBL-1 cells (the IC50 is 10 mM). It blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP. Uses: Skf-86002 could potently inhibit lps-induced il-1 and tnf-α production in human monocytes. it acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. Group: Pharmaceutical. CAS No. 72873-74-6. Pack Sizes: 300 mg. Product ID: B0084-195907. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sulfadimidine-[13C6] | Sulfadimidine-[13C6] is the labelled analogue of Sulfadimidine, which is a sulfonamide antibacterial. It competitively inhibits dihydropteroate synthase and interferes with folic acid synthesis. Group: Pharmaceutical. CAS No. 77643-91-5. Pack Sizes: 10 mg. Product ID: BLP-011697. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sulfadoxine-[d3] | Sulfadoxine-[d3] is the labelled analogue of Sulfadoxine, which is an antibacterial. It competitively inhibits dihydropteroate synthase and interferes with folic acid synthesis. Group: Pharmaceutical. CAS No. 1262770-70-6. Pack Sizes: 25 mg. Product ID: BLP-011696. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sulfadoxine-[d4] | Sulfadoxine-[d4] is the labelled analogue of Sulfadoxine. Sulfadoxine is an antibacterial. It competitively inhibits dihydropteroate synthase, interfering with folate synthesis. Group: Pharmaceutical. CAS No. 1330266-05-1. Pack Sizes: 10 mg. Product ID: BLP-012597. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sulfometuron methyl | Sulfometuron methyl acts as an acetolactate synthase inhibitor, a herbicide, and an active antibacterial agent. Sulfometuron methyl is a substituted pyrimide compound for proteomics research. Group: Pharmaceutical. CAS No. 74222-97-2. Pack Sizes: 1 g. Product ID: B0084-076243. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| TBAJ-876 | A potent anti-tuberculosis agent via inhibiting the mycobacterial F-ATP synthase. Group: Pharmaceutical. CAS No. 2332841-25-3. Pack Sizes: 100 mg. Product ID: B1370-381731. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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