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| Product | Description | |
|---|---|---|
| 3'-O-Methylmurraol | 3'-O-Methylmurraol is a coumarin isolated from the fruits of Cnidium monnieri. It inhibits (IC50 ≤ 7.31 μg/mL) superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB) and exhibits potential anti-inflammatory activity. Group: Pharmaceutical. Alternative Names: 7-methoxy-8-[(E)-3-methoxy-3-methylbut-1-enyl]chromen-2-one. CAS No. 1891097-17-8. Pack Sizes: 5 mg. Product ID: NP1199. Molecular formula: C16H18O4. Mole weight: 274.316. Custom synthesis is available. Send your inquiries for more information. |  London |
| Avasopasem manganese | Avasopasem manganese is a superoxide dismutase mimetic drug candidate. This drug has potential application for radiation-induced esophagitis and oral mucositis, in addition to being currently tested against COVID-19. Group: Pharmaceutical. Alternative Names: GC-4419; GC4419; GC 4419; M 40419; M40419; M-40419. CAS No. 435327-40-5. Pack Sizes: 1mg;1g;10g. Product ID: 435327-40-5. Molecular formula: C21H35Cl2MnN5. Mole weight: 483.38. Custom synthesis is available. Send your inquiries for more information. | London |
| Coelenterazine | Coelenterazine is a luciferin that serves as a substrate for luciferases. Coelenterazine can be used for probing superoxide anion and aequorin assays. Coelenterazine is also used to detect Ca2+ concentration in cells that have been transfected with apoaequorin cDNA. Group: Pharmaceutical. Alternative Names: 2-(4-Hydroxybenzyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo(1,2-a)pyrazin-3-one. CAS No. 55779-48-1. Pack Sizes: 100 mg. Product ID: B1370-375048. Molecular formula: C26H21N3O3. Mole weight: 423.46. Custom synthesis is available. Send your inquiries for more information. | London |
| CORM-3 | CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity. It attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. Group: Pharmaceutical. Alternative Names: Tricarbonylchloro(glycinato)ruthenium; (OC-6-44)-Tricarbonylchloro(glycinato-κN,κO)ruthenium; CORM3; CORM 3. CAS No. 475473-26-8. Pack Sizes: 50 mg. Product ID: B0084-463459. Molecular formula: C5H4ClNO5Ru. Mole weight: 294.61. Custom synthesis is available. Send your inquiries for more information. | London |
| Cyclosporin H | The minor analogues of the cyclosporin family have immunological activity because they do not bind to immunophilins. It is an inhibitor of phorbol ester that effectively promotes tumors on mouse skin, and effectively inhibits calcium/calmodulin-dependent phosphorylation of EF-2 in vitro. It is an effective and selective formyl peptide receptor antagonist and formyl peptide-induced superoxide formation inhibitor. Group: Pharmaceutical. Alternative Names: 5-(N-methyl-D-valine)cyclosporine A. CAS No. 83602-39-5. Pack Sizes: 1mg;1g;10g. Product ID: BBF-05764. Molecular formula: C62H111N11O12. Mole weight: 1202.61. Custom synthesis is available. Send your inquiries for more information. | London |
| Dihydroethidium | Dihydroethidium is a cell-permeable blue fluorescent dye, which intercalates with nucleic acids and emits a red fluorescence detectable qualitatively by fluorescent microscopy or quantitatively by HPLC. It is a superoxide indicator. It exhibits blue fluorescence in the cytosol until oxidizedto ethidium, where it intercalates within the cell's DNA, staining its nucleus a bright fluorescent red. It is neuroprotective by reducing superoxide in mice after stroke. It has been used to detect reactive oxygen species during the phagocytic respiratory burst and for the detection of intracellular superoxide in cultured cells. Group: Pharmaceutical. Alternative Names: Hydroethidine; PD-MY 003; 5-ethyl-5,6-dihydro-6-phenyl-3,8-phenanthridinediamine; 5-Ethyl-6-phenyl-6H-phenanthridine-3,8-diamine. CAS No. 104821-25-2. Pack Sizes: 500 mg. Product ID: B2706-081229. Molecular formula: C21H21N3. Mole weight: 315.4. Custom synthesis is available. Send your inquiries for more information. | London |
| EUK 134 | EUK-134 is a unique small molecule antioxidant and anti-aging active substance with excellent antioxidant properties. It possesses the dual effects of superoxide dismutase SOD and catalase CAT, effectively improving cell damage caused by oxidative stress, and inhibiting the formation of β-amyloid protein and related amyloid protein fibers. The EUK-134 facilitates the penetration and absorption of the skin surface, enabling direct entry into the skin to exert its effects and optimize its potent efficacy. Essentially functioning as a catalyst, it remains unaffected by the number of reactions, allowing for reusability with minimal quantity while maintaining stability in nature. It can be used in anti-aging products, sunscreen products, whitening products and skin repair products. Group: Pharmaceutical. Alternative Names: Manganese, chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]](2-)]-, (SP-5-13)-; (SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]](2-)]manganese; Manganese, chloro[[2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxyphenolato]](2-)-N2,N2',O1,O1']-; Phenol, 2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxy-. CAS No. 81065-76-1. Pack Sizes: 100 mg. Product ID: B2693-098846. Molecular formula: C18H18ClMnN2O4. Mole weight: 416.74. Custom synthesis is available. Send your inquiries for more informatio | London |
| Ginkgolide J | Ginkgolide J is extracted from the seed of Ginkgo biloba L. It reduces apoptotic damage in cultured chick embryonic neurons. It contributes to the antioxidant properties of G. biloba. It has the superoxide scavenging effect and neuroprotective effect. Group: Pharmaceutical. Alternative Names: 7beta-hydroxyginkgolide a; BN 52024; GinkgolideA, 7-hydroxy-, (7β)-; J Ginkgoli. CAS No. 107438-79-9. Pack Sizes: 25 mg. Product ID: B2703-465197. Molecular formula: C20H24O10. Custom synthesis is available. Send your inquiries for more information. | London |
| Imisopasem manganese | Imisopasem manganese is a manganese-based non-peptidyl mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with potential antioxidant and chemo/radioprotective activities. Upon administration, imisopasem manganese mimics the activity of MnSOD and scavenges reactive oxygen species (ROS), such as superoxide anion, which prevents oxygen free radical damage to macromolecules such as DNA. Group: Pharmaceutical. Alternative Names: M40403; M 40403; M 40403; CG4419; CG 4419; CG-4419; SC-72325; SC72325; SC 72325. CAS No. 218791-21-0. Pack Sizes: 10 mg. Product ID: B0084-102510. Molecular formula: C21H35Cl2MnN5. Mole weight: 483.39. Custom synthesis is available. Send your inquiries for more information. | London |
| Isoastragaloside IV | Isoastragaloside IV is a chemical reference substance isolated from Astragalus membranaceus. Astragaloside is the major active constituent of Astragalus membranaceus, and in vitro studies have demonstrated that Astragaloside IV is a strong scavenger for superoxide radicals (IC50 < 0:023 mg/ml) and hydroxyl radicals (IC50 < 0:053 mg/ml). Group: Pharmaceutical. Alternative Names: β-D-Glucopyranoside, (3β,?6α,?16β,?20R,?24S)?-20,?24-epoxy-6,?16-dihydroxy-3-(β-D-xylopyranosyloxy)?-9,?19-cyclolanostan-25-yl. CAS No. 136033-55-1. Pack Sizes: 10 mg. Product ID: B0005-479852. Molecular formula: C41H68O14. Mole weight: 784.98. Custom synthesis is available. Send your inquiries for more information. | London |
| Loganic acid | Loganic acid and geniposide exhibit both sides effect on superoxide generation. Uses: Clearing heat. Group: Pharmaceutical. Alternative Names: (1S,4aS,6S,7R,7aS)-1-(β-D-Glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid; Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-, [1S-(1α,4aα,6α,7α,7aα)]-; Cyclopenta[c]pyran-4-carboxylic acid, 1α-(β-D-glucopyranosyloxy)-1,4aα,5,6,7,7aα-hexahydro-6α-hydroxy-7α-methyl-; Loganin acid. CAS No. 22255-40-9. Pack Sizes: 50 mg. Product ID: NP3772. Molecular formula: C16H24O10. Mole weight: 376.36. Custom synthesis is available. Send your inquiries for more information. | London |
| Loganin | Loganin is isolated from the fruits of Cornus officinalis Sieb. et Zucc. It reduced malondialdehyde and increased superoxide dismutase in serum and kidney. It has great promise for the treatment of diabetic complications. Uses: Anti-inflammatory and anti-oxidant. Group: Pharmaceutical. Alternative Names: 7-Hydroxy-6-desoxyverbenalin; Loganoside. CAS No. 18524-94-2. Pack Sizes: 100 mg. Product ID: BBF-01825. Molecular formula: C17H26O10. Mole weight: 390.39. Custom synthesis is available. Send your inquiries for more information. | London |
| Luvangetin | Luvangetin is a coumarin isolated from the stem bark of Zanthoxylum ailanthoides. Luvangetin exhibits inhibition against superoxide anion (O2 -) generation and elastase release by human neutrophils in response to fMLP/CB. Group: Pharmaceutical. Alternative Names: 10-methoxy-2,2-dimethylpyrano[3,2-g]chromen-8-one. CAS No. 483-92-1. Pack Sizes: 5 mg. Product ID: NP1044. Molecular formula: C15H14O4. Mole weight: 258.273. Custom synthesis is available. Send your inquiries for more information. | London |
| OXi-4503 | OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated levels in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production. CA1 binds to tubulin at the same site as colchicine but with higher affinity. Group: Pharmaceutical. Alternative Names: OXi4503; OXi 4503; CA1P; tetrasodium [3-methoxy-2-phosphonatooxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate. CAS No. 288847-35-8. Pack Sizes: 100 mg. Product ID: B0084-353235. Molecular formula: C18H22O12P2. Mole weight: 492.31. Custom synthesis is available. Send your inquiries for more information. | London |
| Pam3CSK4 | Pam3CSK4 is a TLR 1/2 agonist and a cell-permeable, water-soluble synthetic tripalmitoylated lipopeptide that mimics the acylated amino terminus of bacterial LPs. Bacterial LPs are a family of pro-inflammatory cell wall components found in both Gram-positive and Gram-negative bacteria. Pam3CSK4 is a potent activator of the pro-inflammatory transcription factor NF-κB. It induces production of TNF-α, superoxide, NO, and IL-6, stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells, promotes differentiation of naive CD4+ T cells into Th17 cells, and enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. It is used in prevention of inflammation caused by certain bacterial infection. Group: Pharmaceutical. Alternative Names: Pam3-Cys-Ser-Lys-Lys-Lys-Lys; (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH; P3CSK4; Pam3Cys-SK4; TLR1/TLR2 Agonist I; Pam3Cys-Ser-(Lys)4; Synthetic Triacylated Lipopeptide; L-Lysine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-; L-Lysine, N2-[N2-[N2-[N2-[N-[S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxo. CAS No. 112208-00-1. Pack Sizes: 5 mg. Product ID: BAT-009049. Molecular formula: C81H156N10O13S. Mole weight: 1510.23. Custom synthesis is available. Send your inquiries for more information. | London |
| p-Phlorizin | Trilobatin, coming from the herbs of Lithocarpus pachyphyllus, potentially inhibits the LPS-induced inflammatory response by suppressing the NF-κB signaling pathway. It increased superoxide dismutase (SOD) activity. Besides, Trilobatin is a potential effective α-glucosidase inhibitor for management of postprandial hyperglycemia with less side effect. Uses: Anti-inflammatory. Group: Pharmaceutical. Alternative Names: 1-[4-(β-D-Glucopyranosyloxy)-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone; p-Phloridzin; Phloretin 4'-glucoside; Phloretin 4'-β-D-glucoside; Phloretin-4-O-glycoside; Phloretin-4'-O-β-D-glucopyranoside; Phloretine-4'-glucoside; Prunin dihydrochalcone; Trilobatin. CAS No. 4192-90-9. Pack Sizes: 20 mg. Product ID: NP0949. Molecular formula: C21H24O10. Mole weight: 436.41. Custom synthesis is available. Send your inquiries for more information. | London |
| RTA-408 | RTA-408 is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity. Upon administration, RTA 408 activates the cytoprotective transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH). Nrf2, a leucine zipper transcription factor, plays a key role in the maintenance of redox balance and cytoprotection against oxidative stress. Group: Pharmaceutical. Alternative Names: RTA408; RTA408; RTA-408. Omaveloxolone; Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-. CAS No. 1474034-05-3. Pack Sizes: 20 mg. Product ID: B0084-462776. Molecular formula: C33H44F2N2O3. Mole weight: 554.723. Custom synthesis is available. Send your inquiries for more information. | London |
| SKF-86002 | SKF-86002 is a p38 MAP kinase inhibitor, the IC50 is 0.1 - 1 μM. It potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes, the IC50 is1 μM. It also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO). In vitro: SKF-86002 inhibited prostaglandin H2 synthase activity, the IC50 is 120 mM as well as prostanoid production by rat basophilic leukemia cells, the IC50 is mM and its sonicate ( the IC50 is 100 mM and human monocytes (the IC50 is 1 mM. It inhibited the generation of dihydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid by a high speed supernatant fraction of RBL-1 cells (the IC50 is 10 mM). It blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP. Uses: Skf-86002 could potently inhibit lps-induced il-1 and tnf-α production in human monocytes. it acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. Group: Pharmaceutical. Alternative Names: SKF-86002; SKF 86002; SKF86002. 6-(4-fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole; 4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene. CAS No. 72873-74-6. Pack Sizes: 300 mg. Product ID: B0084-195907. Molecular formula: C16H12FN3S. Mole weight: 297.36. Custom synthesis is available. Send your inquiries for more information. | London |
| Taraxerone | Taraxerone is isolated from the herb of Taraxacum mongolicum Hand. Mazz. It can prevent catalase and superoxide dismutase, and reduce glutathione concentration. Group: Pharmaceutical. Alternative Names: D-Friedoolean-14-en-3-one;Taraxera-14-ene-3-one;Taraxeron;27-Norolean-14-en-3-one,13-methyl-, (13a)-;Tarxerone;27-Norolean-14-en-3-one, 13-methyl-, (13α)-. CAS No. 514-07-8. Pack Sizes: 20 mg. Product ID: NP6262. Molecular formula: C30H48O. Mole weight: 424.7. Custom synthesis is available. Send your inquiries for more information. | London |
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