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| Product | Description | |
|---|---|---|
| Trans-Stilbene oxide | Trans-Stilbene oxide. Uses: Pharmaceuticals, Personal Care, Industrial. Grades: Pharma, Cosmetic, Food, Feed, Technical. CAS No. 1439-07-2. Pack Sizes: Bulk. Cenik is your partner of choice for Hard-to-find chemicals. We don't just provide products, we supply solutions to your technical and regulatory specifications. |  Cenik Chemicals |
| HMN-214 | HMN-214 is an oral prodrug of HMN-176, a stilbene derivative that interferes with the subcellular spatial location of polo-like kinase-1, a serine/threonine kinase that regulates critical mitotic events. Group: Pharmaceutical. CAS No. 173529-46-9. Pack Sizes: 50 mg. Product ID: B2693-321779. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Piceatannol | Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn. Uses: Antioxidant, and anti-inflammatory activities; antitumor activity. Group: Pharmaceutical. CAS No. 10083-24-6. Pack Sizes: 1 g. Product ID: NP4578. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Combretastatin A4 | Combretastatin A4 is a stilbenoid isolated from Combretum caffrum. Combretastatin A4 was shown to inhibit tubulin polymerization (IC50 = 2.2 μM). It has demonstrable antineoplastic activity. Uses: Antineoplastic agents, phytogenic. Group: Pharmaceutical. CAS No. 117048-59-6. Pack Sizes: 1 g. Product ID: BADC-00361. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Fosbretabulin disodium | Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue. Group: Pharmaceutical. CAS No. 168555-66-6. Pack Sizes: 100 mg. Product ID: B0084-085514. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| OXi-4503 | OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated levels in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production. CA1 binds to tubulin at the same site as colchicine but with higher affinity. Group: Pharmaceutical. CAS No. 288847-35-8. Pack Sizes: 100 mg. Product ID: B0084-353235. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Oxyresveratrol 2-O-β-D-glucopyranoside | Oxyresveratrol 2-O-β-D-glucopyranoside is a derivative of Resveratrol. Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi. Group: Pharmaceutical. CAS No. 392274-22-5. Pack Sizes: 5 mg. Product ID: B1821-053447. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Oxyresveratrol 3'-O-β-D-glucopyranoside | A derivative of Resveratrol. Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi. Group: Pharmaceutical. CAS No. 144525-40-6. Pack Sizes: 5 mg. Product ID: B1821-483750. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Resveratrol | Naturally derived stilbenoid with antioxidant and anti-inflammatory properties commonly used as dietary supplements due to its potential health benefits in cardiovascular health, neuroprotection and cancer prevention. Uses: Dietary supplement. Group: Dietary supplements. CAS No. 501-36-0. |  |
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