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| Product | Description | |
|---|---|---|
| 2'-Amino-2'-deoxyuridine | 2'-Amino-2'-deoxyuridine, a nucleoside analogue, finds its use in chemotherapy as an anti-cancer agent. Its ability to cause DNA damage and trigger apoptosis in cancer cells stem from its selective integration in cancer cell DNA. Additionally, it offers immense potential in the field of oncology research, studying tumor cell differentiation and proliferation. Group: Pharmaceutical. Alternative Names: 2'-Amino-2'-deoxy-D-uridine; 2'-deoxy-2'-amino-uridine; 2,4(1H,3H)-pyrimidinedione, 1-(2-amino-2-deoxy-b-D-ribofuranosyl)-; 1-[(2R,3R,4S,5R)-3-amino-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione. CAS No. 26889-39-4. Pack Sizes: 1 g. Product ID: B2706-089006. Molecular formula: C9H13N3O5. Mole weight: 243.22. Custom synthesis is available. Send your inquiries for more information. |  London |
| 3,3,5-Triiodo-L-thyronine | 3,3,5-Triiodo-L-thyronine is a metabolite of thyroxine that binds to both thyroid hormone receptors TRα and TRβ so that might help maintain the metabolic homeostasis. It promotes chondrogenesis of human mesenchymal stem cells. Uses: 3,3,5-triiodo-l-thyronine(t3) is an active metabolite of thyroxine and could be effective in agonizing both thyroid hormone receptors trα and trβ. Group: Pharmaceutical. Alternative Names: Levothyroxine EP Impurity A; Liothyronine; Triiodothyronine; T3; (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid. CAS No. 6893-2-3. Pack Sizes: 1 g. Product ID: B0084-357278. Molecular formula: C15H12I3NO4. Mole weight: 650.97. Custom synthesis is available. Send your inquiries for more information. | London |
| 3-Deazaneplanocin A | 3-Deazaneplanocin A is an inhibitor of S-adenosylmethionine-dependent methyltransferase. In combination with sodium butyrate, 3-Deazaneplanocin A can induce epigenetically reprogramming of human embryonic stem cells (hESC). Group: Pharmaceutical. Alternative Names: DZNep; (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol. CAS No. 102052-95-9. Pack Sizes: 10 mg. Product ID: B0084-462897. Molecular formula: C12H14N4O3. Mole weight: 262.26. Custom synthesis is available. Send your inquiries for more information. | London |
| (4,8-Bis(4-chloro-5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4,5-b']dithiophene-2,6-diyl)bis(trimethylstannane) | (4,8-Bis(4-chloro-5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4,5-b']dithiophene-2,6-diyl)bis(trimethylstannane) is an organic compound conventionally employed in the manufacture of photovoltaic devices due to its ability to enhance solar cell efficiency. Remarkably, it constitutes a critical component within the active layer of the cell. Apart from its photovoltaic application, this compound shows promise as a prospective anticancer agent. Its potency stems from the compound's inhibitory effect on tumor growth, indicating that it may be useful in the development of novel therapeutic modalities for cancer patients. Group: Pharmaceutical. Alternative Names: 1,1'-[4,8-Bis[4-chloro-5-(2-ethylhexyl)-2-thienyl]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl]bis[1,1,1-trimethylstannane]. CAS No. 2239295-69-1. Pack Sizes: 1 g. Product ID: B2699-334043. Molecular formula: C40H56Cl2S4Sn2. Mole weight: 973.46. Custom synthesis is available. Send your inquiries for more information. | London |
| 5-Methoxycarbonylmethyl-2-thiouridine | 5-(Methoxycarbonylmethyl)-2-thiouridine can be used as analyte in biological study for attomole quantification and global profile of RNA modifications in study of epitranscriptome of human neural stem cells. It can also be used to biological computational studies to provide insights into effects of modified ribonucleotides and Mg2+ on structures and stabilities of tRNAs. A trace nucleoside, isolated from yeast transfer RNA. A nucleoside in the anticodon at the wobble position of some Saccharomyces cerevisiae bacteria. Group: Pharmaceutical. Alternative Names: 5-Pyrimidineacetic acid, 1,2,3,4-tetrahydro-4-oxo-1-β-D-ribofuranosyl-2-thioxo-, methyl ester; 5-(Methoxycarbonylmethyl)-2-thiouridine; 5-(2-methoxy-2-oxoethyl)-1-(beta-D-ribofuranosyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; 5-(2-methoxy-2-oxoethyl)2-thiouridine. CAS No. 20299-15-4. Pack Sizes: 25 mg. Product ID: B1370-292000. Molecular formula: C12H16N2O7S. Mole weight: 332.33. Custom synthesis is available. Send your inquiries for more information. | London |
| A 419259 trihydrochloride | Potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo. Group: Pharmaceutical. Alternative Names: A419259 trihydrochloride; A-419259 trihydrochloride; RK 20449 trihydrochloride; RK20449 trihydrochloride; RK-20449 trihydrochloride. CAS No. 1435934-25-0. Pack Sizes: 1mg;1g;10g. Product ID: 1435934-25-0. Molecular formula: C29H37Cl3N6O. Mole weight: 592. Custom synthesis is available. Send your inquiries for more information. | London |
| ALK5 Inhibitor II hydrochloride | ALK5 inhibitor II was identified as a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (ALK5 autophosphorylation, IC50s = 4 nM, TGF-β cellular assay, IC50s = 18 nM, ALK5 binding in HepG2 cells, IC50s = 23 nM). This compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription. This product is a hydrochloride form. Group: Pharmaceutical. Alternative Names: E 616452; RepSox; SJN 2511. CAS No. 446859-33-2. Pack Sizes: 50 mg. Product ID: B0084-068993. Molecular formula: C17H13N5·HCl. Mole weight: 323.8. Custom synthesis is available. Send your inquiries for more information. | London |
| AM580 | AM580 is a selective RARα agonist. It was shown to induce differentiation of human induced pluripotent stem cells into intermediate mesoderm. Group: Pharmaceutical. Alternative Names: AM-580; 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoic acid. CAS No. 102121-60-8. Pack Sizes: 25 mg. Product ID: B2693-286138. Molecular formula: C22H25NO3. Mole weight: 351.44. Custom synthesis is available. Send your inquiries for more information. | London |
| β-Tocotrienol | β-Tocotrienol is isolated from the stem bark of Garcinia virgata. It inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations. β-Tocotrienol can serve as a new anticancer agent for treating human lung and brain cancers. Group: Pharmaceutical. Alternative Names: (2R)-3,4-Dihydro-2,5,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl]-2H-1-benzopyran-6-ol; 2,5,8-Trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-6-chromanol; D-β-Tocotrienol; ε-Tocopherol; ε-Tokoferol. CAS No. 490-23-3. Pack Sizes: 25 mg. Product ID: NP4616. Molecular formula: C28H42O2. Mole weight: 410.63. Custom synthesis is available. Send your inquiries for more information. | London |
| BIO | BIO is a potent and reversible inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β. BIO enhances reprogramming of mouse fibroblasts, neural stem cells, and thymocytes to induced pluripotent stem (iPS) cells. It also promotes differentiation of cardiomyocytes from human ES and iPS cells. Group: Pharmaceutical. Alternative Names: GSK-3 Inhibitor IX; 6-bromoindirubin-3-oxime; 6-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol. CAS No. 667463-62-9. Pack Sizes: 25 mg. Product ID: B2693-286135. Molecular formula: C16H10BrN3O2. Mole weight: 356.17. Custom synthesis is available. Send your inquiries for more information. | London |
| BKT140 | BKT140 is a CXCR4 inhibitor with antineoplastic activity. Studies demonstrated that BKT140 showed a robust mobilization of white blood cells (WBC) and hematopoietic stem cells (HSC). Group: Pharmaceutical. Alternative Names: BL-8040; Motixafortide; 4F-benzoyl-TN14003. CAS No. 664334-36-5. Pack Sizes: 5 mg. Product ID: BAT-006144. Molecular formula: C97H144FN33O19S2. Mole weight: 2159.55. Custom synthesis is available. Send your inquiries for more information. | London |
| CASIN | CASIN is a selective GTPase Cdc42 inhibitor (IC50=2 uM), reducing active levels of Cdc42 in aged hematopoietic stem cells. Uses: Cdc42 gtpase inhibitor. Group: Pharmaceutical. Alternative Names: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol. CAS No. 425399-05-9. Pack Sizes: 100 mg. Product ID: B1370-286220. Molecular formula: C20H22N2O. Mole weight: 306.41. Custom synthesis is available. Send your inquiries for more information. | London |
| CP21R7 | CP21R7 is a potent and selective GSK3β inhibitor. It acts as an activator of stem cells prior to the induction of differentiation of stem cells to endothelial and smooth muscle cells. Uses: Cp21r7 is a selective gsk-3β inhibitor which could probably influence luciferase activity at some extent. Group: Pharmaceutical. Alternative Names: 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione. CAS No. 125314-13-8. Pack Sizes: 300 mg. Product ID: B0084-474432. Molecular formula: C19H15N3O2. Mole weight: 317.34. Custom synthesis is available. Send your inquiries for more information. | London |
| Cyt387 | Cyt387 is an ATP-competitive inhibitor of JAK1 and JAK2 (IC50 = 11 nM and 18 nM respectively). It has been shown to decrease cancer stem cell associated tumor burden in a mouse model of human ovarian cancer. It is commonly used as a therapy for myelofibrosis. Uses: An orally bioavailable small-molecule inhibitor of janus kinases 1 and 2 (jak1/2) with potential antineoplastic activity (ic50s = 11 and 18 nm, respectively). Group: Pharmaceutical. Alternative Names: Momelotinib; N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide; CYT 11387; CYT 387; CYT-387; CYT387; CYT-0387; GS 0387. CAS No. 1056634-68-4. Pack Sizes: 50 mg. Product ID: B0084-307720. Molecular formula: C23H22N6O2. Mole weight: 414.46. Custom synthesis is available. Send your inquiries for more information. | London |
| Decapeptide-18 | Decapeptide-18, also known as CG-WINT, is a synthetic peptide that plays a significant role in promoting hair growth. It is composed of arginine, cysteine, glutamine, glutamic acid, histidine, threonine and valine. It is derived from the Wnt10 signaling pathway and is designed to stimulate the formation of hair placodes, which are essential for hair follicle development. This peptide exhibits higher stability and skin penetration compared to the natural Wnt10 peptide, making it effective in activating hair follicles and promoting the differentiation of hair follicle epithelial stem cells into hair keratinocytes. Additionally, Decapeptide-18 is recognized for its potential in enhancing hair density and strength, making it a valuable ingredient in hair care formulations aimed at combating hair loss and promoting hair growth. Group: Pharmaceutical. Alternative Names: CG-WINT; Decapeptide 18. CAS No. 3032916-63-2. Pack Sizes: 100 mg. Product ID: BAT-016731. Custom synthesis is available. Send your inquiries for more information. | London |
| Dehydrodiconiferyl alcohol | Dehydrodiconiferyl alcohol is purified from the stems of Cucurbita moschata. (+)-(2S,3R)-Dehydrodiconiferyl alcohol is an antioxidant, and has an inhibitory effect on VCAM-1 expression via JNK pathway in endothelial cells and therefore may serve as a novel pharmacological agent to improve endothelial dysfunction. Dehydrodiconiferyl alcohol also shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Group: Pharmaceutical. Alternative Names: 2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxy-1-propen-1-yl)-7-methoxy-3-benzofuranmethanol. CAS No. 4263-87-0. Pack Sizes: 1 mg. Product ID: NP4068. Molecular formula: C20H22O6. Mole weight: 358.39. Custom synthesis is available. Send your inquiries for more information. | London |
| Diclofenac Potassium | Diclofenac potassium is a nonsteroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in certain conditions. It is a competitive inhibitor of cyclooxygenase (COX) that suppresses the production of prostaglandins. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade. Uses: Nsaid. Group: Pharmaceutical. Alternative Names: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Potassium Salt; [o-(2,6-Dichloroanilino)phenyl]acetic Acid Monopotassium Salt; 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monopotassium Salt; Caflam; Cataflam; K-fenak; Potassium diclofenac. CAS No. 15307-81-0. Pack Sizes: 20 g. Product ID: B0084-059596. Molecular formula: C14H10Cl2KNO2. Mole weight: 334.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Dorsomorphin | Dorsomorphin is a potent and selective inhibitor of AMPK (AMP-activated protein kinase) (Ki = 109 nM), induced by AICAR and metformin. It also inhibits bone morphogenetic protein (BMP) receptors including BMPR-IA (ALK3) and BMPR-IB (ALK6). Dorsomorphin can induce myocardial differentiation in mouse embryonic stem cells (mESCs). Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine; Compound C; AMPK Inhibitor, Compound C; BML-275. CAS No. 866405-64-3. Pack Sizes: 10 mg. Product ID: B0084-462934. Molecular formula: C24H25N5O. Mole weight: 399.49. Custom synthesis is available. Send your inquiries for more information. | London |
| DOTA-NOC | DOTA-NOC is a potent chelating agent extensively used in radiopharmaceuticals for the targeted imaging and therapy of neuroendocrine tumors. By combining with diverse radiometals, such as lutetium-177 or yttrium-90, it generates therapeutic agents that specifically bind to neuroendocrine tumor cells. The DOTA-NOC derivatives have displayed remarkable specificity and affinity for somatostatin receptors, endowing it with a unique potential for cancer therapy. Its diverse applications stem from its impressive properties, which include high burstiness in sentence structure and an elevated level of perplexity in its descriptions. Group: Pharmaceutical. Alternative Names: L-Cysteinamide, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide; DOTA-[Nal3]-octreotide; H-D-Phe(DOTA)-Cys(1)-Nal-D-Trp-Lys-Thr-Cys(1)-Thr-ol; DOTA-D-Phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol (2->7)-disulfide. CAS No. 619300-53-7. Pack Sizes: 1 mg. Product ID: B2699-192721. Molecular formula: C69H94N14O17S2. Mole weight: 1455.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Galunisertib | Galunisertib is a potent and selective inhibitor of transforming growth factor beta receptor (TGF-βR) kinase. It was shown to inhibit self-renewal of cancer stem cells. Group: Pharmaceutical. Alternative Names: LY 2157299; LY-2157299; 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide. CAS No. 700874-72-2. Pack Sizes: 100 mg. Product ID: B0084-307752. Molecular formula: C22H19N5O. Mole weight: 369.428. Custom synthesis is available. Send your inquiries for more information. | London |
| Gartanin | Gartanin is isolated from the stem bark of Garcinia mangostana. It could be a multiple targeting agent into its chemopreventive properties for human urinary bladder cancer. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells. Uses: Antifungal property; antioxidant, anti - inflammatory properties; antineoplastic property. Group: Pharmaceutical. Alternative Names: 1,3,5,8-Tetrahydroxy-2,4-bis(3-methyl-2-butenyl)-9H-xanthen-9-one. CAS No. 33390-42-0. Pack Sizes: 10 mg. Product ID: NP7262. Molecular formula: C23H24O6. Mole weight: 396.43. Custom synthesis is available. Send your inquiries for more information. | London |
| Geldanamycin | Geldanamycin is a benzoquinone ansamycin antibiotic that inhibits heat shock protein 90 (HSP90). Geldanamycin has been shown to promote survival of neural stem cells from oxidative stress via inhibition of HSP90. It displays potent antineoplastic properties and inhibits myeloma cell growth. Uses: Antibiotics, antineoplastic. Group: Pharmaceutical. Alternative Names: geldanomycin; NSC 122750; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate. CAS No. 30562-34-6. Pack Sizes: 200 mg. Product ID: BBF-01865. Molecular formula: C29H40N2O9. Mole weight: 560.64. Custom synthesis is available. Send your inquiries for more information. | London |
| Ginsenoside F2 | Ginsenoside F2 is extracted from the root of Panax ginseng C. A. Mey. It was assessed for its antiproliferative activity against breast cancer stem cells (CSCs). It induced apoptosis in breast CSCs by activating the intrinsic apoptotic pathway and mitochondrial dysfunction. It decreased the expression of TGF-β2 and SCAP proteins. Group: Pharmaceutical. Alternative Names: (20S)-3β,20-Bis(β-D-glucopyranosyloxy)-5α-dammar-24-ene-12β-ol; 12β-Hydroxy-5α-dammar-24-ene-3β,20-diylbis(β-D-glucopyranoside); 20(S)-Ginsenoside-F2. CAS No. 62025-49-4. Pack Sizes: 20 mg. Product ID: NP6994. Molecular formula: C42H72O13. Mole weight: 785.01. Custom synthesis is available. Send your inquiries for more information. | London |
| Glasdegib | Glasdegib is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway that binds to Smoothened (Smo) and inhibits signal transduction. It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model. Group: Pharmaceutical. Alternative Names: PF-04449913; PF 04449913; 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea. CAS No. 1095173-27-5. Pack Sizes: 50 mg. Product ID: B0084-462711. Molecular formula: C21H22N6O. Mole weight: 374.44. Custom synthesis is available. Send your inquiries for more information. | London |
| Goralatide acetate | Goralatide is a physiological regulator of hematopoiesis and inhibits the entry into the S-phase of murine and human hematopoietic stem cells. Ac-SDKP is a physiological substrate of angiotensin I- converting enzyme (ACE). Group: Pharmaceutical. Alternative Names: N-acetyl-Ser-Asp-Lys-Pro; Acetyl-serinyl-aspartyl-lysinyl-proline acetate. Pack Sizes: 25 mg. Product ID: B1370-458984. Molecular formula: C22H37N5O11. Mole weight: 547.56. Custom synthesis is available. Send your inquiries for more information. | London |
| Hesperetin | Hesperetin, a flavonoid widely found in citrus, is also one of the vitamin Ps that the human body is generally prone to lack. Study showed that it promoted osteogenic differentiation of human mesenchymal stem cells in vitro. Hesperetin can be used in health products. Hesperetin has an antioxidant effect, reduces the production of free radicals, plays an anti-aging role and removes wrinkles. It can also enhance the homeostasis of epidermal osmotic barrier by stimulating epidermal proliferation and differentiation, so as to repair the skin barrier. In addition, hesperetin has whitening and lightening spots, brightening skin, removing dark circles, anti-inflammatory and antibacterial, hair care and many other effects. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: Hesperitin; 3',5,7-Trihydroxy-4'-methoxyflavanone; Hesperin; (2S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-; Flavanone, 3',5,7-trihydroxy-4'-methoxy-; (-)-Hesperetin; (S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 5,7,3'-Trihydroxy-4'-methoxyflavanone; Eriodictyol 4'-monomethyl ether; NSC 57654; TCI-CA 05. CAS No. 520-33-2. Pack Sizes: 50 g. Product ID: NP1882. Molecular formula: C16H14O6. Mole weight: 302.28. Custom synthesis is available. Send your inquiries for more informat | London |
| Isobavachin | Isobavachin is a flavonoid isolated from Psoralea morisiana. It was shown to promote neurogenesis of mouse embryonic stem cells. Group: Pharmaceutical. Alternative Names: (2S)-7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-chromen-4-one. CAS No. 31524-62-6. Pack Sizes: 5 mg. Product ID: NP1952. Molecular formula: C20H20O4. Mole weight: 324.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Kartogenin | Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ. Group: Pharmaceutical. Alternative Names: KGN; 2-([1,1'-Biphenyl]-4-ylcarbamoyl)benzoic acid; 2-[(4-phenylphenyl)carbamoyl]benzoic acid. CAS No. 4727-31-5. Pack Sizes: 250 mg. Product ID: B0085-462283. Molecular formula: C20H15NO3. Mole weight: 317.344. Custom synthesis is available. Send your inquiries for more information. | London |
| KD025 | KD025 is an orally available and selective ROCK2 inhibitor with IC50 value of 60 nM and Ki value of 41 nm, respectively. It was shown to suppress adipogenesis in human adipose-derived stem cells. Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: SLx 2119; SLx2119; KD-025; 2-[3-[4-(1H-indazol-5-ylamino)quinazolin-2-yl]phenoxy]-N-propan-2-ylacetamide. CAS No. 911417-87-3. Pack Sizes: 100 mg. Product ID: B0084-460389. Molecular formula: C26H24N6O2. Mole weight: 452.51. Custom synthesis is available. Send your inquiries for more information. | London |
| Letermovir | Letermovir is a novel anti-CMV compound which targets the pUL56 (amino acid 230-370) subunit of the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. It has a novel mode of action targets the enzyme UL56 terminase and keep active to other drug-resistant virus. It has been approved in prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT). Uses: Antiviral agents. Group: Pharmaceutical. Alternative Names: AIC246; AIC-246; AIC 246; MK-8828; MK 8828; MK8828. CAS No. 917389-32-3. Pack Sizes: 5 mg. Product ID: B2693-460490. Molecular formula: C29H28F4N4O4. Mole weight: 572.56. Custom synthesis is available. Send your inquiries for more information. | London |
| Loureirin A | Loureirin A is a chalcone extracted from the red resin of the herbs of Dracaena cochinchinensis, which is known as Dragon's Blood. It is a part of traditional Chinese medicine which helps combat neurodegenerative diseases. It inhibits platelet activation by an impairment of PI3K/Akt signaling. It also could inhibit Akt phosphorylation. It negatively affects agonist-induced platelet aggregation such as ADP, collagen, thrombin and collagen-related peptide (CRP). It promotes hair follicle stem cells (FSCs)-seeded tissue-engineered skin to repair skin wound by activating Wnt/-catenin pathway. Group: Pharmaceutical. Alternative Names: 3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone. CAS No. 119425-89-7. Pack Sizes: 250 mg. Product ID: NP0980. Molecular formula: C17H18O4. Mole weight: 286.32. Custom synthesis is available. Send your inquiries for more information. | London |
| L-Theanine | L-Theanine is a glutamine analog found in the green tea plant. It can bind to glutamate receptors and inhibit glutamate transporters, which exhibits a neuroprotective effect. It promotes self-renewal of human embryonic stem cells (hESCs). Uses: L-theanine, an amino acid found primarily in tea leaves, has been widely recognized for its potential applications in drug discovery and development. this natural compound has been widely studied for its various health benefits, including its ability to promote relaxation, reduce stress, and improve cognitive function. in recent years, scientists have begun to explore l-theanine's potential in dru. Group: Pharmaceutical. Alternative Names: N-Ethyl-L-glutamine; Theanin; Suntheanine; (S)-2-Amino-5-(ethylamino)-5-oxopentanoic acid; N5-Ethyl-L-glutamine. CAS No. 3081-61-6. Pack Sizes: 1 kg. Product ID: BAT-014319. Molecular formula: C7H14N2O3. Mole weight: 174.2. Custom synthesis is available. Send your inquiries for more information. | London |
| Minocycline hydrochloride | Minocycline (INN) is a semi-synthetic broad-spectrum tetracycline antibiotic. Minocycline hydrochloride is the most lipid-soluble form, which binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis. In combination with CHIR 99021, (S)-(+)-Dimethindene maleate and human leukemia inhibitory factor, it induces the formation of extended pluripotent stem (EPS) cells. Group: Pharmaceutical. Alternative Names: Minocycline HCl; Arestin; Minomycin. CAS No. 13614-98-7. Pack Sizes: 5 g. Product ID: BBF-03822. Molecular formula: C23H27N3O7.HCl. Mole weight: 493.94. Custom synthesis is available. Send your inquiries for more information. | London |
| NSC 23005 sodium | NSC23005 sodium is a p18INK inhibitor. It can promote hematopoietic stem cell expansion with ED50 of 5.21 nM. Group: Pharmaceutical. Alternative Names: NSC 23005 sodium; NSC23005 sodium; NSC-23005 sodium; 4-[(Cyclohexylamino)sulfonyl]benzoic acid sodium salt. CAS No. 1796596-46-7. Pack Sizes: 100 mg. Product ID: B2693-169415. Molecular formula: C13H16NNaO4S. Mole weight: 305.33. Custom synthesis is available. Send your inquiries for more information. | London |
| OSI-930 | OSI-930 is a selective thiophene-derived tyrosine kinase inhibitor with potential antineoplastic activity. Tyrosine kinase inhibitor OSI-930 inhibits stem cell factor receptor (c-Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of both tumor cell proliferation and tumor angiogenesis. Both c-Kit and VEGFR2 are overexpressed in a variety of cancers. Group: Pharmaceutical. Alternative Names: OSI 930; OSI930. CAS No. 728033-96-3. Pack Sizes: 10 mg. Product ID: B0084-286626. Molecular formula: C22H16F3N3O2S. Mole weight: 443.444. Custom synthesis is available. Send your inquiries for more information. | London |
| OTSSP167 hydrochloride | OTSSP167 is a potent inhibitor of Maternal embryonic leucine zipper kinase (MELK) which regulates neural stem cell selfrenewal through control of the cell cycle. Group: Pharmaceutical. Alternative Names: 4-[7-acetyl-8-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1H-1,5-naphthyridin-2-ylidene]-2,6-dichlorocyclohexa-2,5-dien-1-one hydrochloride; OTSSP167 (hydrochloride); UNII-65P731R507; 65P731R507; OTSSP167 HCl; OTS-167 monohydrochloride; HY-15512A; AKOS025117447. CAS No. 1431698-10-0. Pack Sizes: 50 mg. Product ID: B0084-474572. Molecular formula: C25H29Cl3N4O2. Mole weight: 523.9. Custom synthesis is available. Send your inquiries for more information. | London |
| PD98059 | PD98059 is a potent, selective and cell-permeant inhibitor of MAP kinase kinase. It enhances human embryonic stem cell self-renewal. Group: Pharmaceutical. Alternative Names: PD-98059; 2-(2-amino-3-methoxyphenyl)chromen-4-one. CAS No. 167869-21-8. Pack Sizes: 250 mg. Product ID: B2693-286170. Molecular formula: C16H13NO3. Mole weight: 267.284. Custom synthesis is available. Send your inquiries for more information. | London |
| PF-3084014 | PF-3084014 is a selective γ-secretase inhibitor (IC50 = 6.2 nM in a cell-free assay). It has been shown to inhibit self-renewal and proliferation of cancer stem cells. Group: Pharmaceutical. Alternative Names: Nirogacestat; PF 3084014; PF3084014. CAS No. 1290543-63-3. Pack Sizes: 50 mg. Product ID: B1370-286393. Molecular formula: C27H41F2N5O. Mole weight: 489.66. Custom synthesis is available. Send your inquiries for more information. | London |
| Plerixafor Impurity III | Plerixafor Impurity III is an impurity of Plerixafor, an immunostimulant indicated in combination with G-CSF to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with NHL and MM. Group: Pharmaceutical. Alternative Names: 1,11-Bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane. CAS No. 771464-86-9. Pack Sizes: 5 mg. Product ID: B2694-341919. Molecular formula: C46H84N12. Mole weight: 805.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Pluripotin | SC1 (Pluripotin) was identified in a cell-based chemical library screen for small molecules that regulate mouse embryonic stem (ES) cell self-renewal. SC1 is sufficient to sustain long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of extracellular signal-regulated kinase 1 (ERK1) and Ras GTPase-activating protein (Ras-GAP). Mouse ES cells maintained in the presence of SC1 retain their ability to differentiate into cells representing all three germ layers in vitro, form chimeric mouse, and contribute to germ line in vivo. Uses: Self-renewal. Group: Pharmaceutical. Alternative Names: SC-1; SC 1; SC1; Pluripotin. CAS No. 839707-37-8. Pack Sizes: 100 mg. Product ID: B2693-462953. Molecular formula: C27H25F3N8O2. Mole weight: 550.54. Custom synthesis is available. Send your inquiries for more information. | London |
| Pristimerin | Source from herb of Tripterygium wilfordii Hook.f. Treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell characteristics and EMT in cancer cells, which justifies the potential use of Pristimerin as a practical chemopreventive approach for patients with PCa. The mechanistic understanding of the antitumor activity of Pristimerin could facilitate in vivo efficacy studies of Pristimerin for pancreatic cancer. Uses: Anticancer. Group: Pharmaceutical. Alternative Names: (9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tertraen-29-oic acid methyl ester. CAS No. 1258-84-0. Pack Sizes: 25 mg. Product ID: B1370-125248. Molecular formula: C30H40O4. Mole weight: 464.64. Custom synthesis is available. Send your inquiries for more information. | London |
| Prostaglandin E2 | Prostaglandin E2 is a naturally occurring COX product used as a medication in labor induction, bleeding after delivery, and termination of pregnancy. It directly targets muscle stem cells (MuSCs) via EP4 receptor, resulting in MuSC expansion. Uses: Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Group: Pharmaceutical. Alternative Names: Dinoprostone; PGE2; Prostin E2; Prepidil; Cervidil; Minprostin E2; l-Prostaglandin E2. CAS No. 363-24-6. Pack Sizes: 100 mg. Product ID: B1370-286161. Molecular formula: C20H32O5. Mole weight: 352.47. Custom synthesis is available. Send your inquiries for more information. | London |
| Psoralidin | Psoralidin is a furanocoumarin natural product used in Chinese medicine. Psoralidin, a PTP1B inhibitor, has been shown to have anticancer activity with a variety of mechanisms proposed. Psoralidin induces ROS generation in androgen-independent prostate cancer cells, leading to inhibition of cell proliferation. Psoralidin has been found to downregulate NOTCH1 signaling, causing growth arrest in both breast cancer stem cells and breast cancer cells. Uses: Anticancer and chemopreventive properties. Group: Pharmaceutical. Alternative Names: 3,9-Dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro[3,2-c][1]benzopyran-6-one; 3,9-Dihydroxy-2-prenylcoumestan. CAS No. 18642-23-4. Pack Sizes: 25 mg. Product ID: NP1133. Molecular formula: C20H16O5. Mole weight: 336.34. Custom synthesis is available. Send your inquiries for more information. | London |
| Purmorphamine | Purmorphamine, under the IUPAC name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine, is a cell-permeable 6,9-trisubstituted purine which directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ).So it has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. In vitro: An activator of the hedgehog (Hh) signaling pathway by directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ). In vivo: Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats. Uses: Directly binds and activates smoothened (in hek293t cell:ic50= ~ 1.5 μm ); an activator of the hedgehog (hh) signaling pathway; an inducer of osteoblast differentiation (ec50= 1 μm). Group: Pharmaceutical. Alternative Names: 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine; purmorphamine; Purmorphamine; 483367-10-8; 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; UNII-PB12M2F8KY; Shh Signaling Antagonist VI; PB12M2F8KY; CHEMBL1221984; CHEBI:63053; C31H32N6O2; IN1132; 9-cyclohexyl-N-[4-(morpholin-4-yl)phenyl]-2-(naphthalen-1-yloxy)-9H-purin-6-amine; 9-cyclohexyl-N-(4-morpholin-4-ylp. CAS No. 483367-10-8. Pack Sizes: 100 mg. Product ID: B0084-211514. Molecular formula: C31H32N6O2. Mole weight: 520.6. Custom synthesis is avai | London |
| RG108 | RG108 is a DNA methyltransferase inhibitor with IC50 value of 115 nM. RG108 can enhance reprogramming of somatic cells to induced pluripotent stem (iPS) cells. Group: Pharmaceutical. Alternative Names: N-Phthalyl-L-tryptophan; RG-108; (2S)-2-(1,3-dioxoisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid. CAS No. 48208-26-0. Pack Sizes: 250 mg. Product ID: B0084-462912. Molecular formula: C19H14N2O4. Mole weight: 334.33. Custom synthesis is available. Send your inquiries for more information. | London |
| Semaxinib | Semaxinib is a quinolone derivative with potential antineoplastic activity. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. Uses: Angiogenesis inhibitors. Group: Pharmaceutical. Alternative Names: SU5416; SU-5416; SU 5416; Sugen 5416; semoxind. CAS No. 204005-46-9. Pack Sizes: 100 mg. Product ID: BAT-008962. Molecular formula: C15H14N2O. Mole weight: 238.28. Custom synthesis is available. Send your inquiries for more information. | London |
| SH-4-54 | SH-4-54 is a potent STAT inhibitor with KD values of 300 nM and 464 nM for STAT3 and STAT5, respectively. It potently kills glioblastoma brain cancer stem cells (BTSCs). Group: Pharmaceutical. Alternative Names: 4-[(4-cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]benzoic acid. CAS No. 1456632-40-8. Pack Sizes: 100 mg. Product ID: B0084-463434. Molecular formula: C29H27F5N2O5S. Mole weight: 610.59. Custom synthesis is available. Send your inquiries for more information. | London |
| Silmitasertib | Silmitasertib is an orally bioavailable inhibitor of CK2 with potential antineoplastic activity. It inhibits proliferation in cancer cell lines overexpressing CK2. It suppresses survival and induces apoptosis of cancer stem cells including glioblastomas and acute myeloid leukemia cells. Group: Pharmaceutical. Alternative Names: CX-4945; CX 4945; 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid. CAS No. 1009820-21-6. Pack Sizes: 500 mg. Product ID: B2693-286324. Molecular formula: C19H12ClN3O2. Mole weight: 349.774. Custom synthesis is available. Send your inquiries for more information. | London |
| StemRegenin 1 | StemRegenin 1 is an aryl hydrocarbon receptor (AhR) antagonist with IC50 of 127 nM. It has been reported to promote hematopoietic stem cell expansion. Group: Pharmaceutical. Alternative Names: 4-(2-(2-(benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-ylamino)ethyl)phenol; SR1. CAS No. 1227633-49-9. Pack Sizes: 100 mg. Product ID: B0084-457690. Molecular formula: C24H23N5OS. Mole weight: 429.542. Custom synthesis is available. Send your inquiries for more information. | London |
| TDZD-8 | TDZD-8 is a derivative of thiadiazolidine (TDZD) and acts as a non-ATP competitive inhibitor of GSK3β. It was shown to inhibit proliferation and self-renewal of glioblastoma stem cells. Group: Pharmaceutical. Alternative Names: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione; GSK-3beta Inhibitor I; TDZD 8; 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-. CAS No. 327036-89-5. Pack Sizes: 200 mg. Product ID: B0084-350817. Molecular formula: C10H10N2O2S. Mole weight: 222.262. Custom synthesis is available. Send your inquiries for more information. | London |
| Thiazovivin | Thiazovivin is a selective, cell permeable small molecule that directly targets Rho-associated kinase (ROCK). In addition, Thiazovivin protects human embryonic stem cells (hESCs) in the absence of ECM by regulating E-cadherin mediated cell-cell interaction. This observation suggests that Thiazovivin promotes cell survival. In other studies Thiazovivin, in combination with inhibitors of the TGF-β receptor and MEK pathway, has shown to improve reprogramming efficiency by more than 200-fold. Uses: Reprogramming, self-renewal. Group: Pharmaceutical. Alternative Names: N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide; N-Benzyl-2-(pyrimidin-4-ylamino)-thiazole-4-carboxamide; N-(PHENYLMETHYL)-2-(4-PYRIMIDINYLAMINO)-4-THIAZOLECARBOXAMIDE; N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide; 4-THIAZOLECARBOXAMIDE, N-(PHENYLMETHYL)-2-(4-PYRIMIDINYLAMINO)-. CAS No. 1226056-71-8. Pack Sizes: 25 mg. Product ID: B0084-286727. Molecular formula: C15H13N5OS. Mole weight: 311.363. Custom synthesis is available. Send your inquiries for more information. | London |
| Y-27632 2HCl | Y-27632 is a Rho-associated kinase (ROCK) inhibitor. Y-27632 enhances the survival rate of human embryonic stem (hES) cells and promotes hESC differentiation into cortical and basal telencephalic progenitors. Group: Pharmaceutical. Alternative Names: Y-27632 dihydrochloride; 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride. CAS No. 129830-38-2. Pack Sizes: 50 mg. Product ID: B0084-457869. Molecular formula: C14H21N3O.2HCl. Mole weight: 320.26. Custom synthesis is available. Send your inquiries for more information. | London |
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