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| Product | Description | |
|---|---|---|
| Sorafenib | Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. Group: Pharmaceutical. CAS No. 284461-73-0. Pack Sizes: 1 g. Product ID: NP3268. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Sorafenib-[d3] | Sorafenib-[d3] is the labelled analogue of Sorafenib, which is a potent RAF kinase inhibitor and an antineoplastic. Group: Pharmaceutical. CAS No. 1130115-44-4. Pack Sizes: 5 mg. Product ID: BLP-008211. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib Impurities | Sorafenib Impurities, integral to biomedical exploration, critically evaluate Sorafenib's integrity and safety profile. Essential across hepatic, renal, and thyroid oncological treatments, these impurities augment drug quality by facilitating byproduct identification and control during development, thereby assuring robust and dependable therapeutic efficacy. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib related compound 10 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. CAS No. 1012058-78-4. Pack Sizes: 10 mg. Product ID: B1630-479761. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib Related Compound 15 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. CAS No. 284670-98-0. Pack Sizes: 250 mg. Product ID: B2694-479766. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib related compound 2 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. CAS No. 18585-06-3. Pack Sizes: 2 g. Product ID: B2694-233982. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib tosylate | Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. Group: Pharmaceutical. CAS No. 475207-59-1. Pack Sizes: 50 g. Product ID: BBF-05857. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AMG 925 | AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. AMG 925 inhibited AML xenograft tumor growth by 96% to 99% without significant body weight loss. The antitumor activity of AMG 925 correlated with the inhibition of STAT5 and RB phosphorylation, the pharmacodynamic markers for inhibition of FLT3 and CDK4, respectively. In addition, AMG 925 was also found to inhibit FLT3 mutants (e.g., D835Y) that are resistant to the current FLT3 inhibitors (e.g., AC220 and sorafenib). AMG 925, which combines inhibition of two kinases essential for proliferation and survival of FLT3-mutated AML cells, may improve and prolong clinical responses. Group: Pharmaceutical. CAS No. 1401033-86-0. Pack Sizes: 25 mg. Product ID: B2693-463215. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ethyl (4-((2-(Methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. CAS No. 2206827-12-3. Pack Sizes: 100 mg. Product ID: B2694-479756. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| LB-100 | LB-100 is a water-soluble protein phosphatase 2A (PP2A) inhibitor (IC50 = 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells) that enhanced the effects of sorafenib in HCC cells only during hypoxic environments. Group: Pharmaceutical. CAS No. 1632032-53-1. Pack Sizes: 100 mg. Product ID: B1370-474642. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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