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| Product | Description | |
|---|---|---|
| Sorafenib | Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. Group: Pharmaceutical. Alternative Names: BAY 43-9006. CAS No. 284461-73-0. Pack Sizes: 1 g. Product ID: NP3268. Molecular formula: C21H16ClF3N4O3. Mole weight: 464.82. Custom synthesis is available. Send your inquiries for more information. |  London |
| Sorafenib-[d3] | Sorafenib-[d3] is the labelled analogue of Sorafenib, which is a potent RAF kinase inhibitor and an antineoplastic. Group: Pharmaceutical. Alternative Names: Sorafenib-d3; Sorafenib-(methyl-d3); 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-(methyl-d3)-2-pyridinecarboxamide. CAS No. 1130115-44-4. Pack Sizes: 5 mg. Product ID: BLP-008211. Molecular formula: C21H13D3ClF3N4O3. Mole weight: 467.84. Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib related compound 10 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxylic Acid; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinic Acid; Sorafenib Hydroxydemethylamine. CAS No. 1012058-78-4. Pack Sizes: 10 mg. Product ID: B1630-479761. Molecular formula: C20H13ClF3N3O4. Mole weight: 451.79. Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib Related Compound 15 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: 4,4'-[Carbonylbis(imino-4,1-phenyleneoxy)]bis[N-methyl-2-pyridinecarboxamide]; PAPE-urea; N,N'-Bis[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea. CAS No. 284670-98-0. Pack Sizes: 250 mg. Product ID: B2694-479766. Molecular formula: C27H24N6O5. Mole weight: 512.53. Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib related compound 2 | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: N-[4-Chloro-3-(trifluoromethyl)phenyl]carbamic Acid Ethyl Ester; [4-Chloro-3-(trifluoromethyl)phenyl]carbamic Acid Ethyl Ester; 4-Chloro-3-(trifluoromethyl)carbanilic Acid Ethyl Ester; Ethyl (4-Chloro-3-(trifluoromethyl)phenyl)carbamate. CAS No. 18585-06-3. Pack Sizes: 2 g. Product ID: B2694-233982. Molecular formula: C10H9ClF3NO2. Mole weight: 267.64. Custom synthesis is available. Send your inquiries for more information. | London |
| Sorafenib tosylate | Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. Group: Pharmaceutical. Alternative Names: Sorafenib p-toluenesulfonate; BAY 43-9006 Mono-p-tosylate; BAY 54-9085; Nexavar(R); 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea mono(4-methylbenzenesulfonate); 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-, mono(4-methylbenzenesulfonate); Bay 43-9006. CAS No. 475207-59-1. Pack Sizes: 50 g. Product ID: BBF-05857. Molecular formula: C28H24ClF3N4O6S. Mole weight: 637.03. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide | [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide is an intermediate of Sorafenib, which is a kinase inhibitor drug used for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), FLT3-ITD positive AML and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: 4-(4-Aminophenoxy)-N-methylpicolinamide; 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]aniline; 4-[(4-aminomethyl)phenoxy]-2-pyridine carbonic acid methylamide; Sorafenib Imp -1; Sorafenib Related Compound 23. CAS No. 284462-37-9. Pack Sizes: 1mg;1g;10g. Product ID: NP2695. Molecular formula: C13H13N3O2. Mole weight: 243.26. Custom synthesis is available. Send your inquiries for more information. | London |
| AMG 925 | AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. AMG 925 inhibited AML xenograft tumor growth by 96% to 99% without significant body weight loss. The antitumor activity of AMG 925 correlated with the inhibition of STAT5 and RB phosphorylation, the pharmacodynamic markers for inhibition of FLT3 and CDK4, respectively. In addition, AMG 925 was also found to inhibit FLT3 mutants (e.g., D835Y) that are resistant to the current FLT3 inhibitors (e.g., AC220 and sorafenib). AMG 925, which combines inhibition of two kinases essential for proliferation and survival of FLT3-mutated AML cells, may improve and prolong clinical responses. Group: Pharmaceutical. Alternative Names: AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925. CAS No. 1401033-86-0. Pack Sizes: 25 mg. Product ID: B2693-463215. Molecular formula: C26H29N7O2. Mole weight: 471.55. Custom synthesis is available. Send your inquiries for more information. | London |
| Ethyl (4-((2-(Methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: PAPE-ethyl Carbamate; Sorafenib related compound 7. CAS No. 2206827-12-3. Pack Sizes: 100 mg. Product ID: B2694-479756. Molecular formula: C16H17N3O4. Mole weight: 315.32. Custom synthesis is available. Send your inquiries for more information. | London |
| LB-100 | LB-100 is a water-soluble protein phosphatase 2A (PP2A) inhibitor (IC50 = 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells) that enhanced the effects of sorafenib in HCC cells only during hypoxic environments. Group: Pharmaceutical. Alternative Names: (1S,4R)-2-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-3-carboxylic acid; LB 100; LB100. CAS No. 1632032-53-1. Pack Sizes: 100 mg. Product ID: B1370-474642. Molecular formula: C13H20N2O4. Mole weight: 268.31. Custom synthesis is available. Send your inquiries for more information. | London |
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