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| Product | Description | |
|---|---|---|
| Sofosbuvir | Sofosbuvir is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled sofosbuvir as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Uses: Antiviral agents. Group: Pharmaceutical. Alternative Names: PSI-7977; PSI 7977; PSI7977; GS7977; GS-7977; GS 7977; Sovaldi; N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine, 1-methylethyl ester; Hepcinat; Hepcvir; Resof; SoviHep. CAS No. 1190307-88-0. Pack Sizes: 2.5 g. Product ID: B0084-457411. Molecular formula: C22H29FN3O9P. Mole weight: 529.45. Custom synthesis is available. Send your inquiries for more information. |  London |
| Sofosbuvir Impurity 35 | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Group: Pharmaceutical. Alternative Names: (2'R)-2'-Chloro-2'-deoxy-2'-methyl-uridine; Chloro Sofosbuvir Desphosphate. CAS No. 1496551-72-4. Pack Sizes: 10 mg. Product ID: B2694-479717. Molecular formula: C10H13ClN2O5. Mole weight: 276.68. Custom synthesis is available. Send your inquiries for more information. | London |
| Sofosbuvir impurity C | An impurity of Sofosbuvir, a medication used to treat hepatitis C. Group: Pharmaceutical. Alternative Names: Sofosbuvir impurity A; (2R)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate. CAS No. 1496552-28-3. Pack Sizes: 25 mg. Product ID: B2694-346656. Molecular formula: C22H29FN3O9P. Mole weight: 529.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Sofosbuvir Impurity (GS-566500) | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Group: Pharmaceutical. Alternative Names: L-Alanine, N-[(2'R)?-2'-deoxy-2'-fluoro-2'-methyl-5'-uridylyl]?-; N-[(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylyl]-L-alanine; PSI 352707. CAS No. 1233335-78-8. Pack Sizes: 10 mg. Product ID: B2694-479704. Molecular formula: C13H19FN3O9P. Mole weight: 411.28. Custom synthesis is available. Send your inquiries for more information. | London |
| (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine | PSI-6206 is a selective HCV RNA polymerase inhibitor. It is the unphosphorylated parent compound of triphosphate analog PSI-7409, which is a potent inhibitor of the HCV NS5B RNA dependent RNA polymerase. Group: Pharmaceutical. Alternative Names: RO-2433; RO 2433; RO2433; PSI6206; PSI 6206; PSI-6206; GS331007; GS-331007; GS 331007; 2'-Deoxy-2'-fluoro-2'-C-methyluridine; Sofosbuvir Metabolite GS331007; 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine; ZL-01 metabolite M9; 2'-Deoxy-2'-Fluoro-2'-methyluridine. CAS No. 863329-66-2. Pack Sizes: 5 g. Product ID: B2693-459960. Molecular formula: C10H13FN2O5. Mole weight: 260.22. Custom synthesis is available. Send your inquiries for more information. | London |
| (2S)-Isopropyl 2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Group: Pharmaceutical. Alternative Names: Propan-2-yl (2S)-2-{[pentafluorophenoxy(phenoxy)phosphoryl]amino}propanoate; N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)Phenoxyphosphinyl]-L-Alanine 1-Methylethyl Ester; N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine1-methylethyl ester. CAS No. 1256490-52-4. Pack Sizes: 25 mg. Product ID: B1628-480349. Molecular formula: C18H17F5NO5P. Mole weight: 453.302. Custom synthesis is available. Send your inquiries for more information. | London |
| PSI 7411 | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Group: Pharmaceutical. Alternative Names: 5'-Uridylic acid, 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)?-; (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylic acid; PSI-7411; PSI7411; 2'-Fluoro-2'-methyl(up)-uridine-5'-monophosphate; 2'-F-2'-Me(up)-UMP; Sofosbuvir Impurity 34 (GS-606965). CAS No. 1015073-43-4. Pack Sizes: 10 mg. Product ID: B2694-479716. Molecular formula: C10H14FN2O8P. Mole weight: 340.2. Custom synthesis is available. Send your inquiries for more information. | London |
| PSI-7976 | PSI-7976 is an inhibitor of HCV RNA replication with EC50 value of 1.07μM. PSI-7851 is a phosphoramidate prodrug of PSI-7411 and has potent anti-hepatitis C virus (HCV) activity. It is a mixture of two diastereoisomers. PSI-7976 is one of them. Another one is PSI-7977. PSI-7851 is firstly activated through being hydrolyzed by CatA and CES1in the liver cells. It is found that CatA prefers PSI-7977 as a substrate over PSI-7976 while CES1 preferentially hydrolyzes PSI-7976 over PSI-7977. Since CES1 does not express in clone A replicon cells, the ability of PSI-7976 and PSI-7977 to inhibit HCV RNA replication is different in these cells. PSI-7977 is more potent than PSI-7976 with EC50 value of 92nM. Group: Pharmaceutical. Alternative Names: Sofosbuvir (R)-Phosphate; (2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate; N-[[P(R),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-Methylethyl Ester. CAS No. 1190308-01-0. Pack Sizes: 25 mg. Product ID: B2693-463118. Molecular formula: C22H29FN3O9P. Mole weight: 529.45. Custom synthesis is available. Send your inquiries for more information. | London |
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