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| Product | Description | |
|---|---|---|
| 1,2-Distearoyl-sn-glycero-3-phospho-L-serine sodium salt | 1,2-Distearoyl-sn-glycero-3-phospho-L-serine sodium salt, an imperative lipidic component, finds application in developing liposomes deployed for efficacious drug delivery. This compound exhibits a remarkable efficacy in targeting neoplastic cells and delivering pharmacological agents directly to the site of the malignancy. Moreover, this chemical entity holds immense potential in combating neurodegenerative maladies, such as Alzheimer's. Group: Pharmaceutical. CAS No. 321595-13-5. Pack Sizes: 25 mg. Product ID: B4059-188606. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl-Fmoc serine | 2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl-Fmoc serine is a globally recognized bioactive compound, finding its utility in the synthesis of innovative glycosylated peptides. Group: Pharmaceutical. CAS No. 118358-38-6. Pack Sizes: 25 mg. Product ID: BAT-008016. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-a-D-galactopyranosyl-Fmoc serine | 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-a-D-galactopyranosyl-Fmoc serine, renowned as an indispensible glycosylated amino acid, is commonly utilized during the manufacture of peptides and glycopeptide antibiotics. This amino acid serves as an exemplary substrate for galactosyl transferase, a pivotal element in the aetiology of multifarious pathologies, eliciting cancer as a prominent example. Its ability to function as a progressive component adds to its significance in the realm of biomedicine and allied research. Group: Pharmaceutical. CAS No. 120173-57-1. Pack Sizes: 25 mg. Product ID: BAT-008015. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranosyl-Fmoc serine | 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranosyl-Fmoc serine, an indispensable constituent in the realm of biomedicine, exhibits a profound impact on pharmaceutical progress, specifically in combating diverse afflictions. Its prominence extends to the creation of unprecedented antiviral and anticancer modalities, facilitation of precision drug transportation mechanisms, and exploration of intricate cellular communication routes. Group: Pharmaceutical. CAS No. 160067-63-0. Pack Sizes: 100 mg. Product ID: BAT-015306. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-L-homoserine lactone | It is the shortest and most polar alkyl homologue of a family of mediators of cell to cell interactions in bacterial biofilms. It can cause carbapenem formation in Erwinia carotovora. Group: Pharmaceutical. CAS No. 51524-71-1. Pack Sizes: 1mg; 1g; 10g. Product ID: BBF-04200. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-L-serine methyl ester | Acetyl-L-serine methyl ester. Group: Pharmaceutical. CAS No. 54322-41-7. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003876. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-O-tert-butyl-L-serine | Acetyl-O-tert-butyl-L-serine. Group: Pharmaceutical. CAS No. 77285-09-7. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003884. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BOC-O-Benzyl-L-serine | 5g Pack Size. Group: Amino Acids. Formula: C15H21NO5. CAS No. 23680-31-1. Prepack ID : 66966303-5g. Molecular Weight : 295.33. |  |
| D-Cycloserine | 1g Pack Size. Group: Antibiotics, Bioactive Small Molecules, Chiral Compounds, Organics, Research Organics & Inorganics. Formula: C3H6N2O2. CAS No. 68-41-7. Prepack ID : 90028981-1g. Molecular Weight : 102.09. | |
| D-Cycloserine | 1g Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C3H6N2O2. CAS No. 68-41-7. Prepack ID : 69907662-1g. Molecular Weight : 102.09. | |
| D-Cycloserine | 25g Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C3H6N2O2. CAS No. 68-41-7. Prepack ID : 69907662-25g. Molecular Weight : 102.09. | |
| D-Cycloserine | 5g Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C3H6N2O2. CAS No. 68-41-7. Prepack ID : 69907662-5g. Molecular Weight : 102.09. | |
| DL-Serine | 100g Pack Size. Group: Amino Acids, Biochemicals, Building Blocks, Peptide Reagents. Formula: C3H7NO3. CAS No. 302-84-1. Prepack ID : 19673855-100g. Molecular Weight : 105.09. | |
| Fmoc-L-Serine | 25g Pack Size. Group: Amino Acids. Formula: C18H17NO5. CAS No. 73724-45-5. Prepack ID : 14388650-25g. Molecular Weight : 327.33. | |
| Hexanoyl-L-homoserine lactone | An active quorum sensing modulator first recognised in rhizobium leguminosarum. It is produced by the strain of Nitrosomonas europeae. Group: Pharmaceutical. CAS No. 147852-83-3. Pack Sizes: 100 mg. Product ID: BBF-04581. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| L-Serine | 100g Pack Size. Group: Amino Acids, Biochemicals. Formula: C3H7NO3. CAS No. 56-45-1. Prepack ID : 24133813-100g. Molecular Weight : 105.09. | |
| L-Serine | 500kg Pack Size. Group: Amino Acids, Biochemicals. Formula: C3H7NO3. CAS No. 56-45-1. Prepack ID : 24133813-500kg. Molecular Weight : 105.09. | |
| Micafungin Serine Analog | An impurity of Micafungin, an echinocandin antifungal drug used for the treatment of invasive fungal infections including candidiasis, candidemia and esophageal candidiasis. Micafungin inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall, and represent a valuable treatment option for fungal infections. Group: Pharmaceutical. CAS No. 1392514-04-3. Pack Sizes: 1 mg. Product ID: 1392514-04-3. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-α-(t-Butoxycarbonyl)-O-trityl-L-serine | Utilized extensively in the production of peptides and proteins, N-α-(t-Butoxycarbonyl)-O-trityl-L-serine is a chemical compound boasting diverse applications within the pharmaceutical arena. In addition to its fundamental use in pharmaceutical synthesis, this compound demonstrates further utility as a therapeutic agent in the treatment of cancer and autoimmune disorders. Group: Pharmaceutical. CAS No. 252897-67-9. Pack Sizes: 25 g. Product ID: BAT-003168. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-CBZ-L-Serine-OH | 25g Pack Size. Group: Amino Acids. Formula: C11H13NO5. CAS No. 1145-80-8. Prepack ID : 27070659-25g. Molecular Weight : 239.22. | |
| O-Acetyl-L-homoserine hydrochloride | O-Acetyl-L-homoserine hydrochloride. Uses: A versatile synthon for the synthesis of l-homoserine peptides and 3-amino-2-pyrrolidinones. Group: Pharmaceutical. CAS No. 250736-84-6. Pack Sizes: 25 mg. Product ID: B2699-117029. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AAF-CMK trifluoroacetate salt | AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome function, and reversibly inhibits Cln2 (TPPI). Group: Pharmaceutical. CAS No. 184901-82-4. Pack Sizes: 100 mg. Product ID: BAT-015706. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acein | Acein is a high-affinity angiotensin-converting enzyme (ACE) ligand with a Kd of 2.79 nM. It potentiates NMDA+ D-serine-induced dopamine release from the striatum in vivo and striatal slices in vitro. Group: Pharmaceutical. CAS No. 2022202-76-0. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-016396. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acein acetate | Acein acetate is a high-affinity angiotensin-converting enzyme (ACE) ligand with a Kd of 2.79 nM. It potentiates NMDA+ D-serine-induced dopamine release from the striatum in vivo and striatal slices in vitro. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-016395. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl Tetrapeptide-2 | Acetyl Tetrapeptide-2 is a four amino acid peptide that can stimulate the skin's immune defenses and help skin regeneration. It can promote FBLN5 and LOXL1 synthesis and enhance their activity, improve skin firmness. Uses: acetyl tetrapeptide-2 is a synthetic peptide composed of four amino acids: alanine, glutamine, serine, and arginine. it is a small molecule that is easily absorbed by the body, making it an attractive candidate for drug delivery systems. one of the key mechanisms of at-2 is its ability to modulate the expression of key proteins involved in regulating cellular processes associated with aging and. Group: Pharmaceutical. CAS No. 757942-88-4. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-009988. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ac-IEPD-AFC | Ac-IEPD-AFC is a peptide whose sequence is preferred recognition motif for the serine protease granzyme B. It is a fluorogenic substrate. Group: Pharmaceutical. CAS No. 1135417-31-0. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-010421. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ac-Ile-Glu-Pro-Asp-AMC | Ac-Ile-Glu-Pro-Asp-AMC is a preferred substrate sequence of granzyme B, which is a mammalian serine protease involved in the induction of rapid target cell death by cytotoxic lymphocytes. Group: Pharmaceutical. CAS No. 216757-33-4. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-015136. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ac-Lys-Gln-Leu-Arg-AFC | Ac-Lys-Gln-Leu-Arg-AFC is the optimal substrate for human Hepsin, because KQLR/VVNG corresponds to its cleavage site. Excitation at 395-400 nm, emission at 495-505 nm. Hepsin is a membrane-anchored serine protease that is overexpressed in ovarian, prostate cancer and renal cell carcinomas, and therefore can be used as a prognostic marker. Group: Pharmaceutical. CAS No. 1802078-38-1. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-014545. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Activated Protein C (390-404), human | Activated Protein C (390-404) human, a peptide of the activated protein C (a vitamin K-dependent serine protease), effectively inhibits the anticoagulant activity of APC. Group: Pharmaceutical. CAS No. 146340-20-7. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-010425. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AEBSF HCl | AEBSF is a water-soluble, irreversible serine protease inhibitor that inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. Group: Pharmaceutical. CAS No. 30827-99-7. Pack Sizes: 1 g. Product ID: B2693-369679. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Alisertib | MLN8237 is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Aurora kinase inhibitor MLN8237 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Group: Pharmaceutical. CAS No. 1028486-01-2. Pack Sizes: 100 mg. Product ID: B2693-336876. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AR-A014418 | AR-A014418 is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β), a serine/threonine protein kinase involved in multiple diseases including Alzheimer's disease and type 2 diabetes. Group: Pharmaceutical. CAS No. 487021-52-3. Pack Sizes: 25 mg. Product ID: B0084-258809. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AT9283 | AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50= 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. Group: Pharmaceutical. CAS No. 896466-04-9. Pack Sizes: 10 mg. Product ID: B0084-100114. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AZD-5363 | AZD-5363 is an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AZD-5363 binds to and inhibits all AKT isoforms. This agent may be used as monotherapy or combination therapy for a variety of human cancers. Group: Pharmaceutical. CAS No. 1143532-39-1. Pack Sizes: 10 mg. Product ID: B2693-457058. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bortezomib USP Impurity G | Bortezomib USP Impurity G is an isomer of Bortezomib. It has been demonstrated to inhibit serine proteases shown to lower cellular Aβ concentrations, associated with Alzheimer's or hypertension. Group: Pharmaceutical. CAS No. 1132709-14-8. Pack Sizes: 10 mg. Product ID: B0103-467636. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BX-795 | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, which is 140- and 1600-fold more selective than PKA and PKC. It is also a potent and relatively specific inhibitor of TBK1 with IC50 of 6 nM and IKK? with IC50 of 41 nM. Group: Pharmaceutical. CAS No. 702675-74-9. Pack Sizes: 25 mg. Product ID: B0084-194478. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| C16 Ceramide | C16 ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling. It has also been found to activate NF-κB and PKCζ3. Uses: A predominant, rather hydrophobic natural ceramide. activates a cytosolic serine/threonine protein phosphatase in t9 cells; induces egf receptor phosphorylation in a-431 cells; stimulates ceramide-activated protein kinase. Group: Pharmaceutical. CAS No. 24696-26-2. Pack Sizes: 100 mg. Product ID: B1370-059982. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Camostat Mesylate | Camostat (INN) or FOY-305 is a serine protease inhibitor. Serine protease enzymes have a variety of functions in the body, and so camostat has a diverse range of uses. It is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease orpancreatitis. Uses: Trypsin inhibitors. Group: Pharmaceutical. CAS No. 59721-29-8. Pack Sizes: 5 g. Product ID: B2693-072632. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cobimetinib | Cobimetinib (GDC-0973, RG7420) is a potent, orally available and highly selective MEK1 inhibitor with IC50 of 4.2 nM. It shows more than 100-fold selectively for MEK1 over MEK2 when tested against a panel of more than 100 serine-threonine and tyrosine kinases and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Group: Pharmaceutical. CAS No. 934660-93-2. Pack Sizes: 25 mg. Product ID: B0084-460683. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| D-Val-Leu-Lys 4-nitroanilide dihydrochloride | D-Val-Leu-Lys 4-nitroanilide dihydrochloride stands as a crucial substrate to gauge the efficiency of trypsin-like serine proteases. Proteolysis event leads to the release of a yellow colored product, whose quantification can be done at 405 nm. Its utility can be seen in trypsin activity detection and the evaluation of agents restricting trypsin-like proteases. Consistent usage of this product aids in experimental design and the analysis of diverse protease substrates. Group: Pharmaceutical. CAS No. 62354-43-2. Pack Sizes: 5 mg. Product ID: BAT-014255. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Encorafenib | Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. Group: Pharmaceutical. CAS No. 1269440-17-6. Pack Sizes: 150 mg. Product ID: B0084-462563. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GSK-461364 | GSK-461364 is a Polo-like kinase 1 inhibitor, is also a small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Group: Pharmaceutical. CAS No. 929095-18-1. Pack Sizes: 10 mg. Product ID: B0084-307746. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GSK583 | GSK583 is a selective receptor-interacting serine/threonine-protein kinase 2 (RIP2 Kinase) inhibitor and the RIP2K binding IC50 is 5 nM. GSK583 can inhibit both TNF-α and IL-6 production with an IC50 value of 200 nM in an ex vivo human translational model. Group: Pharmaceutical. CAS No. 1346547-00-9. Pack Sizes: 25 mg. Product ID: B0084-475334. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| HMN-214 | HMN-214 is an oral prodrug of HMN-176, a stilbene derivative that interferes with the subcellular spatial location of polo-like kinase-1, a serine/threonine kinase that regulates critical mitotic events. Group: Pharmaceutical. CAS No. 173529-46-9. Pack Sizes: 50 mg. Product ID: B2693-321779. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ipatasertib | Ipatasertib, also known as GDC-0068 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GDC-0068 binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 1001264-89-6. Pack Sizes: 50 mg. Product ID: B2693-456282. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Isopropyl ethanesulfonate | Propan-2-yl Ethane-1-sulfonate can be used as serine protease inhibitors to inhibit an increase in the blood gluocose level. Group: Pharmaceutical. CAS No. 14245-62-6. Pack Sizes: 1 g. Product ID: B2699-301730. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Kallikrein Inhibitor | Kallikrein Inhibitor, a synthetic peptide, is a serine protease inhibitor that inhibits kallikrein and plasmin, and can attenuate breast cancer cell invasion. Group: Pharmaceutical. CAS No. 97145-43-2. Pack Sizes: 10 mg. Product ID: BAT-006188. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Linifanib | Description of Linifanib: Linifanib is an orally bioavailable, small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Linifanib inhibits members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families; it exhibits much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. This agent does not have a general antiproliferative effect due to its high dose requirement. However, linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as fms-related tyrosine kinase receptor-3 (FLT3). Group: Pharmaceutical. CAS No. 796967-16-3. Pack Sizes: 200 mg. Product ID: B0084-151820. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mesupron | Mesupron is the second generation serine protease inhibitor prodrug targeting the human urokinase plasminogen activator (uPA) system with potential antineoplastic and antimetastatic activities. Group: Pharmaceutical. CAS No. 590368-25-5. Pack Sizes: 5 mg. Product ID: B0084-462232. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Milciclib | Milciclib is an orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and thropomyosin receptor kinase A (TRKA), with potential antineoplastic activity. CDK2/TRKA inhibitor PHA-848125 AC potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits activity against other CDKs including CDK1 and CDK4, in addition to TRKA. Inhibition of these kinases may result in cell cycle arrest and apoptosis of tumor cells that express these kinases. CDKs are serine/threonine kinases involved in regulation of the cell cycle and may be overexpressed in some cancer cell types. The neurotrophin receptor TRKA is mutated in a variety of cancer cell types. Group: Pharmaceutical. CAS No. 802539-81-7. Pack Sizes: 5 mg. Product ID: B0084-459709. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Nafamostat mesilate | Nafamostat Mesylate is a synthetic serine protease inhibitor and an anticoagulant. It is a fast-acting proteolytic inhibitor and used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin. Uses: Anti-inflammatory agents, non-steroidal. Group: Pharmaceutical. CAS No. 82956-11-4. Pack Sizes: 5 g. Product ID: BAT-008979. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| NCT-503 | NCT-503 is a non-competitive phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50= 2.5 μM), reducing the production of glucose-derived serine in cells and suppressing the growth of PHGDH-dependent cancer cells in culture and in orthotopic xenograft tumors. Group: Pharmaceutical. CAS No. 1916571-90-8. Pack Sizes: 100 mg. Product ID: B1370-007403. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-Desmethyl Enzalutamide | N-desmethyl Enzalutamide is a major metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist (IC50 = 36 nM) in LNCaP cells that inhibits the transcriptional activity of a mutant AR protein. Enzalutamide resists against induction of prostate-specific antigen (PSA) and transmembrane serine protease 2 (TMPRSS2). N-desmethyl Enzalutamide can be used for the treatment of disorders involving androgen, estrogen and progesterone receptors. Uses: The treatment of disorders involving androgen, estrogen and progesterone receptors. Group: Pharmaceutical. CAS No. 1242137-16-1. Pack Sizes: 20 mg. Product ID: B0084-474425. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| NMS-1286937 | NMS1286937, also know as NMS-P937, is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis. Uses: Protein kinase inhibitors. Group: Pharmaceutical. CAS No. 1034616-18-6. Pack Sizes: 500 mg. Product ID: B1370-462742. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-p-Tosyl-Gly-Pro-Lys p-nitroanilide acetate salt | N-p-Tosyl-Gly-Pro-Lys p-nitroanilide acetate salt is a chromogenic substrate for plasmin determination, serine protease activity and fibrinogen decomposition determination. Group: Pharmaceutical. CAS No. 88793-79-7. Pack Sizes: 50 mg. Product ID: BAT-010163. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PF-04691502 | PF-04691502 is an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. It inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy. mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K. Group: Pharmaceutical. CAS No. 1013101-36-4. Pack Sizes: 50 mg. Product ID: B0084-456382. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PF-06650833 | PF-06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), which is an omnipresently expressed serine/threonine kinase involved in the regulation of innate immunity. PF-06650833 is useful for the treatment of autoimmune and inflammatory diseases associated with lnterleukin-1 Receptor Associated Kinase (IRAK) and more particularly modulates the function of IRAK. It is undergoing testing in a Phase II clinical study. Group: Pharmaceutical. CAS No. 1817626-54-2. Pack Sizes: 25 mg. Product ID: B0084-474124. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Proteinase K | Proteinase K is a subtilisin-related serine protease. It was discovered from the fungus Engyodontium album. It can be used for removal of endogenous nucleases during the preparation of DNA and RNA, and for preparation of tissue sections for in situ hybridization. It is often used in pH range 7.5-9.0 and 37-70°C. Specific activity is ≥ 34 units/mg of protein. Group: Pharmaceutical. CAS No. 39450-01-6. Pack Sizes: 1 g. Product ID: BBF-04168. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Regorafenib | Regorafenib, also known as BAY 73-4506, is an orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling. Regorafenib is demonstrated to increase the overall survival of patients with metastatic colorectal cancer and has been approved by the US FDA on September 27, 2012. Uses: Antineoplastic agent. Group: Pharmaceutical. CAS No. 755037-03-7. Pack Sizes: 500 mg. Product ID: BBF-05856. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| RGB-286638 Free base | RGB-286638 is a novel CDK inhibitor. It inhibited several tyrosine and serine/threonine non-CDK enzymes, i.e. GSK-3β, TAK1, AMPK, Jak2, MEK1. It demonstrated equimolar (50nM) activity in freshly isolated tumor cells from MM patients, while manifesting less cytotoxicity in healthy donor PBMCs. It reduced the phosphorylation of Rb at S807/811 in MM.1S and MM.1R cells, but had no effects on p-Rb S780. Group: Pharmaceutical. CAS No. 784210-88-4. Pack Sizes: 100 mg. Product ID: B0084-463330. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rigosertib sodium | Rigosertib (ON-01910 sodium salt), a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity, is a non-ATP-competitive inhibitor of PLK1 (IC50=9 nM), inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Group: Pharmaceutical. CAS No. 1225497-78-8. Pack Sizes: 50 mg. Product ID: B0084-286621. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Seliciclib | Seliciclib is an orally bioavailable, small-molecule cyclin-dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Seliciclib primarily inhibits CDK2/E, CDK2/A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, inhibiting RNA polymerase II-dependent transcription, which may result in the down-regulation of antiapoptotic proteins such as induced myeloid leukemia cell differentiation protein Mcl-1. CDKs, serine/threonine kinases that play an important role in cell cycle regulation, are overexpressed in various malignancies. Mcl-1 belongs to the Bcl-2 family of antiapoptotic proteins and is a protein crucial to the survival of a range of tumor cell types. Group: Pharmaceutical. CAS No. 186692-46-6. Pack Sizes: 100 mg. Product ID: B1370-086385. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SPHINX31 | SPHINX31 is a potent and selective inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) (IC50 value of 6 nM). It inhibits SRPK1 activity and phosphorylation of serine/arginine splicing factor 1 (SRSF1), increasing expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells. Group: Pharmaceutical. CAS No. 1818389-84-2. Pack Sizes: 1 g. Product ID: B2693-055365. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Telaprevir-[d4] | Labelled Telaprevir. VX-950 is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). VX-950 forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (K(I)*) of 7 nM. Dissociation of the covalent enzyme-inhibitor complex of VX-950 and genotype 1a HCV protease has a half-life of almost an hour. A >4-log10 reduction in the HCV RNA levels was observed after a 2-week incubation of replicon cells with VX-950, with no rebound of viral RNA observed after withdrawal of the inhibitor. In several animal species, VX-950 exhibits a favorable pharmacokinetic profile with high exposure in the liver. In a recently developed HCV protease mouse model, VX-950 showed excellent inhibition of HCV NS3-4A protease activity in the liver. Group: Pharmaceutical. Pack Sizes: 50 mg. Product ID: BLP-006018. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tozasertib | The Aurora kinases (A, B, and C) are a family of serine-threonine kinases that regulate various stages of mitotic function. With significant roles in cell cycle and cell division, Aurora kinase gene amplification and overexpression are linked to tumorigenesis. MK 0457 is a potent pan-Aurora kinase inhibitor but favors Aurora A (Ki = 0.6 nM) over Aurora B (Ki = 18 nM) or Aurora C (Ki = 4.6 nM). It shows selectivity against a panel of more than 190 different protein kinases. MK 0457 effectively inhibits proliferation of several different cell lines of clear cell renal carcinoma (IC50s < 10 μM) and blocks the growth of tumors in a rodent model of cancer (80 mg/kg), inhibiting histone H3 phosphorylation and increasing apoptosis. By depleting Aurora activity, MK 0457 disrupts bipolar spindle formation during mitosis, arresting cell cycle progression at the G2/M phase. Group: Pharmaceutical. CAS No. 639089-54-6. Pack Sizes: 250 mg. Product ID: B0084-074159. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tricirbine | Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 μM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Group: Pharmaceutical. CAS No. 35943-35-2. Pack Sizes: 100 mg. Product ID: B1370-090988. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Trypsin Inhibitor (soybean) | Trypsin Inhibitor (soybean) is a peptide inhibitor of serine proteases that reduces trypsin, as well as plasma kallikrein, thrombin, plasmin, and other serine proteases. Group: Pharmaceutical. CAS No. 9035-81-8. Pack Sizes: 10 g. Product ID: B2693-194378. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Uprosertib | Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Group: Pharmaceutical. CAS No. 1047634-65-0. Pack Sizes: 25 mg. Product ID: B0084-462537. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Vildagliptin | Glyptins are class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. Aside from there use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects. Antidiabetic. Uses: Dipeptidyl-peptidase iv inhibitors. Group: Pharmaceutical. CAS No. 274901-16-5. Pack Sizes: 5 g. Product ID: NP3358. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| YKL-06-061 | YKL-06-061 is a small molecule serine/threonine-protein kinase SIK1 inhibitor (Ki = 6.56 nM) that is hopefully developed to be a dermatologic drug impacting UV protection and skin cancer risk. It causes a dose-dependent increase in microphthalmia-associated transcription factor (MITF) mRNA expression during 3-hour function in normal human melanocytes, UACC62 human melanoma cells, and UACC257 human melanoma cells. Uses: A potential dermatologic drug. Group: Pharmaceutical. CAS No. 2172617-15-9. Pack Sizes: 50 mg. Product ID: B0084-112344. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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