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| Product | Description | |
|---|---|---|
| Selumetinib | Selumetinib, also known as AZD6244, is an orally bioavailable small molecule with potential antineoplastic activity. Selumetinib inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, and so may inhibit cellular proliferation in MEK-overexpressing tumor cells. MEK 1 and 2 are dual-specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various tumor cell types, and are drivers of diverse cellular activities, including cellular proliferation. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. Alternative Names: ARRY-142886; ARRY 142886; ARRY142886; AZD6244; AZD-6244; AZD 6244; ARRY-886; ARRY886; ARRY 886. CAS No. 606143-52-6. Pack Sizes: 5 g. Product ID: B0084-095434. Molecular formula: C17H15BrClFN4O3. Mole weight: 457.684. Custom synthesis is available. Send your inquiries for more information. |  London |
| AZD0364 | AZD-0364 is a potent and selective ERK2 inhibitor, which has an IC50 value of 0.6 nM. AZD-0364 is measured in the A375 phospho-p90RSK assays with IC50s of 5.7 nM. AZD-0364 can inhibit the growth of a panel of cancer cell lines. The combination of Selumetinib and AZD-0364 ethanesulfonic acid results in a reduction in tumor growth. Group: Pharmaceutical. Alternative Names: AZD-0364; AZD 0364; tizaterkib. CAS No. 2097416-76-5. Pack Sizes: 25 mg. Product ID: B2693-291616. Molecular formula: C24H24F2N8O2. Mole weight: 494.5. Custom synthesis is available. Send your inquiries for more information. | London |
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