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| Product | Description | |
|---|---|---|
| Sacubitril | Sacubitril, also known as AHU377 or LCZ696, is an angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume. Group: Pharmaceutical. Alternative Names: Sacubitril; AHU 377; AHU377. CAS No. 149709-62-6. Pack Sizes: 10 g. Product ID: B0084-458470. Molecular formula: C24H29NO5. Mole weight: 411.49. Custom synthesis is available. Send your inquiries for more information. |  London |
| Sacubitril-[d4] | An isotope labelled AHU377, a methyl ester prodrug form of the neprilysin inhibitor LBQ657. Group: Pharmaceutical. Alternative Names: AHU377-d4; (alphaR,gammaS)-gamma-[(3-carboxy-1-oxopropyl-2,2,3,3-d4)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoicacid,alpha-ethylester. CAS No. 1884269-07-1. Pack Sizes: 10 mg. Product ID: BLP-009582. Molecular formula: C24H25D4NO5. Mole weight: 415.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Sacubitril Enantiomer | Sacubitril enantiomer.Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. Group: Pharmaceutical. Alternative Names: 2R,4S-Sacubitril; (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester; 4-[[(2R,4S)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid; (2S,4R)-Sacubitril; SCHEMBL22420467; CS-M3545; AKOS030528367; HY-78847; MS-27102; PD100765; L10003; EN300-6474615; A854860; [1,1'-Biphenyl]-4-pentanoic acid, |A-[(3-carboxy-1-oxopropyl)amino]-|A-methyl-, 4-ethyl ester, (|AS,|AR)-; 3-{[(2R,4S)-1-{[1,1'-biphenyl]-4-yl}-5-ethoxy-4-methyl-5-oxopentan-2-yl]carbamoyl}propanoic acid; 4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid; (alphaS,gammaR)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester. CAS No. 761373-05-1. Pack Sizes: 25 mg. Product ID: B2694-479381. Molecular formula: C24H29NO5. Mole weight: 411.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Sacubitril Impurity 3 | An impurity of sacubitril. Sacubitril is an antihypertensive drug used in combination with valsartan. Group: Pharmaceutical. Alternative Names: (3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one; (3S,5S)-5-[(Biphenyl-4-yl)methyl]-3-methylpyrrolidin-2-one. CAS No. 1038925-00-6. Pack Sizes: 10 mg. Product ID: B2694-479387. Molecular formula: C18H19NO. Mole weight: 265.36. Custom synthesis is available. Send your inquiries for more information. | London |
| Sacubitril Impurity 4 | Sacubitrilat is one of the impurities of Sacubitril which has been found to be an endopeptidase inhibitor and be effective in the treatment of hypertension and heart failure. Group: Pharmaceutical. Alternative Names: LBQ-657; LBQ 657; LBQ657; Sacubitrilat; UNII-SPI5PBF81S; LBQ657; CHEMBL417007; (2R,4S)-4-(3-carboxypropanoylamino)-2-methyl-5-(4-phenylphenyl)pentanoic acid. CAS No. 149709-44-4. Pack Sizes: 100 mg. Product ID: B0084-475830. Molecular formula: C22H25NO5. Mole weight: 383.44. Custom synthesis is available. Send your inquiries for more information. | London |
| Sacubitril Impurity 5 | An impurity of sacubitril. Sacubitril is an antihypertensive drug used in combination with valsartan. Group: Pharmaceutical. Alternative Names: (αR,?γR)?-γ-[[(1,?1-Dimethylethoxy)?carbonyl]?amino]?-α-methyl-[1,?1'-biphenyl]?-4-pentanoic Acid. CAS No. 1012341-56-8. Pack Sizes: 5 mg. Product ID: B2694-479391. Molecular formula: C23H29NO4. Mole weight: 383.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Sacubitril Impurity 6 | An impurity of sacubitril. Sacubitril is an antihypertensive drug used in combination with valsartan. Group: Pharmaceutical. Alternative Names: (αS,?γR)?-γ-[[(1,?1-Dimethylethoxy)?carbonyl]?amino]?-α-methyl-[1,?1'-biphenyl]?-4-pentanoic Acid. CAS No. 1012341-54-6. Pack Sizes: 5 mg. Product ID: B2694-479392. Molecular formula: C23H29NO4. Mole weight: 383.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Sacubitril Impurity 7 | An impurity of sacubitril. Sacubitril is an antihypertensive drug used in combination with valsartan. Group: Pharmaceutical. Alternative Names: (αS,?γS)?-γ-[[(1,?1-Dimethylethoxy)?carbonyl]?amino]?-α-methyl-[1,?1'-biphenyl]?-4-pentanoic Acid. CAS No. 1012341-52-4. Pack Sizes: 5 mg. Product ID: B2694-479393. Molecular formula: C23H29NO4. Mole weight: 383.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Sacubitril sodium | Sacubitril, also known as AHU377, is a first-in-class medicine that contains a neprilysin (NEP) inhibitor (sacubitril) and an angiotensin II (Ang-II) receptor blocker (valsartan). Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. Group: Pharmaceutical. Alternative Names: sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate; Sacubitril sodium; AHU377; AHU 377; AHU-377; LCZ696. CAS No. 149690-05-1. Pack Sizes: 500 mg. Product ID: B0084-007864. Molecular formula: C24H28NO5.Na. Mole weight: 433.47. Custom synthesis is available. Send your inquiries for more information. | London |
| 2,5-Dioxopyrrolidine Sacubitril | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Group: Pharmaceutical. Alternative Names: (2R,4S)-5-Biphenyl-4-yl-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid ethyl ester. CAS No. 1038924-97-8. Pack Sizes: 100 mg. Product ID: B1604-479386. Molecular formula: C24H27NO4. Mole weight: 393.483. Custom synthesis is available. Send your inquiries for more information. | London |
| 2R,4R-Sacubitril | An isomer of Sacubitril. Sacubitril is a neprilysin inhibitor that is commonly used in combination with valsartan (an angiotensin II receptor blocker) to form a dual-acting medication known as sacubitril/valsartan. Group: Pharmaceutical. Alternative Names: (2R,4R)-Sacubitril; LCZ 696 Impurity B; 4-((rel-(2R,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid; Sacubitril-(2R,4R) Isomer. CAS No. 766480-48-2. Pack Sizes: 5 mg. Product ID: B1370-459004. Molecular formula: C24H29NO5. Mole weight: 411.49. Custom synthesis is available. Send your inquiries for more information. | London |
| (2R,4S)-4-Amino-5-biphenyl-4-yl-2-methylpentanoic acid hydrochloride | An impurity of Sacubitril, a neprilysin inhibitor that is used in combination with valsartan to treat high blood pressure. Group: Pharmaceutical. Alternative Names: 1038924-71-8; (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid hydrochloride(2R,4S)-4-amino-2-methyl-5-(4-phenylphenyl)pentanoic acid;hydrochloride; (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride; SCHEMBL597864. CAS No. 1038924-71-8. Pack Sizes: 100 mg. Product ID: B2694-013668. Molecular formula: C18H22ClNO2. Mole weight: 319.8. Custom synthesis is available. Send your inquiries for more information. | London |
| (2R,4S)-5-Biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Group: Pharmaceutical. Alternative Names: 1012341-50-2; (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid(2R,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid; FJ7AWX8DMFUNII-FJ7AWX8DMF. CAS No. 1012341-50-2. Pack Sizes: 100 mg. Product ID: B1604-479394. Molecular formula: C23H29NO4. Mole weight: 383.488. Custom synthesis is available. Send your inquiries for more information. | London |
| (3R,5S)-5-Biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Group: Pharmaceutical. Alternative Names: 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-. CAS No. 1038924-70-7. Pack Sizes: 100 mg. Product ID: B1604-479385. Molecular formula: C18H19NO. Mole weight: 265.356. Custom synthesis is available. Send your inquiries for more information. | London |
| ((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-Butyl Ester | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Group: Pharmaceutical. CAS No. 149709-58-0. Pack Sizes: 100 mg. Product ID: B1604-284931. Molecular formula: C20H23NO3. Mole weight: 325.408. Custom synthesis is available. Send your inquiries for more information. | London |
| (R)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Group: Pharmaceutical. CAS No. 149709-59-1. Pack Sizes: 100 mg. Product ID: B1604-284930. Molecular formula: C25H31NO4. Mole weight: 409.526. Custom synthesis is available. Send your inquiries for more information. | London |
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