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| Product | Description | |
|---|---|---|
| 2'-O,4'-C-Methyleneguanosine | 2'-O,4'-C-Methyleneguanosine, a modified nucleoside molecule, has demonstrated effective outcomes in the domain of antiviral therapeutics, exemplifying excellent potential as a therapeutic agent for hepatitis C and West Nile virus infections. Substantiated by its unique mechanism of action- hindering viral RNA polymerase, a critical enzyme necessary for viral replication, it is deemed a highly potent approach for viral inhibition. Furthermore, this particular compound presents an enticing opportunity for its application as an antitumor agent, drawing interest from scientific communities. Group: Pharmaceutical. Alternative Names: LNA-G; 2-amino-9-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-1H-purin-6-one; 1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)guanine; 2-Amino-9-[2,5-anhydro-4-(hydroxymethyl)-α-L-lyxofuranosyl]-1,9-dihydro-6H-purin-6-one. CAS No. 207131-16-6. Pack Sizes: 100 mg. Product ID: B2706-038100. Molecular formula: C11H13N5O5. Mole weight: 295.25. Custom synthesis is available. Send your inquiries for more information. |  London |
| 2'-O-Methylcytidine | Cytidine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. Group: Pharmaceutical. Alternative Names: 2'-(O-Methyl) Cytidine; Cytidine, 2'-O-methyl-; 2'-O-Methyl cytidine; O(2')-Methylcytidine; 4-amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 4-Amino-1-(2-O-methyl-β-D-ribofuranosyl)pyrimidin-2(1H)-one. CAS No. 2140-72-9. Pack Sizes: 25 g. Product ID: B1370-187735. Molecular formula: C10H15N3O5. Mole weight: 257.24. Custom synthesis is available. Send your inquiries for more information. | London |
| 2'-O-Methyluridine-5'-triphosphate 100mM Sodium Solution | 2'-O-Methyluridine-5'-triphosphate is a nucleotide analog commonly used in biochemistry research. It can be used as a substrate for RNA polymerases or as a terminoligical ATP analog for use in RNA synthesis reactions. Its effectiveness as an antiviral and antitumor agent is also being investigated. Group: Pharmaceutical. Alternative Names: 2'-methoxy-UTP; 2'-O-Methyluridine 5'-triphosphoric acid; uridine 5'-(tetrahydrogen triphosphate), 2'-O-methyl-; 5'-(tetrahydrogen triphosphate), 2'-O-methyl-Uridine; 2'-O-Methyluridine 5'-(tetrahydrogen triphosphate); 2'-O-Me-UTP; 2'-OMe-UTP. CAS No. 143028-99-3. Pack Sizes: 1 mL. Product ID: B1370-376840. Molecular formula: C10H17N2O15P3. Mole weight: 498.17. Custom synthesis is available. Send your inquiries for more information. | London |
| (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine | PSI-6206 is a selective HCV RNA polymerase inhibitor. It is the unphosphorylated parent compound of triphosphate analog PSI-7409, which is a potent inhibitor of the HCV NS5B RNA dependent RNA polymerase. Group: Pharmaceutical. Alternative Names: RO-2433; RO 2433; RO2433; PSI6206; PSI 6206; PSI-6206; GS331007; GS-331007; GS 331007; 2'-Deoxy-2'-fluoro-2'-C-methyluridine; Sofosbuvir Metabolite GS331007; 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine; ZL-01 metabolite M9; 2'-Deoxy-2'-Fluoro-2'-methyluridine. CAS No. 863329-66-2. Pack Sizes: 5 g. Product ID: B2693-459960. Molecular formula: C10H13FN2O5. Mole weight: 260.22. Custom synthesis is available. Send your inquiries for more information. | London |
| 3'-O-(2-Methoxyethyl)guanosine | 3'-O-(2-Methoxyethyl)guanosine is a remarkable modified nucleoside with immense potential in the field of antiviral drug discovery. This exquisite compound takes center stage in targeting viral RNA-dependent RNA polymerases, thus rendering it a powerful weapon in research of respiratory syncytial virus (RSV) and hepatitis C virus (HCV). Group: Pharmaceutical. Alternative Names: Guanosine, 3'-O-(2-methoxyethyl)-; 3'-O-MOE-G; 2-Amino-9-((2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-(2-methoxyethoxy)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one. CAS No. 256224-03-0. Pack Sizes: 2 g. Product ID: B1370-038131. Molecular formula: C13H19N5O6. Mole weight: 341.32. Custom synthesis is available. Send your inquiries for more information. | London |
| 4'-a-C-Methyluridine | 4'-a-C-Methyluridine, a vital element in biomedical exploration and pharmacological progress, finds significance as it exhibits therapeutic capabilities in addressing a diverse spectrum of ailments, including hepatitis C, cancer, and viral infections. Notably, this compound exerts its impact by effectively obstructing RNA polymerase, thereby impeding viral replication and fostering potent antitumor influences. Group: Pharmaceutical. Alternative Names: Uridine, 4'-C-methyl-; 4'-Methyluridine; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-5-methyl-tetrahydrofuran-2-yl]pyrimidine-2,4-dione; 1-(4-C-methyl-β-D-ribofuranosyl)-uracil; 1-[5-Deoxy-4-(hydroxymethyl)-α-L-lyxofuranosyl]-2,4(1H,3H)-pyrimidinedione. CAS No. 153186-26-6. Pack Sizes: 5 mg. Product ID: B2706-339917. Molecular formula: C10H14N2O6. Mole weight: 258.23. Custom synthesis is available. Send your inquiries for more information. | London |
| AA-UTP | AA-UTP is a substrate for RNA polymerase with amino group that can be labeled with a fluorescent dye, biotin or other markers. Group: Pharmaceutical. Alternative Names: 5- (3- Aminoallyl)uridine- 5'- O- triphosphate. CAS No. 85280-66-6. Pack Sizes: 1mg;1g;10g. Product ID: 85280-66-6. Molecular formula: C12H20N3O14P3 (free acid). Mole weight: 539.2 (free acid). Custom synthesis is available. Send your inquiries for more information. | London |
| AOH1996 | AOH1996 is a small-molecule PCNA inhibitor that enhances the interaction between PCNA and the largest subunit of RNA polymerase II, RPB1, and dissociates PCNA from actively transcribed chromatin regions, while inducing DNA double-stranded breaks in a transcription-dependent manner. AOH1996 was identified as a selective chemotherapeutic. Group: Pharmaceutical. Alternative Names: AOH 1996; AOH-1996; NSC789796; NSC-789796. CAS No. 2089314-64-5. Pack Sizes: 100 mg. Product ID: B1370-426615. Molecular formula: C26H22N2O4. Mole weight: 426.46. Custom synthesis is available. Send your inquiries for more information. | London |
| BMS-791325 HCl | BMS-791325 HCl is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50 < 28 nM). In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. BMS-791325 was found to have distinguishing antiviral, safety, and pharmacokinetic properties that resulted in its selection for clinical evaluation. BMS-791325 is currently under Phase III trials. Group: Pharmaceutical. Alternative Names: Beclabuvir hydrochloride; BMS-791325 HCl; BMS 791325 HCl; BMS791325 HCl. CAS No. 958002-36-3. Pack Sizes: 5 mg. Product ID: B0084-462269. Molecular formula: C36H46ClN5O5S. Mole weight: 696.304. Custom synthesis is available. Send your inquiries for more information. | London |
| dasabuvir | Dasabuvir is an antiviral drug for the treatment of hepatitis C. It inhibits hepatitis C virus (HCV) non-nucleoside NS5B palm polymerase to suppress RNA replicase. Dasabuvir is commonly used in combination with ombitasvir/paritaprevir/ritonavir to effect on HCV type 1. Uses: The treatment of hepatitis c. Group: Pharmaceutical. Alternative Names: ABT333; ABT-333; ABT 333, Dasabuvir. Trade names: Viekira Pak (with ombitasvir/paritaprevir/ritonavir tablets), Exviera; N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide. CAS No. 1132935-63-7. Pack Sizes: 100 mg. Product ID: B0084-462255. Molecular formula: C26H27N3O5S. Mole weight: 493.578. Custom synthesis is available. Send your inquiries for more information. | London |
| Desisobutyrylfidaxomicin | A derivative of Fidaxomycin. Fidaxomycin is a natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria. Group: Pharmaceutical. Alternative Names: OP 1118; Fidaxomicin Metabolite OP-1118; (3E,5E,8S,9E,11S,12R,13E,15E,18S)-3-[[[6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-beta-L-mannopyranosyl]oxy]methyl]-12-[(6-deoxy-5-C-methyl-beta-D-lyxo-hexopyranosyl)oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-oxacyclooctadeca-3,5,9,13,15-pentaen-2-one; OPT 1118; Des Iso Butyryl Fidaxomicin; Fidaxomicin Impurity 3. CAS No. 1030825-28-5. Pack Sizes: 1mg;1g;10g. Product ID: BBF-05694. Molecular formula: C48H68Cl2O17. Mole weight: 987.95. Custom synthesis is available. Send your inquiries for more information. | London |
| N1-MethylpseudoUridine-5'-Triphosphate Sodium | It is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-methylpseudouridine can reduce the immunogenicity of the resulting mRNA. The product has passed the functionality test in transcription reaction. The solution is free of DNase and RNase contamination. Group: Pharmaceutical. Alternative Names: N1-Me-pUTP Sodium salt; 1-Methylpseudouridine-5'-Triphosphate sodium salt; N1-Methylpseudo-UTP sodium salt; 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-1-methyl-, sodium salt; 1-Methylpseudo-UTP sodium salt; N1-methyl-pseudouridine 5'-triphosphate, sodium salt. Pack Sizes: 1 mL. Product ID: B2706-358101. Molecular formula: C10H17N2O15P3.xNa. Mole weight: 498.17 (free acid). Custom synthesis is available. Send your inquiries for more information. | London |
| N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite | N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is used to incorporate 2-O-methyl modified nucleotides into oligonucleotides. It is a novel nucleoside analogue drug that inhibits tumor growth and activates RNA polymerase II promoter transcription. Group: Pharmaceutical. Alternative Names: N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite; 2'-OMe-Ac-C CE phosphoramidite; N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-Cytidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMT-2'-O-methyl-rC(Ac) amidite; 5'-O-(4,4'-Dimethoxytrityl)-N4-Acetyl-2'-O-methylcytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DMT-2'-OMe-C(Ac)-CE-Phosphoramidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-CE-phosphoramidite. CAS No. 199593-09-4. Pack Sizes: 5 g. Product ID: B2706-086845. Molecular formula: C42H52N5O9P. Mole weight: 801.86. Custom synthesis is available. Send your inquiries for more information. | London |
| Rifabutin | Rifabutin inhibits bacterial RNA polymerase. Group: Pharmaceutical. Alternative Names: Spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2',3':7,8]naphth[1,2-d]imidazole-2,4'-piperidine]-5,10,26(3H,9H)-trione, 16-(acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-, (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-; (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-16-(Acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2',3':7,8]naphth[1,2-d]imidazole-2,4'-piperidine]-5,10,26(3H,9H)-trione; Rifamycin XIV, 1',4-didehydro-1-deoxy-1,4-dihydro-5'-(2-methylpropyl)-1-oxo-; Ansamycin; Antibiotic LM 427; LM 427; Mycobutin; R 3530; Rifabutine. CAS No. 72559-06-9. Pack Sizes: 500 mg. Product ID: B0084-075984. Molecular formula: C46H62N4O11. Mole weight: 847.01. Custom synthesis is available. Send your inquiries for more information. | London |
| Rifampicin | It is a semi-synthetic antibiotic of the rifamycin group. It is an inhibitor of bacterial RNA polymerase and has antibacerial activity. Uses: Antibiotics, antitubercular; enzyme inhibitors; leprostatic agents; nucleic acid synthesis inhibitors. Group: Pharmaceutical. Alternative Names: Rimactane; 3-[[(4-Methyl-1-piperazin-yl)imino]methyl]rifamycin; Abrifam; Eremfat; Famcin; NSC 113926; Rifa; Rifacap; Rifadin; Rifadine; Rifaldazine; Rifampicin SV; Rifamycin AMP; Rifaprodin; Rifoldin; Riforal; Rimactan; Rimactane; Rimapen; Sinerdol; Tubocin. CAS No. 13292-46-1. Pack Sizes: 100 g. Product ID: BBF-04562. Molecular formula: C43H58N4O12. Mole weight: 822.94. Custom synthesis is available. Send your inquiries for more information. | London |
| Rifaximin EP Impurity C | Rifaximin EP Impurity C is an antibacterial drug which functions by inhibiting bacterial RNA polymerase (RNAP), is an impurity of Rifaximin. It also has anti-gram-positive bacterial and mycobacterium activities. Uses: Anti-bacterial agents. Group: Pharmaceutical. Alternative Names: Rifamycin SV; Rifocin; Rifamicine SV; (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione. CAS No. 6998-60-3. Pack Sizes: 1mg;1g;10g. Product ID: BBF-02634. Molecular formula: C37H47NO12. Mole weight: 697.77. Custom synthesis is available. Send your inquiries for more information. | London |
| Seliciclib | Seliciclib is an orally bioavailable, small-molecule cyclin-dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Seliciclib primarily inhibits CDK2/E, CDK2/A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, inhibiting RNA polymerase II-dependent transcription, which may result in the down-regulation of antiapoptotic proteins such as induced myeloid leukemia cell differentiation protein Mcl-1. CDKs, serine/threonine kinases that play an important role in cell cycle regulation, are overexpressed in various malignancies. Mcl-1 belongs to the Bcl-2 family of antiapoptotic proteins and is a protein crucial to the survival of a range of tumor cell types. Group: Pharmaceutical. Alternative Names: R-roscovitine; Roscovitin; Roscovitine; CYC202; CYC202; CYC 202; (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol. CAS No. 186692-46-6. Pack Sizes: 100 mg. Product ID: B1370-086385. Molecular formula: C19H26N6O. Mole weight: 354.44. Custom synthesis is available. Send your inquiries for more information. | London |
| Thailanstatin A | Thailanstatin A is a splicesosome inhibitor that acts via suppressing RNA-polymerase II. It is effective against cancers, and can be used as a payload for ADCs. Group: Pharmaceutical. Alternative Names: 1,6-Dioxaspiro[2.5]octane-5-acetic acid, 7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-8-hydroxy-, (3R,5S,7R,8R)-. CAS No. 1426953-21-0. Pack Sizes: 10 mg. Product ID: B2695-292576. Molecular formula: C28H41NO9. Mole weight: 535.63. Custom synthesis is available. Send your inquiries for more information. | London |
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