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| Product | Description | |
|---|---|---|
| Regorafenib | Regorafenib, also known as BAY 73-4506, is an orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling. Regorafenib is demonstrated to increase the overall survival of patients with metastatic colorectal cancer and has been approved by the US FDA on September 27, 2012. Uses: Antineoplastic agent. Group: Pharmaceutical. Alternative Names: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide; 4-[4-[N'-(4-Chloro-3-trifluoromethylphenyl)ureido]-3-fluorophenoxy]pyridine-2-carboxylic Acid Methylamide; Regorafenibum; Stivarga; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; BAY 73-4506; BAY 734506; BAY734506; BAY-734506. CAS No. 755037-03-7. Pack Sizes: 500 mg. Product ID: BBF-05856. Molecular formula: C21H15ClF4N4O3. Mole weight: 482.83. Custom synthesis is available. Send your inquiries for more information. |  London |
| Regorafenib Hydrochloride | Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1. Group: Pharmaceutical. Alternative Names: BAY73-4506 hydrochloride. CAS No. 835621-07-3. Pack Sizes: 25 mg. Product ID: B2693-459775. Molecular formula: C21H16Cl2F4N4O3. Mole weight: 519.28. Custom synthesis is available. Send your inquiries for more information. | London |
| Regorafenib Impurity 6 | An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Group: Pharmaceutical. Alternative Names: Regorafenib Impurity 6; Regorafenib metabolite M6; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic acid; ZU2HG2Y956; UNII-ZU2HG2Y956; 2-Pyridinecarboxylic acid, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)-3-fluorophenoxy)-; 4-(4-((4-Chloro-3-(trifluoromethyl)phenyl)carbamoylamino)-3-fluoro-phenoxy)pyridine-2-carboxylic acid; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]pyridine-2-carboxylic acid; SCHEMBL4609009; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid. CAS No. 1187945-05-6. Pack Sizes: 50 mg. Product ID: B2694-483711. Molecular formula: C20H12ClF4N3O4. Mole weight: 469.78. Custom synthesis is available. Send your inquiries for more information. | London |
| Regorafenib monohydrate | Regorafenib monohydrate is a multitargetedinhibitor of tyrosine kinase with IC50 values of 13nM, 4.2nM, 46nM, 2.5nM, 28nM, 19nM, 202nM, 22nM, 7nM, 1.5nM and 311nM, respectively for VEGFR-1, mVEGFR-2, mVEGFR-3, Raf-1, BRAF WT, BRAFV600E, FGFR-1, PDGFR-β, c-KIT, RET and TIE2. Group: Pharmaceutical. Alternative Names: BAY 73-4506. CAS No. 1019206-88-2. Pack Sizes: 250 mg. Product ID: B2693-463493. Molecular formula: C21H17ClF4N4O4. Mole weight: 500.83. Custom synthesis is available. Send your inquiries for more information. | London |
| Regorafenib N-Oxide (M2 Metabolite) | A metabolite of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Group: Pharmaceutical. Alternative Names: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide 1-Oxide. CAS No. 835621-11-9. Pack Sizes: 25 mg. Product ID: B2694-483714. Molecular formula: C21H15ClF4N4O4. Mole weight: 498.82. Custom synthesis is available. Send your inquiries for more information. | London |
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