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| Product | Description | |
|---|---|---|
| 2-Amino-2'-fluorobenzophenone | An intermediate in the synthesis of Pitavastatin, a HMG-CoA reductase inhibitor that lowers LDL cholesterol and triglycerides and increase HDL cholesterol in your blood. Group: Pharmaceutical. CAS No. 1581-13-1. Pack Sizes: 1 g. Product ID: B2694-010195. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 2-((Z)-5-((E)-2-methyl-3-phenylallylidene)-2,4-dioxothiazolidin-3-yl)acetic acid | An impurity of Epalrestat, a carboxylic acid-based inhibitor of aldose reductase. Group: Pharmaceutical. CAS No. 794510-29-5. Pack Sizes: 10 mg. Product ID: B2694-343860. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 3'-Azido-3'-deoxycytidine | It is a ribonucleotide reductase inhibitor. Group: Pharmaceutical. CAS No. 70580-87-9. Pack Sizes: 100 mg. Product ID: B1370-339244. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (3S,5R)-Pitavastatin Calcium | A metabolite of Pitavastatin which is a potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM). Group: Pharmaceutical. CAS No. 254452-88-5. Pack Sizes: 1 mg. Product ID: B0192-478912. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (3S,5S)-Atorvastatin Acetonide tert-Butyl Ester | (3S,5S)-Atorvastatin Acetonide tert-Butyl Ester is a pharmaceutical compound employed in managing hyperlipidemia and cardiovascular disorders. It is a modified form of atorvastatin, acting as a potent HMG-CoA reductase inhibitor to mitigate cholesterol biosynthesis within hepatic cells. This medication plays a pivotal role in ameliorating lipid profiles and averting atherosclerosis progression. Uses: An intermediate for the preparation of (3s,5s)-atorvastatin. Group: Pharmaceutical. CAS No. 472967-95-6. Pack Sizes: 25 mg. Product ID: B2692-117415. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acelarin | Acelarin is a DNA synthesis inhibitor with EC50 of 0.2 nM. Acelarin is a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine. It is converted into the active metabolites dFdCDP and dFdCTP. dFdCDP can inhibit ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA replication; dFdCTP can be incorporated into DNA, resulting in premature termination of DNA replication and eventually induction of apoptosis. Phase III clinical trials for the treatment of Pancreatic cancer are on-going. Uses: Pancreatic cancer. Group: Pharmaceutical. CAS No. 840506-29-8. Pack Sizes: 50 mg. Product ID: B2693-476645. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atorvastatin EP Impurity D | Atorvastatin EP Impurity D is an impurity of Atorvastatin, which is an HMG-CoA reductase inhibitor used to reduce cholesterol and prevent cardiovascular-related disease. Group: Pharmaceutical. CAS No. 148146-51-4. Pack Sizes: 25 mg. Product ID: B2694-466943. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atorvastatin Epoxy Tetrahydrofuran Impurity | Atorvastatin Epoxy Tetrahydrofuran Impurity is an impurity of Atorvastatin, which is an HMG-CoA reductase inhibitor used to reduce cholesterol and prevent cardiovascular-related disease. Group: Pharmaceutical. CAS No. 873950-19-7. Pack Sizes: 1 mg. Product ID: B0190-466978. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atorvastatin Ethyl Ester | Atorvastatin Ethyl Ester is the impuritiy of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Group: Pharmaceutical. CAS No. 1146977-93-6. Pack Sizes: 25 mg. Product ID: B2694-466959. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atorvastatin Methyl Ester | Atorvastatin Methyl Ester is an impurity of Atorvastatin, which is an HMG-CoA reductase inhibitor used to reduce cholesterol and prevent cardiovascular-related disease. Group: Pharmaceutical. CAS No. 345891-62-5. Pack Sizes: 50 mg. Product ID: B0190-466944. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atorvastatin N-(3,5-Dihydroxy-7-heptanoic Acid)amide | Atorvastatin N-(3,5-Dihydroxy-7-heptanoic Acid)amide is a prominent compound in the research of dyslipidemia and associated cardiovascular disorders. Its efficacious mechanism of action lies in its tremendous capacity to inhibit HMG-CoA reductase, a pivotal enzyme profoundly engaged in the intricate process of cholesterol biosynthesis. Uses: Atorvastatin (a791750) impurity. Group: Pharmaceutical. CAS No. 1105067-87-5. Pack Sizes: 10 mg. Product ID: B0190-258830. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atorvastatin USP Related Compound A | Atorvastatin USP Related Compound A is an impurity in the synthesis of Atorvastatin, which is a competitive HMG-CoA reductase inhibitor. Atorvastatin is a lipid-lowering medication of the statin class. Atorvastatin suppresses the production of cholesterol and prevents some cardiovascular diseases. Group: Pharmaceutical. CAS No. 433289-83-9. Pack Sizes: 100 mg. Product ID: B0190-168852. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atorvastatin USP Related Compound C | Atorvastatin USP Related Compound C is an impurity of Atorvastatin, which is an HMG-CoA reductase inhibitor used to reduce cholesterol and prevent cardiovascular-related disease. Group: Pharmaceutical. CAS No. 693793-53-2. Pack Sizes: 10 mg. Product ID: B2694-168854. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atorvastatin USP Related Compound E | Atorvastatin USP Related Compound E is an impurity of Atorvastatin, which is an HMG-CoA reductase inhibitor used to reduce cholesterol and prevent cardiovascular-related disease. Group: Pharmaceutical. CAS No. 1105067-88-6. Pack Sizes: 5 mg. Product ID: B0190-466957. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Auranofin | Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA, as an inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Uses: Auranofin inhibits various leukocyte activation pathways at multiple sites. Group: Pharmaceutical. CAS No. 34031-32-8. Pack Sizes: 1 g. Product ID: B2693-397760. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Byakangelicin | Byakangelicin is an effective inhibitor of sex hormones and affects the catabolism of endogenous hormones. It directly affects the cytochrome P450 isoform (CY) P3A4 in human hepatocytes. It is an inhibitor of aldose reductase used in the treatment of diabetic cataracts. Byakangelicin is a natural coumarin compound found in Murraya koenigii, Triphasia trifoliata, and other organisms. Group: Pharmaceutical. CAS No. 482-25-7. Pack Sizes: 10 mg. Product ID: NP1139. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cladribine | 2-Chloro-2'-deoxyadenosine is an analog of adenosine that is resistant to both proliferating and non-dividing lymphocytes (IC50 = 45 nM). When phosphorylated, 2-Chloro-2'-deoxyadenosine accumulates in cells and inhibits ribonucleotide reductase. Group: Pharmaceutical. CAS No. 4291-63-8. Pack Sizes: 1 g. Product ID: B2693-004182. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cycloguanil hydrochloride | Cycloguanil is an active metabolite of proguanil, produced by the cytochrome P450 2C19 isoform. It is also an inhibitor of dihydrofolate reductase (DHFR) (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively). Uses: Antimalarials. Group: Pharmaceutical. CAS No. 152-53-4. Pack Sizes: 500 mg. Product ID: B2693-118548. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Des(2-methylbutyryl) Lovastatin Hydroxy Acid Sodium Salt | An impurity of Lovastatin. Lovastatin is an HMG CoA reductase inhibitor used to treat high blood cholesterol. Group: Pharmaceutical. CAS No. 132294-94-1. Pack Sizes: 10 mg. Product ID: B2694-255494. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Engeletin | Engeletin is a flavonoid glycoside isolated from the leaves of Engelhardtia roxburghiana Wall. It inhibits a recombinant human aldose reductase. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 572-31-6. Pack Sizes: 100 mg. Product ID: NP1964. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Epalrestat Impurities | Epalrestat Impurities play a crucial role in pharmaceutical research, enabling precise identification and quantification of Epalrestat, an aldose reductase inhibitor. Predominantly utilized for diabetic neuropathy treatment, the investigation of these impurities ensures the safety and efficacy of the drug, advancing diabetes-related therapeutic strategies for improved patient outcomes. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ethaselen | Ethaselen, also known as BBSKE, is a novel organoselenium thioredoxin reductase inhibitor, is currently being investigated in a phase I clinical trial in China. Ethaselen enhanced the efficacy of radiation therapy both in vivo and in vitro without observable toxicity. BBSKE was found to suppress irradiation-induced activation dramatically when using A549 cells stably transfected with luciferase reporter. Ethaselen is a potentially promising agent for the treatment of patients with NSCLC clinically. Group: Pharmaceutical. CAS No. 217798-39-5. Pack Sizes: 5 mg. Product ID: B2693-462513. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Finasteride | Finasteride (INN, USAN, BAN) (brand names Proscar, and Propecia by Merck, among other generic names; former developmental code name MK-906) is a drug used for the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB). It is a type II and type III 5α-reductase inhibitor; 5α-reductase, an enzyme, converts testosterone to dihydrotestosterone (DHT). Uses: Api. Group: Pharmaceutical. CAS No. 98319-26-7. Pack Sizes: 50 g. Product ID: NP3378. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Finasteride EP Impurity B | An intermediate in the synthesis of Finasteride. Finasteride is a 4-azasteroid analog of testosterone that competitively blocks type II 5α-reductase activity with 100-fold greater affinity than for the type I enzyme. Group: Pharmaceutical. CAS No. 103335-41-7. Pack Sizes: 100 mg. Product ID: B2694-255935. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ganoderic acid A | Ganoderic acid A has been reported to exhibit antitumor activity, which is mainly mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. Uses: Anti-tumor effects, hepatoprotection, and 5-alpha reductase inhibition. Group: Pharmaceutical. CAS No. 81907-62-2. Pack Sizes: 20 mg. Product ID: NP7000. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Gemcitabine elaidate | Gemcitabine elaidate (also known as CO-101; CP-4126) is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Due to its lipophilicity, gemcitabine 5'-elaidic acid ester exhibits an increased cellular uptake and accumulation, resulting in an increased conversion to active metabolites, compared to gemcitabine. In addition, this formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase. Group: Pharmaceutical. CAS No. 210829-30-4. Pack Sizes: 25 mg. Product ID: B2706-225221. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ginsenoside Rd2 | Ginsenoside Rd2 is a composition of roots of Panax ginseng. Ginsenoside Rd is a primary constituent of the ginseng rhizome and the administration of ginsenoside Rd significantly increased the reduced GSHPx and glutathione reductase activity. Group: Pharmaceutical. CAS No. 83480-64-2. Pack Sizes: 10 mg. Product ID: B0005-479871. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| IACS-010759 | IACS-010759 is an orally bioavailable inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targeting complex I of the electron transport chain (NADH ubiquinone oxidoreductase). Study showed that IACS-010759 induced AMPK activation leading to mTOR suppression which resulted in cell growth inhibition in AML cells. Group: Pharmaceutical. CAS No. 1570496-34-2. Pack Sizes: 10 mg. Product ID: B2693-291404. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Iclaprim | Iclaprim is a diaminopyrimidine and acts as a dihydrofolate reductase (DHFR) inhibitor active against gram-positive organisms being developed for the treatment of complicated skin and soft tissue infections caused by antibiotic-resistant bacteria. Group: Pharmaceutical. CAS No. 192314-93-5. Pack Sizes: 2 mg. Product ID: B0084-244921. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Isoliquiritigenin | Isoliquiritigenin, a flavonoid from the root of Glycyrrhiza glabrat, inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μm. It has antioxidant, anti-inflammatory, and anti-tumor activities. Uses: Antidiabetic; antitumour; antioxidant; anti-inflammatory; antimutagenic; antifungal. Group: Pharmaceutical. CAS No. 961-29-5. Pack Sizes: 5 g. Product ID: BBF-05884. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| LCS3 | LCS3 is a reversible inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50 of 3.3 μM and 3.8 μM, respectively. Group: Pharmaceutical. CAS No. 109844-92-0. Pack Sizes: 50 mg. Product ID: B1370-185021. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Leucovorin Calcium | leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Group: Pharmaceutical. CAS No. 1492-18-8. Pack Sizes: 5 g. Product ID: B2693-301409. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Lovastatin-[d3] | Lovastatin-[d3] is the labelled analogue of Lovastatin, which is a fungal metabolite and an inhibitor of HMG-CoA reductase. Lovastatin is an antihypercholesterolemic agent. Group: Pharmaceutical. CAS No. 1002345-93-8. Pack Sizes: 1 mg. Product ID: BLP-011607. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Methotrexate disodium | Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia). Group: Pharmaceutical. CAS No. 7413-34-5. Pack Sizes: 1 g. Product ID: B1335-076226. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mevastatin | It is produced by the strain of Penicillum brevicompactum. It has weak anti-fungal activity and can inhibit the key enzyme (3-hydroxy-3-methyl glutaryl coenzyme A(HMGCoA) reductase) in the cholesterol biosynthesis pathway. It has been shown to lower cholesterol in animals and humans. It led the discovery of statins, lipid-lowering drugs. It is now used as a biochemical reagent. Uses: Hydroxymethylglutaryl-coa reductase inhibitors. Group: Pharmaceutical. CAS No. 73573-88-3. Pack Sizes: 25 g. Product ID: BBF-01732. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pitavastatin 5-Oxo Impurity Calcium Salt | An impurity in the synthesis of Pitavastatin, a HMG-CoA reductase inhibitor that lowers LDL cholesterol and triglycerides and increase HDL cholesterol in your blood. Group: Pharmaceutical. CAS No. 2180095-22-9. Pack Sizes: 5 mg. Product ID: B2694-008615. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pitavastatin Lactone | A metabolite of Pitavastatin which is a member of the blood cholesterol lowering medication class of statins. Uses: Hydroxymethylglutaryl-coa reductase inhibitors. Group: Pharmaceutical. CAS No. 141750-63-2. Pack Sizes: 50 mg. Product ID: B2694-058508. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pravastatin Sodium | Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. Group: Pharmaceutical. CAS No. 81131-70-6. Pack Sizes: 500 mg. Product ID: BBF-04559. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rosuvastain Calcium | Rosuvastatin Calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM. Uses: Anticholesteremic agents. Group: Pharmaceutical. CAS No. 147098-20-2. Pack Sizes: 2 g. Product ID: NP3042. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rosuvastatin Impurity 12 | An impurity of Rosuvastatin. Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. Group: Pharmaceutical. CAS No. 894787-93-0. Pack Sizes: 2 mg. Product ID: B2694-338785. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| RTA-408 | RTA-408 is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity. Upon administration, RTA 408 activates the cytoprotective transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH). Nrf2, a leucine zipper transcription factor, plays a key role in the maintenance of redox balance and cytoprotection against oxidative stress. Group: Pharmaceutical. CAS No. 1474034-05-3. Pack Sizes: 20 mg. Product ID: B0084-462776. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Simvastatin EP Impurity B | An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Group: Pharmaceutical. CAS No. 145576-25-6. Pack Sizes: 100 mg. Product ID: B2694-223423. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Simvastatin EP Impurity C | An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Group: Pharmaceutical. CAS No. 210980-68-0. Pack Sizes: 100 mg. Product ID: B2694-260207. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Simvastatin EP Impurity D | An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Group: Pharmaceutical. CAS No. 476305-24-5. Pack Sizes: 10 mg. Product ID: B2694-263916. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Simvastatin EP Impurity F | An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Group: Pharmaceutical. CAS No. 79952-44-6. Pack Sizes: 50 mg. Product ID: B2694-261180. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Simvastatin EP Impurity G | An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Group: Pharmaceutical. CAS No. 1449248-72-9. Pack Sizes: 25 mg. Product ID: B2694-479627. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Simvastatin EP Impurity H | An intermediate in the synthesis of Simvastatin, Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Group: Pharmaceutical. CAS No. 79952-42-4. Pack Sizes: 50 mg. Product ID: B2694-257205. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Simvastatin EP Impurity I | An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Group: Pharmaceutical. CAS No. 79902-42-4. Pack Sizes: 10 mg. Product ID: B2694-334169. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Simvastatin EP Impurity J | An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Group: Pharmaceutical. CAS No. 864357-88-0. Pack Sizes: 50 mg. Product ID: B2694-121702. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Simvastatin hydroxy acid sodium salt | A metabolite of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Group: Pharmaceutical. CAS No. 101314-97-0. Pack Sizes: 100 mg. Product ID: B2694-479622. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Sulforaphane | Sulforaphaneis a naturally-occurring phytochemical belonging to the class of isothiocyanates. As the aglycone metabolite of glucosinolate glucoraphanin (sulforaphane glucosinolate), sulforaphane acts as an antioxidant and potent stimulator of endogenous detoxifying enzymes. This agent displays anticarcinogenic properties due to its ability to induce phase II detoxification enzymes, such as glutathione S-transferase and quinone reductase, thereby providing protection against certain carcinogens and toxic, reactive oxygen species. Broccoli sprouts contain large amounts of sulforaphane, which is also found in other cruciferous vegetables including cabbage and kale. Uses: Anti-inflammatory/antitumor. Group: Pharmaceutical. CAS No. 4478-93-7. Pack Sizes: 1 g. Product ID: NP4355. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Thiabendazole-[d4] | Labelled Thiabendazole. Thiabendazole inhibits the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property. Group: Pharmaceutical. CAS No. 1190007-20-5. Pack Sizes: 5 mg. Product ID: BLP-004619. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tirapazamine | Tirapazamine is a benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. CAS No. 27314-97-2. Pack Sizes: 1 g. Product ID: B2693-350792. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Topiroxostat | Topiroxostat is a novel and potent xanthine oxidoreductase (XOR) inhibitor. Uses: Enzyme inhibitors. Group: Pharmaceutical. CAS No. 577778-58-6. Pack Sizes: 50 mg. Product ID: B0084-463289. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tretazicar | Tretazicar (CB1954) is a dinitrobenzamide prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide (EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr). Ntr converts CB1954 to 2- and 4-hydroxylamino derivatives, whereupon the non-enzymatic reaction of the 4-hydroxylamino derivative with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA. Ntr delivery has been achieved in vitro using retroviral and adenoviral vectors and confirmed by immunocytochemical demonstration of Ntr expression. The Ntr-expressing cells have been shown to be sensitized to CB1954 by up to 2000-fold. The Ntr-CB1954 system shows effective bystander killing in mixed populations of Ntr-expressing and non-expressing cells treated with CB1954. The efficacy of this enzyme-prodrug approach in model systems compared with other VDEPT approaches demonstrates the feasibility and future promise of this gene therapy strategy. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 21919-05-1. Pack Sizes: 1 g. Product ID: B2693-366889. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Xanthohumol D | Xanthohumol D usually comes from the herbs of Humulus lupulus. Xanthohumol and Xanthohumol D were confirmed to be potent inducers of quinone reductase. Uses: Inducers. Group: Pharmaceutical. CAS No. 274675-25-1. Pack Sizes: 1 mg. Product ID: NP0954. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Zopolrestat | Zopolrestat is an inhibitor of Aldose Reductase(AR). It has been shown to play roles in inflammation and cancer. It is used for the treatment of diabetic nephropathy and cardiac disease. It was developed by Pfizer and was terminated in clinic phase 2 trials. Uses: Zopolrestat is used for the treatment of diabetic nephropathy and cardiac disease. Group: Pharmaceutical. CAS No. 110703-94-1. Pack Sizes: 25 mg. Product ID: B0084-358923. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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