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| Product | Description | |
|---|---|---|
| TUG-770 | TUG-770 displayed excellent physicochemical and in vitro ADME properties, with good aqueous solubility, good chemical stability, low lipophilicity, and decreased plasma protein binding (PPB). TUG-770 furthermore showed excellent stability toward human liver microsomes (HLM), no inhibition of selected CYP-enzymes implicated in drug-drug interactions, no P-glycoprotein (P-gp) inhibition, and good permeability in the Caco-2 cell assay. Examination of TUG-770 in an acute intraperitoneal glucose tolerance test (IPGTT) in normal mice revealed a good dose dependent response with maximal reduction in glucose level reached at 50 mg/kg. The effect of TUG-770 was fully sustained after 29 days of daily oral treatment. Additional evaluation of TUG-770 in rats confirmed a significant glucose lowering effect for the high doses already after 10 min and for all doses after 30 min. Group: Pharmaceutical. Alternative Names: TUG-770; TUG 770; TUG770. CAS No. 1402601-82-4. Pack Sizes: 25 mg. Product ID: B0084-463218. Molecular formula: C19H14FNO2. Mole weight: 307.32. Custom synthesis is available. Send your inquiries for more information. |  London |
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