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| Product | Description | |
|---|---|---|
| Rapamycin | 100mg Pack Size. Group: Biochemicals, Organics, Research Organics & Inorganics. Formula: C51H79NO13. CAS No. 53123-88-9. Prepack ID : 41676136-100mg. Molecular Weight : 914.17. |  |
| Rapamycin | Rapamycin is an mTOR inhibitor immunosuppressant and kinase inhibitor with both antifungal and antineoplastic properties. It selectively inhibits the transcriptional activation of cytokines. Uses: Antifungal and antineoplastic agent. Group: Pharmaceutical. Alternative Names: Sirolimus; (-)-Rapamycin; AY 22989; AY-22989; I-2190A; NSC 226080; RAPA; RAP; RPM; SLM; WY-090217; Everolimus EP Impurity A. CAS No. 53123-88-9. Pack Sizes: 500 mg. Product ID: BBF-02627. Molecular formula: C51H79NO13. Mole weight: 914.19. Custom synthesis is available. Send your inquiries for more information. |  London |
| Rapamycin-[d3] | Rapamycin-[d3] is the labelled analogue of Rapamycin. Rapamycin is an immunosuppressant and a kinase inhibitor with both antifungal and antineoplastic properties. It selectively inhibits the transcriptional activation of cytokines. Group: Pharmaceutical. Alternative Names: Rapamycin-d3; (-)-Rapamycin-d3; Sirolimus-d3. CAS No. 392711-19-2. Pack Sizes: 1mg;1g;10g. Product ID: BLP-008244. Molecular formula: C51H76D3NO13. Mole weight: 917.19. Custom synthesis is available. Send your inquiries for more information. | London |
| Rapamycin Impurity 3 | An impurity of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Group: Pharmaceutical. CAS No. 157054-84-7. Pack Sizes: 1mg;1g;10g. Product ID: 157054-84-7. Molecular formula: C52H81NO13. Mole weight: 928.22. Custom synthesis is available. Send your inquiries for more information. | London |
| Rapamycin Impurity 4 (Sirolimus-31,42-Diester Impurity) | An impurity of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Group: Pharmaceutical. Pack Sizes: 1mg;1g;10g. Molecular formula: C61H95NO19. Mole weight: 1146.43. Custom synthesis is available. Send your inquiries for more information. | London |
| (19Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin Sodium Salt | (19Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin Sodium Salt. Uses: Metabolite of the immunosuppressant macrolide sdz rad (also known as everolimus e945400) which is an analog of the parent drug rapamycin (r124000). Group: Pharmaceutical. Alternative Names: (2S)-1-[2-oxo-2-[(2R,3R,6S)-tetrahydro-2-hydroxy-6-[(2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19Z,21R)-14-hydroxy-22-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxo-3,5,7,15,19-docosapentaen-1-yl]-3-methyl-2H-pyran-2-yl]acetyl]-2-piperidinecarboxylic Acid Sodium Salt; seco Everolimus Sodium Salt. CAS No. 220127-31-1. Pack Sizes: 1mg;1g;10g. Product ID: 220127-31-1. Molecular formula: C53H82NNaO14. Mole weight: 980.21. Custom synthesis is available. Send your inquiries for more information. | London |
| 27-O-Desmethyl Rapamycin (27-O-Desmethyl Sirolimus) | A metabolite of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Group: Pharmaceutical. Pack Sizes: 1mg;1g;10g. Molecular formula: C50H77NO13. Mole weight: 900.17. Custom synthesis is available. Send your inquiries for more information. | London |
| 28-epi-Rapamycin | An epimer of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Group: Pharmaceutical. Alternative Names: 28-epi-Rapamycin; (31S)-Rapamycin. CAS No. 253431-35-5. Pack Sizes: 1mg;1g;10g. Product ID: 253431-35-5. Molecular formula: C51H79NO13. Mole weight: 914.2. Custom synthesis is available. Send your inquiries for more information. | London |
| 32-Desmethylrapamycin | 32-Desmethylrapamycin is a rapamycin derivative with antifungal activity. It is active against Candida albicans, Saccharomyces cerevisiae and Fusarium oxysporum. Group: Pharmaceutical. Alternative Names: 32-O-Desmethylrapamycin; Rapamycin, 32-O-demethyl-. CAS No. 141392-23-6. Pack Sizes: 5 mg. Product ID: B1370-381780. Molecular formula: C50H77NO13. Mole weight: 900.15. Custom synthesis is available. Send your inquiries for more information. | London |
| 41-Oxo-rapamycin | An impurity of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Group: Pharmaceutical. CAS No. 136293-03-3. Pack Sizes: 1mg;1g;10g. Product ID: 136293-03-3. Molecular formula: C51H77NO13. Mole weight: 912.17. Custom synthesis is available. Send your inquiries for more information. | London |
| 42-O-[2-[[Hydroxy[2-(trimethylammonio)ethoxy]phosphinyl]oxy]ethyl] Rapamycin Inner Salt | 42-O-[2-[[Hydroxy[2-(trimethylammonio)ethoxy]phosphinyl]oxy]ethyl] Rapamycin Inner Salt. Uses: A phosphocholine ester metabolite of the immunosuppressant macrolide sdz rad (also known as everolimus e945400) which is an analog of the parent drug rapamycin (r124000). Group: Pharmaceutical. Alternative Names: ATG 181. CAS No. 1062645-51-5. Pack Sizes: 1mg;1g;10g. Product ID: 1062645-51-5. Molecular formula: C58H95N2O17P. Mole weight: 1123.35. Custom synthesis is available. Send your inquiries for more information. | London |
| 42-O-tert-Butyldimethylsilyloxyethyl-[d4] Rapamycin | 42-O-tert-Butyldimethylsilyloxyethyl-[d4] Rapamycin. Group: Pharmaceutical. CAS No. 1356839-88-7. Pack Sizes: 1mg;1g;10g. Product ID: BLP-021271. Molecular formula: C59H93D4NO14Si. Mole weight: 1076.51. Custom synthesis is available. Send your inquiries for more information. | London |
| 7-Epi-Rapamycin | An impurity of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Group: Pharmaceutical. Alternative Names: Rapamycin, (7R)-; Sirolimus Impurity 2; Rapamycin C-7, analog 1. CAS No. 157182-37-1. Pack Sizes: 1mg;1g;10g. Product ID: 157182-37-1. Molecular formula: C51H79NO13. Mole weight: 914.19. Custom synthesis is available. Send your inquiries for more information. | London |
| 7-O-Desmethyl Rapamycin | A metabolite of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Group: Pharmaceutical. Alternative Names: 7-O-Demethyl Cypher; 7-O-Demethyl Rapammune; 7-O-Demethyl Sirolimus. CAS No. 151519-50-5. Pack Sizes: 1mg;1g;10g. Product ID: 151519-50-5. Molecular formula: C50H77NO13. Mole weight: 900.17. Custom synthesis is available. Send your inquiries for more information. | London |
| 9,14-Deepoxy-15-deoxo-14-deoxy-9,15-epoxy-15-hydroxy-14-oxorapamycin | It can be prepared as an immunosuppressant. Group: Pharmaceutical. Alternative Names: Rapamycin, 9,14-deepoxy-15-deoxo-14-deoxy-9,15-epoxy-15-hydroxy-14-oxo-. CAS No. 150821-39-9. Pack Sizes: 1mg;1g;10g. Product ID: 150821-39-9. Molecular formula: C51H79NO13. Mole weight: 914.17. Custom synthesis is available. Send your inquiries for more information. | London |
| Demethoxy Rapamycin | A derivative of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Group: Pharmaceutical. Alternative Names: Demethoxyrapamycin; Rapamycin, 32-demethoxy-; Desmethoxyrapamycin; 83482-58-0; AY 24668; (16E,24E,26E,28E)-1,18-dihydroxy-12-[1-(4-hydroxy-3-methoxycyclohexyl)propan-2-yl]-30-methoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; AY-24668; 19-O-Desmethoxy rapamycin. CAS No. 83482-58-0. Pack Sizes: 1mg;1g;10g. Product ID: 83482-58-0. Molecular formula: C50H77NO12. Mole weight: 884.17. Custom synthesis is available. Send your inquiries for more information. | London |
| Prolyl-rapamycin | An impurity of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Group: Pharmaceutical. Alternative Names: Rapamycin Impurity 2; 21-Norrapamycin; Prolylrapamycin; 23,27-Epoxy-1H,3H-pyrrolo[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,31,32,33,33a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,33aS)-; (. CAS No. 156223-31-3. Pack Sizes: 1mg;1g;10g. Product ID: 156223-31-3. Molecular formula: C50H77NO13. Mole weight: 900.15. Custom synthesis is available. Send your inquiries for more information. | London |
| Seco Rapamycin | Seco-rapamycin is the first in vivo open-ring metabolite of rapamycin that does not affect mTOR. Group: Pharmaceutical. Alternative Names: Secorapamycin A. CAS No. 147438-27-5. Pack Sizes: 1mg;1g;10g. Product ID: 147438-27-5. Molecular formula: C51H79NO13. Mole weight: 914.17. Custom synthesis is available. Send your inquiries for more information. | London |
| Secorapamycin B | Secorapamycin B is an impurity of Rapamycin. Rapamycin is a macrolide compound. It inhibits activation of T cells and B cells by reducing the production of interleukin-2. Rapamycin can be used to coat coronary stents and prevent organ transplant rejection. Group: Pharmaceutical. Alternative Names: 34-Hydroxy Sirolimus; 34-Hydroxy Rapamycin. CAS No. 185107-79-3. Pack Sizes: 1mg;1g;10g. Product ID: 185107-79-3. Molecular formula: C51H81NO14. Mole weight: 932.19. Custom synthesis is available. Send your inquiries for more information. | London |
| Seco Rapamycin (sodium salt) | Seco-rapamycin is the first in vivo open-ring metabolite of rapamycin which is a natural macrolide immunosuppressant. Seco-rapamycin inhibits the ChT-L (D) and PGPH (E) peptidases, and activate the T-L (F) peptidase and poorly activates mTOR. IC50: ChT-L. Uses: A decomposition product of rapamycin (r124000). Group: Pharmaceutical. Alternative Names: seco Rapamycin Sodium Salt. CAS No. 148554-65-8. Pack Sizes: 1mg;1g;10g. Product ID: 148554-65-8. Molecular formula: C51H78NNaO13. Mole weight: 936.15. Custom synthesis is available. Send your inquiries for more information. | London |
| Wortmannin-Rapamycin Conjugate | Wortmannin is a potent inhibitor of PI3K enzymes, and rapamycin blocks mTOR. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Group: Pharmaceutical. Alternative Names: Wortmannin-Rapamycin Conjugate; 1067892-47-0; AKOS040755180. CAS No. 1067892-47-0. Pack Sizes: 1mg;1g;10g. Product ID: 1067892-47-0. Molecular formula: C88H131N3O23. Mole weight: 1598.9. Custom synthesis is available. Send your inquiries for more information. | London |
| ABTL-0812 | ABTL-0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR), rictor-mTOR and dihydrofolate reductase with potential antineoplastic activity. It binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells upon oral administration. It was developed by Ability Pharmaceuticals and is in phase I/II clinical trials for the treatment of solid tumors. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015. Uses: Abtl-0812 has potential antineoplastic activity. it is used for the treatment of solid tumors. Group: Pharmaceutical. Alternative Names: ABTL0812; ABTL 0812; ABTL-0812; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoate. CAS No. 57818-44-7. Pack Sizes: 1mg;1g;10g. Product ID: 57818-44-7. Molecular formula: C18H31O3. Mole weight: 294.93. Custom synthesis is available. Send your inquiries for more information. | London |
| Chrysophanol | Chrysophanic acid (Chrysophanol) is a natural anthraquinone with anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 μm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. Chrysophanol is a natural compound found in the roots and rhizomes of Rheum palmatum L. It can be used in cosmetics material. Uses: Anti-inflammatory. Group: Pharmaceutical. Alternative Names: 1,8-dihydroxy-3-methylanthracene-9,10-dione. CAS No. 481-74-3. Pack Sizes: 1 g. Product ID: NP0901. Molecular formula: C15H10O4. Mole weight: 254.24. Custom synthesis is available. Send your inquiries for more information. | London |
| δ-Tocotrienol | δ-Tocotrienol is from palm oil. Delta-tocotrienol is a potential angiogenic inhibitor that significantly suppresses human colorectal adenocarcinoma cells (DLD-1-CM)-induced tube formation, migration, and adhesion on human umbilical vein endothelial cells. Delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offer a potential starting point for the design of novel anticancer agents. Delta-tocotrienol displays significant radioprotective effects that protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. Group: Pharmaceutical. Alternative Names: [R-(E,E)]-3,4-Dihydro-2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol; (2R)-3,4-Dihydro-2,8-dimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol; 2,8-Dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-6-chromanol; (R)-δ-Tocotrienol; 8-Methyltocotrienol; d-δ-Tocotrienol. CAS No. 25612-59-3. Pack Sizes: 50 mg. Product ID: NP4617. Molecular formula: C27H40O2. Mole weight: 396.6. Custom synthesis is available. Send your inquiries for more information. | London |
| Everolimus | Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cytokine-mediated lymphocyte proliferation. Everolimus can be used as an immunosuppressant in the treatment of renal cell cancer and other cancers. Uses: Immunosuppressant. Group: Pharmaceutical. Alternative Names: RAD-001; RAD001; RAD 001; Afinitor; Certican; Zortress; RAD001; SDZ-RAD. CAS No. 159351-69-6. Pack Sizes: 100 mg. Product ID: BAT-010106. Molecular formula: C53H83NO14. Mole weight: 958.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Everolimus, Cyclosporine and Tacrolimus Mix Standard | Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Cyclosporine is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Tacrolimus is also an immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Group: Pharmaceutical. Pack Sizes: 1mg;1g;10g. Molecular formula: C53H83NO14/C62H111N11O12/C44H69N. Mole weight: 958.22/1202.61/612.02. Custom synthesis is available. Send your inquiries for more information. | London |
| PF-04691502 | PF-04691502 is an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. It inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy. mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K. Group: Pharmaceutical. Alternative Names: PF04691502; PF 04691502; PF-04691502; PF4691502; PF 4691502; PF-4691502; 2-amino-8-((1R,4R)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one. CAS No. 1013101-36-4. Pack Sizes: 50 mg. Product ID: B0084-456382. Molecular formula: C22H27N5O4. Mole weight: 425.489. Custom synthesis is available. Send your inquiries for more information. | London |
| Sirolimus triketone isomer | Sirolimus triketone isomer is an impurity of Rapamycin, which is a macrolide compound used to coat coronary stents and prevent organ transplant rejection. Group: Pharmaceutical. Alternative Names: Sirolimus isomer A; Rapamycin isomer A; 10,21-Dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,13,14,21,22,23,24,25,26,32,33,34,34a-tetradecahydro-3H-pyrido[2,1-c][1]oxa[4]azacyclohentriacontine-1,5,11,27,28,29(4H,6H,12H,31H)-hexaone. Pack Sizes: 25 mg. Product ID: B1370-421319. Molecular formula: C51H79NO13. Mole weight: 914.17. Custom synthesis is available. Send your inquiries for more information. | London |
| Temsirolimus | Temsirolimus is an mTOR inhibitor produced by Streptomyces. Temsirolimus potently inhibits mTOR kinase activity with IC50 of 1.76 μM, similar to that of rapamycin with IC50 of 1.74 μM. Group: Pharmaceutical. Alternative Names: CCI779; CCI-779; CCI 779. CAS No. 162635-04-3. Pack Sizes: 200 mg. Product ID: BBF-03842. Molecular formula: C56H87NO16. Mole weight: 1030.29. Custom synthesis is available. Send your inquiries for more information. | London |
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