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| Product | Description | |
|---|---|---|
| Rapamycin | 100mg Pack Size. Group: Biochemicals, Organics, Research Organics & Inorganics. Formula: C51H79NO13. CAS No. 53123-88-9. Prepack ID : 41676136-100mg. Molecular Weight : 914.17. |  |
| Rapamycin | Rapamycin is an mTOR inhibitor immunosuppressant and kinase inhibitor with both antifungal and antineoplastic properties. It selectively inhibits the transcriptional activation of cytokines. Uses: Antifungal and antineoplastic agent. Group: Pharmaceutical. CAS No. 53123-88-9. Pack Sizes: 500 mg. Product ID: BBF-02627. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Rapamycin Impurities | Rapamycin Impurities, quintessential in the pharmaceutical sector, function as pivotal indicators of drug purity and stability. Essential for confirming the efficacy and safety of Rapamycin, a critical mTOR pathway inhibitor, their role spans organ transplant rejection prevention and oncological applications, thus serving as sentinels in therapeutic precision. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Chrysophanol | Chrysophanic acid (Chrysophanol) is a natural anthraquinone with anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 μm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. Chrysophanol is a natural compound found in the roots and rhizomes of Rheum palmatum L. It can be used in cosmetics material. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 481-74-3. Pack Sizes: 1 g. Product ID: NP0901. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| δ-Tocotrienol | δ-Tocotrienol is from palm oil. Delta-tocotrienol is a potential angiogenic inhibitor that significantly suppresses human colorectal adenocarcinoma cells (DLD-1-CM)-induced tube formation, migration, and adhesion on human umbilical vein endothelial cells. Delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offer a potential starting point for the design of novel anticancer agents. Delta-tocotrienol displays significant radioprotective effects that protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. Group: Pharmaceutical. CAS No. 25612-59-3. Pack Sizes: 50 mg. Product ID: NP4617. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Everolimus | Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cytokine-mediated lymphocyte proliferation. Everolimus can be used as an immunosuppressant in the treatment of renal cell cancer and other cancers. Uses: Immunosuppressant. Group: Pharmaceutical. CAS No. 159351-69-6. Pack Sizes: 100 mg. Product ID: BAT-010106. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PF-04691502 | PF-04691502 is an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. It inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy. mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K. Group: Pharmaceutical. CAS No. 1013101-36-4. Pack Sizes: 50 mg. Product ID: B0084-456382. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Temsirolimus | Temsirolimus is an mTOR inhibitor produced by Streptomyces. Temsirolimus potently inhibits mTOR kinase activity with IC50 of 1.76 μM, similar to that of rapamycin with IC50 of 1.74 μM. Group: Pharmaceutical. CAS No. 162635-04-3. Pack Sizes: 200 mg. Product ID: BBF-03842. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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