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5g Pack Size. Group: Building Blocks, Organics. Formula: C8H6N2. CAS No. 253-82-7. Prepack ID : 13438099-5g. Molecular Weight : 130.15.
4-Chloro-6-iodoquinazoline
4-Chloro-6-iodoquinazoline is used as a chemical reagent in the synthesis of pharmaceutical drugs targeting various diseases including cancer and inflammatory disorders. It acts as a building block for creating novel compounds with potential therapeutic applications. Group: Pharmaceutical. Alternative Names: 4-chloro-6-iodoquinazoline98556-31-14-chloro-6-iodo-quinazolineQUINAZOLINE, 4-CHLORO-6-IODO-MFCD01862193. CAS No. 98556-31-1. Pack Sizes: 1mg;1g;10g. Product ID: NP3165. Molecular formula: C8H4ClIN2. Mole weight: 290.49. Custom synthesis is available. Send your inquiries for more information.
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4-Chloroquinazoline-6,7-diol
4-Chloroquinazoline-6,7-diol. Group: Pharmaceutical. Alternative Names: 6,7-Quinazolinediol, 4-chloro-; 4-Chloro-6,7-dihydroxyquinazoline. CAS No. 1145671-36-8. Pack Sizes: 5 g. Product ID: BB073112. Molecular formula: C8H5ClN2O2. Mole weight: 196.59. Custom synthesis is available. Send your inquiries for more information.
An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Group: Pharmaceutical. Alternative Names: (R)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine; (R)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine. CAS No. 402855-03-2. Pack Sizes: 10 mg. Product ID: B2694-292473. Molecular formula: C18H16ClFN4O2. Mole weight: 374.8. Custom synthesis is available. Send your inquiries for more information.
6-(Benzyloxy)-4-(3-chloro-4-fluorophenylamino)-7-methoxy-quinazoline (CAS# 913819-12-2 ) is a useful research chemical. Group: Pharmaceutical. Alternative Names: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(phenylmethoxy)-4-quinazolinamine. CAS No. 913819-12-2. Pack Sizes: 1 g. Product ID: B2699-100471. Molecular formula: C22H17ClFN3O2. Mole weight: 409.84. Custom synthesis is available. Send your inquiries for more information.
One impurity of Terazosin, which is a piperazine derivative and has been found to be an α-1-adrenergic blocker. Group: Pharmaceutical. Alternative Names: 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE; SCHEMBL11079651; AUMKUQAWVQJGTR-UHFFFAOYSA-N; 2-Piperazine-4-amino-6,7-dimethoxy quinaoline hydrochloride; AKOS015960996; AB16715; AC-12620; FT-0641937; 2-Piperazine-4-amino-6,7-dimethoxyquinoline hydrochloride; 2-(piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline.hydrochloride; 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline hydrochloride; 6,7-DIMETHOXY-2-(PIPERAZIN-1-YL)QUINAZOLIN-4-AMINE HYDROCHLORIDE; 6,7-Dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine hydrochloride(1:x); 6,7-Dimethoxy-2-(piperazin-1-yl)quinazolin-4-aminehydrochloride(1:x). CAS No. 70843-11-7. Pack Sizes: 20 mg. Product ID: B2694-338833. Molecular formula: C14H20ClN5O2. Mole weight: 325.79. Custom synthesis is available. Send your inquiries for more information.
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A2B receptor antagonist 2
A2B receptor antagonist 2 is a member of quinazolines. It is also an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively. Group: Pharmaceutical. Alternative Names: N-(4,6,7-trimethylquinazolin-2-yl)guanidine; 1-(4,6,7-trimethylquinazolin-2-yl)guanidine. CAS No. 784-90-7. Pack Sizes: 1mg;1g;10g. Product ID: 784-90-7. Molecular formula: C12H15N5. Mole weight: 229.28. Custom synthesis is available. Send your inquiries for more information.
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Afatinib Impurity B
An analogue of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Group: Pharmaceutical. Alternative Names: Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl; N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine; (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine. CAS No. 314771-76-1. Pack Sizes: 10 mg. Product ID: B2694-466202. Molecular formula: C18H16ClFN4O2. Mole weight: 374.81. Custom synthesis is available. Send your inquiries for more information.
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Cediranib maleate
Cediranib maleate is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM. It also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM. It inhibits VEGF-stimulated proliferation with IC50 of 0.4 nM in vitro. It suppresses PDGF-AA with IC50 of 0.04 μM in MG63 cell lines. It even suppresses tubule sprouting at subnanomolar concentrations and inhibits VEGF-induced angiogenesis in vivo. It causes hypertrophy in bone growth plate and prevents luteal development in ovary. It shows broad spectrum activity in human tumor models at doses that are well tolerated. It causes regression of vascular tissues in human lung tumor xenografts. Group: Pharmaceutical. Alternative Names: AZD 2171 maleate; Recentin; 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline maleate. CAS No. 857036-77-2. Pack Sizes: 100 mg. Product ID: B2693-459903. Molecular formula: C29H31FN4O7. Mole weight: 566.6. Custom synthesis is available. Send your inquiries for more information.
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Erlotinib-[d6] Hydrochloride
Erlotinib-[d6] Hydrochloride is the labelled analogue of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Erlotinib is a medication used to treat non-small cell lung cancer and pancreatic cancer. Group: Pharmaceutical. Alternative Names: N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy-d3)-4-quinazolinamine Hydrochloride; 6,7-Bis(2-methoxyethoxy-d3)-4-(3-ethynylanilino)quinazoline Hydrochloride; [6,7-Bis(2-methoxyethoxy-d3)quinazolin-4-yl]-(3-ethynylphenyl)amine Hydrochloride; Erlotinib D6 Hydrochloride. CAS No. 1189953-78-3. Pack Sizes: 5 mg. Product ID: BLP-006076. Molecular formula: C22H18D6ClN3O4. Mole weight: 435.93. Custom synthesis is available. Send your inquiries for more information.
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Erlotinib hydrochloride
Erlotinib HCl potently inhibits EGFR activation in intact cells including HNS human head and neck tumor cells (IC50 = 20 nM), DiFi humancolon cancer cells and MDA MB-468 human breast cancer cells. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: OSI-744; OSI744; OSI 744; Tarceva; 4-(m-Ethynylanilino)-6,7-bis(2-methoxyethoxy)quinazoline monohydrochloride; 6,7-bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride. CAS No. 183319-69-9. Pack Sizes: 25 g. Product ID: BBF-04613. Molecular formula: C22H23N3O4.HCl. Mole weight: 429.9. Custom synthesis is available. Send your inquiries for more information.
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HZ-1157
HZ-1157 is an inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease. Group: Pharmaceutical. Alternative Names: HZ-1157; HZ 1157; HZ1157. Dengue Virus Inhibitor II; 5-tert-butoxyquinazoline-2,4-diamine; 5-(tert-Butoxy)quinazoline-2,4-diamine; 2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-. CAS No. 1009734-33-1. Pack Sizes: 50 mg. Product ID: B0084-284802. Molecular formula: C12H16N4O. Mole weight: 232.287. Custom synthesis is available. Send your inquiries for more information.
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Icotinib hydrochloride
Icotinib Hydrochloride is a quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), which is upregulated in a variety of cancer cell types. Icotinib supresses the cancer cell proliferation via EGFR tyrosine kinase inhibition. Group: Pharmaceutical. Alternative Names: Icotinib HCl; BPI-2009; BPI 2009; BPI2009. CAS No. 1204313-51-8. Pack Sizes: 300 mg. Product ID: BBF-04036. Molecular formula: C22H22ClN3O4. Mole weight: 427.88. Custom synthesis is available. Send your inquiries for more information.
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Irak4-IN-1
Irak4-IN-1 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4). Group: Pharmaceutical. Alternative Names: Irak4-IN-1; Irak4 IN 1; 4-[(4-morpholin-4-ylcyclohexyl)amino]quinazoline-6-carbonitrile. CAS No. 1820787-94-7. Pack Sizes: 2 mg. Product ID: B0084-284756. Molecular formula: C19H23N5O. Mole weight: 337.427. Custom synthesis is available. Send your inquiries for more information.
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Lapatinib Ditosylate
Lapatinib is a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: GW-572016; GW 572016; GW572016. CAS No. 388082-77-7. Pack Sizes: 1 g. Product ID: B0084-067756. Molecular formula: C29H26ClFN4O4S.2C7H8O3S. Mole weight: 925.46. Custom synthesis is available. Send your inquiries for more information.
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Lapatinib ditosylate hydrate
Lapatinib is a synthetic, orally-active quinazoline drug with potential antitumor activity. Group: Pharmaceutical. Alternative Names: Tykerb; Tyverb; 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, bis(4-methylbenzenesulfonate), monohydrate; Lapatinib ditosylate Monohydrate. CAS No. 388082-78-8. Pack Sizes: 1mg;1g;10g. Product ID: 388082-78-8. Molecular formula: C29H26ClFN4O4S.2C7H8O3S.H2O. Mole weight: 943.48. Custom synthesis is available. Send your inquiries for more information.
Reagent used for : Suzuki-Miyaura cross-coupling using palladium phosphine catalyst ; Palladium-catalyzed ligand-controlled regioselective Suzuki coupling ; Palladium-catalyzed Suzuki-Miyaura coupling ; Suzuki coupling followed by iodolactonization reaction ; Wrenchnolol derivative optimized for gene activation in cells Reagent used in Preparation of several enzymatic inhibitors and receptor ligands; Orally active anaplastic lymphoma kinase inhibitors ; Oxazolecarboxamides as diacylglycerol acyltransferase-1 inhibitors for treatment of obesity and diabetes ; 4-arylpiperidinyl amides and N-arylpiperidin-3-yl-cyclopropanecarboxamides as novel melatonin receptor ligands ; Quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for treatment of Gaucher disease, a lysosomal storage disorder ; Arylpiperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists. Group: Pharmaceutical. Alternative Names: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester; tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylate. CAS No. 286961-14-6. Pack Sizes: 100 g. Product ID: BB019917. Molecular formula: C16H28NO4B. Mole weight: 309.21. Custom synthesis is available. Send your inquiries for more information.
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N-Desmethyl Vandetanib
N-Desmethyl Vandetanib is a metabolite of Vandetanib. Vandetanib is an antitumor drug used for the treatment of medullary thyroid cancer. Vandetanib effects through inhibiting vascular endothelial growth factor receptor-2 (VEGFR), epidermal growth factor receptor (EGFR) and the RET-tyrosine kinase activity. Group: Pharmaceutical. Alternative Names: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(4-piperidinylmethoxy)-4-quinazolinamine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(piperidin-4-yl)methoxy]quinazoline. CAS No. 338992-12-4. Pack Sizes: 5 mg. Product ID: B1926-260255. Molecular formula: C21H22BrFN4O2. Mole weight: 461.34. Custom synthesis is available. Send your inquiries for more information.
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Nolatrexed dihydrochloride
Nolatrexed, also known as AG337, is a thymidylate synthase inhibitor with potential anticancer activity. A phase II study of nolatrexed in 2007 in advanced HCC patients demonstrated minimal activity and significant stomatitis. Group: Pharmaceutical. Alternative Names: AG 337; Thymitaq; 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride; 2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)-1,4-dihydroquinazolin-4-one dihydrochloride; 3,4-Dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)quinazoline dihydrochloride. CAS No. 152946-68-4. Pack Sizes: 50 mg. Product ID: B0084-059576. Molecular formula: C14H14Cl2N4OS. Mole weight: 357.25. Custom synthesis is available. Send your inquiries for more information.
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Rosuvastatin EP Impurity FP-B (6R-isomer) calcium salt
Rosuvastatin EP Impurity FP-B (6R-isomer) calcium salt is an impurity of Rosuvastatin, which is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. Group: Pharmaceutical. Alternative Names: (3R,5S)-5-((R)-8-fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate calcium(II) salt; Benzo[h]quinazoline-6-pentanoic acid, 8-fluoro-5,6-dihydro-β,δ-dihydroxy-4-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-, calcium salt (2:1), (βR,δS,6R)-; (βR,δS,6R)-8-Fluoro-5,6-dihydro-β,δ-dihydroxy-4-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]benzo[h]quinazoline-6-pentanoic acid calcium salt; Rosuvastatin Dihydrobenzoquinazoline (6R)-Isomer calcium salt. CAS No. 854898-49-0. Pack Sizes: 20 mg. Product ID: B2699-009723. Molecular formula: C22H27FN3O6S.1/2Ca. Mole weight: 500.57. Custom synthesis is available. Send your inquiries for more information.
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Rosuvastatin EP Impurity FP-B (6S-isomer) calcium salt
Rosuvastatin EP Impurity FP-B (6S-isomer) calcium salt is an impurity of Rosuvastatin, which is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. Group: Pharmaceutical. Alternative Names: Benzo[h]quinazoline-6-pentanoic acid, 8-fluoro-5,6-dihydro-β,δ-dihydroxy-4-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-, calcium salt (2:1), (βR,δS,6S)-; (3R,5S)-5-((S)-8-fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate calcium(II) salt; (βR,δS,6S)-8-Fluoro-5,6-dihydro-β,δ-dihydroxy-4-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]benzo[h]quinazoline-6-pentanoic acid calcium salt; Rosuvastatin Dihydrobenzoquinazoline (6S)-Isomer calcium salt. CAS No. 854898-50-3. Pack Sizes: 20 mg. Product ID: B2699-009805. Molecular formula: C22H28FN3O6S.1/2Ca. Mole weight: 500.57. Custom synthesis is available. Send your inquiries for more information.
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Vandetanib
Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM. Uses: Antineoplastic. Group: Pharmaceutical. Alternative Names: ZD6474; ZD 6474; ZD-6474; 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; AZD 6474; AZD-6474; AZD6474; Caprelsa; CH 331; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(N-methylpiperidin-4-ylmethoxy)quinazolin-4-amine; Zactima. CAS No. 443913-73-3. Pack Sizes: 100 mg. Product ID: B2693-344311. Molecular formula: C22H24BrFN4O2. Mole weight: 475.35. Custom synthesis is available. Send your inquiries for more information.
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1-Hydroxyrutaecarpine
1-Hydroxyrutaecarpine is isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. It exhibits cytotoxicities (ED50 values < 4 mg/mL) against P-388 or HT-29 cell lines. Uses: Antiplatelet aggregation. Group: Pharmaceutical. Alternative Names: 1-Hydroxy-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one. CAS No. 53600-24-1. Pack Sizes: 1 mg. Product ID: NP0444. Molecular formula: C18H13N3O2. Mole weight: 303.3. Custom synthesis is available. Send your inquiries for more information.
Lapatinib intermediate. Group: Pharmaceutical. Alternative Names: 5-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-furancarboxaldehyde. CAS No. 231278-84-5. Pack Sizes: 1mg;1g;10g. Product ID: NP3184. Molecular formula: C26H17ClFN3O3. Mole weight: 473.88. Custom synthesis is available. Send your inquiries for more information.
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7β-Hydroxyrutaecarpine
7β-Hydroxyrutaecarpine is isolated from the fruits of Euodia ruticarpa. Group: Pharmaceutical. Alternative Names: (R)-7-hydroxy-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one. CAS No. 163815-35-8. Pack Sizes: 2 mg. Product ID: NP0226. Molecular formula: C18H13N3O2. Mole weight: 303.3. Custom synthesis is available. Send your inquiries for more information.
7-(But-2-yn-1-yl)-3-methyl-8-(methylamino)-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione is an impurity of Linagliptin. Linagliptin is an inhibitor of dipeptidyl peptidase-4 (DPP-4) that is a medication used to treat type 2 diabetes in conjunction with exercise and diet. Group: Pharmaceutical. Alternative Names: Linagliptin Impurity 33; 1H-Purine-2,6-dione, 7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-8-(methylamino)-1-[(4-methyl-2-quinazolinyl)methyl]. CAS No. 2468656-63-3. Pack Sizes: 50 mg. Product ID: B1370-426211. Molecular formula: C21H21N7O2. Mole weight: 403.45. Custom synthesis is available. Send your inquiries for more information.
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A 987306
A 987306 is a potent histamine H4 receptor antagonist (pKi = 8.24 and 8.47 in human and rat H4 receptors, respectively) with 162-, 620-, and > 1600-fold selectivity over human H3, H1 and H2 receptors. It suppresses zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo (ED50 = 42 μmol/kg, ip). Group: Pharmaceutical. Alternative Names: A 987306; A987306; A-987306; (±)-(7aR,11aR)-5,6,7a,8,9,10,11,11a-Octahydro-4-(1-piperazinyl)-benzofuran[2,3-h]quinazolin-2-amine. CAS No. 1082954-71-9. Pack Sizes: 1mg;1g;10g. Product ID: 1082954-71-9. Molecular formula: C18H25N5O. Mole weight: 327.42. Custom synthesis is available. Send your inquiries for more information.
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AC410
AC410 is a Janus kinase 2 (JAK2) inhibitor with Kd of 0.18 nM. AC410 is selective for JAK2 and Kd is 2.5 nM for JAK1 and 5nM for JAK3. Phase I for the treatment of Autoimmune disorders and Inflammation is on-going. Uses: Autoimmune disorders; inflammation. Group: Pharmaceutical. Alternative Names: AC410; AC 410; AC-410; (S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol;1361415-86-2 (HCl). CAS No. 1361415-84-0. Pack Sizes: 1mg;1g;10g. Product ID: 1361415-84-0. Molecular formula: C19H16FN5O. Mole weight: 349.4. Custom synthesis is available. Send your inquiries for more information.
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Afatinib
Afatinib irreversibly inhibits EGFR/HER2 including EGFR, EGFR(L858R), EGFR(L858R/T790M) and HER2. It is 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; BIBW 2992; Gilotrif; Giotrif; Tovok; (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. CAS No. 850140-72-6. Pack Sizes: 500 mg. Product ID: B0084-258486. Molecular formula: C24H25ClFN5O3. Mole weight: 485.94. Custom synthesis is available. Send your inquiries for more information.
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Afatinib-[d6]
Afatinib-[d6] is the labelled analogue of Afatinib. Afatinib is a medication approved for the treatment of metastatic non-small cell lung cancer (NSCLC) that has certain EGFR mutations. It acts via inhibiting EGFR and HER2. Group: Pharmaceutical. Alternative Names: Afatinib-d6; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide-d6; BIBW 2992-d6; Tovok-d6; Tomtovok-d6. CAS No. 1313874-96-2. Pack Sizes: 5 mg. Product ID: BLP-011554. Molecular formula: C24H19D6ClFN5O3. Mole weight: 491.98. Custom synthesis is available. Send your inquiries for more information.
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Afatinib dimaleate
Afatinib Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively. Group: Pharmaceutical. Alternative Names: (2E)-N-[4-[(3,4-difluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide. CAS No. 850140-73-7. Pack Sizes: 500 mg. Product ID: NP3632. Molecular formula: C32H33ClFN5O11. Mole weight: 717.18. Custom synthesis is available. Send your inquiries for more information.
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Afatinib Impurity 52
Afatinib Impurity 52 is an impurity of Afatinib, a drug used to treat non-small cell lung cancer (NSCLC). Group: Pharmaceutical. Alternative Names: (S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate; Diethyl {[4-(3-Chloro-4-Fluoro-Phenylamino)-7-((S)-Tetrahydrofuran-3-Yloxy)-Quinazolin-6-Ylcarbamoyl]-Methyl}-Phosphonate. CAS No. 618061-76-0. Pack Sizes: 100 mg. Product ID: B2699-424124. Molecular formula: C24H27ClFN4O6P. Mole weight: 552.92. Custom synthesis is available. Send your inquiries for more information.
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Afatinib Impurity C
An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Group: Pharmaceutical. Alternative Names: 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)?amino]?-7-[[(3R)?-tetrahydro-3-furanyl]?oxy]?-6-quinazolinyl]?-4-(dimethylamino)?-, (2E)?-. CAS No. 945553-91-3. Pack Sizes: 10 mg. Product ID: B2694-466206. Molecular formula: C24H25ClFN5O3. Mole weight: 485.95. Custom synthesis is available. Send your inquiries for more information.
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Afatinib Impurity D
An analogue of Afatinib, a medication indicated for the treatment of non-small cell lung carcinoma (NSCLC). Group: Pharmaceutical. Alternative Names: (2Z)-Afatinib; Z-Afatinib; (S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. CAS No. 1680184-59-1. Pack Sizes: 5 mg. Product ID: B2694-466207. Molecular formula: C24H25ClFN5O3. Mole weight: 485.95. Custom synthesis is available. Send your inquiries for more information.
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Afatinib Impurity I
An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Group: Pharmaceutical. Alternative Names: Bromo-Afatinib; (S,E)-4-bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide. CAS No. 1637254-93-3. Pack Sizes: 2.5 mg. Product ID: B1370-377782. Molecular formula: C22H19BrClFN4O3. Mole weight: 521.78. Custom synthesis is available. Send your inquiries for more information.
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Afatinib Impurity J
An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Group: Pharmaceutical. Alternative Names: (2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; (S,E)-4-(DIMETHYLAMINO)-N-(4-HYDROXY-7-((TETRAHYDROFURAN-3-YL)OXY)QUINAZOLIN-6-YL)BUT-2-ENAMIDE; (S,e)-4-(dimethylamino)-N-(4-oxo-7-((tetrahydrofuran-3-yl)oxy)-3,4-dihydroquinazolin-6-yl)but-2-enamide; Afatinib Impurity J; SCHEMBL17352060; SCHEMBL17352063; GSUSIQVMAQBROU-PCAWENJQSA-N; CS-0164268; E82037; (S,E)-4-(Dimethylamino)-N-(4-hydroxy-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide (Afatinib Impurity). CAS No. 1456696-14-2. Pack Sizes: 10 mg. Product ID: B2694-466213. Molecular formula: C18H22N4O4. Mole weight: 358.4. Custom synthesis is available. Send your inquiries for more information.
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ARQ-087
ARQ-087, also known as Derazantinib, is an oral fibroblast growth factor receptor (FGFR) inhibitor with antitumor property. FGFR plays a role in the regulation of key cellular behaviors including proliferation, cell differentiation and so on. FGFR dysregulation is considered as a driver in multiple cancers. ARQ 087 binds to FGFR and effectively inhibits the activation of FGFR thus can suppress tumorigenesis and tumor growth. Group: Pharmaceutical. Alternative Names: ARQ 087; ARQ087; ARQ-087; Derazantinib; (6R)-6-(2-fluorophenyl)-N-[3-[2-(2-methoxyethylamino)ethyl]phenyl]-5,6-dihydrobenzo[h]quinazolin-2-amine. CAS No. 1234356-69-4. Pack Sizes: 5 mg. Product ID: B0084-008116. Molecular formula: C29H29FN4O. Mole weight: 468.576. Custom synthesis is available. Send your inquiries for more information.
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ARS-1323
ARS-1323 is an inhibitor of mutant K-ras G12C. Group: Pharmaceutical. Alternative Names: ARS-1323; ARS 1323; ARS1323; 6-[6-chloro-8-fluoro-4-(4-prop-2-enoylpiperazin-1-yl)-1H-quinazolin-7-ylidene]-5-fluorocyclohexa-2,4-dien-1-one. CAS No. 1698024-73-5. Pack Sizes: 5 mg. Product ID: B0084-260280. Molecular formula: C21H17ClF2N4O2. Mole weight: 430.84. Custom synthesis is available. Send your inquiries for more information.
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ARS-1620
ARS-1620 is a potent and selective KRAS-G12C inhibitor. ARS-1620 achieves rapid and sustained in vivo target occupancy to induce tumor regression. Group: Pharmaceutical. Alternative Names: ARS-1620; ARS 1620; ARS1620; BCP29125; BCP 29125; BCP-29125; 6-[6-chloro-8-fluoro-4-(4-prop-2-enoylpiperazin-1-yl)-1H-quinazolin-7-ylidene]-5-fluorocyclohexa-2,4-dien-1-one sulfane. CAS No. 1698055-85-4. Pack Sizes: 5 mg. Product ID: B0084-169263. Molecular formula: C21H17ClF2N4O2. Mole weight: 430.84. Custom synthesis is available. Send your inquiries for more information.
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ARS-1630
ARS-1630 is the R-enantiomer of ARS-1620. It is an inhibitor of mutant K-ras G12C. Group: Pharmaceutical. Alternative Names: ARS-1630; ARS 1630; ARS1630; (R)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one. CAS No. 1698055-86-5. Pack Sizes: 5 mg. Product ID: B0084-260281. Molecular formula: C21H17ClF2N4O2. Mole weight: 430.84. Custom synthesis is available. Send your inquiries for more information.
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AV-412
AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Group: Pharmaceutical. Alternative Names: AV 412; AV412; N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide. CAS No. 451492-95-8. Pack Sizes: 20 mg. Product ID: B0084-324573. Molecular formula: C27H28ClFN6O. Mole weight: 507.01. Custom synthesis is available. Send your inquiries for more information.
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BLU-554
BLU-554 is a potent and selective inhibitor of fibroblast growth factor receptor 4 (FGFR4) (IC50 = 5 nM), which is promisingly to be used for the treatment of hepatocellular carcinoma and cholangiocarcinoma. Group: Pharmaceutical. Alternative Names: BLU-554; BLU 554; BLU554, Fisogatinib; SCHEMBL16668287; EX-A841; MFCD30496704; N-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]oxan-4-yl]prop-2-enamide; BLU554. CAS No. 1707289-21-1. Pack Sizes: 10 mg. Product ID: B0084-008122. Molecular formula: C24H24Cl2N4O4. Mole weight: 503.38. Custom synthesis is available. Send your inquiries for more information.
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CGS 15943
CGS 15943 is a potent and orally bioactive adenosine receptor antagonist (Ki = 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors, respectively). Group: Pharmaceutical. Alternative Names: CGS 15943; CGS15943; CGS-15943; 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine. CAS No. 104615-18-1. Pack Sizes: 100 mg. Product ID: B2693-159610. Molecular formula: C13H8ClN5O. Mole weight: 285.69. Custom synthesis is available. Send your inquiries for more information.
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Copanlisib
Copanlisib is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BAY 80-6946 inhibits the activation of the PI3K signaling pathway, which may result in the inhibition of tumor cell growth and survival in susceptible tumor cell populations. Group: Pharmaceutical. Alternative Names: BAY 80-6946; Aliqopa; BAY-80-6946; 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide. CAS No. 1032568-63-0. Pack Sizes: 50 mg. Product ID: B0084-456551. Molecular formula: C23H28N8O4. Mole weight: 480.529. Custom synthesis is available. Send your inquiries for more information.
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Desmethyl Erlotinib
A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Group: Pharmaceutical. Alternative Names: 2-[[4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]ethanol. CAS No. 183321-86-0. Pack Sizes: 5 mg. Product ID: B2694-263407. Molecular formula: C21H21N3O4. Mole weight: 379.42. Custom synthesis is available. Send your inquiries for more information.
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Erlotinib-3-vinyl Hydrochloride
A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Group: Pharmaceutical. Alternative Names: 6,7-Bis(2-methoxyethoxy)-N-(3-vinylphenyl)quinazolin-4-amine hydrochloride; 4-Quinazolinamine, N-(3-ethenylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1). CAS No. 1624294-38-7. Pack Sizes: 25 mg. Product ID: B1370-173396. Molecular formula: C22H26ClN3O4. Mole weight: 431.91. Custom synthesis is available. Send your inquiries for more information.
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Erlotinib Impurity 8
A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Group: Pharmaceutical. Alternative Names: N-(3-Desethynylphenyl)-N-(3-bromophenyl) Erlotinib; N-(3-bromophenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine. CAS No. 328528-74-1. Pack Sizes: 25 mg. Product ID: B2694-471125. Molecular formula: C20H22BrN3O4. Mole weight: 448.32. Custom synthesis is available. Send your inquiries for more information.
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Febrifugine dihydrochloride
Febrifugine is a quinazolinone alkaloid isolated from the Chinese herb Dichroa febrifuga. Group: Pharmaceutical. Alternative Names: (+)-Febrifugine dihydrochloride. CAS No. 32434-42-7. Pack Sizes: 25 mg. Product ID: B2703-334742. Molecular formula: C16H21Cl2N3O3. Mole weight: 374.26. Custom synthesis is available. Send your inquiries for more information.
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Gefitinib
Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Group: Pharmaceutical. Alternative Names: ZD1839; ZD 1839; ZD-1839; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine; Iressa; gefitinibum. CAS No. 184475-35-2. Pack Sizes: 5 g. Product ID: BBF-04570. Molecular formula: C22H24ClFN4O3. Mole weight: 446.9. Custom synthesis is available. Send your inquiries for more information.
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Gefitinib-[d6]
One of the isotopic labelled form of Gefitinib, which could be used as an antineoplastic agent. Group: Pharmaceutical. Alternative Names: Gefitinib-d6; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine-d6; Iressa-d6. CAS No. 1228664-49-0. Pack Sizes: 10 mg. Product ID: BLP-014883. Molecular formula: C22H18ClFN4O3D6. Mole weight: 452.95. Custom synthesis is available. Send your inquiries for more information.
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Halofuginone
Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. Uses: Semisynthetic quinazolinone alkaloid anticoccidial. Group: Pharmaceutical. Alternative Names: Halofuginone; Tempostatin; RU 19110; RU19110; RU-19110. CAS No. 55837-20-2. Pack Sizes: 100 mg. Product ID: B0084-071625. Molecular formula: C16H17BrClN3O3. Mole weight: 414.684. Custom synthesis is available. Send your inquiries for more information.
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Halofuginone hydrobromide
Halofuginone hydrobromide is a salt form of Halofuginone, which is a coccidiostat used in veterinary medicine. Group: Pharmaceutical. Alternative Names: DL-trans-7-Bromo-6-chloro-3-[3-(3-hydroxypiperidin-2-yl)-2-oxopropyl]-3H-quinazolin-4-one hydrobromide. CAS No. 64924-67-0. Pack Sizes: 1 g. Product ID: B2692-074439. Molecular formula: C16H18Br2ClN3O3. Mole weight: 495.596. Custom synthesis is available. Send your inquiries for more information.
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hVEGF-IN-1
hVEGF-IN-1 inhibits human VEGF-A translation and has antitumor activity. Tumor bearing mice treated with hVEGF-IN-1 have an average tumor volume of less than 300 mm. The tumor weight in the presence of hVEGF-IN-1 reduces around 60.1% to a final weight of 0.18 g. No significant change in body weight is observed during the treatment. Group: Pharmaceutical. Alternative Names: 1-Piperazinepropanamide, N-[2-[4-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-2-quinazolinyl]phenyl]-4-methyl. CAS No. 1637443-98-1. Pack Sizes: 2 mg. Product ID: B0084-267747. Molecular formula: C34H43N7O2. Mole weight: 581.75. Custom synthesis is available. Send your inquiries for more information.
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Ispinesib
Ispinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. Group: Pharmaceutical. Alternative Names: SB-715992; SB715992; SB 715992; CK 0238273; CK-0238273; CK0238273. CAS No. 336113-53-2. Pack Sizes: 50 mg. Product ID: B0084-066412. Molecular formula: C30H33ClN4O2. Mole weight: 517.07. Custom synthesis is available. Send your inquiries for more information.
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KD025
KD025 is an orally available and selective ROCK2 inhibitor with IC50 value of 60 nM and Ki value of 41 nm, respectively. It was shown to suppress adipogenesis in human adipose-derived stem cells. Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: SLx 2119; SLx2119; KD-025; 2-[3-[4-(1H-indazol-5-ylamino)quinazolin-2-yl]phenoxy]-N-propan-2-ylacetamide. CAS No. 911417-87-3. Pack Sizes: 100 mg. Product ID: B0084-460389. Molecular formula: C26H24N6O2. Mole weight: 452.51. Custom synthesis is available. Send your inquiries for more information.
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KL-11743
KL-11743 is a potent, orally active and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90 and 68 nM for GLUT1, GLUT2, GLUT3 and GLUT4, respectively. It specifically blocks glucose metabolism and induces cell death in concert with electron transport inhibitors. Group: Pharmaceutical. Alternative Names: NSC783733; Acetamide, 2-[3-[6-ethoxy-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-. CAS No. 1369452-53-8. Pack Sizes: 5 mg. Product ID: B2693-381869. Molecular formula: C30H30N6O3. Mole weight: 522.6. Custom synthesis is available. Send your inquiries for more information.
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Lapatinib-[13C,d7]
Lapatinib-[13C,d7] is the labelled analogue of Lapatinib, a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. It can be used for the treatment of breast cancer and other solid tumours. Group: Pharmaceutical. Alternative Names: Lapatinib-13C,D7; Lapatinib Ditosylate-13C,d7; Tykerb-13C,d7; GW 572016-13C,d7; Tyverb-13C,d7; N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-[5-({[2-(13C,D3)methanesulfonyl(D4)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine. CAS No. 1210608-87-9. Pack Sizes: 1 mg. Product ID: BLP-011601. Molecular formula: C28[13C]H19D7ClFN4O4S. Mole weight: 589.09. Custom synthesis is available. Send your inquiries for more information.
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Lapatinib Hydroxylamine
a complex used in human metabolism of lapatinib which is a dual kinase inhibitor. Group: Pharmaceutical. Alternative Names: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[hydroxy[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine. CAS No. 1360431-86-2. Pack Sizes: 10 mg. Product ID: B2694-473628. Molecular formula: C29H26ClFN4O5S. Mole weight: 597.07. Custom synthesis is available. Send your inquiries for more information.
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Linagliptin-[d4]
Linagliptin-[d4] is a labelled form of Linagliptin, a medication used to treat diabetes mellitus type 2. Group: Pharmaceutical. Alternative Names: (R)-8-(3-Aminopiperidin-1-yl-2,2,6,6-d4)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione; 8-[(3S)-3-Amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione. CAS No. 2140263-92-7. Pack Sizes: 10 mg. Product ID: BLP-013101. Molecular formula: C25H24D4N8O2. Mole weight: 476.58. Custom synthesis is available. Send your inquiries for more information.
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Linagliptin Impurity 10 (S-Isomer)
a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes. Group: Pharmaceutical. Alternative Names: (S)-Linagliptin; 8-[(3S)-3-Amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione. CAS No. 668270-11-9. Pack Sizes: 50 mg. Product ID: B0012-473823. Molecular formula: C25H28N8O2. Mole weight: 472.55. Custom synthesis is available. Send your inquiries for more information.
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Linagliptin Impurity B
An impurity of Linagliptin, a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes. Group: Pharmaceutical. Alternative Names: 8-Bromo-3-methyl-1,7-bis((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione; 1H-Purine-2,6-dione, 8-bromo-3,7-dihydro-3-methyl-1,7-bis[(4-methyl-2-quinazolinyl)methyl]-; 8-Bromo-3,7-dihydro-3-methyl-1,7-bis[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione. CAS No. 2138392-83-1. Pack Sizes: 10 mg. Product ID: B2694-473825. Molecular formula: C26H21BrN8O2. Mole weight: 557.41. Custom synthesis is available. Send your inquiries for more information.
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Linagliptin Methyldimer
An impurity of Linagliptin, a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes. Group: Pharmaceutical. Alternative Names: 8-[(3R)-3-Amino-1-piperidinyl]-1-[[4-[[2-[[8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl)-2,3,6,7-tetrahydro-3-methyl-2,6-dioxo-1H-purin-1-yl]methyl]-1,4-dihydro-4-methyl-4-quinazolinyl]methyl]-2-quinazolinyl]methyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione; 8-((R)-3-Aminopiperidin-1-yl)-1-((4-((2-((8-((R)-3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)methyl)-4-methyl-1,4-dihydroquinazolin-4-yl)methyl)quinazolin-2-yl)methyl)-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione; Linagliptin Dimer Impurity. CAS No. 1418133-47-7. Pack Sizes: 10 mg. Product ID: B2694-473827. Molecular formula: C50H56N16O4. Mole weight: 945.08. Custom synthesis is available. Send your inquiries for more information.
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Linagliptin N-Boc Impurity
An impurity of Linagliptin. Linagliptin is a dipeptidyl peptidase-4 inhibitor with a hpyerglycemic activity. It was approved for the treatment of diabetes mellitus type 2. Group: Pharmaceutical. Alternative Names: Linagliptin Related Compound B, N-[(3R)-1-[7-(2-butyn-1-yl)-2,3,6,7-tetrahydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-2,6-dioxo-1H-purin-8-yl]-3-piperidinyl]-carbamic Acid 1,1-Dimethylethyl Ester. CAS No. 668273-75-4. Pack Sizes: 50 mg. Product ID: B0012-007234. Molecular formula: C30H36N8O4. Mole weight: 572.67. Custom synthesis is available. Send your inquiries for more information.
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MPO-IN-28
MPO-IN-28 is a myeloperoxidase (MPO) inhibitor with IC50 of 44 nM. Group: Pharmaceutical. Alternative Names: GNF-Pf-3346; 1-(7-methoxy-4-methylquinazolin-2-yl)guanidine; (7-methoxy-4-methyl-quinazolin-2-yl)-guanidine. CAS No. 37836-90-1. Pack Sizes: 50 mg. Product ID: B1370-381586. Molecular formula: C11H13N5O. Mole weight: 231.25. Custom synthesis is available. Send your inquiries for more information.
6-Iodo-N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]quinazolin-4-amine is a chemical compound employed in the synthesis of novel anticancer agents that selectively modulate pivotal signaling cascades crucial for malignant cell growth and viability, exhibiting notable efficacy against diverse malignancies such as lung carcinoma and breast adenocarcinoma. Group: Pharmaceutical. CAS No. 231278-20-9. Pack Sizes: 1mg;1g;10g. Product ID: NP3186. Molecular formula: C21H14ClFIN3O. Mole weight: 505.71. Custom synthesis is available. Send your inquiries for more information.
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide is an impurity of Afatinib, which is a tyrosine kinase inhibitor used to treat non-small cell lung carcinoma (NSCLC). Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-; (S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. CAS No. 439081-18-2. Pack Sizes: 500 mg. Product ID: B0084-092426. Molecular formula: C24H25ClFN5O3. Mole weight: 485.94. Custom synthesis is available. Send your inquiries for more information.
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NCB-0846
NCB-0846 is an orally available, first-in-class TNIK inhibitor (IC50 = 21?nM) and shows marked anti-tumour and anti-CSC activities. Group: Pharmaceutical. Alternative Names: NCB-0846; NCB 0846; NCB0846; 4-[2-(3H-benzimidazol-5-ylamino)quinazolin-8-yl]oxycyclohexan-1-ol. CAS No. 1792999-26-8. Pack Sizes: 100 mg. Product ID: B0084-007723. Molecular formula: C21H21N5O2. Mole weight: 375.42. Custom synthesis is available. Send your inquiries for more information.
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Olcegepant
Olcegepant is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide (CGRP) receptor, primarily explored for the prevention of migraines in adults. CGRP is a neuropeptide that plays a significant role in migraine pathophysiology, and its receptors are found in the trigeminal ganglion and the central nervous system. By blocking the CGRP receptor, olcegepant aims to prevent the activation of pain pathways associated with migraines. Group: Pharmaceutical. Alternative Names: BIBN-4096; BIBN4096; BIBN 4096; BIBN-4096BS; BIBN4096BS; BIBN 4096BS; N-((R)-1-(((S)-6-Amino-1-oxo-1-(4-(pyridin-4-yl)piperazin-1-yl)hexan-2-yl)amino)-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxopropan-2-yl)-4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carboxamide; 1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-piperazine. CAS No. 204697-65-4. Pack Sizes: 10 mg. Product ID: B0084-441440. Molecular formula: C38H47Br2N9O5. Mole weight: 869.65. Custom synthesis is available. Send your inquiries for more information.
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Prazosin-[d8]
An isotope labelled Prazosin. Prazosin is an inverse agonist at alpha-1 adrenergic receptor. Prazosin is a sympatholytic drug used to treat high blood pressure, anxiety, and posttraumatic stress disorder (PTSD). Group: Pharmaceutical. Alternative Names: 4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl-d8]-2-furanylmethanone; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonxyl) piperazine-d8; Adversuten-d8; Adverszuten-d8; Alpress LP-d8; Furazosin-d8; Lentopres-d8; NSC 292810-d8; Peripress-d8. CAS No. 1006717-55-0. Pack Sizes: 1 mg. Product ID: BLP-013106. Molecular formula: C19H13D8N5O4. Mole weight: 391.46. Custom synthesis is available. Send your inquiries for more information.
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Rafigrelide
Rafigrelide is a platelet aggregation inhibitor, which plays a central role in atherothrombotic events. It could prolonge clot formation time and reduce clot strength. Uses: Rafigrelide plays a central role in atherothrombotic events. Group: Pharmaceutical. Alternative Names: 6,7-Dichloro-3,3-dimethyl-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one;6,7-Dichloro-3,3-dimethyl-5,10-dihydroimidazo[2,1-b]quinazolin-2-one. CAS No. 1029711-88-3. Pack Sizes: 5 mg. Product ID: B0084-474985. Molecular formula: C12H11Cl2N3O. Mole weight: 284.14. Custom synthesis is available. Send your inquiries for more information.
London
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