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| Product | Description | |
|---|---|---|
| Pyrazine-2-carbonitrile (2-Cyanopyrazine) | 100g Pack Size. Group: Building Blocks, Organics, Pyrazines. Formula: C5H3N3. CAS No. 19847-12-2. Prepack ID : 20080479-100g. Molecular Weight : 105.1. |  |
| Pyrazine, 99% | 25g Pack Size. Group: Organics, Reagents, Research Organics & Inorganics. Formula: C4H4N2. CAS No. 290-37-9. Prepack ID : 90030980-25g. Molecular Weight : 80.09. | |
| 2,3-Pyrazinecarboxylic anhydride | 5g Pack Size. Group: Building Blocks, Organics. Formula: C6H2N2O3. CAS No. 4744-50-7. Prepack ID : 89988369-5g. Molecular Weight : 150.09. | |
| 2,5-Pyrazinedicarboxylic Acid | 2,5-Pyrazinedicarboxylic Acid (CAS# 122-05-4) is a useful research chemical. Group: Pharmaceutical. Alternative Names: pyrazine-2,5-dicarboxylic acid; pyrazine-2,5-dicarboxylic acid. CAS No. 122-05-4. Pack Sizes: 100 g. Product ID: BB005330. Molecular formula: C6H4N2O4. Mole weight: 168.11. Custom synthesis is available. Send your inquiries for more information. |  London |
| 2-Ethyl-3,5-dimethylpyrazine | 2-Ethyl-3,5-dimethylpyrazine. Group: Pharmaceutical. Alternative Names: Pyrazine, 2-ethyl-3,5-dimethyl-; 2,6-Dimethyl-3-ethylpyrazine; 3,5-Dimethyl-2-ethylpyrazine; 3-Ethyl-2,6-dimethylpyrazine. CAS No. 13925-07-0. Pack Sizes: 100 mg. Product ID: B1370-058249. Molecular formula: C8H12N2. Mole weight: 136.19. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Ethyl-3,6-dimethylpyrazine | 2-Ethyl-3,6-dimethylpyrazine, a flavoring constituent prevalently utilized in the food domain, exudes a roasted, nutty relish, and is frequently detected in baked items, meaty comestibles, and piquant munchies. Furthermore, its potential as an antioxidizing and anti-inflammatory agent in treating sundry diseases has captivated scientific examination. Group: Pharmaceutical. Alternative Names: Pyrazine, 3-ethyl-2,5-dimethyl-; 2,5-dimethyl-3-ethylpyrazine. CAS No. 13360-65-1. Pack Sizes: 100 mg. Product ID: B1370-048490. Molecular formula: C8H12N2. Mole weight: 136.19. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Ethyl-5-methylpyrazine | 2-Ethyl-5-methylpyrazine, a well-known pyrazine derivative, has garnered immense attention from the food and fragrance industries owing to its distinctive nutty and roasted scent profile. Intriguingly, current research has also highlighted the possible therapeutic benefits of this compound in managing neurodegenerative afflictions such as Alzheimer's, further reinforcing its versatile bioactivity. Group: Pharmaceutical. Alternative Names: Pyrazine, 2-ethyl-5-methyl-; 5-ethyl-2-methylpyrazine; 2-Methyl-5-ethylpyrazine. CAS No. 13360-64-0. Pack Sizes: 100 mg. Product ID: B1370-386657. Molecular formula: C7H10N2. Mole weight: 122.17. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Isopropyl-5-methylpyrazine | 2-Isopropyl-5-methylpyrazine (CAS# 13925-05-8 ) is a useful research chemical. Group: Pharmaceutical. Alternative Names: Femano.3919; 5-isopropyl-2-methylpyrazine; 2-methyl-5-(1-methylethyl)-pyrazine; Pyrazine, 2-methyl-5-(1-methylethyl)-; 5-isopropyl-2-methylpyrazine; 2-methyl-5-isopropylpyrazine; 2-methyl-5-propan-2-yl-pyrazine. CAS No. 13925-05-8. Pack Sizes: 100 mg. Product ID: B2699-083772. Molecular formula: C8H12N2. Mole weight: 136.19. Custom synthesis is available. Send your inquiries for more information. | London |
| 5-Methylpyrazine-2-carboxylic acid | 100g Pack Size. Group: Building Blocks, Organics, Pyrazines. Formula: C6H6N2O2. CAS No. 5521-55-1. Prepack ID : 30353495-100g. Molecular Weight : 138.12. | |
| 5-Methylpyrazine-2-carboxylic acid | 25g Pack Size. Group: Building Blocks, Organics, Pyrazines. Formula: C6H6N2O2. CAS No. 5521-55-1. Prepack ID : 30353495-25g. Molecular Weight : 138.12. | |
| SCR7 pyrazine | SCR7 pyrazine is a DNA Ligase IV inhibitor. SCR7 pyrazine has been shown to potentiate CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold, and inhibits nonhomologous end-joining (NHEJ). Group: Pharmaceutical. Alternative Names: SCR7 pyrazine; SCR-7 pyrazine; SCR 7 pyrazine; 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone; 2-mercapto-6,7-diphenylpteridin-4-ol; 6,7-diphenyl-2-sulfanylpteridin-4-ol. CAS No. 14892-97-8. Pack Sizes: 100 mg. Product ID: B2693-170606. Molecular formula: C18H12N4OS. Mole weight: 332.38. Custom synthesis is available. Send your inquiries for more information. | London |
| BAM 15 | BAM 15 is a novel mitochondrial protonophore uncoupler that uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). BAM 15 cannot depolarize the plasma membrane, and protects mice from acute renal ischemic-reperfusion injury. BAM 15 has the potential to treat obesity, Parkinson's disease, and aging. Group: Pharmaceutical. Alternative Names: BAM15; BAM-15; N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine; N-[6-(2-Fluoroanilino)[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl]-N-(2-fluorophenyl)amine. CAS No. 210302-17-3. Pack Sizes: 100 mg. Product ID: B1370-119162. Molecular formula: C16H10F2N6O. Mole weight: 340.29. Custom synthesis is available. Send your inquiries for more information. | London |
| Bortezomib | Bortezomib is a potent, reversible and selective 20S proteasome inhibitor with a Ki of 0.6 nM. It is an antineoplastic agent that is used in treatment of refractory multiple myeloma and certain lymphomas. Group: Pharmaceutical. Alternative Names: PS-341; PS 341; PS341; LDP 341; LDP-341; LDP341; MLN341; MLN-341; MLN 341; B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; Velcade; ((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid; N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(2-pyrazinylcarbonyl)-L-phenylalaninamide. CAS No. 179324-69-7. Pack Sizes: 1 g. Product ID: BBF-05860. Molecular formula: C19H25BN4O4. Mole weight: 384.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Bortezomib Impurity (R,S-Isomer) | Bortezomib Impurity (R,S-Isomer) is a diastereomer of Bortezomib. Group: Pharmaceutical. Alternative Names: (1S,2R)-Bortezomib; B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; N-(2-Pyrazinecarbonyl)-D-phenylalanine-D-leucine boronic anhydride. CAS No. 1132709-16-0. Pack Sizes: 50 mg. Product ID: B2694-467635. Molecular formula: C19H25BN4O4. Mole weight: 384.25. Custom synthesis is available. Send your inquiries for more information. | London |
| Bortezomib USP Impurity G | Bortezomib USP Impurity G is an isomer of Bortezomib. It has been demonstrated to inhibit serine proteases shown to lower cellular Aβ concentrations, associated with Alzheimer's or hypertension. Group: Pharmaceutical. Alternative Names: (1S,2S)-Bortezomib; ((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid. CAS No. 1132709-14-8. Pack Sizes: 10 mg. Product ID: B0103-467636. Molecular formula: C19H25BN4O4. Mole weight: 384.243. Custom synthesis is available. Send your inquiries for more information. | London |
| Bortezomib USP Related Compoud B | Bortezomib USP Related Compoud B is an impurity of the acclaimed drug Bortezomib, which is a drug tailored towards the affliction of multiple myeloma. Group: Pharmaceutical. Alternative Names: Bortezomib Amide Impurity; N-[(1S)-2-Amino-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide; N-[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]pyrazinecarboxamide; (S)-N-(1-AMino-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide. CAS No. 289472-80-6. Pack Sizes: 100 mg. Product ID: B1370-150142. Molecular formula: C14H14N4O2. Mole weight: 270.29. Custom synthesis is available. Send your inquiries for more information. | London |
| CYCLO(-GLY-GLN) | CYCLO(-GLY-GLN) is a peptide composed of cyclic glycine (Gly) and glutamine (Gln) residues. Research suggests that CYCLO(-GLY-GLN) shows promising activity against certain diseases, particularly in the research of cancer, neurodegenerative disorders and metabolic diseases. Group: Pharmaceutical. Alternative Names: Cyclo(-Gly-Gln); (S)-3-(3,6-Dioxopiperazin-2-Yl)Propanamide; (2S)-Hexahydro-3,6-Dioxo-Pyrazinepropanamide; 2-Piperazinepropanamide, 3,6-Dioxo-, (S)-. CAS No. 52662-00-7. Pack Sizes: 1mg;1g;10g. Product ID: BAT-008052. Molecular formula: C7H11N3O3. Mole weight: 185.18. Custom synthesis is available. Send your inquiries for more information. | London |
| Cyclo(L-Ala-L-Pro) | Cyclo(L-Ala-L-Pro) is a cyclodipeptide found in Phellinus igniarius. Cyclo(L-Ala-L-Pro) exhibits an inhibitory effect on Aflatoxin Production of Aspergillus flavus. Group: Pharmaceutical. Alternative Names: Cyclo(alanylprolyl); cyclo(prolylalanyl); Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-methyl-, (3S,8aS)-; Cyclo-(L-alanine-L-proline); cyclo(Pro-Ala); L-Prolyl-L-alaninediketopiperazine. CAS No. 36357-32-1. Pack Sizes: 10 mg. Product ID: BBF-04407. Molecular formula: C8H12N2O2. Mole weight: 168.19. Custom synthesis is available. Send your inquiries for more information. | London |
| EIPA | EIPA is a TRPP3 channel inhibitor (IC50 = 10.5 μM). EIPA also acts as an Na+/H+ exchange inhibitor that suppresses the Na+/H+ exchanger (NHE). Uses: Epithelial sodium channel blockers. Group: Pharmaceutical. Alternative Names: Ethylisopropylamiloride; L 593754; MH 12-43; 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide. CAS No. 1154-25-2. Pack Sizes: 50 mg. Product ID: B2693-047130. Molecular formula: C11H18ClN7O. Mole weight: 299.76. Custom synthesis is available. Send your inquiries for more information. | London |
| EIPA hydrochloride | EIPA is a TRPP3 channel inhibitor (IC50 = 10.5 μM). EIPA also acts as an Na+/H+ exchange inhibitor that suppresses the Na+/H+ exchanger (NHE). Group: Pharmaceutical. Alternative Names: L593754 hydrochloride; L 593754 hydrochloride; L-593754 hydrochloride; Ethylisopropylamiloride hydrochloride; MH 12-43 hydrochloride; 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide hydrochloride. CAS No. 1345839-28-2. Pack Sizes: 250 mg. Product ID: B2693-334168. Molecular formula: C11H19Cl2N7O. Mole weight: 336.22. Custom synthesis is available. Send your inquiries for more information. | London |
| Favipiravir | Favipiravir, also known as T-705 or Avigan, is an experimental antiviral drug being developed by Toyama Chemical of Japan with activity against many RNA viruses. Like some other experimental antiviral drugs (T-1105 and T-1106), it is a pyrazinecarboxamide derivative. Favipiravir is active against influenza viruses, West Nile virus, yellow fever virus, foot-and-mouth disease virus as well as other flaviviruses, arenaviruses, bunyaviruses and alphaviruses. Activity against enteroviruses and Rift Valley fever virus has also been demonstrated. Group: Pharmaceutical. Alternative Names: T-705; avigan; 6-Fluoro-3-hydroxypyrazine-2-carboxamide. CAS No. 259793-96-9. Pack Sizes: 1 g. Product ID: B0084-463609. Molecular formula: C5H4FN3O2. Mole weight: 157.1. Custom synthesis is available. Send your inquiries for more information. | London |
| Gilteritinib | Gilteritinib, also known as (ASP2215, is a potent FLT3/AXL inhibitor, which showed potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations. In invitro, among the 78 tyrosine kinases tested, ASP2215 inhibited FLT3, LTK, ALK, and AXL kinases by over 50% at 1 nM with an IC50 value of 0.29 nM for FLT3, approximately 800-fold more potent than for c-KIT, the inhibition of which is linked to a potential risk of myelosuppression. ASP2215 inhibited the growth of MV4-11 cells, which harbor FLT3-ITD, with an IC50 value of 0.92 nM, accompanied with inhibition of pFLT3, pAKT, pSTAT5, pERK, and pS6. ASP2215 decreased tumor burden in bone marrow and prolonged the survival of mice intravenously transplanted with MV4-11 cells. ASP2215 may have potential use in treating AML. Group: Pharmaceutical. Alternative Names: ASP2215; ASP-2215; ASP 2215; Xospata; Gilteritinibum; 6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide; 6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide. CAS No. 1254053-43-4. Pack Sizes: 100 mg. Product ID: B0084-462531. Molecular formula: C29H44N8O3. Mole weight: 552.71. Custom synthesis is available. Send your inquiries for more information. | London |
| Glipizide | Glipizide is an oral rapid- and short-acting anti-diabetic drug from the sulfonylurea class. Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. Uses: Hypoglycemic agents. Group: Pharmaceutical. Alternative Names: 2-Pyrazinecarboxamide, N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl-; N-[2-[4-[[[(Cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl-2-pyrazinecarboxamide; Pyrazinecarboxamide, N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl-; Urea, 1-cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]-; Aldiab; CP 28720; Digrin; Dipazide; Glibenese; Glibetin; Glican; Glidiab; Glipid; Glipizid; Gluco-Rite; Glucolip; Glucotrol; Glucotrol Xl; Glucozide; Glupitel; Glupizide; Glyde; Glydiazinamide; Glynase; K 4024; Melizide; Mindiab; Minidab; Minidiab; Minodiab; N-(4-[β-(5-Methylpyrazine-2-carboxamido)ethyl]benzenesulfonyl)-N'-cyclohexylurea; Napizide; Ozidia; Samarium(III) ionophore I; Semiglynase; Sucrazide; TK 1320. CAS No. 29094-61-9. Pack Sizes: 50 g. Product ID: B2692-089502. Molecular formula: C21H27N5O4S. Mole weight: 445.54. Custom synthesis is available. Send your inquiries for more information. | London |
| L-Pyroglutamic Anhydride | An impurity of Pidotimod which is a synthetic dipeptide molecule with biological and immunological activity on both the adaptive and the innate immune responses. Group: Pharmaceutical. Alternative Names: (5aS,10aS)-Tetrahydrodipyrrolo[1,2-a:1',2'-d]pyrazine-3,5,8,10(2H,5aH)-tetraone; (5aS,10aS)-tetrahydro-3H,5H-dipyrrolo[1,2-a:1',2'-d]pyrazine-3,5,8,10(2H,5aH)-tetraone. CAS No. 14842-41-2. Pack Sizes: 500 mg. Product ID: B1370-103506. Molecular formula: C10H10N2O4. Mole weight: 222.2. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Acetyl Sitagliptin | N-Acetyl Sitagliptin is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Group: Pharmaceutical. Alternative Names: 7-[(3R)-3-[(N-Acetyl)Amino]-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine; N-[(2R)-4-Oxo-4-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-1-(2,4,5-trifluorophenyl)butan-2-yl]acetamide. CAS No. 1379666-94-0. Pack Sizes: 50 mg. Product ID: B2694-479646. Molecular formula: C18H17F6N5O2. Mole weight: 449.35. Custom synthesis is available. Send your inquiries for more information. | London |
| Naquotinib | Naquotinib is an irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity with IC50 of 8-33 nM toward EGFR mutants. Group: Pharmaceutical. Alternative Names: ASP 8273; ASP8273; ASP-8273; (R)-5-((1-acryloylpyrrolidin-3-yl)oxy)-6-ethyl-3-((4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazine-2-carboxamide. CAS No. 1448232-80-1. Pack Sizes: 5 mg. Product ID: B0084-475727. Molecular formula: C30H42N8O3. Mole weight: 562.719. Custom synthesis is available. Send your inquiries for more information. | London |
| Pedatisectine F | Pedatisectine F is an alkaloid isolated from the tubers of Pinellia pedatisecta Schott. Group: Pharmaceutical. Alternative Names: 2-Methyl-6-(1,2,3,4-tetrahydroxybutyl)pyrazine; 1-(6-Methyl-2-pyrazinyl)-1,2,3,4-butanetetrol. CAS No. 206757-32-6. Pack Sizes: 5 mg. Product ID: NP0125. Molecular formula: C9H14N2O4. Mole weight: 214.221. Custom synthesis is available. Send your inquiries for more information. | London |
| Pidotimod Impurity Y | An impurity of Pidotimod which is an immunomodulator. Group: Pharmaceutical. Alternative Names: Pidotimod Impurity Y; 161771-76-2; 1H,3H,5H-pyrrolo[1,2-a]thiazolo[3,4-d]pyrazine5,8,10(5aH,10aH)-trione,dihydro-; Dihydro-1H-pyrrolo[1,2-a]thiazolo[3,4-d]pyrazine-5,8,10(3H,5aH,10aH)-trione; 5-thia-1,7-diazatricyclo[7.3.0.03,7]dodecane-2,8,12-trione; tetrahydro-3H,5H,10H-pyrrolo[1,2-a]thiazolo[3,4-d]pyrazine-5,8,10(5aH)-trione; Pidotimod Diketopiperazine; DTXSID801137585; BCP33578; Dihydro-1H,3H,5H-pyrrolo[1,2-a]thiazolo[3,4-d]pyrazine-5,8,10(5aH,10aH)-trione; F78340; J-009858; 5-thia-1,7-diazatricyclo[7.3.0.0,dodecane-2,8,12-trione; 5-THIA-1,7-DIAZATRICYCLO[7.3.0.0(3),?]DODECANE-2,8,12-TRIONE; Pidotimod Diketopiperazine; 5-Thia-1,7-diazatricyclo[7.3.0.03,7]dodecane-2,8,12-trione. CAS No. 161771-76-2. Pack Sizes: 50 mg. Product ID: B0015-461894. Molecular formula: C9H10N2O3S. Mole weight: 226.26. Custom synthesis is available. Send your inquiries for more information. | London |
| Pyrazinamide | Pyrazinamide is a pyrazine that is used therapeutically as an antitubercular agent. It is a prodrug that stops the growth of Mycobacterium tuberculosis. It is thought to inhibit the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids although this has been discounted. It binds to the ribosomal protein S1 (RpsA) and inhibits trans-translation. Group: Pharmaceutical. Alternative Names: Pyrazinecarboxamide; Pyrazinoic acid amide; 2-Pyrazinecarboxamide; Zinamide; Aldinamide; Tebrazid; Pirazinamid; Unipyranamide; Farmizina; Eprazin; Novamid. CAS No. 98-96-4. Pack Sizes: 1mg;1g;10g. Product ID: BBF-04531. Molecular formula: C5H5N3O. Mole weight: 123.11. Custom synthesis is available. Send your inquiries for more information. | London |
| Pyrazinamide-[d3] | Pyrazinamide-[d3] is the labelled analogue of Pyrazinamide. Pyrazinamide is a medication used to treat tuberculosis. Group: Pharmaceutical. Alternative Names: Pyrazinamide D3; Pyrazinecarboxamide-d3; Pyrazinamide-3,5,6-d3. CAS No. 1432059-16-9. Pack Sizes: 100 mg. Product ID: BLP-012544. Molecular formula: C5H2D3N3O. Mole weight: 126.13. Custom synthesis is available. Send your inquiries for more information. | London |
| Rac-Sitagliptin | Rac-Sitagliptin is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Uses: Dipeptidyl-peptidase iv inhibitors. Group: Pharmaceutical. Alternative Names: Sitagliptin Raccemate; Sitagliptin impurity E; 7-[3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine; 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine. CAS No. 823817-56-7. Pack Sizes: 50 mg. Product ID: B2693-211737. Molecular formula: C16H15F6N5O. Mole weight: 407.31. Custom synthesis is available. Send your inquiries for more information. | London |
| Rac-Vildagliptin Impurity F | An impurity of Vildagliptin. Vildagliptin is a new dipeptidyl peptidase-4 (DPP-4) inhibitor that is used as an anti-hyperglycemic agent. Vildagliptin could reduce hyperglycemia in type 2 diabetes mellitus via the suppressive effect of inactivation of GLP-1 and GIP by DPP-4. Group: Pharmaceutical. Alternative Names: Vildagliptin Impurity C (IP); Vildagliptin Related Compound 3; Vildagliptin Lactam; 2-(3-Hydroxy-adamant-1-yl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione; Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-; Hexahydro-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)pyrrolo[1,2-a]pyrazine-1,4-dione; 2-(3-Hydroxyadamantan-1-yl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione. CAS No. 1789703-36-1. Pack Sizes: 10 mg. Product ID: B2694-485167. Molecular formula: C17H24N2O3. Mole weight: 304.39. Custom synthesis is available. Send your inquiries for more information. | London |
| R)-(+)-Piperazine-2-carboxylic acid dihydrochloride | 5g Pack Size. Group: Building Blocks, Chiral Compounds, Pyrazines. Formula: C5H12Cl2N2O2. CAS No. 126330-90-3. Prepack ID : 11959793-5g. Molecular Weight : 203.07. | |
| Sitagliptin | Sitagliptin (MK 0431) is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is used as a hypoglycemic agent to treat type 2 diabetes. Uses: The treatment of type 2 diabetes. Group: Pharmaceutical. Alternative Names: 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine; MK0431; Xelevia; Januvia; Tesavel; NSC813215; (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone; 1,2,4-triazolo[4,3-a]pyrazine-7(8H)-propanamine, 5,6-dihydro-γ-oxo-3-(trifluoromethyl)-α-[(2,4,5-trifluorophenyl)methyl]-, (αR)-. CAS No. 486460-32-6. Pack Sizes: 500 mg. Product ID: BBF-05866. Molecular formula: C16H15N5OF6. Mole weight: 407.31. Custom synthesis is available. Send your inquiries for more information. | London |
| Sitagliptin EP Impurity A Phosphate | Sitagliptin EP Impurity A Phosphate is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Group: Pharmaceutical. Alternative Names: Sitagliptin S-Isomer Phosphate; ent-Sitagliptin Phosphate; (S)-Sitagliptin Phosphate; 7-[(3S)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Phosphate. CAS No. 823817-58-9. Pack Sizes: 100 mg. Product ID: B0017-479659. Molecular formula: C16H15F6N5O.H3PO4. Mole weight: 505.31. Custom synthesis is available. Send your inquiries for more information. | London |
| Sitagliptin Phosphate Monohydrate | Sitagliptin Phosphate Monohydrate is the phosphate salt form of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Group: Pharmaceutical. Alternative Names: MK-0431 phosphate monohydrate; 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate monohydrate. CAS No. 654671-77-9. Pack Sizes: 100 g. Product ID: B2692-335254. Molecular formula: C16H20F6N5O6P. Mole weight: 523.32. Custom synthesis is available. Send your inquiries for more information. | London |
| Spirotryprostatin A | Spirotryprostatin A is an indole alkaloid found in Aspergillus fumigatus fungus, which exhibits anti-mitotic activity. Group: Pharmaceutical. Alternative Names: Spiro[5H,10H-dipyrrolo[1,2-a:1',2'-d]pyrazine-2(3H),3'-[3H]indole]-2',5,10(1'H)-trione, 1,5a,6,7,8,10a-hexahydro-6'-methoxy-3-(2-methyl-1-propenyl)-, (2S,3S,5aS,10aS)-; (2S,3S,5aS,10aS)-1,5a,6,7,8,10a-Hexahydro-6'-methoxy-3-(2-methyl-1-propen-1-yl)spiro[5H,10H-dipyrrolo[1,2-a:1',2'-d]pyrazine-2(3H),3'-[3H]indole]-2',5,10(1'H)-trione; (-)-Spirotryprostatin A; (3S,3'S,5'aS,10'aS)-6-Methoxy-3'-(2-methylprop-1-enyl)spiro[1H-indole-3,2'-3,5a,6,7,8,10a-hexahydro-1H-dipyrrolo[1,2-c:1',4'-f]pyrazine]-2,5',10'-trione. CAS No. 182234-25-9. Pack Sizes: 1 mg. Product ID: BBF-04375. Molecular formula: C22H25N3O4. Mole weight: 395.45. Custom synthesis is available. Send your inquiries for more information. | London |
| (S,R)-Bortezomib Hydroxyisopentyl Amide Analog | (S,R)-Bortezomib Hydroxyisopentyl Amide Analog is an isomer of Bortezomib. It has been demonstrated to inhibit serine proteases shown to lower cellular Aβ concentrations, associated with Alzheimer's or hypertension. Group: Pharmaceutical. Alternative Names: N-((S)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide; (R)-Hydroxy Des(boric Acid) Bortezomib; Bortezomib Hydroxy Impurity (1R,2S)-Isomer. CAS No. 289472-78-2. Pack Sizes: 25 mg. Product ID: B1370-150146. Molecular formula: C19H24N4O3. Mole weight: 356.43. Custom synthesis is available. Send your inquiries for more information. | London |
| Tadalafil EP Impurity I | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Group: Pharmaceutical. Alternative Names: Tadalafil Spiro-oxindole Impurity; (8a'R)-6'-(1,3-Benzodioxol-5-yl)-2'-methyl-2',3',8',8a'-tetrahydro-6'H-spiro[indole-3,7'-pyrrolo[1,2-a]pyrazine]-1',2,4'(1H)-trione. CAS No. 1795790-92-9. Pack Sizes: 10 mg. Product ID: B2694-482887. Molecular formula: C22H19N3O5. Mole weight: 405.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Tryprostatin A | Tryprostatin A is a natural compound isolated from Aspergillus fumigatus and arrests cell cycle progression at the G2/M phase. Group: Pharmaceutical. Alternative Names: (3S,8aS)-3-{[6-methoxy-2-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl}hexahydropyrrolo[1,2-a]pyrazine-1,4-dione. CAS No. 171864-80-5. Pack Sizes: 1 mg. Product ID: BBF-03425. Molecular formula: C22H27N3O3. Mole weight: 381.47. Custom synthesis is available. Send your inquiries for more information. | London |
| 6S,12S-Tadalafil | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Group: Pharmaceutical. Alternative Names: ent-Tadalafil; Tadalafil USP Impurity B; (6S,12aS)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; L-Tadalafil; L-Tildenafil. CAS No. 629652-72-8. Pack Sizes: 25 mg. Product ID: B2694-263979. Molecular formula: C22H19N3O4. Mole weight: 389.41. Custom synthesis is available. Send your inquiries for more information. | London |
| 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine | 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine is used to prepare varenicline, which is a smoking cessation. Varenicline is a nicotinic receptor partial agonist. Group: Pharmaceutical. Alternative Names: 2,2,2-Trifluoro-1-(6,7,9,10-tetrahydro-6,10-methano-8H-pyrazino[2,3-h][3]benzazepin-8-yl)ethanone; 1-(9,10-Dihydro-6H-6,10-methanoazepino[4,5-g]quinoxalin-8(7H)-yl)-2,2,2-trifluoroethanone; 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine,7,8,9,10-tetrahydro-8-(trifluoroacetyl)-(9CI); Varenicline Impurity 16. CAS No. 230615-70-0. Pack Sizes: 50 mg. Product ID: B2694-014620. Molecular formula: C15H12F3N3O. Mole weight: 307.27. Custom synthesis is available. Send your inquiries for more information. | London |
| ABC34 | ABC34 is an inactive control probe for JJH260 , the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). Group: Pharmaceutical. Alternative Names: 1,3-dioxo-7-(4-phenoxybenzyl)hexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-methoxyphenyl)piperazine-1-carboxylate. CAS No. 1831135-56-8. Pack Sizes: 1mg;1g;10g. Product ID: 1831135-56-8. Molecular formula: C31H33N5O6. Mole weight: 571.6. Custom synthesis is available. Send your inquiries for more information. | London |
| ABT-639 hydrochloride | ABT-639 hydrochloride is a peripherally acting and selective T-type calcium channel blocker. Group: Pharmaceutical. Alternative Names: 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylcarbonyl]benzenesulfonamide hydrochloride (1:1); Benzenesulfonamide, 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-, hydrochloride (1:1). CAS No. 1235560-31-2. Pack Sizes: 1mg;1g;10g. Product ID: 1235560-31-2. Molecular formula: C20H21Cl2F2N3O3S. Mole weight: 492.37. Custom synthesis is available. Send your inquiries for more information. | London |
| Acalabrutinib | Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Group: Pharmaceutical. Alternative Names: ACP-196; ACP196; ACP 196; Acalabrutinib; 4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide. CAS No. 1420477-60-6. Pack Sizes: 250 mg. Product ID: B0084-470855. Molecular formula: C26H23N7O2. Mole weight: 465.52. Custom synthesis is available. Send your inquiries for more information. | London |
| Acalabrutinib-[d4] | Acalabrutinib-[d4] is a labelled version of Acalabrutinib. Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Group: Pharmaceutical. Alternative Names: (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl-d4)benzamide; Acalabrutinib D4; Acalabrutinib-d4; 4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide-d4; ACP 196-d4; Calquence-d4. CAS No. 2699608-18-7. Pack Sizes: 5 mg. Product ID: BLP-003188. Molecular formula: C26H19D4N7O2. Mole weight: 469.53. Custom synthesis is available. Send your inquiries for more information. | London |
| Bortezomib Impurity (R,R-Isomer) | Bortezomib Impurity (R,R-Isomer) is a diastereomer of Bortezomib. Group: Pharmaceutical. Alternative Names: (1R,2R)-Bortezomib; B-[(1R)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; [(1R)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid. CAS No. 1132709-15-9. Pack Sizes: 25 mg. Product ID: B2694-467634. Molecular formula: C19H25BN4O4. Mole weight: 384.25. Custom synthesis is available. Send your inquiries for more information. | London |
| CC-223 | CC-223, a mTOR kinase inhibitor, has been found to be effective in inducing the apoptosis and reducing the proliferation of tumor cells. It is still under Phase I/II clinical trial by Celgene Corporation. IC50: 16 nM. Uses: Cc-223 is a mtor kinase inhibitor that has been found to be effective in inducing the apoptosis and reducing the proliferation of tumor cells. Group: Pharmaceutical. Alternative Names: CC-223; CC 223; CC223; UNII-I8RA3543SY; I8RA3543SY; 7-(6-(2-Hydroxypropan-2-yl)pyridin-3-yl)-1-(trans-4-methoxycyclohexyl)-3,4-dihydropyrazino(2,3-b)pyrazin-2(1H)-one; 7-(6-(2-Hydroxypropan-2-yl)pyridin-3-yl)-1-(trans-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyraz. CAS No. 1228013-30-6. Pack Sizes: 300 mg. Product ID: B0084-474093. Molecular formula: C21H27N5O3. Mole weight: 397.47. Custom synthesis is available. Send your inquiries for more information. | London |
| Coelenterazine | Coelenterazine is a luciferin that serves as a substrate for luciferases. Coelenterazine can be used for probing superoxide anion and aequorin assays. Coelenterazine is also used to detect Ca2+ concentration in cells that have been transfected with apoaequorin cDNA. Group: Pharmaceutical. Alternative Names: 2-(4-Hydroxybenzyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo(1,2-a)pyrazin-3-one. CAS No. 55779-48-1. Pack Sizes: 100 mg. Product ID: B1370-375048. Molecular formula: C26H21N3O3. Mole weight: 423.46. Custom synthesis is available. Send your inquiries for more information. | London |
| Defactinib | Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. The tyrosine kinase FAK is , a signal transducer for integrins that is upregulated in many tumor cell types and is involved in tumor cell invasion, migration and proliferation. Group: Pharmaceutical. Alternative Names: N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide; VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878. CAS No. 1073154-85-4. Pack Sizes: 200 mg. Product ID: B0084-462762. Molecular formula: C20H21F3N8O3S. Mole weight: 510.496. Custom synthesis is available. Send your inquiries for more information. | London |
| Demethoxyfumitremorgin C | Demethoxyfumitremorgin C is a metabolite of Aspergillus fumigatus. Demethoxyfumitremorgin C acts as a fungal inhibitor of mammalian cell cycle progression at the G(2)/M transition. Group: Pharmaceutical. Alternative Names: (5aS,12S,14aS)-12-(2-methylprop-1-en-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione; (+)-Demethoxyfumitremorgin C; (5aS,12S,14aS)-12-(2-Methylprop-1-en-1-yl)-1,2,3,5a,6,14a-hexahydropyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14(11H,12H)-dione. CAS No. 111768-16-2. Pack Sizes: 1 mg. Product ID: BBF-04374. Molecular formula: C21H23N3O2. Mole weight: 349.43. Custom synthesis is available. Send your inquiries for more information. | London |
| Ditryptophenaline | Ditryptophenaline is an alkaloid metabolite of Aspergillus flavus. Ditryptophenaline exhibits potential analgesic and anti-inflammatory activities. It is a tachykinin antagonist. Group: Pharmaceutical. Alternative Names: (-)-ditryptophenaline; Chaetocin, 2,5:2',5'-dide(epidithio)-19,19'-dideoxy-19,19'-diphenyl-, (2'beta,5'alpha,7'S,15'beta)-; [10b,10'b-Bi-10bH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone, 2,2',3,3',5a,5'a,6,6',11,11',11a,11'a-dodecahydro-2,2'-dimethyl-3,3'-bis(phenylmethyl)-, (3S,3'S,5aS,5'aS,10bS,10'bS,11aS,11'aS)-. CAS No. 64947-43-9. Pack Sizes: 1 mg. Product ID: BBF-04373. Molecular formula: C42H40N6O4. Mole weight: 692.8. Custom synthesis is available. Send your inquiries for more information. | London |
| (D)-(+)-Neopterin | Neopterin, a pyrazino-pyrimidine compound derived from GTP, n is a precursor of tetrahydrobiopterin and can be used as a biochemical marker indicative of cell proliferation. Neopterin is synthesized in response to interferon-γ stimulation, and used as a marker of T helper cell-induced immune activation. Neopterin is also an indicator of oxidative stress, and modulates the effects of reactive oxygen species (ROS). Group: Pharmaceutical. Alternative Names: 2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone; Neopterin; 2-Amino-4-hydroxy-6-(1,2,3-trihydroxypropyl)pteridine; 2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)-4(8H)-pteridone; 6-D-erythro-Neopterin; D-(+)-Neopterin; D-erythro-Neopterin. CAS No. 2009-64-5. Pack Sizes: 100 mg. Product ID: B2693-070923. Molecular formula: C9H11N5O4. Mole weight: 253.21. Custom synthesis is available. Send your inquiries for more information. | London |
| (E)-KPT330 | (E)-Kpt-330 is an E-isomer of Kpt-330, also known as Selinexor, which is an orally available inhibitor of CRM1 with potential antineoplastic activity. Group: Pharmaceutical. Alternative Names: (E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide; Selinexor trans-isomer; KPT-330, (E)-; UNII-MVY2AE6R24; MVY2AE6R24; KPT330,(E)-; 2-Propenoic acid, 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-, 2-(2-pyrazinyl)hydrazide, (2E)-; 1421923-86-5 (E-isomer); KPT330Selinexor; O=C(NNC1=NC=CN=C1)/C=C/N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2; 2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2E)-; (E)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide. CAS No. 1421923-86-5. Pack Sizes: 25 mg. Product ID: B0084-284796. Molecular formula: C17H11F6N7O. Mole weight: 443.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Enalapril EP Impurity D | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Group: Pharmaceutical. Alternative Names: Enalapril diketopiperazine; Ethyl (2S)-2-[(3S,8aS)-3-methyl-1,4-dioxooctahydropyrrolo [1,2-a]pyrazin-2-yl]-4-phenylbutanoate. CAS No. 115729-52-7. Pack Sizes: 500 mg. Product ID: B2694-470980. Molecular formula: C20H26N2O4. Mole weight: 358.44. Custom synthesis is available. Send your inquiries for more information. | London |
| ETP-46321 | ETP-46321 is a potent and orally bioavailable PI3K α, δ inhibitor with potent biochemical and cellular activity and good pharmacokinetic properties (PK) after oral dosing. ETP-46321 PK/PD studies showed time dependent downregulation of AKT(Ser473) phosphorylation, which correlates with compound levels in tumor tissue and demonstrating to be efficacious in a GEMM mouse tumor model driven by a K-Ras(G12V) oncogenic mutation. Treatment with ETP-46321 resulted in significant tumor growth inhibition. Group: Pharmaceutical. Alternative Names: ETP46321; ETP-46321; ETP 46321; 5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine. CAS No. 1252594-99-2. Pack Sizes: 300 mg. Product ID: B0084-462342. Molecular formula: C20H27N9O3S. Mole weight: 473.556. Custom synthesis is available. Send your inquiries for more information. | London |
| Furimazine | Furimazine is an imidazopyrazinone substrate and a Coelenterazine analogue. Group: Pharmaceutical. Alternative Names: 8-benzyl-2-(furan-2-ylmethyl)-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one. CAS No. 1374040-24-0. Pack Sizes: 10 mg. Product ID: B1370-449754. Molecular formula: C24H19N3O2. Mole weight: 381.44. Custom synthesis is available. Send your inquiries for more information. | London |
| GDC-0853 | GDC-0853 is a Bruton's tyrosine kinase (BTK) inhibitor originated by Genentech. GDC-0853 can inhibit the activity of BTK and prevent the activation of the B-cell antigen receptor (BCR) signaling pathway. This leads to the inhibition of the growth of malignant B-cells that overexpress BTK. Phase III clinical trials for the treatment of Multiple sclerosis and Phase II clinical trials for the treatment of Chronic urticaria and Systemic lupus erythematosus are on-going. Uses: Rheumatoid arthritis; autoimmune disorders. Group: Pharmaceutical. Alternative Names: Fenebrutinib; RG 7845; RG7845; GDC0853; RG-7845; GDC 0853; (S)-2-(3'-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4'-bipyridin]-2'-yl)-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one. CAS No. 1434048-34-6. Pack Sizes: 100 mg. Product ID: B2693-475436. Molecular formula: C37H44N8O4. Mole weight: 664.81. Custom synthesis is available. Send your inquiries for more information. | London |
| KIRA6 | KIRA6 allosterically inhibits IRE1α RNase kinase activity in vivo and promotes cell survival under ER stress. Systemically, KIRA6 preserves pancreatic β cells, increases insulin, and reduces hyperglycemia in Akita diabetic mice. Group: Pharmaceutical. Alternative Names: KIRA6; KIRA-6; KIRA 6; 1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea; 1-(4-(8-amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea; KIRA analog, 2. CAS No. 1589527-65-0. Pack Sizes: 20 mg. Product ID: B0084-007192. Molecular formula: C28H25F3N6O. Mole weight: 518.53. Custom synthesis is available. Send your inquiries for more information. | London |
| LGK974 | LGK974 is a selective and orally bioavailable Porcupine inhibitor under development for the treatment of cancers that are driven by the Wnt pathway in a Wnt ligand-dependent manner. LGK974 was shown to induce tumor regression in a Wnt-driven murine tumor model. Group: Pharmaceutical. Alternative Names: LGK-974; LGK 974; WNT-974; 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide. CAS No. 1243244-14-5. Pack Sizes: 100 mg. Product ID: B1370-286295. Molecular formula: C23H20N6O. Mole weight: 396.44. Custom synthesis is available. Send your inquiries for more information. | London |
| Lisinopril Impurity D | An impurity of ACE inhibitor Lisinopril, which is indicated for the treatment of high blood pressure and heart failure. Group: Pharmaceutical. Alternative Names: Lisinopril (S,S,R)-Diketopiperazine; (2S)-2-[(3S,8aR)-3-(4-Aminobutyl)-1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-4-phenylbutanoic acid. CAS No. 219677-82-4. Pack Sizes: 100 mg. Product ID: B2694-102578. Molecular formula: C21H29N3O4. Mole weight: 387.47. Custom synthesis is available. Send your inquiries for more information. | London |
| MRE-269 | MRE-269 is an orally available and long-acting prostacyclin receptor agonist prodrug used for the treatment of pulmonary arterial hypertension. Uses: Prostacyclin receptor agonist. Group: Pharmaceutical. Alternative Names: MRE-269; MRE269; MRE 269; ACT-333679; ACT 333679; ACT333679. [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid; 2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-acetic Acid. CAS No. 475085-57-5. Pack Sizes: 10 mg. Product ID: B0084-475745. Molecular formula: C25H29N3O3. Mole weight: 419.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Necrosulfonamide | Necrosulfonamide is a pharmacological inhibitor of MLKL with IC50 values of 124 nM in human HT-29, which significantly decreases BV6/DAC-induced cell death in MV4-11 cells. It prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Group: Pharmaceutical. Alternative Names: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide. CAS No. 1360614-48-7. Pack Sizes: 100 mg. Product ID: B1370-170273. Molecular formula: C18H15N5O6S2. Mole weight: 461.47. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Formyl Varenicline | N-Formyl Varenicline is a metabolite of Varenicline. Varenicline is a partial agonist of nicotinic receptor used for smoking cessation. It reduces both the desire for and the pleasure of cigarettes. Group: Pharmaceutical. Alternative Names: 6,7,9,10-Tetrahydro-6,10-methano-8H-pyrazino[2,3-h][3]benzazepine-8-carboxaldehyde. CAS No. 796865-82-2. Pack Sizes: 25 mg. Product ID: B1370-001978. Molecular formula: C14H13N3O. Mole weight: 239.27. Custom synthesis is available. Send your inquiries for more information. | London |
| NS-304 | NS-304 is a selective prostacyclin IP1 receptor agonist as prodrug of the active form of MRE-269 with a Ki value of 20 nM. Uses: Antihypertensive agents. Group: Pharmaceutical. Alternative Names: Selexipag; NS304; NS 304; ACT-293987; ACT293987; ACT 293987; 2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)acetamide. CAS No. 475086-01-2. Pack Sizes: 5 g. Product ID: B2693-313936. Molecular formula: C26H32N4O4S. Mole weight: 496.6. Custom synthesis is available. Send your inquiries for more information. | London |
| Praziquantel | Praziquantel, marketed as Biltricide, is an anthelmintic used in humans and animals for the treatment of tapeworms and flukes. Specifically, it is effective against schistosoma, Clonorchis sinensis the fish tapeworm Diphyllobothrium latum. Uses: Anthelmintics. Group: Pharmaceutical. Alternative Names: 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one; (+/-)-Praziquantel; Azinox; Biltricide; Cesol; Cysticide; Distocide; Droncit; Embay 8440; Prazinon; Pyquiton; Warmnil. CAS No. 55268-74-1. Pack Sizes: 1mg;1g;10g. Product ID: BBF-04560. Molecular formula: C19H24N2O2. Mole weight: 312.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Pyrazinamide | 100g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C5H5N3O. CAS No. 98-96-4. Prepack ID : 17143121-100g. Molecular Weight : 123.11. | |
| Quarfloxin | Quarfloxin, also known as Quarfloxacin and CX-3543, is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells. Disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis. Group: Pharmaceutical. Alternative Names: 3H-Benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide, 5-fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]-; 3H-Benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide, 5-fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-(3-pyrazinyl-1-pyrrolidinyl)-; 5-Fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide; CX 3543; Itarnafloxin; Quarfloxacin. CAS No. 865311-47-3. Pack Sizes: 5 mg. Product ID: B2693-153274. Molecular formula: C35H33FN6O3. Mole weight: 604.69. Custom synthesis is available. Send your inquiries for more information. | London |
| Radotinib | Radotinib, also known as IY-5511, is an orally available, hydrochloride salt form of radotinib, a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome-positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. This agent has shown potent efficacy in CML cells that are resistant to the first-generation standard tyrosine kinase inhibitors, such as imatinib, nilotinib and dasatinib. PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. Alternative Names: IY-5511; IY 5511; IY5511; 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyrazin-2-ylpyrimidin-2-yl)amino]benzamide. CAS No. 926037-48-1. Pack Sizes: 50 mg. Product ID: B0084-465339. Molecular formula: C27H21F3N8O. Mole weight: 530.515. Custom synthesis is available. Send your inquiries for more inf | London |
| Radotinib-[d6] | Radotinib-[d6] is deuterium labelled Radotinib. Radotinib, also known as IY-5511, is a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Group: Pharmaceutical. Alternative Names: 4-(Methyl-d3)-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzamide-2,5,6-d3. CAS No. 2754051-83-5. Pack Sizes: 1 mg. Product ID: BLP-014895. Molecular formula: C27H15D6F3N8O. Mole weight: 536.55. Custom synthesis is available. Send your inquiries for more information. | London |
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