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| Product | Description | |
|---|---|---|
| Purvalanol B | Purvalanol B is a potent, selective, reversible and ATP-competitive inhibitor of CDK with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1 and CDK5-p35, respectively. Group: Pharmaceutical. Alternative Names: NG 95; NG95; NG-95. CAS No. 212844-54-7. Pack Sizes: 100 mg. Product ID: B1370-087426. Molecular formula: C20H25ClN6O3. Mole weight: 432.91. Custom synthesis is available. Send your inquiries for more information. |  London |
| Purvalanol A | Purvalanol A is a potent CDK inhibitor, which effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. indicating that the activation of CDKs contributes to the c-Src transformation. Purvalanol A suppressed the c-Src activity as effectively as the Src-selective inhibitor PP2, and that it reverted the transformed morphology to a nearly normal shape with less cytotoxicity than PP2. Purvalanol A induced a strong G2-M arrest, whereas PP2 weakly acted on the G1-S transition. Furthermore, when compared with PP2, purvalanol A more effectively suppressed the growth of human colon cancer HT29 and SW480 cells, in which Src family kinases and CDKs are activated. These findings demonstrate that the coordinated inhibition of cell cycle progression and tyrosine kinase signaling by the multi-selective purvalanol A is effective in suppressing cancer progression associated with c-Src up-regulation. Group: Pharmaceutical. Alternative Names: Purv; NG60; NG-60; NG 60; 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine; 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine. CAS No. 212844-53-6. Pack Sizes: 100 mg. Product ID: B1370-102089. Molecular formula: C19H25ClN6O. Mole weight: 388.89. Custom synthesis is available. Send your inquiries for more information. | London |
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