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| Product | Description | |
|---|---|---|
| Purmorphamine | Purmorphamine, under the IUPAC name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine, is a cell-permeable 6,9-trisubstituted purine which directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ).So it has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. In vitro: An activator of the hedgehog (Hh) signaling pathway by directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ). In vivo: Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats. Uses: Directly binds and activates smoothened (in hek293t cell:ic50= ~ 1.5 μm ); an activator of the hedgehog (hh) signaling pathway; an inducer of osteoblast differentiation (ec50= 1 μm). Group: Pharmaceutical. Alternative Names: 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine; purmorphamine; Purmorphamine; 483367-10-8; 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; UNII-PB12M2F8KY; Shh Signaling Antagonist VI; PB12M2F8KY; CHEMBL1221984; CHEBI:63053; C31H32N6O2; IN1132; 9-cyclohexyl-N-[4-(morpholin-4-yl)phenyl]-2-(naphthalen-1-yloxy)-9H-purin-6-amine; 9-cyclohexyl-N-(4-morpholin-4-ylp. CAS No. 483367-10-8. Pack Sizes: 100 mg. Product ID: B0084-211514. Molecular formula: C31H32N6O2. Mole weight: 520.6. Custom synthesis is avaiĀ |  London |
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