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| Product | Description | |
|---|---|---|
| Purine Derivatives | Purine Derivatives represent a cornerstone in biomedical sciences, vital for synthesizing therapeutic agents like allopurinol, targeting gout via xanthine oxidase inhibition. Their critical functionality extends to anticancer and antiviral domains, offering potential solutions for managing viral infections, such as HIV and hepatitis, thus fortifying therapeutic interventions across diverse pathologies. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 2-Amino-6-purinethiol (6-Thioguanine) | 1g Pack Size. Group: Analytical Reagents, Bioactive Small Molecules. Formula: C5H5N5S. CAS No. 154-42-7. Prepack ID : 66238710-1g. Molecular Weight : 167.19. |  |
| 8-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-3,9-dihydro-1H-purine-2,6-dione | 8-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-3,9-dihydro-1H-purine-2,6-dione, a small molecule drug used in the treatment of a variety of neoplastic diseases, exhibits its antineoplastic effects by impeding the actions of an enzyme critical to DNA synthesis and repair. As a consequence, its administration inhibits growth and restricts the metastasis of malignant cells, thus representing an efficacious therapeutic option for cancer. The scientific community reveres the tremendous potential of this drug in the field of oncology. Group: Pharmaceutical. CAS No. 155270-98-7. Pack Sizes: 500 mg. Product ID: B2699-084865. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 3'-Deoxy-3'-fluorocytidine | 3'-Deoxy-3'-fluorocytidine is a purine nucleoside analogue. It is an antiviral agent. Group: Pharmaceutical. CAS No. 123402-20-0. Pack Sizes: 5 mg. Product ID: B1370-279821. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 3'-O-Methylguanosine | 3'-O-Methylguanosine is an endogenous methylated nucleoside found in human fluids. Methylated purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls. DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents. When chemical bonds to DNA, it becomes damaged and proper and complete replication cannot occur to make the normal intended cell. A DNA adduct is an abnormal piece of DNA covalently-bonded to a cancer-causing chemical. This has shown to be the start of a cancerous cell, or carcinogenesis. DNA adducts in scientific experiments are used as bio-markers and as such are themselves measured to reflect quantitatively, for comparison, the amount of cancer in the subject. Group: Pharmaceutical. CAS No. 10300-27-3. Pack Sizes: 50 mg. Product ID: B2706-306475. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 7-Deaza-2'-deoxyadenosine | It is a purine nucleoside phosphorylase inhibitor. Group: Pharmaceutical. CAS No. 60129-59-1. Pack Sizes: 250 mg. Product ID: B2706-039342. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 7-Methylguanosine | 7-Methylguanosine is a modified form of the purine nucleotides. When present in human urine, it may be a biomarker for certain cancers. Group: Pharmaceutical. CAS No. 20244-86-4. Pack Sizes: 100 mg. Product ID: B1370-062405. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 8-Iodo-guanosine | 8-Iodo-guanosine, a chemical compound used in biomedical research, has proven instrumental in studying the impacts of purine nucleoside analogs on cancers and viral infections. As an iodine-substituted guanosine derivative, it exhibits the potential to act as an inhibitor of RNA viruses like HIV and hepatitis C. Group: Pharmaceutical. CAS No. 18438-99-8. Pack Sizes: 1 g. Product ID: B1370-004370. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bendamustine hydrochloride | Bendamustine hydrochloride is the hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Group: Pharmaceutical. CAS No. 3543-75-7. Pack Sizes: 500 mg. Product ID: NP3323. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Binodenoson | Binodenoson is a pharmacologic stress agent specific to the only adenosine receptor necessary for increased cardiac blood flow, the A2A receptor agonist. It is used to diagnose coronary artery disease. Uses: Purinergic p1 receptor agonists. Group: Pharmaceutical. CAS No. 144348-08-3. Pack Sizes: 10 mg. Product ID: B1370-078439. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BzATP triethylammonium salt | The P2X purinergic receptors are ligand-gated ion channels that are activated by extracellular ATP. BzATP triethylammonium salt is a prototypic P2X7 receptor agonist that exhibits 5-10 fold greater potency than ATP with EC50 of 0.7 μM. It also exhibits partial agonist activity at P2X1 and P2Y1 receptors. BzATP can also be used as a photoaffinity probe to study adenine nucleotide binding to ATPases. Group: Pharmaceutical. CAS No. 112898-15-4. Pack Sizes: 25 mg. Product ID: B2693-359261. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cladribine Related Compound A | 2-Methoxy-2'-deoxyadenosine is an impurity in the synthesis of Cladribine, a substituted purine nucleoside with antileukemic activity. Group: Pharmaceutical. CAS No. 24757-70-8. Pack Sizes: 25 mg. Product ID: B2694-469085. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CVT-313 | A cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 μM for Cdk2/A and Cdk2/E; 4.2 μM for Cdk1/B; 215 μM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 = ~1.25-20 μM) in vitro and prevent neointima formation in vivo. Group: Pharmaceutical. CAS No. 199986-75-9. Pack Sizes: 50 mg. Product ID: B0084-196573. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Purmorphamine | Purmorphamine, under the IUPAC name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine, is a cell-permeable 6,9-trisubstituted purine which directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ).So it has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. In vitro: An activator of the hedgehog (Hh) signaling pathway by directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ). In vivo: Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats. Uses: Directly binds and activates smoothened (in hek293t cell:ic50= ~ 1.5 μm ); an activator of the hedgehog (hh) signaling pathway; an inducer of osteoblast differentiation (ec50= 1 μm). Group: Pharmaceutical. CAS No. 483367-10-8. Pack Sizes: 100 mg. Product ID: B0084-211514. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (S)-5'-(S)-(3-amino-3-carboxypropyl)-5'-thioadenosine | (S)-5'-(S)-(3-amino-3-carboxypropyl)-5'-thioadenosine, an important compound, is frequently utilized in scientific endeavors towards the development of medications for the treatment of diverse ailments, encompassing cancer and autoimmune diseases. Typically employed as a substrate for enzymes participating in the purine metabolic pathway, this substance exhibits notably high perplexity, owing to its intricate chemical composition. In addition, it boasts considerable burstiness, with some instances of relatively lucid nomenclature alongside more elaborative descriptions of its molecular properties. Uses: A novel biomarker for predicting susceptibility of a subject to a mental or neurodegenerative disorder. Group: Pharmaceutical. CAS No. 979-92-0. Pack Sizes: 100 mg. Product ID: B0001-080350. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Triuret | Triuret is a byproduct of purine degradation in living organisms. Group: Pharmaceutical. CAS No. 556-99-0. Pack Sizes: 250 mg. Product ID: B2699-253276. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 1,4-Butanediol, 2-[2-(2-amino-9H-purin-9-yl)ethyl]-, 1,4-diacetate | An impurity of Famciclovir, a guanine analogue antiviral drug used for the treatment of various herpesvirus infections. Group: Pharmaceutical. CAS No. 174155-69-2. Pack Sizes: 10 mg. Product ID: B1370-244938. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl Benzoate | An impurity of Acyclovir. Acyclovir is an antiviral drug used for the treatment of infections caused by herpes simplex virus and herpes zoster virus. It acts via inhibiting the production of virus' DNA. Group: Pharmaceutical. CAS No. 59277-91-7. Pack Sizes: 50 mg. Product ID: B0093-007231. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (6-Benzhydryloxycarbonylamino-purin-9-yl)-acetic acid | (6-Benzhydryloxycarbonylamino-purin-9-yl)-acetic acid. Group: Pharmaceutical. CAS No. 186046-80-0. Pack Sizes: 10 g. Product ID: B2699-202345. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N- [ [ [ (1R) -2- (6-Amino-9H-purin-9-yl) -1-methylethoxy] methyl] hydroxyphosphinyl] -D-alanine | An impurity of Tenofovir, which is an acyclic phosphonate nucleotide derivative, could be used in antiviral treatment as an everse transcriptase inhibitor. Group: Pharmaceutical. CAS No. 376633-24-8. Pack Sizes: 50 mg. Product ID: B2694-085564. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Phosphoramidochlorid?ic acid, N,?N-?dimethyl-?, [ (2S, ?6R) ?-?6-?[6-? (benzoylamino) ?-?9H-?purin-?9-?yl]?-?4-? (triphenylmethyl) ?-?2-?morpholinyl]?methyl ester | Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-[6-(benzoylamino)-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester is a novel biomedical compound. With its unique molecular structure, it exhibits potential as a targeted therapeutic agent for treating various diseases. Group: Pharmaceutical. CAS No. 956139-18-7. Pack Sizes: 1 g. Product ID: B2706-339312. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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