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| Product | Description | |
|---|---|---|
| Proteinase K | 100mg Pack Size. Group: Biochemicals, Diagnostic Raw Materials, Research Organics & Inorganics. Formula: C29H27N2O12P. CAS No. 39450-01-6. Prepack ID : 49085587-100mg. Molecular Weight : 626.5. |  |
| Proteinase K | Proteinase K is a subtilisin-related serine protease. It was discovered from the fungus Engyodontium album. It can be used for removal of endogenous nucleases during the preparation of DNA and RNA, and for preparation of tissue sections for in situ hybridization. It is often used in pH range 7.5-9.0 and 37-70°C. Specific activity is ≥ 34 units/mg of protein. Group: Pharmaceutical. CAS No. 39450-01-6. Pack Sizes: 1 g. Product ID: BBF-04168. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 4',6,7-Trihydroxyisoflavone | 4',6,7-Trihydroxyisoflavone is an isoflavone isolated from the seeds of Glycine max with antioxidant activity. It is also a novel inhibitor of PKCα that suppresses solar UV-induced matrix metalloproteinase 1. Group: Pharmaceutical. CAS No. 17817-31-1. Pack Sizes: 5 mg. Product ID: B0005-395761. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Abametapir-[d6] | Abametapir-[d6] is an isotopic labelled of Abametapir. Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases, enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. Group: Pharmaceutical. CAS No. 1803416-92-3. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-003174. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Abz-Ala-Phe-Ala-Phe-Asp-Val-Phe-3-nitro-Tyr-Asp-OH | Abz-Ala-Phe-Ala-Phe-Asp-Val-Phe-3-nitro-Tyr-Asp-OH is a fluorogenic (FRET) substrate for endoproteinase AspN, Asp-specific proteases from Staphylococcus aureus, Bacillus licheniformis and Streptomyces griseus. Group: Pharmaceutical. CAS No. 143147-74-4. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-015248. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ac-DEVD-CHO | Ac-DEVD-CHO is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2. Uses: Cysteine proteinase inhibitors. Group: Pharmaceutical. CAS No. 169332-60-9. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-015950. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl Hexapeptide-49 acetate | Acetyl Hexapeptide-49 acetate is a photoprotectic cosmetic peptide that diminishes Proteinase-Activated Receptor 2 (PAR-2)-induced release of pro-inflammatory mediators, attenuating neurogenic inflammation and itch response in sensitive skin (Lipotec, Barcelona, Spain). Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-016153. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AY-NH2 | AY-NH is a selective proteinase-activated receptor 4 (PAR4) receptor agonist peptide. It stimulates aggregation of rat and human platelets in vitro. It reduces expression of glycoprotein (GP) Ib, and increases expression of GPIIb/IIIa on the surface of human platelets. It induces relaxation of isolated rat aortic rings and contraction of rat gastric longitudinal muscle strips. It also inhibits calcium mobilization evoked by capsaicin in rat sensory neurons. It increases paw thickness in a rat paw edema inflammation model in vivo. Group: Pharmaceutical. CAS No. 352017-71-1. Pack Sizes: 5 mg. Product ID: BAT-006106. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Batimastat | Batimastat (also known as BB-94) is a synthetic matrix metalloproteinase inhibitor that has shown antineoplastic and antiangiogenic activity in various tumor models. Batimastat acts as an inhibitor of metalloproteinase activity by binding the zinc ion in the active site of MMPs. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 130370-60-4. Pack Sizes: 10 mg. Product ID: B2693-082981. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Calpeptin | Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Uses: Cysteine proteinase inhibitors. Group: Pharmaceutical. CAS No. 117591-20-5. Pack Sizes: 100 mg. Product ID: B2693-161534. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cirsimaritin | Cirsimaritin is purified from the herbs of Microtea debilis. Cirsimaritin has the potential use in patients with congestive heart failure that can mitigate cardiac remodeling and left ventricular dysfunction through augmenting myocardial autophagy and decreasing matrix metalloproteinase-2&9 activities. Cirsimaritin inhibits the growth of tumor cells and induces mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), and it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt. Cirsimaritin shows moderate anti-proliferative activity against COLO-205 cells with IC 50 values of 13.1uM. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner; support the putative application of cirsimaritin in ultraviolet photoprotection and hair coloration treatments. Group: Pharmaceutical. CAS No. 6601-62-3. Pack Sizes: 5 mg. Product ID: NP2021. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| FOY 251 | FOY 251 is a metabolite of camostat mesilate, and a proteinase inhibitor. Group: Pharmaceutical. CAS No. 71079-09-9. Pack Sizes: 5 mg. Product ID: B2693-115860. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Halofuginone | Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. Uses: Semisynthetic quinazolinone alkaloid anticoccidial. Group: Pharmaceutical. CAS No. 55837-20-2. Pack Sizes: 100 mg. Product ID: B0084-071625. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Histatin 5 | Histatin 5, a human salivary peptide, has been shown to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. Group: Pharmaceutical. CAS No. 104339-66-4. Pack Sizes: 5 mg. Product ID: BAT-006217. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ilomastat | Ilomastat is a broad-spectrum matrix metalloproteinase inhibitor, displaying potential anticancer activity. Ilomastat is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc. Ilomastat inhibits enzymes including thermolysin, peptide deformylase, and anthrax lethal factor endopeptidase (LF) produced by the bacterium Bacillus anthracis. Group: Pharmaceutical. CAS No. 142880-36-2. Pack Sizes: 25 mg. Product ID: B0084-302725. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PAR4 (1-6) (human) | PAR4 (1-6) is a synthetic hexapeptide agonist of proteinase-activated receptor 4 (PAR4). PAR4 is a thrombin receptor activated by platelet, and acts as a modulator of cellular responses that serve as hallmarks of inflammation. Group: Pharmaceutical. CAS No. 225779-44-2. Pack Sizes: 25 mg. Product ID: BAT-006098. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Phloretin | Phloretin, a type of natural phenol found in the peels of apples, is a dihydrochalcone that shows beneficial effects on diabetes. Phloretin has whitening, freckle removal, anti-aging, strong antioxidant, and photoprotective effects. It can also inhibit the activity of matrix metalloproteinase (MMP-1) and elastase, which can degrade skin connective tissue and play an important role in the process of skin photoaging. Phloretin has excellent immunosuppressive and anti-inflammatory effects. Phloretin can significantly inhibit the levels of nitrogen oxide, prostaglandin E2, IL-6, TNF-α, iNOS and COX-2, inhibit the nuclear translocation of NF-JB subunit p65 protein, and reduce phosphorylation in the MAPK pathway. It can be used in facial masks, skin creams, lotions and essences. Uses: Antimicrobial activity. Group: Pharmaceutical. CAS No. 60-82-2. Pack Sizes: 100 g. Product ID: NP0981. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SB-3CT | SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. SB-3CT is a 2-[(arylsulfonyl)methyl]thiirane that achieves potent inhibition, by a thiirane-opening mechanism, of the MMP2 and MMP9 zinc metalloproteases. SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury in rat. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. Besides, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. Group: Pharmaceutical. CAS No. 292605-14-2. Pack Sizes: 20 mg. Product ID: B0084-369142. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| TMC-58B | Aurantiamide, a natural alkaloid found in the herbs of Walsura yunnanensis, is used as significant anti-inflammatory and antinociceptive. it can serve as the natural compound for inhibiting cysteine proteinases, in particular, cathepsin L (3.4.22.15) and B (3.4.22.1) with IC50 of 12 microM and 49 microM, respectively. It may suppress the growth of malignant gliomas by blocking autophagic flux. Uses: Anti-neuroinflammatory; anti-inflammatory; antinociceptive. Group: Pharmaceutical. CAS No. 58115-31-4. Pack Sizes: 1 mg. Product ID: NP0417. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Z-DEVD-FMK | Z-DEVD-FMK is a cell-permeant, irreversible caspase-3 inhibitor that can be used as an anaesthetic agent. It has been shown to suppress tumor cell apoptosis. Uses: Cysteine proteinase inhibitors. Group: Pharmaceutical. CAS No. 210344-95-9. Pack Sizes: 10 mg. Product ID: BAT-010236. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Z-Phe-DL-Ala-FMK | Z-FA-FMK is an irreversible cysteine protease inhibitor, and it also inhibits caspases-2, -3, -6, and -7. Z-FA-FMK suppresses the degradation of fibrillar collagen by fibroblasts and osteoclasts, and reduces LPS-induced cytokine production via inhibition of NF-kappaB-dependent gene expression in macrophages. Uses: Cysteine proteinase inhibitors. Group: Pharmaceutical. CAS No. 197855-65-5. Pack Sizes: 50 mg. Product ID: B0084-209259. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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