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| Product | Description | |
|---|---|---|
| 1,2-Dioleoyl-sn-glycerol | 1,2-Dioleoyl-sn-glycerol is an analog of the protein kinase C-activating second messenger DAG. Group: Pharmaceutical. Alternative Names: Sn-1,2-Diolein; DG(18:1(9Z)/18:1(9Z)/0:0); 1,2-di-(9Z-octadecenoyl)-sn-glycerol; (S)-glyceryl 1,2-dioleate; DG(18:1/18:1/0:0). CAS No. 24529-88-2. Pack Sizes: 100 mg. Product ID: B0084-203872. Molecular formula: C39H72O5. Mole weight: 620.98. Custom synthesis is available. Send your inquiries for more information. |  London |
| 17-DMAG hydrochloride | 17-DMAG hydrochloride (Alvespimycin hydrochloride) is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Group: Pharmaceutical. Alternative Names: 17-DMAG HCl; Alvespimycin HCl; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride; 17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride; 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin Hydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride. CAS No. 467214-21-7. Pack Sizes: 100 mg. Product ID: BBF-05796. Molecular formula: C32H48N4O8.HCl. Mole weight: 653.21. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide | 2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide, is a precursor in the synthesis of Dasatinib, a protein tyrosine kinase inhibitor, and also for 2-Amino-thiazole-5-carboxylic Acid Phenylamide Derivatives, used as potent and selective anti-tumor drugs. Group: Pharmaceutical. Alternative Names: 2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide. CAS No. 302964-24-5. Pack Sizes: 1mg;1g;10g. Product ID: NP3528. Molecular formula: C11H10ClN3OS. Mole weight: 267.73. Custom synthesis is available. Send your inquiries for more information. | London |
| [(2S,6R)-6-{N4-Benzoylcydin-1-yl}-4-tritylmorpholin-2-yl]methyl dimethyl-phosphoramidochloridate | This product is a potent inhibitor of Abl kinases and was developed for the treatment of chronic myeloid leukemia (CML). It works by blocking the activity of the Bcr-Abl fusion protein, which drives the growth of CML cells. Clinical trials have shown promising results, with high rates of complete remission and durable responses in patients with CML who were resistant or intolerant to previous treatments. Group: Pharmaceutical. Alternative Names: PMO-BzC; Morpholino C subunit; Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester; [(2S,6R)-6-[4-(Benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate; N4-Bz protected C PMO Monomer. CAS No. 956139-21-2. Pack Sizes: 1 g. Product ID: B2706-339313. Molecular formula: C37H37ClN5O5P. Mole weight: 698.15. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Chloro-5H-pyrrolo[3,2-d]pyrimidin-2-amine | 4-Chloro-5H-pyrrolo[3,2-d]pyrimidin-2-amine is a highly potent and selective protein kinase CK1ε inhibitor. Evidence suggests that this compound exhibits strong neuroprotective and anti-tumor activity, and holds great promise as a potential treatment for Alzheimer's disease and select cancers. Its unique chemical structure and mechanism of action make it an exciting candidate for further preclinical and clinical development. Group: Pharmaceutical. Alternative Names: 4-Chloro-5H-pyrrolo[3,2-d]pyrimidin-2-ylamine; 5H-Pyrrolo[3,2-d]pyrimidin-2-amine, 4-chloro-. CAS No. 943736-58-1. Pack Sizes: 10 g. Product ID: B2699-100946. Molecular formula: C6H5ClN4. Mole weight: 168.58. Custom synthesis is available. Send your inquiries for more information. | London |
| 5,7-Dihydrox -4'-methoxyisoflavone | Biochanin A, an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM. Uses: Anti-tumorigenesis, anti-oxidation, and anti-inflammatory. Group: Pharmaceutical. Alternative Names: Biochanin; Pratensol; olmelin; 4'-methyl Genistein; 4-methylGenistein; 5,7-dihydroxy-4'-Methoxyisoflavone; NSC 123538; NSC-123538; NSC123538. CAS No. 491-80-5. Pack Sizes: 5 g. Product ID: NP1827. Molecular formula: C16H12O5. Mole weight: 284.26. Custom synthesis is available. Send your inquiries for more information. | London |
| A 1070722 | A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β) with 50-fold selectivity over other protein kinases such as CDK. It decreases phosphorylation of microtubule-associated protein Tau in vitro. A 1070722 exhibits neuroprotective activity thus is identified as a therapeutic drug candidate for neurodegenerative and psychiatric disorders. Uses: Potential treatment of neurodegenerative disorders. Group: Pharmaceutical. Alternative Names: A 1070722; A1070722; A-1070722; 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea. CAS No. 1384424-80-9. Pack Sizes: 1mg;1g;10g. Product ID: 1384424-80-9. Molecular formula: C17H13F3N4O2. Mole weight: 362.31. Custom synthesis is available. Send your inquiries for more information. | London |
| A12B4C3 | A12B4C3 is a potent and selective inhibitor of polynucleotide kinase/phosphatase (PNKP) (IC50 = 60 nM), a DNA repair enzyme. A12B4C3 is inactive to calcineurin, protein PP-1 or APTX. Group: Pharmaceutical. Alternative Names: A12B4C3; A-12-B-4-C-3; A 12 B 4 C 3; A12 B4 C3; A12-B4-C3; 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione. CAS No. 1005129-80-5. Pack Sizes: 1mg;1g;10g. Product ID: 1005129-80-5. Molecular formula: C30H38N4O5. Mole weight: 534.65. Custom synthesis is available. Send your inquiries for more information. | London |
| AAKIQASFRGHMARKK | AAKIQASFRGHMARKK. Group: Pharmaceutical. Alternative Names: RC3; PROTEIN KINASE SELECTIDE; PROTEIN KINASE C SELECTIDE(TM) SUBSTRATE; NEUROGRANIN (28-43); NEUROGRANIN FRAGMENT 28-43; NEUROGRANIN 28-43 [AAKIQASFRGHMARKK]. CAS No. 146554-17-8. Pack Sizes: 1mg;1g;10g. Product ID: 146554-17-8. Molecular formula: C78H134N28O19S. Mole weight: 1800.14. Custom synthesis is available. Send your inquiries for more information. | London |
| Abn-CBD | Abn-CBD is a neurobehaviorally inactive cannabinoid and acts as a selective and potent agonist for GPR55 with EC50 value of 2.5 μM. It increases migration and phosphorylation of protein kinases in human umbilical vein endothelial cells. Group: Pharmaceutical. Alternative Names: 1,3-Benzenediol, 4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-; 1,3-Benzenediol, 4-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-, trans-(-)-; 4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol; Resorcinol, 4-p-mentha-1,8-dien-3-yl-5-pentyl-, trans-(-)-; Abnormal Cannabidiol; (1'R,2'R)-5'-methyl-6-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,4-diol; trans-(-)-4-p-Mentha-1,8-dien-3-yl-5-pentylresorcinol; trans-(-)-4-[3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol. CAS No. 22972-55-0. Pack Sizes: 1mg;1g;10g. Product ID: 22972-55-0. Molecular formula: C21H30O2. Mole weight: 314.47. Custom synthesis is available. Send your inquiries for more information. | London |
| Acteoside | Verbascoside is a bioactive polyphenol from olive oil mill wastewater with known antioxidant activity, which is a protein kinase C inhibitor. Uses: Antineoplastic; antimetastatic;antimicrobial activity. Group: Pharmaceutical. Alternative Names: Verbascoside; Kusaginin; β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-, 4-[3-(3,4-dihydroxyphenyl)-2-propenoate]. (E)-; (3,4-Dihydroxyphenyl)ethyl O-α-rhamnopyranosyl(1→3)-4-O-caffeoyl-β-D glucopyranoside; Acteroside; Distinctive Active Powder SL Special; Distinctive Phytostem Lilac; NSC 603831; O'''-Desarabinosyllavandulifolioside A; Russetinol; Stereospermin; TJC 160; trans-Acteoside; trans-Verbascoside. CAS No. 61276-17-3. Pack Sizes: 100 mg. Product ID: NP5345. Molecular formula: C29H36O15. Mole weight: 624.59. Custom synthesis is available. Send your inquiries for more information. | London |
| Afuresertib | Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Group: Pharmaceutical. Alternative Names: GSK-2110183; GSK 2110183; GSK2110183; GSK-2110183B; GSK 2110183B; GSK2110183B. CAS No. 1047644-62-1. Pack Sizes: 50 mg. Product ID: B1370-109132. Molecular formula: C18H17Cl2FN4OS. Mole weight: 427.32. Custom synthesis is available. Send your inquiries for more information. | London |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Group: Pharmaceutical. Alternative Names: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. CAS No. 118409-62-4. Pack Sizes: 100 mg. Product ID: B1370-195904. Molecular formula: C10H5N3O3. Mole weight: 215.16. Custom synthesis is available. Send your inquiries for more information. | London |
| Alectinib | Alectinib, marketed as Alecensa, is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). Alectinib has a low potential for interactions. While it is metabolised by the liver enzyme CYP3A4, and blockers of this enzyme accordingly increase its concentrations in the body, they also decrease concentrations of the active metabolite M4, resulting in only a small overall effect. Conversely, CYP3A4 inducers decrease alectinib concentrations and increase M4 concentrations. Interactions via other CYP enzymes and transporter proteins cannot be excluded but are unlikely to be of clinical significance. Group: Pharmaceutical. Alternative Names: CH-5424802; CH5424802; CH 5424802; AF-802; RG-7853; RO5424802. CAS No. 1256580-46-7. Pack Sizes: 200 mg. Product ID: B0084-454466. Molecular formula: C30H34N4O2. Mole weight: 482.62. Custom synthesis is available. Send your inquiries for more information. | London |
| Alisertib | MLN8237 is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Aurora kinase inhibitor MLN8237 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Group: Pharmaceutical. Alternative Names: MLN8237; MLN-8237; MLN 8237; alisertib. Benzoic acid, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-. CAS No. 1028486-01-2. Pack Sizes: 100 mg. Product ID: B2693-336876. Molecular formula: C27H20ClFN4O4. Mole weight: 518.9. Custom synthesis is available. Send your inquiries for more information. | London |
| Alpelisib | Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Group: Pharmaceutical. Alternative Names: BYL-719; BYL719; BYL 719; Alpelisib. CAS No. 1217486-61-7. Pack Sizes: 100 mg. Product ID: B0084-457654. Molecular formula: C19H22F3N5O2S. Mole weight: 441.473. Custom synthesis is available. Send your inquiries for more information. | London |
| α-Amyloid Precursor Protein Modulator | α-Amyloid Precursor Protein Modulator is a cell-permeable protein kinase C (PKC) activator. It was shown to induce differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. Group: Pharmaceutical. Alternative Names: TPPB; alpha-APP Modulator; (2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide. CAS No. 497259-23-1. Pack Sizes: 2.5 mg. Product ID: B0084-314011. Molecular formula: C27H30F3N3O3. Mole weight: 501.55. Custom synthesis is available. Send your inquiries for more information. | London |
| α-Amyrin | α-Amyrin is a triterpenoid that has been found in B. copallifera and has diverse biological activities. It activates the ERK and GSK-3β signaling pathways. α-Amyrin is a potential protein kinase A inhibitor. Group: Pharmaceutical. Alternative Names: Viminalol; alpha-Amyrenol; Urs-12-en-3beta-ol; (3β)-urs-12-en-3-ol. CAS No. 638-95-9. Pack Sizes: 10 mg. Product ID: B1370-147265. Molecular formula: C30H50O. Mole weight: 426.73. Custom synthesis is available. Send your inquiries for more information. | London |
| α-Viniferin | α-Viniferin isolated from the herb of Carex humilis Leyss. It inhibits AChE activity is specific, reversible and noncompetitive,down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages. Uses: Anti-inflammatory activity; antifungal; inhibits protein kinase c; inhibits prostaglandin h2 synthase carex humilis. Group: Pharmaceutical. Alternative Names: (+)-α-viniferin. CAS No. 62218-13-7. Pack Sizes: 1 mg. Product ID: NP4646. Molecular formula: C42H30O9. Mole weight: 678.7. Custom synthesis is available. Send your inquiries for more information. | London |
| AR-A014418 | AR-A014418 is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β), a serine/threonine protein kinase involved in multiple diseases including Alzheimer's disease and type 2 diabetes. Group: Pharmaceutical. Alternative Names: SN 4521; SN4521; SN-4521; AR-A 014418; AR-A014418; AR-A-014418; AR-AO-14418; GSK-3beta Inhibitor VIII; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea. CAS No. 487021-52-3. Pack Sizes: 25 mg. Product ID: B0084-258809. Molecular formula: C12H12N4O4S. Mole weight: 308.312. Custom synthesis is available. Send your inquiries for more information. | London |
| AVL-292 | AVL-292, also known as CC-292, is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, AVL-292 targets and covalently binds to BTK, thereby preventing its activity. Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: CC-292; CC292; CC 292; AVL292; AVL 292; spebrutinib. CAS No. 1202757-89-8. Pack Sizes: 1 g. Product ID: B2693-462475. Molecular formula: C22H22FN5O3. Mole weight: 423.44. Custom synthesis is available. Send your inquiries for more information. | London |
| Axitinib | Axitinib (AG013736) is a tyrosine kinase inhibitor developed by Pfizer. Axitinib is a tyrosine kinase inhibitor that blocks the activation of VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ (IC50 = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively). It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models. Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: AG 013736; N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide; Inlyta. CAS No. 319460-85-0. Pack Sizes: 5 g. Product ID: NP3631. Molecular formula: C22H18N4OS. Mole weight: 386.5. Custom synthesis is available. Send your inquiries for more information. | London |
| AZD-5363 | AZD-5363 is an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AZD-5363 binds to and inhibits all AKT isoforms. This agent may be used as monotherapy or combination therapy for a variety of human cancers. Group: Pharmaceutical. Alternative Names: AZD5363; AZD 5363; Capivasertib. CAS No. 1143532-39-1. Pack Sizes: 10 mg. Product ID: B2693-457058. Molecular formula: C21H25ClN6O2. Mole weight: 428.9152. Custom synthesis is available. Send your inquiries for more information. | London |
| Balanol | It is produced by the strain of Streptomyces sp. Tu 4128. Balanol, a fungal metabolite, is a potent ATP-competitive inhibitor of Protein Kinase C (PKC) and Protein Kinase A (PKA). It is an important target in oncology. Group: Pharmaceutical. Alternative Names: 4-(2-Carboxy-6-hydroxybenzoyl)-3,5-dihydroxybenzoic Acid (3R,4R)-Hexahydro-3-[(4-hydroxybenzoyl)amino]-1H-azepin-4-yl Ester; (3R-trans)-Balanol; (-)-Balanol; Azepinostatin; Ophiocordin. CAS No. 63590-19-2. Pack Sizes: 1mg;1g;10g. Product ID: BBF-00627. Molecular formula: C28H26N2O10. Mole weight: 550.53. Custom synthesis is available. Send your inquiries for more information. | London |
| Brigatinib | Brigatinib, also known as AP-26113, is an orally active, potent and selective dual ALK/EGFR inhibitor. AP26113 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK; IC50 < 100 nM in Ba/F3 cells). AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. It blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants. Group: Pharmaceutical. Alternative Names: AP26113. CAS No. 1197953-54-0. Pack Sizes: 1 g. Product ID: B0084-470820. Molecular formula: C29H39ClN7O2P. Mole weight: 584.1. Custom synthesis is available. Send your inquiries for more information. | London |
| BX-795 | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, which is 140- and 1600-fold more selective than PKA and PKC. It is also a potent and relatively specific inhibitor of TBK1 with IC50 of 6 nM and IKK? with IC50 of 41 nM. Group: Pharmaceutical. Alternative Names: BX 795; BX795. CAS No. 702675-74-9. Pack Sizes: 25 mg. Product ID: B0084-194478. Molecular formula: C23H26IN7O2S. Mole weight: 591.47. Custom synthesis is available. Send your inquiries for more information. | London |
| C16 Ceramide | C16 ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling. It has also been found to activate NF-κB and PKCζ3. Uses: A predominant, rather hydrophobic natural ceramide. activates a cytosolic serine/threonine protein phosphatase in t9 cells; induces egf receptor phosphorylation in a-431 cells; stimulates ceramide-activated protein kinase. Group: Pharmaceutical. Alternative Names: C16 Ceramide (d18:1/16:0); N-(hexadecanoyl)-sphing-4-enine; N-Palmitoylsphingosine. CAS No. 24696-26-2. Pack Sizes: 100 mg. Product ID: B1370-059982. Molecular formula: C34H67NO3. Mole weight: 537.9. Custom synthesis is available. Send your inquiries for more information. | London |
| Caftaric acid | Caftaric acid is a natural compound found in the juice of grapes. It is an inhibitor of the protein-protein interactions mediated by the Src-family kinases. Uses: Used in cancer therapy as an anticancer drug. Group: Pharmaceutical. Alternative Names: 2-Caffeoyl-L-tartaric acid; (2R,3R)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-3-hydroxybutanedioic acid. CAS No. 67879-58-7. Pack Sizes: 250 mg. Product ID: B2703-075022. Molecular formula: C13H12O9. Mole weight: 312.23. Custom synthesis is available. Send your inquiries for more information. | London |
| Calcineurin substrate | Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. Group: Pharmaceutical. Alternative Names: H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH; L-alpha-aspartyl-L-leucyl-L-alpha-aspartyl-L-valyl-L-prolyl-L-isoleucyl-L-prolyl-glycyl-L-arginyl-L-phenylalanyl-L-alpha-aspartyl-L-arginyl-L-arginyl-L-valyl-L-seryl-L-valyl-L-alanyl-L-alanyl-L-glutamic acid. CAS No. 113873-67-9. Pack Sizes: 5 mg. Product ID: BAT-006181. Molecular formula: C92H150N28O29. Mole weight: 2112.35. Custom synthesis is available. Send your inquiries for more information. | London |
| Chelerythrine | Chelerythrine is a benzophenanthridine alkaloid extracted from the plant Greater celandine (Chelidonium majus). It is a potent, selective, and cell-permeable protein kinase C inhibitor. It is also the major active natural product found in the plant Zanthoxylum clava-herculis, exhibiting anti-bacterial activity against Staphylococcus aureus. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy. Uses: Antibacterial agent. Group: Pharmaceutical. Alternative Names: Toddalin; cheleritrine; broussonpapyrine; Toddaline; [1,3]Benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-; NSC646662; 1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride. CAS No. 34316-15-9. Pack Sizes: 50 mg. Product ID: NP0509. Molecular formula: C21H18NO4+. Mole weight: 348.37. Custom synthesis is available. Send your inquiries for more information. | London |
| Chelerythrine chloride | Chelerythrine is a cell-permeable inhibitor of protein kinase C (IC50 = 660 nM) with a wide range of biological activities. Group: Pharmaceutical. Alternative Names: Broussonpapyrine Chloride. CAS No. 3895-92-9. Pack Sizes: 50 mg. Product ID: BBF-04087. Molecular formula: C21H19NO4. Mole weight: 383.82. Custom synthesis is available. Send your inquiries for more information. | London |
| Chrysophanol | Chrysophanic acid (Chrysophanol) is a natural anthraquinone with anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 μm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. Chrysophanol is a natural compound found in the roots and rhizomes of Rheum palmatum L. It can be used in cosmetics material. Uses: Anti-inflammatory. Group: Pharmaceutical. Alternative Names: 1,8-dihydroxy-3-methylanthracene-9,10-dione. CAS No. 481-74-3. Pack Sizes: 1 g. Product ID: NP0901. Molecular formula: C15H10O4. Mole weight: 254.24. Custom synthesis is available. Send your inquiries for more information. | London |
| CL-387785 | CL-387785, also known as EKI-785, is an irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM). CL-387785 covalently bound to EGF-R. It also specifically inhibited kinase activity of the protein (IC50 = 370+/-120 pM), blocked EGF-stimulated autophosphorylation of the receptor in cells (ic50 approximately 5 nM), inhibited cell proliferation (IC50 = 31-125 nM) primarily in a cytostatic manner in cell lines that overexpress EGF-R or c-erbB-2, and profoundly blocked the growth of a tumor that overexpresses EGF-R in nude mice (when given orally at 80 mg/kg/day for 10 days, daily). CL-387,785 is useful for studying the interaction of small molecules with EGF-R and may have clinical utility. Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: CL-387785; CL 387785; CL-387,785; CL387785; EKI-785; EKI 785; EKI785. CAS No. 194423-06-8. Pack Sizes: 50 mg. Product ID: B0084-458793. Molecular formula: C18H13BrN4O. Mole weight: 381.233. Custom synthesis is available. Send your inquiries for more information. | London |
| CZ415 | CZ415 is a highly selective potent mTOR inhibitor with little activity on other lipid and protein kinases with efficacy in a collagen induced arthritis model and exhibits excellent cell permeability. In the issue, Bergamini et al., who has identified CZ415, confirmed with its extraordinary selectivity, drug-like properties and proven efficacy in vivo, CZ415 represents an ideal molecule for the pharmacological investigation of mTOR pathophysiological role in vivo. Assessed in dose response format from HEK293T cells after treatment with CZ415: 1. inhibition of S6RP (downstream of mTORC1) phosphorylation in HEK293T: IC50 = 14.5 nM; 2. inhibition of Akt (mTORC2 substrate) phosphorylation in HEK293T: IC50 = 14.8 nM; 3. inhibition of IFNγ release in stimulated human whole blood: IC50 = 226 nM. Group: Pharmaceutical. Alternative Names: CZ415; CZ-415; CZ 415; (S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea. CAS No. 1429639-50-8. Pack Sizes: 5 mg. Product ID: B0084-474821. Molecular formula: C22H29N5O4S. Mole weight: 459.57. Custom synthesis is available. Send your inquiries for more information. | London |
| Dasatinib | Dasatinib, also known as BMS-354825, is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. Group: Pharmaceutical. Alternative Names: BMS-354825; BMS354825; BMS354825. CAS No. 302962-49-8. Pack Sizes: 25 g. Product ID: NP3264. Molecular formula: C22H26ClN7O2S. Mole weight: 488.01. Custom synthesis is available. Send your inquiries for more information. | London |
| D-erythro-Sphingosine | D-erythro-Sphingosine is a natural isomer of sphingosine and acts as an inhibitor of protein kinase C and calmodulin-dependent enzymes with no effects on protein kinase A or myosin light chain kinase. It may stimulate mast cells by activation of protein kinase C. Group: Pharmaceutical. Alternative Names: Sphingosine (d18:1); sphingosine; D-Sphingosine; 4-Sphingenine; 2S, 3R(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol; (2S,3R,4E)-2-amino-1,3-octadec-4-enediolsphing-4-enine. CAS No. 123-78-4. Pack Sizes: 250 mg. Product ID: B2693-162633. Molecular formula: C18H37NO2. Mole weight: 299.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Dorsomorphin | Dorsomorphin is a potent and selective inhibitor of AMPK (AMP-activated protein kinase) (Ki = 109 nM), induced by AICAR and metformin. It also inhibits bone morphogenetic protein (BMP) receptors including BMPR-IA (ALK3) and BMPR-IB (ALK6). Dorsomorphin can induce myocardial differentiation in mouse embryonic stem cells (mESCs). Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine; Compound C; AMPK Inhibitor, Compound C; BML-275. CAS No. 866405-64-3. Pack Sizes: 10 mg. Product ID: B0084-462934. Molecular formula: C24H25N5O. Mole weight: 399.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Dracorhodin perchlorate | Dracorhodin perchlorate can inhibit high glucose-induced serum and glucocorticoid induced protein kinase 1 (SGK1) and fibronectin (FN) expression in human mesangial cells, and this may be a part of the mechanism of preventing and treating renal fibrosis of DN. Group: Pharmaceutical. Alternative Names: Dracorhodin perochlorate; Dracohodin perochlorate. CAS No. 125536-25-6. Pack Sizes: 100 mg. Product ID: B1370-252868. Molecular formula: C17H15ClO7. Mole weight: 366.75. Custom synthesis is available. Send your inquiries for more information. | London |
| Elsinochrome A | It is produced by the strain of Elsinoe annonae, Sphaceloma randii. It's the same as Hypericin, it has photodynamic activity and inhibits protein kinase C activity. Group: Pharmaceutical. Alternative Names: (1r,2r)-1,2-diacetyl-4,11-dihydroxy-3,7,8,12-tetramethoxy-1,2-dihydrobenzo[ghi]perylene-5,10-dione; 1alpha,2beta-Diacetyl-1,2-dihydro-5,10-dihydroxy-3,7,8,12-tetramethoxybenzo[ghi]perylene-4,11-dione; Benzo(ghi)perylene-4,11-dione, 1,2-diacetyl-1,2-dihydro-5,10-dihydroxy-3,7,8,12-tetramethoxy-, trans-. CAS No. 24568-67-0. Pack Sizes: 1mg;1g;10g. Product ID: BBF-01206. Molecular formula: C30H24O10. Mole weight: 544.51. Custom synthesis is available. Send your inquiries for more information. | London |
| Encorafenib | Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. Group: Pharmaceutical. Alternative Names: LGX818; LGX-818; LGX 818; Methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate. CAS No. 1269440-17-6. Pack Sizes: 150 mg. Product ID: B0084-462563. Molecular formula: C22H27ClFN7O4S. Mole weight: 540.011. Custom synthesis is available. Send your inquiries for more information. | London |
| Entrectinib | Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Phase 2. Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: RXDX101; RXDX 101; RXDX-101; NMS E628; NMS-E628; Entrectinib; N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide. CAS No. 1108743-60-7. Pack Sizes: 250 mg. Product ID: B0084-470812. Molecular formula: C31H34F2N6O2. Mole weight: 560.64. Custom synthesis is available. Send your inquiries for more information. | London |
| Enzastaurin | Enzastaurin is a protein kinase C beta inhibitor with 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. Group: Pharmaceutical. Alternative Names: 3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione; LY-317615. CAS No. 170364-57-5. Pack Sizes: 200 mg. Product ID: B0084-085618. Molecular formula: C32H29N5O2. Mole weight: 515.617. Custom synthesis is available. Send your inquiries for more information. | London |
| ETC-1002 | ETC-1002 is a novel, first-in-class, orally available, once-daily LDL-C lowering small molecule and is activator of hepatic AMP-activated protein kinase (AMPK). It also has potent inhibitory activity against hepatic ATP-citrate lyase. Group: Pharmaceutical. Alternative Names: ESP-55016; ESP55016; ESP 55016; ETC-1002; ETC 1002; ETC1002; Bempedoate; Bempedoic acid. CAS No. 738606-46-7. Pack Sizes: 250 mg. Product ID: B0084-463320. Molecular formula: C19H36O5. Mole weight: 344.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Ethyl (4-((2-(Methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: PAPE-ethyl Carbamate; Sorafenib related compound 7. CAS No. 2206827-12-3. Pack Sizes: 100 mg. Product ID: B2694-479756. Molecular formula: C16H17N3O4. Mole weight: 315.32. Custom synthesis is available. Send your inquiries for more information. | London |
| (E/Z)-Endoxifen | One of the impurities of Tamoxifen, which is an estrogen response modifier as well as protein kinase C inhibitor. Group: Pharmaceutical. Alternative Names: 4-Hydroxy-N-Desmethyl Tamoxifen; N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture); 4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol. CAS No. 110025-28-0. Pack Sizes: 10 mg. Product ID: B2694-257357. Molecular formula: C25H27NO2. Mole weight: 373.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Fasudil hydrochloride | Fasudil HCl, a 5-isoquinolinesulfonamide derivative, is a highly selective Rho-associated protein kinase inhibitor that might have a rate in romoting the recovery of neurological function, reducing clinical symptoms and the morbidity. Uses: Fasudil hcl, a 5-isoquinolinesulfonamide derivative, is a highly selective rho-associated protein kinase inhibitor that might have a rate in romoting the recovery of neurological function, reducing clinical symptoms and the morbidity. Group: Pharmaceutical. Alternative Names: Fasudil HCl; Eril; Fasudil (Hydrochloride); Fasudil Monohydrochloride; AT-877; HA-1077; AT 877; HA 1077; AT877; HA1077. CAS No. 105628-07-7. Pack Sizes: 1 g. Product ID: B2693-053715. Molecular formula: C14H18ClN3O2S. Mole weight: 327.83. Custom synthesis is available. Send your inquiries for more information. | London |
| Ganoderiol F | Lansiumarin C is a natural coumarin found in the branches of Clausena lansium. and found to induce senescence of cancer cell lines, it induces growth arrest of cancer cell lines HepG2, Huh7 and K562; activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 were found in early stages of Ganoderiol F treatment and were presumed to cause cell-cycle arrest and trigger premature senescence of HepG2 cells; suggests that the growth-arrest and senescence induction capability on cancer cells suggest anticancer potential of Ganoderiol F. It could be developed further as both anti-HIV and antimalaria.In Compared to plasmepsin I, ganoderiol-F is higher towards HIV-1 protease. Uses: Anti-inflammatory; anti-hiv. Group: Pharmaceutical. Alternative Names: 26,27-Dihydroxylanosta-7,9(11),24-trien-3-one. CAS No. 114567-47-4. Pack Sizes: 1 mg. Product ID: NP6829. Molecular formula: C30H46O3. Mole weight: 454.7. Custom synthesis is available. Send your inquiries for more information. | London |
| GDC-0994 | GDC-0994, also known as RG7842, is an orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: GDC0994; GDC 0994; RG7842; RG-7842; RG 7842; Ravoxertinib. CAS No. 1453848-26-4. Pack Sizes: 50 mg. Product ID: B2693-462528. Molecular formula: C21H18ClFN6O2. Mole weight: 440.863. Custom synthesis is available. Send your inquiries for more information. | London |
| Genistein | Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. Genistein is developed to be an antitumor agent. Genistein has antioxidant effect, it can be used in cosmetics material. It is a plant polyphenol that can inhibit tyrosinase, block melanin synthesis, reduce skin pigment intensity, absorb UV, prevent photoaging, reduce sun damage and age spot formation, and whiten and lighten spots. It also has the anti-glycation and antibacterial effect, can effectively improve skin tone and skin texture, prevent the generation of age spots, remove red bloodlines, and improve skin blood microcirculation. Uses: Antitumor agent. Group: Pharmaceutical. Alternative Names: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Baichanin A; Bonistein; 4',5,7-Trihydroxyisoflavone; GeniVida; Genisteol; NSC 36586; Prunetol; Sophoricol; Differenol A. CAS No. 446-72-0. Pack Sizes: 5 g. Product ID: BBF-01840. Molecular formula: C15H10O5. Mole weight: 270.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Ginsenoside F4 | Ginsenoside F4 is extracted from the root of Panax ginseng C. A. Mey. It has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. It was found to strongly inhibit activation of p38 mitogen-activated protein kinase in signal transduction pathways. Group: Pharmaceutical. Alternative Names: Ginsenoside Rg6; (20E)-Ginsenoside F4. CAS No. 181225-33-2. Pack Sizes: 10 mg. Product ID: B0005-454183. Molecular formula: C42H70O12. Mole weight: 767. Custom synthesis is available. Send your inquiries for more information. | London |
| Ginsenoside Rb1 | A major bioactive component of panax ginseng that promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. It has been reported to display immunostimulatory and anticancer effects. It has anti-aging effect, can be used in health products. Uses: Anti-oxidative damage,immunostimulatory,anticancer. Group: Pharmaceutical. Alternative Names: β-D-Glucopyranoside, (3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-; (3β,12β)-20-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside; Arasaponin E1; Gynosaponin C; Gypenoside III; Notoginsenoside Rb1; NSC 310103; Panaxoside Rb1; RB 1; Sanchinoside E1; Sanchinoside Rb1. CAS No. 41753-43-9. Pack Sizes: 100 mg. Product ID: NP6991. Molecular formula: C54H92O23. Mole weight: 1109.32. Custom synthesis is available. Send your inquiries for more information. | London |
| Glutathione EP Impurity C | Oxiglutatione is a stabilized formulation of disodium glutathione disulfide (GSSG; oxidized glutathione) and cisplatin (1000:1) with potential chemoprotective and immunomodulating activities. Mimicking endogenous GSSG, Oxiglutatione acts as a competitive substrate for gamma-glutamyl-transpeptidase (GGT), which may result in the S-glutathionylation of proteins, predominantly actin, a redox stress on endoplasmic reticulum (ER), and ER stress-induced apoptosis. S-glutathionylation may be stimulated by reactive oxygen species (ROS) liberated by an oxiglutatione-induced increase in GGT activity. Oxiglutatione may also induce phosphorylation of proteins such as ERK and p38, two kinases that play critical regulatory roles in cell proliferation and apoptosis. The cisplatin component of this agent does not provide an effective therapeutic concentration of cisplatin in vivo. Group: Pharmaceutical. Alternative Names: L-Glutathione Oxidised; Oxiglutatione; glutathione disulfide; GSSG; NOV-002; NOV 002; NOV002. CAS No. 27025-41-8. Pack Sizes: 25 g. Product ID: B0084-064728. Molecular formula: C20H32N6O12S2. Mole weight: 612.63. Custom synthesis is available. Send your inquiries for more information. | London |
| GSK 2606414 | GSK 2606414 is a potent and selective PERK inhibitor that suppresses PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival stimulated our search for small-molecule inhibitors. Group: Pharmaceutical. Alternative Names: GSK2606414; GSK-2606414; GSK 2606414; GSK PERK Inhibitor. 1-(5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone. CAS No. 1337531-36-8. Pack Sizes: 100 mg. Product ID: B0084-462365. Molecular formula: C24H20F3N5O. Mole weight: 451.453. Custom synthesis is available. Send your inquiries for more information. | London |
| GSK-461364 | GSK-461364 is a Polo-like kinase 1 inhibitor, is also a small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Group: Pharmaceutical. Alternative Names: GSK461364; GSK 461364; GSK-461364; GSK461364A; GSK 461364A; GSK-461364A. 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide. CAS No. 929095-18-1. Pack Sizes: 10 mg. Product ID: B0084-307746. Molecular formula: C27H28F3N5O2S. Mole weight: 543.609. Custom synthesis is available. Send your inquiries for more information. | London |
| Guanosine 3',5'-cyclic monophosphate | Cyclic guanosine monophosphate (Cyclic GMP) is a guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'-and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. 3',5'-cyclic GMP is a 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine. It has a role as a plant metabolite, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a guanyl ribonucleotide and a 3',5'-cyclic purine nucleotide. It is a conjugate acid of a 3',5'-cyclic GMP(1-). Group: Pharmaceutical. Alternative Names: 3:5-CGMP; D-Guanosine 3',5'-cyclic monophosphate; 3',5'-cyclic GMP; 2-Amino-6-oxo-6,9-dihydro-1H-purine 3-oxide; guanine-3-N-oxide; 2-Amino-1,7-dihydro-6H-purin-6-one 3-oxide; Cyclic guanosine monophosphate. CAS No. 7665-99-8. Pack Sizes: 250 mg. Product ID: B1370-013547. Molecular formula: C10H12N5O7P. Mole weight: 345.21. Custom synthesis is available. Send your inquiries for more information. | London |
| GYY-4137 Morpholine salt | GYY-4137 Morpholine salt is a novel water-soluble and slow releasing Hydrogen sulfide(H2S) donor. It protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats. It inhibits the inflammatory response by suppressing the activation of nuclear factor-kappa B and mitogen-activated protein kinases in Coxsackie virus B3-infected rat cardiomyocytes. It exhibits potent anti-cancer activity. It exhibits vasodilator and antihypertensive activity in rats, in either the acute or chronic hypertension models. It does not influence vascular smooth muscle cell viability in culture. It also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation. Uses: Gyy-4137 morpholine salt inhibits the inflammatory response. it exhibits potent anti-cancer activity. it exhibits vasodilator and antihypertensive activity. Group: Pharmaceutical. Alternative Names: GYY4137; GYY-4137; GYY 4137; GYY 4137 morpholine salt; ZYJ1122; ZYJ 1122; ZYJ-1122. GYY4137 Morpholine salt;(4-Methoxyphenyl)morpholino-phosphinodithioic acid compound with morpholine;ZYJ1122 morpholine salt;ZYJ-1122 morpholine salt. CAS No. 106740-09-4. Pack Sizes: 100 mg. Product ID: B2693-272139. Molecular formula: C15H25N2O3PS2. Mole weight: 376 | London |
| Ipatasertib | Ipatasertib, also known as GDC-0068 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GDC-0068 binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: GDC-0068; GDC0068; GDC 0068; RG7440; RG-7440; RG 7440; Ipatasertib. CAS No. 1001264-89-6. Pack Sizes: 50 mg. Product ID: B2693-456282. Molecular formula: C24H32ClN5O2. Mole weight: 458. Custom synthesis is available. Send your inquiries for more information. | London |
| Isoprenaline hydrochloride | Isoprenaline is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block. It would increase cAMP levels and activate protein kinase A and ERK1/2 through its effect on β-adrenoceptor. Uses: The treatment of bradycardia and heart block. Group: Pharmaceutical. Alternative Names: 4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol Hydrochloride; Isovon; Isuprel; Mistarel; NSC 37745; NSC 89747; Proternol; Saventrine; Suscardia; Vapo-Iso; dl-Isadrine Hydrochloride; dl-Isoprenaline Hydrochloride; dl-Isopropylnoradrenaline Hydrochloride; dl-Isopropylnorepinephrine Hydrochloride; α-(Isopropylaminomethyl)-3,4-dihydroxybenzyl alcohol Hydrochloride; 1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol Hydrochloride. CAS No. 51-30-9. Pack Sizes: 50 g. Product ID: NP3260. Molecular formula: C11H18ClNO3. Mole weight: 247.72. Custom synthesis is available. Send your inquiries for more information. | London |
| JNK-IN-8 | JNK-IN-8 inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively. Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: JNK-IN-8; JNK-IN 8; JNK-IN8; JNK Inhibitor XVI; c-Jun N-terminal Kinase Inhibitor XVI. CAS No. 1410880-22-6. Pack Sizes: 20 mg. Product ID: B0084-463416. Molecular formula: C29H29N7O2. Mole weight: 507.59. Custom synthesis is available. Send your inquiries for more information. | London |
| K252A | K252a, an analog of staurosporine, has been found to be a protein kinase inhibitor and exhibit antitumor activity at some extent. Group: Pharmaceutical. Alternative Names: NZ0550000; Antibiotic K 252a. CAS No. 99533-80-9. Pack Sizes: 50 mg. Product ID: BBF-04182. Molecular formula: C27H21N3O5. Mole weight: 467.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Kahweol | Kahweol is a natural product isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis. Group: Pharmaceutical. Alternative Names: 5a,8-Methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b-decahydro-7-hydroxy-10b-methyl-, (3bS,5aS,7R,8R,10aR,10bS)-; (3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b-Decahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol. CAS No. 6894-43-5. Pack Sizes: 100 mg. Product ID: B1370-148681. Molecular formula: C20H26O3. Mole weight: 314.42. Custom synthesis is available. Send your inquiries for more information. | London |
| KD025 | KD025 is an orally available and selective ROCK2 inhibitor with IC50 value of 60 nM and Ki value of 41 nm, respectively. It was shown to suppress adipogenesis in human adipose-derived stem cells. Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: SLx 2119; SLx2119; KD-025; 2-[3-[4-(1H-indazol-5-ylamino)quinazolin-2-yl]phenoxy]-N-propan-2-ylacetamide. CAS No. 911417-87-3. Pack Sizes: 100 mg. Product ID: B0084-460389. Molecular formula: C26H24N6O2. Mole weight: 452.51. Custom synthesis is available. Send your inquiries for more information. | London |
| Ku-0063794 | KU-0063794 is an inhibitor of both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks (phosphoinositide 3-kinases) at 1000-fold higher concentrations. KU-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC kinase not regulated by mTOR. It also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1). It does not affect Thr308 phosphorylation in fibroblasts lacking essential mTORC2 subunits. KU-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. KU-0063794 will be useful in delineating the physiological roles of mTOR and may have utility in treatment of cancers in which this pathway is inappropriately activated. Uses: Differentiation. Group: Pharmaceutical. Alternative Names: KU0063794; KU-0063794; KU 0063794; Ku0063794; Ku 0063794; Ku-0063794; KU63794; KU 63794; KU-63794; [5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol. CAS No. 938440-64-3. Pack Sizes: 100 mg. Product ID: B0084-100850. Molecular formula: C25H31N5O4. Mole weight: 465.554. Custom synthesis is available. Send your inquiries for more information. | London |
| Lapatinib | Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. Uses: Antineoplastic agents; protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: GW-572016; GSK-572016; GSK 572016. CAS No. 231277-92-2. Pack Sizes: 1 g. Product ID: NP3214. Molecular formula: C29H26ClFN4O4S. Mole weight: 581.06. Custom synthesis is available. Send your inquiries for more information. | London |
| Lapatinib Ditosylate | Lapatinib is a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: GW-572016; GW 572016; GW572016. CAS No. 388082-77-7. Pack Sizes: 1 g. Product ID: B0084-067756. Molecular formula: C29H26ClFN4O4S.2C7H8O3S. Mole weight: 925.46. Custom synthesis is available. Send your inquiries for more information. | London |
| LDS 867 | LDS 867 is a potent and selective protein kinase D (PKD) inhibitor used in the biomedical industry for research on cancer treatment. It effectively inhibits PKD and displays anticancer activity against a range of malignancies, including breast and pancreatic cancers. LDS 867 is a valuable tool in the study of PKD signaling pathways and potential therapeutic strategies for various diseases. Group: Pharmaceutical. Alternative Names: Benzothiazolium, 2-[[4-[4-[4-(dimethylamino)phenyl]-1,3-butadienyl]-2H-1-benzopyran-2-ylidene]methyl]-3-ethyl perchlorate. CAS No. 106025-71-2. Pack Sizes: 250 mg. Product ID: B2708-285552. Molecular formula: C31H29N2OS?ClO4. Mole weight: 577.1. Custom synthesis is available. Send your inquiries for more information. | London |
| Liraglutide-[d4] | Liraglutide-[d4] is the labelled analogue of Liraglutide. Liraglutide activates AMP-activated protein kinase thus enhancing insulin sensitivity, is the long-acting analogue of glucagon-like peptide-1 (GLP-1) receptor which could protect b-cells from apoptosis under conditions associated with the development of type 1 and type 2 diabetes. Group: Pharmaceutical. Alternative Names: L-Histidyl-L-alanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(1-oxohexadecyl)-L-γ-glutamyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginyl-glycine-d4; Liraglutide D4. Pack Sizes: 10 mg. Product ID: BLP-004354. Molecular formula: C172H261D4N43O51. Mole weight: 3755.23. Custom synthesis is available. Send your inquiries for more information. | London |
| LY2606368 | LY2606368 is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase. Group: Pharmaceutical. Alternative Names: LY-2606368; LY 2606368. CAS No. 1234015-52-1. Pack Sizes: 10 mg. Product ID: B0084-462722. Molecular formula: C18H19N7O2. Mole weight: 365.397. Custom synthesis is available. Send your inquiries for more information. | London |
| Masitinib | Masitinib is an orally bioavailable and multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Group: Pharmaceutical. Alternative Names: AB-1010; AB 1010; AB1010; Masitinib. Brand name: Kinavet; Masivet. CAS No. 790299-79-5. Pack Sizes: 250 mg. Product ID: B0084-077384. Molecular formula: C28H30N6OS. Mole weight: 498.649. Custom synthesis is available. Send your inquiries for more information. | London |
| Melittin (honeybee) | Melittin is a polypeptide isolated from the venom of the honey bee (Apis mellifera). It inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane). Group: Pharmaceutical. Alternative Names: Honeybee melittin; Bee venom melittin; Forapin; H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2; glycyl-L-isoleucyl-glycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonyl-glycyl-L-leucyl-L-prolyl-L-alanyl-L-leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-L-glutaminamide. CAS No. 20449-79-0. Pack Sizes: 25 mg. Product ID: BAT-010534. Molecular formula: C131H229N39O31. Mole weight: 2846.46. Custom synthesis is available. Send your inquiries for more information. | London |
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