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| Product | Description | |
|---|---|---|
| 3-Tert-Butyldimethylsilyl-2-propyn-1-ol | 3-Tert-Butyldimethylsilyl-2-propyn-1-ol, a widely used chemical compound in organic synthesis, serves as a safeguarding agent for alcohols, impeding undesired chemical reactions. It displays versatility in various applications ranging from stable protecting group synthesis to the development of potent drugs such as Atazanavir, a prominent HIV protease inhibitor. The compound's multifunctional competence and adaptability make it an indispensable component of organic synthesis. Group: Pharmaceutical. CAS No. 120789-51-7. Pack Sizes: 1 g. Product ID: B2699-232842. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| AAF-CMK trifluoroacetate salt | AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome function, and reversibly inhibits Cln2 (TPPI). Group: Pharmaceutical. CAS No. 184901-82-4. Pack Sizes: 100 mg. Product ID: BAT-015706. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetylpepstatin | Acetylpepstatin is an aspartyl protease inhibitor that is effective against HIV-1 and HIV-2 protease. Group: Pharmaceutical. CAS No. 28575-34-0. Pack Sizes: 10 mg. Product ID: BAT-010206. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-pepstatin | Acetyl-pepstatin is a potent classical inhibitor of aspartic proteases (PRs) with XMRV PR and HIV-1 PR Ki values of 712 nM and 13 nM. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl Pepstatin | Acetyl Pepstatin is a high affinity HIV-1 protease inhibitor and aspartic protease inhibitor. It inhibits HIV-1 protease with Ki value of 20 nM at pH 4.7 and HIV-2 protease with Ki value of 5 nM at pH 4.7. It is used as an antiviral agent. Group: Pharmaceutical. CAS No. 11076-29-2. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-010271. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acivicin | Acivicin is an isoxazole antibiotic isolated from Streptomyces. sviceus. Acivicin is a glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase, respectively) as a potent antitumor antibiotic that induces apoptosis in human lymphoblastoid cells. Acivicin is an inhibitor of GGT used for solid tumor research. Uses: Protease inhibitor. Group: Pharmaceutical. CAS No. 42228-92-2. Pack Sizes: 1mg; 1g; 10g. Product ID: BBF-00541. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acriflavine-hydrochloride | Acriflavine hydrochloride is a potent HIF-1 inhibitor, with antitumor activity. It also has antimicrobial and antiviral activities. Acriflavine hydrochloride is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2. Group: Pharmaceutical. CAS No. 69235-50-3. Pack Sizes: 1mg; 1g; 10g. Product ID: 69235-50-3. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ac-Thr-Ile-Nle-psi(CH2NH)Nle-Gln-Arg-NH2 | Ac-Thr-Ile-Nle-psi(CH2NH)Nle-Gln-Arg-NH2 is an HIV-1 protease inhibitor whose sequence is derived from the cleavage site of the viral gag-pol poly-protein. Electron density studies have shown that this inhibitor binds to the active site of the HIV-1 protease. Group: Pharmaceutical. CAS No. 128657-47-6. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-015166. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AEBSF HCl | AEBSF is a water-soluble, irreversible serine protease inhibitor that inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. Group: Pharmaceutical. CAS No. 30827-99-7. Pack Sizes: 1 g. Product ID: B2693-369679. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Asunaprevir | Asunaprevir is a potent hepatitis C virus (HCV) non-structural protein protease inhibitor currently in Phase III clinical trials for the treatment of HCV infection. Uses: Protease inhibitors. Group: Pharmaceutical. CAS No. 630420-16-5. Pack Sizes: 50 mg. Product ID: B0084-463296. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atazanavir | Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir. Group: Pharmaceutical. CAS No. 198904-31-3. Pack Sizes: 1 g. Product ID: B0084-062263. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bevirimat | Bevirimat, also known as MPC-4326 and PA-457, is an anti-HIV drug derived from a betulinic acid-like compound, first isolated from Syzygium claviflorum, a Chinese herb. It is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition. Like protease inhibitors, bevirimat and other maturation inhibitors interfere with protease processing of newly translated HIV polyprotein precursor, called gag. Bevirimat prevents this viral replication by specifically inhibiting cleavage of the capsid protein (CA) from the SP1 spacer protein. Group: Pharmaceutical. CAS No. 174022-42-5. Pack Sizes: 5 mg. Product ID: B0084-244897. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Camostat Mesylate | Camostat (INN) or FOY-305 is a serine protease inhibitor. Serine protease enzymes have a variety of functions in the body, and so camostat has a diverse range of uses. It is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease orpancreatitis. Uses: Trypsin inhibitors. Group: Pharmaceutical. CAS No. 59721-29-8. Pack Sizes: 5 g. Product ID: B2693-072632. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Darunavir | Darunavir is a second generation protease inhibitor that targets the HIV-1 protease. It demonstrates extremely potent activity against the infectivity and replication of various strains of HIV-1, including several that are resistant to first generation protease inhibitors (IC50s = 3-30 nM). Darunavir has been reported to inhibit both cell-free diffusion and cell-to-cell spread of HIV-1 with IC50 values of 2.5 and 2.8 nM, respectively. Uses: Hiv protease inhibitors. Group: Pharmaceutical. CAS No. 206361-99-1. Pack Sizes: 50 mg. Product ID: B0084-062615. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Darunavir Ethanolate | Darunavir Ethanolate is a nonpeptidic HIV protease inhibitor, used to treat HIV infection. Uses: Hiv protease inhibitors. Group: Pharmaceutical. CAS No. 635728-49-3. Pack Sizes: 1 g. Product ID: B0084-459375. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| E-64 | E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. Uses: For research used only. Group: Pharmaceutical. CAS No. 66701-25-5. Pack Sizes: 50 mg. Product ID: BAT-015060. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Freselestat | Freselestat is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM) with >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Freselestat can be used as treatment for neutrophil-predominant inflammatory lung diseases. Group: Pharmaceutical. CAS No. 208848-19-5. Pack Sizes: 10 mg. Product ID: B0084-101783. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| γ-Mangostin | gamma-Mangostin isolated from the fruit of Garcinia cambogia is an HIV protease inhibitor. gamma-Mangostin is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, and SW480 cancer cells and BEAS-2B non-cancerous pulmonary epithelial cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively). Uses: Hiv protease inhibitor. Group: Pharmaceutical. CAS No. 31271-07-5. Pack Sizes: 25 mg. Product ID: BBF-04088. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ganoderiol F | Lansiumarin C is a natural coumarin found in the branches of Clausena lansium. and found to induce senescence of cancer cell lines, it induces growth arrest of cancer cell lines HepG2, Huh7 and K562; activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 were found in early stages of Ganoderiol F treatment and were presumed to cause cell-cycle arrest and trigger premature senescence of HepG2 cells; suggests that the growth-arrest and senescence induction capability on cancer cells suggest anticancer potential of Ganoderiol F. It could be developed further as both anti-HIV and antimalaria.In Compared to plasmepsin I, ganoderiol-F is higher towards HIV-1 protease. Uses: Anti-inflammatory; anti-hiv. Group: Pharmaceutical. CAS No. 114567-47-4. Pack Sizes: 1 mg. Product ID: NP6829. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| H-D-allo-Threonine Methyl Ester Hydrochloride | H-D-allo-Threonine Methyl Ester Hydrochloride is used to prepare hepatitis A virus 3C cysteine protease inhibitors. Group: Pharmaceutical. CAS No. 60538-18-3. Pack Sizes: 1 g. Product ID: B2699-039416. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| HY-17542 | HY-17542 is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 μM. Group: Pharmaceutical. CAS No. 1093070-14-4. Pack Sizes: 100 mg. Product ID: B1370-450321. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| HZ-1157 | HZ-1157 is an inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease. Group: Pharmaceutical. CAS No. 1009734-33-1. Pack Sizes: 50 mg. Product ID: B0084-284802. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Isopropyl ethanesulfonate | Propan-2-yl Ethane-1-sulfonate can be used as serine protease inhibitors to inhibit an increase in the blood gluocose level. Group: Pharmaceutical. CAS No. 14245-62-6. Pack Sizes: 1 g. Product ID: B2699-301730. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| JE-2147 | JE-2147 is a dipeptide HIV protease inhibitor (PI) that is effective against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro. Group: Pharmaceutical. CAS No. 186538-00-1. Pack Sizes: 10 mg. Product ID: B2693-008706. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Kallikrein Inhibitor | Kallikrein Inhibitor, a synthetic peptide, is a serine protease inhibitor that inhibits kallikrein and plasmin, and can attenuate breast cancer cell invasion. Group: Pharmaceutical. CAS No. 97145-43-2. Pack Sizes: 10 mg. Product ID: BAT-006188. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| L-685,458 | L-685,458 is a potent and selective inhibitor of γ-secretase (IC50 = 17 nM) that shows 50-fold selectivity over a variety of aspartyl proteases. It also inhibits Aβ40 and Aβ42 peptides (in human neuroblastoma cells: IC50 = 48 and 67 nM respectively). Uses: Gamma secretase inhibitors and modulators. Group: Pharmaceutical. CAS No. 292632-98-5. Pack Sizes: 25 mg. Product ID: B2693-286396. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Lopinavir | An antiretroviral medication acts as a protease inhibitor. It is a co-formulation with a sub-therapeutic dose of ritonavir, as a component of combination therapy to treat HIV/AIDS. Group: Pharmaceutical. CAS No. 192725-17-0. Pack Sizes: 1 g. Product ID: B0084-086623. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mesupron | Mesupron is the second generation serine protease inhibitor prodrug targeting the human urokinase plasminogen activator (uPA) system with potential antineoplastic and antimetastatic activities. Group: Pharmaceutical. CAS No. 590368-25-5. Pack Sizes: 5 mg. Product ID: B0084-462232. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MK-5172 | Grazoprevir is a hepatitis C virus protease inhibitor developed for the treatment of hepatitis C. It suppresses NS3 and NS4A, which play a role in the virus splitting its polyprotein into the functional virus proteins. Grazoprevir is often used in combination with elbasvir or ribavirin. Uses: Antiviral agents. Group: Pharmaceutical. CAS No. 1350514-68-9. Pack Sizes: 100 mg. Product ID: B2693-007134. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Nafamostat mesilate | Nafamostat Mesylate is a synthetic serine protease inhibitor and an anticoagulant. It is a fast-acting proteolytic inhibitor and used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin. Uses: Anti-inflammatory agents, non-steroidal. Group: Pharmaceutical. CAS No. 82956-11-4. Pack Sizes: 5 g. Product ID: BAT-008979. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Nelfinavir Impurities | Nelfinavir Impurities are crucial analytical tools in the biomedical industry for ensuring the quality and safety of Nelfinavir, an antiretroviral protease inhibitor used in treating HIV-1 infections. These impurities aid in developing purification processes and conducting rigorous stability studies, thereby enhancing therapeutic efficacy and patient safety. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Odanacatib | Odanacatib, also known as MK-0822, is an inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption. Uses: For research used only. Group: Pharmaceutical. CAS No. 603139-19-1. Pack Sizes: 100 mg. Product ID: B0084-095375. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| P22077 | P22077 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor. P22077 potently induces apoptosis in NB cells with an intact USP7-HDM2-p53 axis but not in NB cells with mutant p53 or without human homolog of MDM2 (HDM2) expression. P22077 was found to be able to sensitize chemoresistant LA-N-6 NB cells to chemotherapy. In an in vivo orthotopic NB mouse model, P22077 significantly inhibited the xenograft growth of three NB cell lines. USP7-specific inhibitors like P22077 may serve not only as a stand-alone therapy but also as an effective adjunct to current chemotherapeutic regimens for treating NB with an intact USP7-HDM2-p53 axis. Group: Pharmaceutical. CAS No. 1247819-59-5. Pack Sizes: 100 mg. Product ID: B0084-462597. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pepstatin A | Pepstatin A is a potent aspartic protease inhibitor, and also inhibits HIV replication.It is a hexa-peptide containing the unusual amino acid statine (Sta, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid), having the sequence Isovaleryl-Val-Val-Sta-Ala-Sta (Iva-Val-Val-Sta-Ala-Sta). Uses: Protease inhibitors. Group: Pharmaceutical. CAS No. 26305-03-3. Pack Sizes: 500 mg. Product ID: BAT-010775. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PF-07321332 | PF-07321332 is an orally available SARS-CoV 3C-like protease (3CLPRO) inhibitor. 3C-like protease (3CLPRO) is the main protease found in coronaviruses, which cleaves the coronavirus polyprotein at eleven conserved sites. PF-07321332 has demonstrated oral activity in a mouse-adapted SARS-CoV-2 model and has achieved oral plasma concentrations exceeding the in vitro antiviral cell potency in a phase I clinical trial in healthy human participants. Group: Pharmaceutical. CAS No. 2628280-40-8. Pack Sizes: 100 mg. Product ID: B2693-074195. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PF 429242 dihydrochloride | PF 429242 is a reversible and competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM), a transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. It reduces hepatic synthesis of cholesterol and fatty acid in mice. Group: Pharmaceutical. CAS No. 2248666-66-0. Pack Sizes: 100 mg. Product ID: B1370-291470. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ritonavir | Ritonavir is an HIV protease inhibitor. It is often used in a low dose with another protease inhibitor lopinavir. Ritonavir was approved for COVID-19 treatment in combination with Nirmatrelvir. Group: Pharmaceutical. CAS No. 155213-67-5. Pack Sizes: 1 g. Product ID: NP2679. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ritonavir Impurities | Ritonavir Impurities, essential constituents in pharmaceutical realms, play a critical role in quality assurance and antiretroviral research. Their presence aids in discerning drug stability, efficiency, and safety parameters. As a protease inhibitor pivotal in HIV-1 management, ritonavir's impurities are indispensable for refining its formulation strategies. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Telaprevir-[d4] | Labelled Telaprevir. VX-950 is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). VX-950 forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (K(I)*) of 7 nM. Dissociation of the covalent enzyme-inhibitor complex of VX-950 and genotype 1a HCV protease has a half-life of almost an hour. A >4-log10 reduction in the HCV RNA levels was observed after a 2-week incubation of replicon cells with VX-950, with no rebound of viral RNA observed after withdrawal of the inhibitor. In several animal species, VX-950 exhibits a favorable pharmacokinetic profile with high exposure in the liver. In a recently developed HCV protease mouse model, VX-950 showed excellent inhibition of HCV NS3-4A protease activity in the liver. Group: Pharmaceutical. Pack Sizes: 50 mg. Product ID: BLP-006018. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Thiorphan | Thiorphan is a potent and specific enkephalinase inhibitor with antinociceptive activity. Uses: Protease inhibitors. Group: Pharmaceutical. CAS No. 76721-89-6. Pack Sizes: 50 mg. Product ID: BAT-008030. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Trypsin Inhibitor (soybean) | Trypsin Inhibitor (soybean) is a peptide inhibitor of serine proteases that reduces trypsin, as well as plasma kallikrein, thrombin, plasmin, and other serine proteases. Group: Pharmaceutical. CAS No. 9035-81-8. Pack Sizes: 10 g. Product ID: B2693-194378. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ulinastatin | Ulinastatin is an acid-resistant protease inhibitor derived from human urine, acting as a potent anti-inflammatory agent. It was shown to inhibit the activities of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin, lipase, hyaluronidase, factors IXa, Xa, XIa, and XlIa, and polymorphonuclear leukocyte elastase. Group: Pharmaceutical. CAS No. 80449-31-6. Pack Sizes: 1 g. Product ID: B2693-135299. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Z-Phe-DL-Ala-FMK | Z-FA-FMK is an irreversible cysteine protease inhibitor, and it also inhibits caspases-2, -3, -6, and -7. Z-FA-FMK suppresses the degradation of fibrillar collagen by fibroblasts and osteoclasts, and reduces LPS-induced cytokine production via inhibition of NF-kappaB-dependent gene expression in macrophages. Uses: Cysteine proteinase inhibitors. Group: Pharmaceutical. CAS No. 197855-65-5. Pack Sizes: 50 mg. Product ID: B0084-209259. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Z-VAD-FMK | Z-VAD-FMK is a broad spectrum pan-caspase inhibitor that inhibits the intracellular activation of caspase-like proteases. Group: Pharmaceutical. CAS No. 187389-52-2. Pack Sizes: 25 mg. Product ID: BAT-010214. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bortezomib | Bortezomib is a potent, reversible and selective 20S proteasome inhibitor with a Ki of 0.6 nM. It is an antineoplastic agent that is used in treatment of refractory multiple myeloma and certain lymphomas. Group: Pharmaceutical. CAS No. 179324-69-7. Pack Sizes: 1 g. Product ID: BBF-05860. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bortezomib Impurities | Bortezomib Impurities hold paramount importance in biomedical research, serving as key indicators for assessing degradation and stability profiles of the proteasome inhibitor Bortezomib. Their analysis aids scientists in determining drug purity and efficacy, thereby facilitating advancements in therapeutic strategies, particularly for multiple myeloma and specific lymphomas. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Broussonin B | Broussonin B is a natural phenols found in the branch of Broussonetia papyrifera, it has moderate inhibitory activities against a chymotrypsin-like activity of the proteasome. Group: Pharmaceutical. CAS No. 73731-86-9. Pack Sizes: 1 mg. Product ID: NP5061. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Carfilzomib | Carfilzomib is a tetrapeptide epoxyketone and an analog of epoxomicin, acting as a selective proteasome inhibitor, such as the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM). It has been used as an injectable antineoplastic agent (IV only). Group: Pharmaceutical. CAS No. 868540-17-4. Pack Sizes: 250 mg. Product ID: B0084-305419. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Carfilzomib Impurities | Carfilzomib Impurities are crucial in biomedical research, serving as key substances for assessing the purity and efficacy of Carfilzomib, a proteasome inhibitor used in treating multiple myeloma. These impurities help ensure quality control and regulatory compliance in drug formulation, supporting therapeutic advancements and patient safety in cancer treatments. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| HSP990 | HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (HSP90) with potential antineoplastic activity. HSP990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. HSP90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses. Group: Pharmaceutical. CAS No. 934343-74-5. Pack Sizes: 100 mg. Product ID: B1370-460667. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ixazomib Citrate | The citrate salt form of Ixazomib which is a proteasome inhibitor. It is undergoing a rollover Phase II trial against multiple myeloma, amyloidosis and lymphoma in sorts of countries. IC50 = 3.4 nM. Group: Pharmaceutical. CAS No. 1239908-20-3. Pack Sizes: 100 mg. Product ID: BBF-04173. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ixazomib Impurities | Ixazomib Impurities play a critical role in the quality control and characterization of Ixazomib, a proteasome inhibitor used primarily in treating multiple myeloma. Identifying and analyzing these impurities ensure the safety and efficacy of the drug, supporting ongoing research into proteasome-related cancer therapies. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| K-7174 dihydrochloride | K-7174, one of proteasome inhibitory homopiperazine derivatives, exhibits a therapeutic effect, which is stronger when administered orally than intravenously, without obvious side effects in a murine myeloma model. Moreover, K-7174 kills bortezomib-resistant myeloma cells carrying a β5-subunit mutation in vivo and primary cells from a patient resistant to bortezomib. Group: Pharmaceutical. CAS No. 191089-60-8. Pack Sizes: 100 mg. Product ID: B2693-463577. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Luminespib | Luminespib, also known as AUY-922 (or NVP-AUY922), is a derivative of 4,5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90 inhibitor AUY922 has been shown to bind with high affinity to and inhibit Hsp90, resulting in the proteasomal degradation of oncogenic client proteins. Group: Pharmaceutical. CAS No. 747412-49-3. Pack Sizes: 50 mg. Product ID: B0084-251226. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Marizomib Impurities | Marizomib Impurities, integral to the biomedical field, are essential in the characterization and quality assurance of the proteasome inhibitor marizomib, chiefly employed in combating multiple myeloma and hematologic malignancies. These impurities enable detailed pharmacological scrutiny, ensuring the drugs therapeutic effectiveness and safety across research and manufacturing stages. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MG-132 | MG-132 is a potent Proteasome inhibitor with potential anticancer activity. MG-132 induces MCPIP1 expression; induces C6 glioma cell apoptosis via oxidative stress; induces AIF nuclear translocation through down-regulation of ERK and Akt/mTOR pathway. Group: Pharmaceutical. CAS No. 133407-82-6. Pack Sizes: 100 mg. Product ID: B2693-361205. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ML241 | ML241 is a selective p97 ATPase inhibitor and IC50 value is 100 nM. It can inhibit degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the treatment of cancer. Uses: Anticancer. Group: Pharmaceutical. CAS No. 1346528-06-0. Pack Sizes: 100 mg. Product ID: B0084-475332. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Oprozomib Impurities | Oprozomib Impurities are chemical byproducts occurring during the synthesis of Oprozomib, a potent proteasome inhibitor used primarily in the treatment of multiple myeloma. These impurities are meticulously characterized to ensure pharmaceutical purity and efficacy, playing a crucial role in quality control and regulatory compliance within the drug development process. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (R)-MG132 | (R)-MG-132 is a reversible, cell permeable and selective tripeptide aldehyde proteasome inhibitor (IC50 = 0.22 μM), the most potent stereoisomer of MG-132. It exhibits cytostatic and cytotoxic effects in tumor cells in vitro. Group: Pharmaceutical. CAS No. 1211877-36-9. Pack Sizes: 10 mg. Product ID: BAT-010215. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| VER-155008 | VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 μM) that is selective over Hsp90. It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 μM) and glucose-regulated protein 78 (Grp78; KD = 80 nM). VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death. It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors. VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells. Group: Pharmaceutical. CAS No. 1134156-31-2. Pack Sizes: 100 mg. Product ID: B1370-272446. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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