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| Product | Description | |
|---|---|---|
| Protease-Activated Receptor-2 Activating Peptide | LIGRL-NH2 is a PAR2 activator with EC50 value of ~5 μM. It can be used to explore signaling through PAR2 in cells. Group: Pharmaceutical. Alternative Names: Thrombin Receptor-Like 1 (1-6) amide (mouse, rat); SLIGRL amide; Proteinase Activated Receptor 2 (1-6) amide (mouse, rat); Coagulation Factor II Receptor-Like 1 (1-6) amide (mouse, rat); PAR-2 (1-6) amide (mouse, rat); Ser-Leu-Ile-Gly-Arg-Leu-NH2; L-Seryl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucinamide. CAS No. 171436-38-7. Pack Sizes: 10 mg. Product ID: BAT-006095. Molecular formula: C29H56N10O7. Mole weight: 656.82. Custom synthesis is available. Send your inquiries for more information. |  London |
| Protease-Activated Receptor-2, amide | SLIGKV-NH2 is a protease-activated receptor 2 (PAR2) agonist (Ki = 9.64 μM; IC50 = 10.4 μM). Group: Pharmaceutical. Alternative Names: Thrombin Receptor-Like 1 (1-6) amide (human); SLIGKV amide; Proteinase Activated Receptor 2 (1-6) amide (human); Coagulation Factor II Receptor-Like 1 (1-6) amide (human); Ser-Leu-Ile-Gly-Lys-Val; PAR2 activating peptide; PAR2-AP; PAR-2 (1-6) Human; L-seryl-L-leucyl-L-isoleucyl-glycyl-L-lysyl-L-valinamide. CAS No. 190383-13-2. Pack Sizes: 25 mg. Product ID: BAT-006099. Molecular formula: C28H54N8O7. Mole weight: 614.78. Custom synthesis is available. Send your inquiries for more information. | London |
| 24-Methylenecycloartan-3-ol | 24-Methylenecycloartan-3-ol, a natural triterpenoid found in the barks of Larix kaemferi, has inhibitory effects on HIV-1 protease. Group: Pharmaceutical. Alternative Names: 24-methylene cycloartanol; 24-Methylenecycloartan-3β-ol; (9β)-24-Methylene-9,19-cyclolanostan-3β-ol. CAS No. 1449-09-8. Pack Sizes: 1 mg. Product ID: NP6702. Molecular formula: C31H52O. Mole weight: 440.76. Custom synthesis is available. Send your inquiries for more information. | London |
| 3-Tert-Butyldimethylsilyl-2-propyn-1-ol | 3-Tert-Butyldimethylsilyl-2-propyn-1-ol, a widely used chemical compound in organic synthesis, serves as a safeguarding agent for alcohols, impeding undesired chemical reactions. It displays versatility in various applications ranging from stable protecting group synthesis to the development of potent drugs such as Atazanavir, a prominent HIV protease inhibitor. The compound's multifunctional competence and adaptability make it an indispensable component of organic synthesis. Group: Pharmaceutical. Alternative Names: 3-(tert-butyldimethylsilyl)-2-propyn-1-ol. CAS No. 120789-51-7. Pack Sizes: 1 g. Product ID: B2699-232842. Molecular formula: C9H18OSi. Mole weight: 170.32. Custom synthesis is available. Send your inquiries for more information. | London |
| AAF-CMK trifluoroacetate salt | AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome function, and reversibly inhibits Cln2 (TPPI). Group: Pharmaceutical. Alternative Names: N-Ala-Ala-Phe-CMK; Tripeptidyl Peptidase Inhibitor II; L-Alaninamide,L-alanyl-N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-. CAS No. 184901-82-4. Pack Sizes: 100 mg. Product ID: BAT-015706. Molecular formula: C18H23ClF3N3O5. Mole weight: 453.84. Custom synthesis is available. Send your inquiries for more information. | London |
| ABZ-GLU-THR-LEU-PHE-GLN-GLY-PRO-VAL-P-NITRO-PHE-NH2 | ABZ-GLU-THR-LEU-PHE-GLN-GLY-PRO-VAL-P-NITRO-PHE-NH2. Group: Pharmaceutical. Alternative Names: ABZ-GLU-THR-LEU-PHE-GLN-GLY-PRO-VAL-P-NITRO-PHE-NH2; HUMAN RHINOVIRUS 3C PROTEASE SUBSTRATE; HRV 3C PROTEASE SUBSTRATE; H-2-ABZ-GLU-THR-LEU-PHE-GLN-GLY-PRO-VAL-4-NITRO-PHE-NH2. CAS No. 396096-53-0. Pack Sizes: 1mg;1g;10g. Product ID: 396096-53-0. Molecular formula: C57H77N13O16. Mole weight: 1200.3. Custom synthesis is available. Send your inquiries for more information. | London |
| AC 264613 | AC 264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). AC 264613 inhibits interferon regulatory factor 5 and decreases interleukin-12p40 production via lipopolysaccharide-stimulated macrophages. PI hydrolysis, Ca2+ mobilization and cellular proliferation are activated by AC 264613 in vitro (pEC50 = 6.9, 7.0 and 7.5, respectively). Group: Pharmaceutical. Alternative Names: AC-264613; AC 264613; AC264613; (±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide. CAS No. 1051487-82-1. Pack Sizes: 1mg;1g;10g. Product ID: 1051487-82-1. Molecular formula: C19H18BrN3O2. Mole weight: 400.27. Custom synthesis is available. Send your inquiries for more information. | London |
| AC-55541 | AC-55541 is a novel small-molecule protease-activated receptor 2(PAR2) agonist which displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. It activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. It was well absorbed when administered intraperitoneally to rats, reaching micromolar peak plasma concentrations. It was stable to metabolism by liver microsomes and maintained sustained exposure in rats. Uses: Ac-55541 stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization. Group: Pharmaceutical. Alternative Names: AC-55541; AC 55541; AC55541. (2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide;AC 55541;alpha-(Benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide;N-[2-[(2E)-2-[1-(3-bromophenyl)ethylidene]hydrazinyl]-2-oxo-1-(4-oxo-3H-phthalazin-1-yl)ethyl]benzamide. CAS No. 916170-19-9. Pack Sizes: 300 mg. Product ID: B0084-271988. Molecular formula: C25H20BrN5O3. Mole weight: 518.36. Custom synthesis is available. Send your inquiries for more information. | London |
| AEBSF HCl | AEBSF is a water-soluble, irreversible serine protease inhibitor that inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. Group: Pharmaceutical. Alternative Names: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride; AEBSF hydrochloride; AEBSF. CAS No. 30827-99-7. Pack Sizes: 1 g. Product ID: B2693-369679. Molecular formula: C8H11ClFNO2S. Mole weight: 239.69. Custom synthesis is available. Send your inquiries for more information. | London |
| Asunaprevir | Asunaprevir is a potent hepatitis C virus (HCV) non-structural protein protease inhibitor currently in Phase III clinical trials for the treatment of HCV infection. Uses: Protease inhibitors. Group: Pharmaceutical. Alternative Names: BMS-650032; BMS 650032; BMS650032; Asunaprevir. brand name: Sunvepra. CAS No. 630420-16-5. Pack Sizes: 50 mg. Product ID: B0084-463296. Molecular formula: C35H46ClN5O9S. Mole weight: 748.29. Custom synthesis is available. Send your inquiries for more information. | London |
| Atazanavir | Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir. Group: Pharmaceutical. Alternative Names: Atazanavir ; Reyataz ; Atazanavir sulfate ; CGP75136 ; CGP75176 ; CGP75355 ; BMS232632 ; CGP 73547 ; CGP 75136 ; CGP 75176 ; CGP 75355 ; CGP-73547 ; CGP-75136 ; CGP-75176 ; CGP-75355 ; BMS 232632 ; BMS-232632 ; BMS-232632-05 ; C413408. CAS No. 198904-31-3. Pack Sizes: 1 g. Product ID: B0084-062263. Molecular formula: C38H52N6O7. Mole weight: 704.869. Custom synthesis is available. Send your inquiries for more information. | London |
| Bevirimat | Bevirimat, also known as MPC-4326 and PA-457, is an anti-HIV drug derived from a betulinic acid-like compound, first isolated from Syzygium claviflorum, a Chinese herb. It is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition. Like protease inhibitors, bevirimat and other maturation inhibitors interfere with protease processing of newly translated HIV polyprotein precursor, called gag. Bevirimat prevents this viral replication by specifically inhibiting cleavage of the capsid protein (CA) from the SP1 spacer protein. Group: Pharmaceutical. Alternative Names: MPC4326; MPC 4326; MPC-4326; PA457; PA 457; PA-457; FH11327; FH-11327; FH 11327; YK FH312; Bevirimat; YKFH312. CAS No. 174022-42-5. Pack Sizes: 5 mg. Product ID: B0084-244897. Molecular formula: C36H56O6. Mole weight: 584.83. Custom synthesis is available. Send your inquiries for more information. | London |
| Boc-Gly-Gly-Phe-Gly-OH | Boc-Gly-Gly-Phe-Gly-OH is a self-assembly of N- and C-protected tetrapeptide. It is also a protease-cleavable linker for antibody-drug conjugates (ADCs). Group: Pharmaceutical. Alternative Names: N-tert-butoxycarbonyl-glycyl-glycyl-L-phenylalanyl-glycine; N-(tert-butoxycarbonyl)-glycylglycyl-L-phenylalanylglycine; (S)-12-Benzyl-2,2-dimethyl-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oic acid. CAS No. 187794-49-6. Pack Sizes: 250 mg. Product ID: BAT-009192. Molecular formula: C20H28N4O7. Mole weight: 436.46. Custom synthesis is available. Send your inquiries for more information. | London |
| Boc-GRR-AMC TFA | Boc-GRR-AMC (TFA) is a tri-peptide Substrate. BOC-GRR-AMC is cleaved by type II Metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana. It is a substrate for flavivirus proteases such as West Nile virus protease, yellow fever virus NS3 protease, and dengue virus NS2B-NS3 protease. Group: Pharmaceutical. Pack Sizes: 100 mg. Product ID: BAT-016508. Molecular formula: C29H44N10O7.xC2HF3O2. Mole weight: 644.72 (free base). Custom synthesis is available. Send your inquiries for more information. | London |
| Bortezomib USP Impurity G | Bortezomib USP Impurity G is an isomer of Bortezomib. It has been demonstrated to inhibit serine proteases shown to lower cellular Aβ concentrations, associated with Alzheimer's or hypertension. Group: Pharmaceutical. Alternative Names: (1S,2S)-Bortezomib; ((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid. CAS No. 1132709-14-8. Pack Sizes: 10 mg. Product ID: B0103-467636. Molecular formula: C19H25BN4O4. Mole weight: 384.243. Custom synthesis is available. Send your inquiries for more information. | London |
| Camostat Mesylate | Camostat (INN) or FOY-305 is a serine protease inhibitor. Serine protease enzymes have a variety of functions in the body, and so camostat has a diverse range of uses. It is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease orpancreatitis. Uses: Trypsin inhibitors. Group: Pharmaceutical. Alternative Names: 4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate methanesulfonate; Camostat Mesilate; Camostat Mesylate; FOY 305; FOY-305; FOY305. CAS No. 59721-29-8. Pack Sizes: 5 g. Product ID: B2693-072632. Molecular formula: C20H22N4O5.CH4O3S. Mole weight: 494.52. Custom synthesis is available. Send your inquiries for more information. | London |
| Darunavir | Darunavir is a second generation protease inhibitor that targets the HIV-1 protease. It demonstrates extremely potent activity against the infectivity and replication of various strains of HIV-1, including several that are resistant to first generation protease inhibitors (IC50s = 3-30 nM). Darunavir has been reported to inhibit both cell-free diffusion and cell-to-cell spread of HIV-1 with IC50 values of 2.5 and 2.8 nM, respectively. Uses: Hiv protease inhibitors. Group: Pharmaceutical. Alternative Names: TMC-114; TMC 114; TMC114; Prezista. CAS No. 206361-99-1. Pack Sizes: 50 mg. Product ID: B0084-062615. Molecular formula: C27H37N3O7S. Mole weight: 547.67. Custom synthesis is available. Send your inquiries for more information. | London |
| Darunavir Ethanolate | Darunavir Ethanolate is a nonpeptidic HIV protease inhibitor, used to treat HIV infection. Uses: Hiv protease inhibitors. Group: Pharmaceutical. Alternative Names: Phosphonoformate. CAS No. 635728-49-3. Pack Sizes: 1 g. Product ID: B0084-459375. Molecular formula: C27H37N3O7S·C2H5OH. Mole weight: 593.73. Custom synthesis is available. Send your inquiries for more information. | London |
| D-Val-Leu-Lys 4-nitroanilide dihydrochloride | D-Val-Leu-Lys 4-nitroanilide dihydrochloride stands as a crucial substrate to gauge the efficiency of trypsin-like serine proteases. Proteolysis event leads to the release of a yellow colored product, whose quantification can be done at 405 nm. Its utility can be seen in trypsin activity detection and the evaluation of agents restricting trypsin-like proteases. Consistent usage of this product aids in experimental design and the analysis of diverse protease substrates. Group: Pharmaceutical. Alternative Names: (S)-6-Amino-2-((S)-2-((R)-2-amino-3-methylbutanamido)-4-methylpentanamido)-N-(4-nitrophenyl)hexanamide dihydrochloride; H-D-Val-Leu-Lys-pNA 2HCl. CAS No. 62354-43-2. Pack Sizes: 5 mg. Product ID: BAT-014255. Molecular formula: C23H40Cl2N6O5. Mole weight: 551.5. Custom synthesis is available. Send your inquiries for more information. | London |
| E-64 | E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. Uses: For research used only. Group: Pharmaceutical. Alternative Names: L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide; Proteinase inhibitor E 64; 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-(2S,3S)-oxiranecarboxylic acid; Thiol protease inhibitor; trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane; 2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-; L-Trans-Epoxysuccinyl-Leu-agmatine. CAS No. 66701-25-5. Pack Sizes: 50 mg. Product ID: BAT-015060. Molecular formula: C15H27N5O5. Mole weight: 357.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Escin Ia | Escin Ia is a triterpenoid saponin isolated from A. chinensis. It was shown to inhibit HIV-1 protease with IC50 value of 35 μM. Group: Pharmaceutical. Alternative Names: Aescin A; alpha-Escin. CAS No. 123748-68-5. Pack Sizes: 10 mg. Product ID: NP7065. Molecular formula: C55H86O24. Mole weight: 1131.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Fmoc-GGFG-OH | Fmoc-GGFG-OH is a protease cleavable linker used for the antibody-drug conjugate (ADC). Group: Pharmaceutical. Alternative Names: Fmoc-Gly-Gly-Phe-Gly-OH; (((9H-Fluoren-9-yl)methoxy)carbonyl)glycylglycyl-L-phenylalanylglycine. CAS No. 1817857-75-2. Pack Sizes: 500 mg. Product ID: BADC-01446. Molecular formula: C30H30N4O7. Mole weight: 558.6. Custom synthesis is available. Send your inquiries for more information. | London |
| Freselestat | Freselestat is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM) with >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Freselestat can be used as treatment for neutrophil-predominant inflammatory lung diseases. Group: Pharmaceutical. Alternative Names: 2-(5-amino-6-oxo-2-phenylpyrimidin-1-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl]acetamide; ONO6818; ONO 6818; ONO-6818. CAS No. 208848-19-5. Pack Sizes: 10 mg. Product ID: B0084-101783. Molecular formula: C23H28N6O4. Mole weight: 452.51. Custom synthesis is available. Send your inquiries for more information. | London |
| γ-Mangostin | gamma-Mangostin isolated from the fruit of Garcinia cambogia is an HIV protease inhibitor. gamma-Mangostin is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, and SW480 cancer cells and BEAS-2B non-cancerous pulmonary epithelial cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively). Uses: Hiv protease inhibitor. Group: Pharmaceutical. Alternative Names: Normangostin. CAS No. 31271-07-5. Pack Sizes: 25 mg. Product ID: BBF-04088. Molecular formula: C23H24O6. Mole weight: 396.43. Custom synthesis is available. Send your inquiries for more information. | London |
| Ganoderiol F | Lansiumarin C is a natural coumarin found in the branches of Clausena lansium. and found to induce senescence of cancer cell lines, it induces growth arrest of cancer cell lines HepG2, Huh7 and K562; activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 were found in early stages of Ganoderiol F treatment and were presumed to cause cell-cycle arrest and trigger premature senescence of HepG2 cells; suggests that the growth-arrest and senescence induction capability on cancer cells suggest anticancer potential of Ganoderiol F. It could be developed further as both anti-HIV and antimalaria.In Compared to plasmepsin I, ganoderiol-F is higher towards HIV-1 protease. Uses: Anti-inflammatory; anti-hiv. Group: Pharmaceutical. Alternative Names: 26,27-Dihydroxylanosta-7,9(11),24-trien-3-one. CAS No. 114567-47-4. Pack Sizes: 1 mg. Product ID: NP6829. Molecular formula: C30H46O3. Mole weight: 454.7. Custom synthesis is available. Send your inquiries for more information. | London |
| H-D-allo-Threonine Methyl Ester Hydrochloride | H-D-allo-Threonine Methyl Ester Hydrochloride is used to prepare hepatitis A virus 3C cysteine protease inhibitors. Group: Pharmaceutical. Alternative Names: H-D-allo-Thr-OMe HCl; (2R,3R)-Methyl 2-Amino-3-hydroxybutanoate Hydrochloride; Methyl D-allo-Threoninate Hydrochloride. CAS No. 60538-18-3. Pack Sizes: 1 g. Product ID: B2699-039416. Molecular formula: C5H12ClNO3. Mole weight: 169.61. Custom synthesis is available. Send your inquiries for more information. | London |
| HY-17542 | HY-17542 is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 μM. Group: Pharmaceutical. Alternative Names: PLpro inhibitor 6; (R)-5-acetamido-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide; HY 17542; HY17542. CAS No. 1093070-14-4. Pack Sizes: 100 mg. Product ID: B1370-450321. Molecular formula: C22H22N2O2. Mole weight: 346.43. Custom synthesis is available. Send your inquiries for more information. | London |
| HZ-1157 | HZ-1157 is an inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease. Group: Pharmaceutical. Alternative Names: HZ-1157; HZ 1157; HZ1157. Dengue Virus Inhibitor II; 5-tert-butoxyquinazoline-2,4-diamine; 5-(tert-Butoxy)quinazoline-2,4-diamine; 2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-. CAS No. 1009734-33-1. Pack Sizes: 50 mg. Product ID: B0084-284802. Molecular formula: C12H16N4O. Mole weight: 232.287. Custom synthesis is available. Send your inquiries for more information. | London |
| Isopropyl ethanesulfonate | Propan-2-yl Ethane-1-sulfonate can be used as serine protease inhibitors to inhibit an increase in the blood gluocose level. Group: Pharmaceutical. Alternative Names: Ethanesulfonic acid isopropyl ester; Ethanesulfonic acid, isopropyl ester. CAS No. 14245-62-6. Pack Sizes: 1 g. Product ID: B2699-301730. Molecular formula: C5H12O3S. Mole weight: 152.21. Custom synthesis is available. Send your inquiries for more information. | London |
| JE-2147 | JE-2147 is a dipeptide HIV protease inhibitor (PI) that is effective against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro. Group: Pharmaceutical. Alternative Names: JE-2147;186538-00-1;KNI-764;AG1776;AG 1776;CHEMBL300891;(4R)-3-[(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl]-5,5-dimethyl-N-[(2-methylphenyl)methyl]-1,3-thiazolidine-4-carboxamide;(4r)-3-{(2s,3s)-2-Hydroxy-3-[(3-Hydroxy-2-Methylbenzoyl)amino]-4-Phenylbutanoyl}-5,5-Dimethyl-N-(2-Methylbenzyl)-1,3-Thiazolidine-4-Carboxamide;(4R)-3-[(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methyl. CAS No. 186538-00-1. Pack Sizes: 10 mg. Product ID: B2693-008706. Molecular formula: C32H37N3O5S. Mole weight: 575.72. Custom synthesis is available. Send your inquiries for more information. | London |
| Kallikrein Inhibitor | Kallikrein Inhibitor, a synthetic peptide, is a serine protease inhibitor that inhibits kallikrein and plasmin, and can attenuate breast cancer cell invasion. Group: Pharmaceutical. Alternative Names: KKI 5; KKI-5; KKI5; Ac-Pro-phe-arg-ser-val-gln-NH2; (S)-2-((3S,6S,9S,12S)-1-((S)-1-acetylpyrrolidin-2-yl)-3-benzyl-6-(3-guanidinopropyl)-9-(hydroxymethyl)-12-isopropyl-1,4,7,10-tetraoxo-2,5,8,11-tetraazatridecan-13-amido)pentanediamide; N-acetyl-L-prolyl-L-phenylalanyl-L-arginyl-L-seryl-L-valyl-L-glutaminamide. CAS No. 97145-43-2. Pack Sizes: 10 mg. Product ID: BAT-006188. Molecular formula: C35H55N11O9. Mole weight: 773.88. Custom synthesis is available. Send your inquiries for more information. | London |
| L-685,458 | L-685,458 is a potent and selective inhibitor of γ-secretase (IC50 = 17 nM) that shows 50-fold selectivity over a variety of aspartyl proteases. It also inhibits Aβ40 and Aβ42 peptides (in human neuroblastoma cells: IC50 = 48 and 67 nM respectively). Uses: Gamma secretase inhibitors and modulators. Group: Pharmaceutical. Alternative Names: L-685458; tert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate. CAS No. 292632-98-5. Pack Sizes: 25 mg. Product ID: B2693-286396. Molecular formula: C39H52N4O6. Mole weight: 672.85. Custom synthesis is available. Send your inquiries for more information. | London |
| Leupeptin hemisulfate | Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It can be used in skincare products to help reduce inflammation and provide soothing effects to the skin. Group: Pharmaceutical. Alternative Names: Ac-Leu-Leu-Arg-CHO.1/2H2SO4; Acetyl Tripeptide; L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-, sulfate (2:1); L-Leucinamide, N-acetyl-L-leucyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-, (S)-, sulfate (2:1); Leupeptin sulfate (2:1); N-Acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-leucinamide hemisulfate; Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate; N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate; Ac-Leu-Leu-Arg-al.1/2H2SO4; Ac-LLR-al.1/2H2SO4. CAS No. 103476-89-7. Pack Sizes: 300 mg. Product ID: BAT-010325. Molecular formula: C20H38N6O4.1/2H2SO4. Mole weight: 475.59. Custom synthesis is available. Send your inquiries for more information. | London |
| Lopinavir | An antiretroviral medication acts as a protease inhibitor. It is a co-formulation with a sub-therapeutic dose of ritonavir, as a component of combination therapy to treat HIV/AIDS. Group: Pharmaceutical. Alternative Names: ABT 378; ABT-378; ABT378; Aluviran; Kaletra. CAS No. 192725-17-0. Pack Sizes: 1 g. Product ID: B0084-086623. Molecular formula: C37H48N4O5. Mole weight: 628.81. Custom synthesis is available. Send your inquiries for more information. | London |
| Mesupron | Mesupron is the second generation serine protease inhibitor prodrug targeting the human urokinase plasminogen activator (uPA) system with potential antineoplastic and antimetastatic activities. Group: Pharmaceutical. Alternative Names: 1-Piperazinecarboxylic acid, 4-[(2S)-3-[3-[(hydroxyamino)iminomethyl]phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-, ethyl ester; Ethyl 4-[(2S)-3-[3-[(hydroxyamino)iminomethyl]phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-1-piperazinecarboxylate; (S)-Ethyl 4-(3-(3-(N-hydroxycarbamimidoyl)phenyl)-2-(2,4,6-triisopropylphenylsulfonamido)propanoyl)piperazine-1-carboxylate; WX 671; WX671; WX-671. CAS No. 590368-25-5. Pack Sizes: 5 mg. Product ID: B0084-462232. Molecular formula: C32H47N5O6S. Mole weight: 629.82. Custom synthesis is available. Send your inquiries for more information. | London |
| MK-5172 | Grazoprevir is a hepatitis C virus protease inhibitor developed for the treatment of hepatitis C. It suppresses NS3 and NS4A, which play a role in the virus splitting its polyprotein into the functional virus proteins. Grazoprevir is often used in combination with elbasvir or ribavirin. Uses: Antiviral agents. Group: Pharmaceutical. Alternative Names: Cyclopropanecarboxamide, N-[[[(1R,2R)-2-[5-(3-hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, cyclic (1→2)-ether, (1R,2S)-; Grazoprevir; (1R,2S)-N-[[[(1R,2R)-2-[5-(3-Hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide Cyclic (1→2)-Ether. CAS No. 1350514-68-9. Pack Sizes: 100 mg. Product ID: B2693-007134. Molecular formula: C38H50N6O9S. Mole weight: 766.91. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Acetyl-D-tryptophan | N-acetyl-D-tryptophan is the N-acetyl derivative of D-tryptophan. Uses: Protease inhibitors. Group: Pharmaceutical. Alternative Names: Ac-D-Trp-OH; acetyl-D-tryptophan. CAS No. 2280-1-5. Pack Sizes: 1mg;1g;10g. Product ID: BAT-008036. Molecular formula: C13H14N2O3. Mole weight: 246.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Nafamostat mesilate | Nafamostat Mesylate is a synthetic serine protease inhibitor and an anticoagulant. It is a fast-acting proteolytic inhibitor and used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin. Uses: Anti-inflammatory agents, non-steroidal. Group: Pharmaceutical. Alternative Names: 6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate; Nafamostat mesylate; nafamostat mesilate; FUT-175; FUT 175; FUT175. CAS No. 82956-11-4. Pack Sizes: 5 g. Product ID: BAT-008979. Molecular formula: C21H25N5O8S2. Mole weight: 539.58. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Desmethyl Enzalutamide | N-desmethyl Enzalutamide is a major metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist (IC50 = 36 nM) in LNCaP cells that inhibits the transcriptional activity of a mutant AR protein. Enzalutamide resists against induction of prostate-specific antigen (PSA) and transmembrane serine protease 2 (TMPRSS2). N-desmethyl Enzalutamide can be used for the treatment of disorders involving androgen, estrogen and progesterone receptors. Uses: The treatment of disorders involving androgen, estrogen and progesterone receptors. Group: Pharmaceutical. Alternative Names: N-desmethylenzalutamide; 1242137-16-1; 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzamide; 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzamide; Enzalutamide metabolite. CAS No. 1242137-16-1. Pack Sizes: 20 mg. Product ID: B0084-474425. Molecular formula: C20H14F4N4O2S. Mole weight: 450.412. Custom synthesis is available. Send your inquiries for more information. | London |
| N-p-Tosyl-Gly-Pro-Lys p-nitroanilide acetate salt | N-p-Tosyl-Gly-Pro-Lys p-nitroanilide acetate salt is a chromogenic substrate for plasmin determination, serine protease activity and fibrinogen decomposition determination. Group: Pharmaceutical. Alternative Names: N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt; Tos-GPK-pNA; Tos-Gly-Pro-Lys-pNA acetate; N-[(4-methylphenyl)sulfonyl]glycyl-L-prolyl-N-(4-nitrophenyl)-L-lysinamide, monoacetate. CAS No. 88793-79-7. Pack Sizes: 50 mg. Product ID: BAT-010163. Molecular formula: C28H38N6O9S. Mole weight: 634.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Odanacatib | Odanacatib, also known as MK-0822, is an inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption. Uses: For research used only. Group: Pharmaceutical. Alternative Names: MK0822; MK-0822; MK 0822; Odanacatib. CAS No. 603139-19-1. Pack Sizes: 100 mg. Product ID: B0084-095375. Molecular formula: C25H27F4N3O3S. Mole weight: 525.56. Custom synthesis is available. Send your inquiries for more information. | London |
| P22077 | P22077 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor. P22077 potently induces apoptosis in NB cells with an intact USP7-HDM2-p53 axis but not in NB cells with mutant p53 or without human homolog of MDM2 (HDM2) expression. P22077 was found to be able to sensitize chemoresistant LA-N-6 NB cells to chemotherapy. In an in vivo orthotopic NB mouse model, P22077 significantly inhibited the xenograft growth of three NB cell lines. USP7-specific inhibitors like P22077 may serve not only as a stand-alone therapy but also as an effective adjunct to current chemotherapeutic regimens for treating NB with an intact USP7-HDM2-p53 axis. Group: Pharmaceutical. Alternative Names: P-22077; P 22077. CAS No. 1247819-59-5. Pack Sizes: 100 mg. Product ID: B0084-462597. Molecular formula: C12H7F2NO3S2. Mole weight: 315.309. Custom synthesis is available. Send your inquiries for more information. | London |
| Pepstatin A | Pepstatin A is a potent aspartic protease inhibitor, and also inhibits HIV replication.It is a hexa-peptide containing the unusual amino acid statine (Sta, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid), having the sequence Isovaleryl-Val-Val-Sta-Ala-Sta (Iva-Val-Val-Sta-Ala-Sta). Uses: Protease inhibitors. Group: Pharmaceutical. Alternative Names: Pepstatin; NSC 272671; NSC-272671; NSC272671; Pepstatin A; Pepstatina; Pepstatinum; Pepstatin A. CAS No. 26305-03-3. Pack Sizes: 500 mg. Product ID: BAT-010775. Molecular formula: C34H63N5O9. Mole weight: 685.89. Custom synthesis is available. Send your inquiries for more information. | London |
| Pepstatin acetate | Acetylpepstatin is an aspartyl protease inhibitor that is effective against HIV-1 and HIV-2 protease. Group: Pharmaceutical. Alternative Names: Acetyl-pepstatin;Acetylpepstatin;28575-34-0;Acetyl pepstatin;(3S,4S)-4-[[(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]propanoyl]amino]-3-hydroxy-6-methylheptanoic acid;Pepstatin A (acetate);L-Valinamide, N-(3-methyl-1-oxobutyl)-L-valyl-N-[4-[[2-[[1-(2-carboxy-1-hydroxyethyl)-3-methylbutyl]amino]-1-methyl-2-oxoethyl. CAS No. 28575-34-0. Pack Sizes: 10 mg. Product ID: BAT-010206. Molecular formula: C22H24F2N6O3. Mole weight: 458.5. Custom synthesis is available. Send your inquiries for more information. | London |
| PF-07321332 | PF-07321332 is an orally available SARS-CoV 3C-like protease (3CLPRO) inhibitor. 3C-like protease (3CLPRO) is the main protease found in coronaviruses, which cleaves the coronavirus polyprotein at eleven conserved sites. PF-07321332 has demonstrated oral activity in a mouse-adapted SARS-CoV-2 model and has achieved oral plasma concentrations exceeding the in vitro antiviral cell potency in a phase I clinical trial in healthy human participants. Group: Pharmaceutical. Alternative Names: PF 07321332; PF07321332. CAS No. 2628280-40-8. Pack Sizes: 100 mg. Product ID: B2693-074195. Molecular formula: C23H32F3N5O4. Mole weight: 499.53. Custom synthesis is available. Send your inquiries for more information. | London |
| PF 429242 dihydrochloride | PF 429242 is a reversible and competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM), a transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. It reduces hepatic synthesis of cholesterol and fatty acid in mice. Group: Pharmaceutical. Alternative Names: PF-429242 dihydrochloride; PF429242 dihydrochloride. CAS No. 2248666-66-0. Pack Sizes: 100 mg. Product ID: B1370-291470. Molecular formula: C25H35N3O2·2HCl. Mole weight: 482.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Proteinase K | Proteinase K is a subtilisin-related serine protease. It was discovered from the fungus Engyodontium album. It can be used for removal of endogenous nucleases during the preparation of DNA and RNA, and for preparation of tissue sections for in situ hybridization. It is often used in pH range 7.5-9.0 and 37-70°C. Specific activity is ≥ 34 units/mg of protein. Group: Pharmaceutical. Alternative Names: EC 3.4.21.64; endopeptidase K; Tritirachium alkaline proteinase; Tritirachium album serine proteinase; Tritirachium album proteinase K. CAS No. 39450-01-6. Pack Sizes: 1 g. Product ID: BBF-04168. Custom synthesis is available. Send your inquiries for more information. | London |
| Pseudolaric acid B | Pseudolaric acid B (PAB), which comes from the bark of Pseudolarix kaempferi Gordon, has diverse effects that are relevant to cancer therapy, including apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo. pseudolaric acid B can trigger apoptosis by decreasing Bcl-2 levels and activating caspase-3 protease. The future development of PAB as a cancer therapeutic is ongoing. Besides, PAB significantly suppressed proliferation of DU145 cells in a dose-dependent manner without obvious cytotoxicity. PAB may inhibit growth of HRPC DU145 cells and induce apoptosis through ROS generation and Bcl-2 degradation via the activation of the ubiquitin-proteasome pathway. Uses: Antifungal/antifertility. Group: Pharmaceutical. Alternative Names: PLAB; 1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylicacid,4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methyl ester, (3R,4S,4aS,9aR)-; Pseudolarix acid B; Pseudolaric acid. CAS No. 82508-31-4. Pack Sizes: 10 mg. Product ID: NP1536. Molecular formula: C23H28O8. Mole weight: 432.46. Custom synthesis is available. Send your inquiries for more information. | London |
| Ritonavir | Ritonavir is an HIV protease inhibitor. It is often used in a low dose with another protease inhibitor lopinavir. Ritonavir was approved for COVID-19 treatment in combination with Nirmatrelvir. Group: Pharmaceutical. Alternative Names: Norvir; ABT-538; A-84538; 538, ABT; ABT 538; ABT-538; ABT538; Abbott 84538. CAS No. 155213-67-5. Pack Sizes: 1 g. Product ID: NP2679. Molecular formula: C37H48N6O5S2. Mole weight: 720.95. Custom synthesis is available. Send your inquiries for more information. | London |
| Seco-DUBA | seco-DUBA hydrochloride is a cell-permeable pro-drug that is cleaved into the active toxin (DUBA) in intracellular lysosomes by proteases, after internalization. The payload then alkylates the DNA, causing DNA damage and cell death. Group: Pharmaceutical. Alternative Names: Seco-duocarmycin; (S)-N-(2-(9-chloro-1-ethyl-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)imidazo[1,2-a]pyridin-6-yl)-4-hydroxybenzamide; Benzamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-9-methyl-3H-benz[e]indol-3-yl]carbonyl]imidazo[1,2-a]pyridin-6-yl]-4-hydroxy-; N-[2-[[(1S)-1-(Chloromethyl)-1,2-dihydro-5-hydroxy-9-methyl-3H-benz[e]indol-3-yl]carbonyl]imidazo[1,2-a]pyridin-6-yl]-4-hydroxybenzamide. CAS No. 1227961-59-2. Pack Sizes: 1 mg. Product ID: BADC-01400. Molecular formula: C29H23ClN4O4. Mole weight: 526.97. Custom synthesis is available. Send your inquiries for more information. | London |
| (S,R)-Bortezomib Hydroxyisopentyl Amide Analog | (S,R)-Bortezomib Hydroxyisopentyl Amide Analog is an isomer of Bortezomib. It has been demonstrated to inhibit serine proteases shown to lower cellular Aβ concentrations, associated with Alzheimer's or hypertension. Group: Pharmaceutical. Alternative Names: N-((S)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide; (R)-Hydroxy Des(boric Acid) Bortezomib; Bortezomib Hydroxy Impurity (1R,2S)-Isomer. CAS No. 289472-78-2. Pack Sizes: 25 mg. Product ID: B1370-150146. Molecular formula: C19H24N4O3. Mole weight: 356.43. Custom synthesis is available. Send your inquiries for more information. | London |
| Telaprevir-[d4] | Labelled Telaprevir. VX-950 is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). VX-950 forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (K(I)*) of 7 nM. Dissociation of the covalent enzyme-inhibitor complex of VX-950 and genotype 1a HCV protease has a half-life of almost an hour. A >4-log10 reduction in the HCV RNA levels was observed after a 2-week incubation of replicon cells with VX-950, with no rebound of viral RNA observed after withdrawal of the inhibitor. In several animal species, VX-950 exhibits a favorable pharmacokinetic profile with high exposure in the liver. In a recently developed HCV protease mouse model, VX-950 showed excellent inhibition of HCV NS3-4A protease activity in the liver. Group: Pharmaceutical. Alternative Names: (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-[(cyclopropyl-d4)amino]-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide; LY 570310-d4; MP 424-d4; VRT 111950-d4; VX 950-d4. Pack Sizes: 50 mg. Product ID: BLP-006018. Molecular formula: C36H49D4N7O6 | London |
| TFLLR-NH2 | TFLLR-NH2, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM. Group: Pharmaceutical. Alternative Names: TFLLR amide; (Thr1)-TRAP-5 amide; (Thr1)-PAR-1 (1-5) amide (human); PAR-1-activating peptide; PAR-1-AP; L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-L-argininamide. CAS No. 197794-83-5. Pack Sizes: 5 mg. Product ID: BAT-010746. Molecular formula: C31H53N9O6. Mole weight: 647.81. Custom synthesis is available. Send your inquiries for more information. | London |
| Thiorphan | Thiorphan is a potent and specific enkephalinase inhibitor with antinociceptive activity. Uses: Protease inhibitors. Group: Pharmaceutical. Alternative Names: N-[2-(Mercaptomethyl)-1-oxo-3-phenylpropyl]glycine; 2-Mercaptomethyl-3-phenylpropionylaminoacetic Acid; D,L-3-Mercapto-2-benzylpropanoylglycine; (+/-)-Thiorphan. CAS No. 76721-89-6. Pack Sizes: 50 mg. Product ID: BAT-008030. Molecular formula: C12H15NO3S. Mole weight: 253.32. Custom synthesis is available. Send your inquiries for more information. | London |
| Tomentin | Tomentin, a natural plant coumarin which is isolated from the barks of Jatropha curcas, exhibits anti-inflammatory activity. Tomentin also can inhibit papain-like protease. Uses: Anti-inflammatory. Group: Pharmaceutical. Alternative Names: 5-Hydroxy-6,7-dimethoxycoumarin. CAS No. 28449-62-9. Pack Sizes: 5 mg. Product ID: NP1173. Molecular formula: C11H10O5. Mole weight: 222.2. Custom synthesis is available. Send your inquiries for more information. | London |
| Trypsin Inhibitor (soybean) | Trypsin Inhibitor (soybean) is a peptide inhibitor of serine proteases that reduces trypsin, as well as plasma kallikrein, thrombin, plasmin, and other serine proteases. Group: Pharmaceutical. Alternative Names: Kunitz Trypsin Inhibitor; MR 20; SBTI. CAS No. 9035-81-8. Pack Sizes: 10 g. Product ID: B2693-194378. Custom synthesis is available. Send your inquiries for more information. | London |
| Tumulosic acid | Tumulosic acid is a triterpenoid found in Daedalea dickinsii and Wolfiporia cocos. It inhibits KLK5 protease activity with IC50 of 14.84 μM. Group: Pharmaceutical. Alternative Names: Tumulosic acid; 508-24-7; (2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3,16-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid; Tumulosicacid; CHEMBL461484. CAS No. 508-24-7. Pack Sizes: 10 mg. Product ID: B2703-379034. Molecular formula: C31H50O4. Mole weight: 486.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Ulinastatin | Ulinastatin is an acid-resistant protease inhibitor derived from human urine, acting as a potent anti-inflammatory agent. It was shown to inhibit the activities of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin, lipase, hyaluronidase, factors IXa, Xa, XIa, and XlIa, and polymorphonuclear leukocyte elastase. Group: Pharmaceutical. Alternative Names: Urinastatin; 2,4-Dioxaspiro[5.5]undec-8-ene, 3-(2-furanyl)-. CAS No. 80449-31-6. Pack Sizes: 1 g. Product ID: B2693-135299. Molecular formula: C13H16O3. Mole weight: 220.26. Custom synthesis is available. Send your inquiries for more information. | London |
| Val-cit-PAB-OH | Val-cit-PAB-OH is a protease cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). Group: Pharmaceutical. Alternative Names: L-valyl-N5-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-omithinamide; Val-cit-PAB; (S)-2-((S)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide. CAS No. 159857-79-1. Pack Sizes: 100 mg. Product ID: BADC-00708. Molecular formula: C18H29N5O4. Mole weight: 379.46. Custom synthesis is available. Send your inquiries for more information. | London |
| VKGILS-NH2 | VKGILS-NH2 is a reversed control peptide for SLIGKV-NH2, which is a protease-activated receptor 2 (PAR2) agonist. Group: Pharmaceutical. Alternative Names: retro-PAR-2 (1-6) amide (human); retro-SLIGKVamide; Thrombin Receptor-Like 1 (6-1) amide (human); Proteinase Activated Receptor 2 (6-1) amide (human); PAR-2 (6-1) amide (human). CAS No. 942413-05-0. Pack Sizes: 10 mg. Product ID: BAT-006100. Molecular formula: C28H54N8O7. Mole weight: 614.79. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-Phe-DL-Ala-FMK | Z-FA-FMK is an irreversible cysteine protease inhibitor, and it also inhibits caspases-2, -3, -6, and -7. Z-FA-FMK suppresses the degradation of fibrillar collagen by fibroblasts and osteoclasts, and reduces LPS-induced cytokine production via inhibition of NF-kappaB-dependent gene expression in macrophages. Uses: Cysteine proteinase inhibitors. Group: Pharmaceutical. Alternative Names: Z-Phe-DL-Ala-fluoromethylketone; Zfa-fmk; benzyloxycarbonyl-Phe-Ala-fluormethylketone; benzyloxycarbonylphenylalanyl-alanine fluoromethyl ketone; Carbamic acid, N-((1S)-2-((3-fluoro-1-methyl-2-oxopropyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-, phenylmethyl ester. CAS No. 197855-65-5. Pack Sizes: 50 mg. Product ID: B0084-209259. Molecular formula: C21H23FN2O4. Mole weight: 386.42. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-VAD-FMK | Z-VAD-FMK is a broad spectrum pan-caspase inhibitor that inhibits the intracellular activation of caspase-like proteases. Group: Pharmaceutical. Alternative Names: Z-VAD (OMe)-FMK; Caspase Inhibitor I. CAS No. 187389-52-2. Pack Sizes: 25 mg. Product ID: BAT-010214. Molecular formula: C22H30FN3O7. Mole weight: 467.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Acetylcorynoline | Acetylcorynoline, which can be extracted from the tubers of Corydalis ambigua, inhibits the maturing of bone marrow-derived dendritic cells in mice. However, it is only cytotoxic in amounts of greater than 20 μM. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. Acetylcorynoline significantly decreases dopaminergic neuron degeneration induced by 6-hydroxydopamine in BZ555 strain; prevents α-synuclein aggregation; recovers lipid content in OW13 strain; restores food-sensing behavior, and dopamine levels; and prolongs life-span in 6-hydroxydopamine-treated N2 strain, thus showing its potential as a possible antiparkinsonian drug. Acetylcorynoline may exert its effects by decreasing egl-1 expression to suppress apoptosis pathways and by increasing rpn5 expression to enhance the activity of proteasomes. Uses: Antifungal/anti-inflammatory. Group: Pharmaceutical. Alternative Names: (5bR,6S,12bR)-5b,6,7,12b,13,14-Hexahydro-5b,13-dimethyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol 6-acetate; Corynoline acetate; O-Acetylcorynoline; [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol,5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-, 6-acetate, (5bR,6S,12bR)-. CAS No. 18797-80-3. Pack Sizes: 10 mg. Product ID: B2703-464490. Molecular formula: C23H23NO6. Mole weight: 409.43. Custom synthesis is available. Send your inqui | London |
| ARV-471 | ARV-471, an oral estrogen receptor PROTAC protein degrader for the treatment of breast cancer, is an heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes. It leads to ubiquitylation and subsequent degradation of estrogen receptors through the proteasome. In ER positive breast cancer cell lines, it has a strong ability to degrade ER with a half-maximal degradation concentration (DC50) of ~2 nM. Group: Pharmaceutical. Alternative Names: ARV471; ARV 471; (S)-3-(5-(4-((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-; Vepdegestrant; (3S)-3-[1,3-Dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione. CAS No. 2229711-68-4. Pack Sizes: 5 mg. Product ID: B1370-380753. Molecular formula: C45H49N5O4. Mole weight: 723.9. Custom synthesis is available. Send your inquiries for more information. | London |
| Boc-LRR-AMC (trifluoroacetate salt) | Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Group: Pharmaceutical. Alternative Names: Boc-Leu-Arg-Arg-AMC.TFA; N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide, trifluoroacetate salt. Pack Sizes: 50 mg. Product ID: BAT-016477. Molecular formula: C35H53F3N10O9. Mole weight: 814.87. Custom synthesis is available. Send your inquiries for more information. | London |
| Bortezomib | Bortezomib is a potent, reversible and selective 20S proteasome inhibitor with a Ki of 0.6 nM. It is an antineoplastic agent that is used in treatment of refractory multiple myeloma and certain lymphomas. Group: Pharmaceutical. Alternative Names: PS-341; PS 341; PS341; LDP 341; LDP-341; LDP341; MLN341; MLN-341; MLN 341; B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; Velcade; ((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid; N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(2-pyrazinylcarbonyl)-L-phenylalaninamide. CAS No. 179324-69-7. Pack Sizes: 1 g. Product ID: BBF-05860. Molecular formula: C19H25BN4O4. Mole weight: 384.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Broussonin B | Broussonin B is a natural phenols found in the branch of Broussonetia papyrifera, it has moderate inhibitory activities against a chymotrypsin-like activity of the proteasome. Group: Pharmaceutical. Alternative Names: 4-[3-(4-Hydroxyphenyl)propyl]-3-methoxyphenol. CAS No. 73731-86-9. Pack Sizes: 1 mg. Product ID: NP5061. Molecular formula: C16H18O3. Mole weight: 258.32. Custom synthesis is available. Send your inquiries for more information. | London |
| Carfilzomib | Carfilzomib is a tetrapeptide epoxyketone and an analog of epoxomicin, acting as a selective proteasome inhibitor, such as the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM). It has been used as an injectable antineoplastic agent (IV only). Group: Pharmaceutical. Alternative Names: Kyprolis; PR171; PR-171; PR 171; (2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide. CAS No. 868540-17-4. Pack Sizes: 250 mg. Product ID: B0084-305419. Molecular formula: C40H57N5O7. Mole weight: 719.9. Custom synthesis is available. Send your inquiries for more information. | London |
| Corosolic acid | Corosolic acid, that is isolated from the barks of Lagerstroemia speciosa, contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts its anticancer activity against colon cancer cells by promoting the N-terminal phosphorylation and subsequent proteasomal degradation of β-catenin. Besides, Corosolic acid induced apoptosis in colorectal cancer (CRC), rendering this compound a potential anticancer agent for the treatment of CRC. Corosolic acid, as a new plant medicine for preventing and treating obesity and type II diabetes, and a functional natural health food and pharmaceutical raw material, has become a popular product in the market. Uses: Anti-angiogenic/anticancer. Group: Pharmaceutical. Alternative Names: 2-A-HYDROXYURSOLIC ACID; 2ALPHA-HYDROXYURSOLIC ACID; 2,3-DIHYDROXYURS-12-EN-28-OIC ACID; HYDROXYURSOLIC ACID; COROSOLIC ACID; Corsolicacid; Corosolic; (2a,3b)-2,3-Dihydroxy-urs-12-en-28-oic acid. CAS No. 4547-24-4. Pack Sizes: 50 mg. Product ID: NP7232. Molecular formula: C30H48O4. Mole weight: 472.7. Custom synthesis is available. Send your inquiries for more information. | London |
| HSP990 | HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (HSP90) with potential antineoplastic activity. HSP990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. HSP90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses. Group: Pharmaceutical. Alternative Names: NVP-HSP990; NVP HSP990; NVPHSP990; HSP 990; HSP-990. CAS No. 934343-74-5. Pack Sizes: 100 mg. Product ID: B1370-460667. Molecular formula: C20H18FN5O2. Mole weight: 379.39. Custom synthesis is available. Send your inquiries for more information. | London |
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