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| Product | Description | |
|---|---|---|
| PP2 | PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). Group: Pharmaceutical. Alternative Names: PP-2; PP 2; AG 1879; AG-1879; AG1879. CAS No. 172889-27-9. Pack Sizes: 100 mg. Product ID: B2693-169928. Molecular formula: C15H16ClN5. Mole weight: 301.77. Custom synthesis is available. Send your inquiries for more information. |  London |
| PP242 | PP242 is a novel potent and selective mTOR inhibitor with an IC50 of 8 nM. PP242 also shows residual (micromolar) activity against panel of tyrosine kinases. But PP242 was much less active against other PI3K family members with IC50 of 2, 2.2, 0.1, 1.3 and 0.41 μM for p110α, p110β, p110δ, p110γ and DNA-PK, respectively. Group: Pharmaceutical. Alternative Names: PP 242; PP-242; Torkinib. CAS No. 1092351-67-1. Pack Sizes: 100 mg. Product ID: B2693-272305. Molecular formula: C16H16N6O. Mole weight: 308.345. Custom synthesis is available. Send your inquiries for more information. | London |
| Fostriecin sodium salt | Fostriecin sodium salt is a protein phosphatase types 2A (PP2A) and 4 (PP4) inhibitor (IC50 = 1.5 nM and 3 nM, respectively). It also has an inhibitory effect on topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM). Fostriecin is found in Streptomyces pulveraceous. Uses: Enzyme inhibitors. Group: Pharmaceutical. Alternative Names: Fostriecin Sodium; Antibiotic CI 920 sodium salt; (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt. CAS No. 87860-39-7. Pack Sizes: 1 mg. Product ID: B1370-381555. Molecular formula: C19H26O9PNa. Mole weight: 452.37. Custom synthesis is available. Send your inquiries for more information. | London |
| LB-100 | LB-100 is a water-soluble protein phosphatase 2A (PP2A) inhibitor (IC50 = 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells) that enhanced the effects of sorafenib in HCC cells only during hypoxic environments. Group: Pharmaceutical. Alternative Names: (1S,4R)-2-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-3-carboxylic acid; LB 100; LB100. CAS No. 1632032-53-1. Pack Sizes: 100 mg. Product ID: B1370-474642. Molecular formula: C13H20N2O4. Mole weight: 268.31. Custom synthesis is available. Send your inquiries for more information. | London |
| Purvalanol A | Purvalanol A is a potent CDK inhibitor, which effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. indicating that the activation of CDKs contributes to the c-Src transformation. Purvalanol A suppressed the c-Src activity as effectively as the Src-selective inhibitor PP2, and that it reverted the transformed morphology to a nearly normal shape with less cytotoxicity than PP2. Purvalanol A induced a strong G2-M arrest, whereas PP2 weakly acted on the G1-S transition. Furthermore, when compared with PP2, purvalanol A more effectively suppressed the growth of human colon cancer HT29 and SW480 cells, in which Src family kinases and CDKs are activated. These findings demonstrate that the coordinated inhibition of cell cycle progression and tyrosine kinase signaling by the multi-selective purvalanol A is effective in suppressing cancer progression associated with c-Src up-regulation. Group: Pharmaceutical. Alternative Names: Purv; NG60; NG-60; NG 60; 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine; 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine. CAS No. 212844-53-6. Pack Sizes: 100 mg. Product ID: B1370-102089. Molecular formula: C19H25ClN6O. Mole weight: 388.89. Custom synthesis is available. Send your inquiries for more information. | London |
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