Phosphorylation Suppliers UK
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Product | Description | |
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N-Desethyl Sunitinib Quick enquiry Where to buy Suppliers range | N-Desethyl Sunitinib is a major and pharmacologically active metabolite of the tyrosine kinase inhibitor and anticancer drug Sunitinib. Sunitinib also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Sunitinib exhibits antiangiogenic and antitumor activity in multiple xenograft models. Group: Pharmaceuticals. Alternative Names: SU11662; SU 11662; SU-11662. CAS No. 356068-97-8. Pack Sizes: 1mg; 1g; 10g. Product ID: 356068-97-8. Custom synthesis is available. Send your inquiries for more information. | London |
PF-4708671 Quick enquiry Where to buy Suppliers range | PF-4708671 is a novel cell-permeable inhibitor of S6K1. PF-4708671 specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 was also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 is the first S6K1-specific inhibitor to be reported and will be a useful tool for delineating S6K1-specific roles downstream of mTOR. Group: Pharmaceuticals. Alternative Names: PF-4708671; PF4708671; PF 4708671. CAS No. 1255517-76-0. Pack Sizes: 1mg; 1g; 10g. Product ID: 1255517-76-0. Custom synthesis is available. Send your inquiries for more information. | London |