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| Product | Description | |
|---|---|---|
| Phosphorylating Phosphitylating Agents | Phosphorylating Phosphitylating Agents are critical reagents in the biomedical field, facilitating the synthesis of nucleotide analogs used in antiviral medications, such as those targeting HIV and hepatitis. These agents are essential for modifying nucleoside structures, thereby enabling the development of therapies that disrupt viral replication mechanisms and advance antiviral drug efficacy. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 2-Methacryloyloxyethyl phosphorylcholine | 2-Methacryloyloxyethyl phosphorylcholine is a biomaterial widely used in biomedicine. It is employed in the development of drug delivery systems, coatings, and implants due to its excellent biocompatibility and bioactive properties. Group: Pharmaceutical. CAS No. 67881-98-5. Pack Sizes: 10 g. Product ID: B0001-096817. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (2S)-Isopropyl 2- ( ( (perfluorophenoxy) (phenoxy)phosphoryl)amino)propanoate | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Group: Pharmaceutical. CAS No. 1256490-52-4. Pack Sizes: 25 mg. Product ID: B1628-480349. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one | 3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one Uses: Pharmaceutical R&D. Group: Coupling Reagents. Alternative Names: DEPBT. CAS No. 165534-43-0. Pack Sizes: Enquire for MOQ. Categories: Nordmann UK Fine Chemicals (Formerly Melrob-Eurolabs). |  UK / EU / USA / Japan |
| 3- (Diethoxyphosphoryl oxy) -1, 2, 3-benzotri azin-4- (3H) -one (DEPBT) | 5g Pack Size. Group: Building Blocks, Organics, Peptide Reagents. Formula: C11H14N3O5P. CAS No. 165534-43-0. Prepack ID : 20889478-5g. Molecular Weight : 299.22. |  |
| Thiophosphoryl chloride | 100g Pack Size. Group: Building Blocks, Inorganic Chemicals, Salts. Formula: Cl3PS. CAS No. 3982-91-0. Prepack ID : 75254135-100g. Molecular Weight : 169.4. | |
| (±)-10-Hydroxycamptothecin | (±)-10-Hydroxycamptothecin is an alkaloid derived from the seed or root bark of the deciduous plant Camptotheca acuminata. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. It exhibits anticancer and antiangiogenic activities. It can be used in cosmetics material. Group: Pharmaceutical. CAS No. 64439-81-2. Pack Sizes: 1 g. Product ID: B2703-051417. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine | PSI-6206 is a selective HCV RNA polymerase inhibitor. It is the unphosphorylated parent compound of triphosphate analog PSI-7409, which is a potent inhibitor of the HCV NS5B RNA dependent RNA polymerase. Group: Pharmaceutical. CAS No. 863329-66-2. Pack Sizes: 5 g. Product ID: B2693-459960. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 7-Deaza-2'-deoxyadenosine | It is a purine nucleoside phosphorylase inhibitor. Group: Pharmaceutical. CAS No. 60129-59-1. Pack Sizes: 250 mg. Product ID: B2706-039342. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| A-83-01 | A 83-01 is an inhibitor of TGF-β type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively). It blocks the phosphorylation of SMAD2/3 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Group: Pharmaceutical. CAS No. 909910-43-6. Pack Sizes: 50 mg. Product ID: B0084-155117. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acacetin | Acacetin isolated from the bark of Acacia farnesiana. It can inhibit p38 and JNK phosphorylation and reduces MMP-1, MMP-3 and MMP-13 expression in interleukin-1β-induced FLSs. Uses: Anti-inflammatory; anti-plasmodial activity; anti-peroxidant activity; anti-cancer and antitumor activities. Group: Pharmaceutical. CAS No. 480-44-4. Pack Sizes: 1mg; 1g; 10g. Product ID: NP1861. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AEE-788 | AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. Group: Pharmaceutical. CAS No. 497839-62-0. Pack Sizes: 10 mg. Product ID: B0084-258485. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Group: Pharmaceutical. CAS No. 118409-62-4. Pack Sizes: 100 mg. Product ID: B1370-195904. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AG 1406 | AG 1406 is an inhibitor of tyrosine phosphorylation. Group: Pharmaceutical. CAS No. 71308-34-4. Pack Sizes: 25 mg. Product ID: B0084-284859. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AG-490 | Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 133550-30-8. Pack Sizes: 25 mg. Product ID: B0084-164022. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AG-879 | AG-879, a tyrphostin compound, is a dual EGFR/HER2 inhibitor that was administered together with androgen withdrawal therapy. It inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM). Group: Pharmaceutical. CAS No. 148741-30-4. Pack Sizes: 20 mg. Product ID: B0084-195953. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ALK5 Inhibitor II hydrochloride | ALK5 inhibitor II was identified as a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (ALK5 autophosphorylation, IC50s = 4 nM, TGF-β cellular assay, IC50s = 18 nM, ALK5 binding in HepG2 cells, IC50s = 23 nM). This compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription. This product is a hydrochloride form. Group: Pharmaceutical. CAS No. 446859-33-2. Pack Sizes: 50 mg. Product ID: B0084-068993. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AMG 925 | AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. AMG 925 inhibited AML xenograft tumor growth by 96% to 99% without significant body weight loss. The antitumor activity of AMG 925 correlated with the inhibition of STAT5 and RB phosphorylation, the pharmacodynamic markers for inhibition of FLT3 and CDK4, respectively. In addition, AMG 925 was also found to inhibit FLT3 mutants (e.g., D835Y) that are resistant to the current FLT3 inhibitors (e.g., AC220 and sorafenib). AMG 925, which combines inhibition of two kinases essential for proliferation and survival of FLT3-mutated AML cells, may improve and prolong clinical responses. Group: Pharmaceutical. CAS No. 1401033-86-0. Pack Sizes: 25 mg. Product ID: B2693-463215. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Amlexanox | Amlexanox is a specific inhibitor of IKKε and TBK1, which inhibits IKKε and TBK1 activity as determined by MBP phosphorylation. Uses: Anti-allergic agents. Group: Pharmaceutical. CAS No. 68302-57-8. Pack Sizes: 100 g. Product ID: NP3492. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| APY29 | Allosteric modulator of IRE1&alpha. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity. Group: Pharmaceutical. CAS No. 1216665-49-4. Pack Sizes: 10 mg. Product ID: B2693-463139. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Aromadendrin | Aromadendrin, which usually comes from the bark of Eucalyptus calophylla, exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-κB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells. Aromadendrin may represent a potential therapeutic candidate for the management of type 2 DM. Uses: Anti-inflammatory/antioxidant/anti-diabetic. Group: Pharmaceutical. CAS No. 480-20-6. Pack Sizes: 50 mg. Product ID: NP1939. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AT13148 | AT13148 is an orally available multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. It can block phosphorylation of AKT, p70S6K, PKA, ROCK and SGK substrates, and induce apoptosis in cancer cells. Group: Pharmaceutical. CAS No. 1056901-62-2. Pack Sizes: 50 mg. Product ID: B0084-462670. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atractyloside potassium salt | Atractyloside potassium salt is the potassium salt of atractyloside, which inhibits oxidative phosphorylation by blocking the transfer of adenosine nucleotides through the mitochondrial membrane. Uses: Inhibitor of the adenine nucleotide translocator (ant). Group: Pharmaceutical. CAS No. 102130-43-8. Pack Sizes: 20 mg. Product ID: B0005-158965. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Aureobasidin A | Aureobasidin A is a cyclic depsipeptide antibiotic isolated from the filamentous fungus Aureobasidium pullulans R106. It is an antifungal agent that inhibits phosphorylceramide synthase. Group: Pharmaceutical. CAS No. 127785-64-2. Pack Sizes: 1 mg. Product ID: BBF-04146. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AZ7371 | AZ7371 is a novel non-covalent inhibitor of decaprenylphosphoryl-D-ribose oxidase (DprE1) with IC50 of 10 nM. Group: Pharmaceutical. CAS No. 1494675-86-3. Pack Sizes: 50 mg. Product ID: B2693-470868. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BAM 15 | BAM 15 is a novel mitochondrial protonophore uncoupler that uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). BAM 15 cannot depolarize the plasma membrane, and protects mice from acute renal ischemic-reperfusion injury. BAM 15 has the potential to treat obesity, Parkinson's disease, and aging. Group: Pharmaceutical. CAS No. 210302-17-3. Pack Sizes: 100 mg. Product ID: B1370-119162. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bemcentinib | Bemcentinib is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metast | London |
| Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite | A useful phosphorylating reagent. Group: Pharmaceutical. CAS No. 102690-88-0. Pack Sizes: 5 g. Product ID: B2699-159097. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Boc-D-FMK | BOC-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα). It has been found to reduce the activation of nuclear factor kappa light chain enhancer of activated B cells (NF-kB), suppress the phosphorylation of subunit nuclear factor kappa light polypeptide gene enhancer in B cells inhibitor α (IkBα) and inhibit TNF-induced expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1). Moreover, it has also effectively attenuated the hepatocyte apoptosis in bile duct-ligated rats potentially improving the survival rates. Uses: Caspase inhibitors. Group: Pharmaceutical. CAS No. 187389-53-3. Pack Sizes: 100 mg. Product ID: BAT-010386. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BX-795 | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, which is 140- and 1600-fold more selective than PKA and PKC. It is also a potent and relatively specific inhibitor of TBK1 with IC50 of 6 nM and IKK? with IC50 of 41 nM. Group: Pharmaceutical. CAS No. 702675-74-9. Pack Sizes: 25 mg. Product ID: B0084-194478. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| C16 Ceramide | C16 ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling. It has also been found to activate NF-κB and PKCζ3. Uses: A predominant, rather hydrophobic natural ceramide. activates a cytosolic serine/threonine protein phosphatase in t9 cells; induces egf receptor phosphorylation in a-431 cells; stimulates ceramide-activated protein kinase. Group: Pharmaceutical. CAS No. 24696-26-2. Pack Sizes: 100 mg. Product ID: B1370-059982. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (-)-Catechin gallate | (-)-Catechin gallate, a minor polyphenolic constituent in green tea, is used to study its cytotoxicity. It enhances Fe(2+)-induced, lipid peroxidation. It also inhibits aromatase activity, an enzyme that converts androgens to estrogen and is thought to play a role in the etiology of breast cancer. Uses: (-)-catechin gallate has been found to be probably effective in restraining tyrosine phosphorylation caused by vegf and have potential activity in the study of breast cancer. Group: Pharmaceutical. CAS No. 130405-40-2. Pack Sizes: 25 mg. Product ID: B2703-464825. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CGI1746 | CGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation. CGI1746 has exquisite selectivity for Btk and inhibits both auto- and transphosphorylation steps necessary for enzyme activation. Group: Pharmaceutical. CAS No. 910232-84-7. Pack Sizes: 100 mg. Product ID: B0084-430556. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Chrysoeriol | Chrysoeriol is a natural compound isolated from the herbs of Medicago sativa. Chrysoeriol can potently inhibit the induction of nitric oxide synthase by blocking activator protein 1 (AP-1) activation and its anti-inflammatory effects. Chrysoeriol can induce nod genes in rhizobium meliloti. Chrysoeriol can inhibit the downstream signal transduction pathways of platelet-derived growth factor (PDGF)-Rbeta, including ERK1/2, p38, and Akt phosphorylation, which suggests that chrysoeriol may be used for the prevention and treatment of vascular diseases during restenosis after coronary angioplasty. Group: Pharmaceutical. CAS No. 491-71-4. Pack Sizes: 25 mg. Product ID: NP2023. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Chrysophanol | Chrysophanic acid (Chrysophanol) is a natural anthraquinone with anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 μm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. Chrysophanol is a natural compound found in the roots and rhizomes of Rheum palmatum L. It can be used in cosmetics material. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 481-74-3. Pack Sizes: 1 g. Product ID: NP0901. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cidofovir dihydrate | Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is an acyclic nucleoside phosphonate, and is therefore independent of phosphorylation by viral enzymes, unlike acyclovir. Cidofovir was discovered at the Institute of Organic Chemistry and Biochemistry, Prague, and developed by Gilead Sciences and is marketed with the brand name Vistide by Gilead in the USA, and by Pfizer elsewhere. Maintenance therapy with cidofovir involves an infusion only once every two weeks, making it a convenient treatment option. Because dosing is relatively infrequent, a permanent catheter is not necessary for infusions. Uses: Antiviral agents. Group: Pharmaceutical. CAS No. 149394-66-1. Pack Sizes: 250 mg. Product ID: BBF-03991. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cirsimaritin | Cirsimaritin is purified from the herbs of Microtea debilis. Cirsimaritin has the potential use in patients with congestive heart failure that can mitigate cardiac remodeling and left ventricular dysfunction through augmenting myocardial autophagy and decreasing matrix metalloproteinase-2&9 activities. Cirsimaritin inhibits the growth of tumor cells and induces mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), and it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt. Cirsimaritin shows moderate anti-proliferative activity against COLO-205 cells with IC 50 values of 13.1uM. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner; support the putative application of cirsimaritin in ultraviolet photoprotection and hair coloration treatments. Group: Pharmaceutical. CAS No. 6601-62-3. Pack Sizes: 5 mg. Product ID: NP2021. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CL-387785 | CL-387785, also known as EKI-785, is an irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM). CL-387785 covalently bound to EGF-R. It also specifically inhibited kinase activity of the protein (IC50 = 370+/-120 pM), blocked EGF-stimulated autophosphorylation of the receptor in cells (ic50 approximately 5 nM), inhibited cell proliferation (IC50 = 31-125 nM) primarily in a cytostatic manner in cell lines that overexpress EGF-R or c-erbB-2, and profoundly blocked the growth of a tumor that overexpresses EGF-R in nude mice (when given orally at 80 mg/kg/day for 10 days, daily). CL-387,785 is useful for studying the interaction of small molecules with EGF-R and may have clinical utility. Uses: Protein kinase inhibitors. Group: Pharmaceutical. CAS No. 194423-06-8. Pack Sizes: 50 mg. Product ID: B0084-458793. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cladribine | 2-Chloro-2'-deoxyadenosine is an analog of adenosine that is resistant to both proliferating and non-dividing lymphocytes (IC50 = 45 nM). When phosphorylated, 2-Chloro-2'-deoxyadenosine accumulates in cells and inhibits ribonucleotide reductase. Group: Pharmaceutical. CAS No. 4291-63-8. Pack Sizes: 1 g. Product ID: B2693-004182. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Corosolic acid | Corosolic acid, that is isolated from the barks of Lagerstroemia speciosa, contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts its anticancer activity against colon cancer cells by promoting the N-terminal phosphorylation and subsequent proteasomal degradation of β-catenin. Besides, Corosolic acid induced apoptosis in colorectal cancer (CRC), rendering this compound a potential anticancer agent for the treatment of CRC. Corosolic acid, as a new plant medicine for preventing and treating obesity and type II diabetes, and a functional natural health food and pharmaceutical raw material, has become a popular product in the market. Uses: Anti-angiogenic/anticancer. Group: Pharmaceutical. CAS No. 4547-24-4. Pack Sizes: 50 mg. Product ID: NP7232. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cosmosiin | Cosmosiin also called Apigenin 7-O-glucoside, is a natural flavonoid found in the flowers of Cosmos bipinnatus. Cosmosiin exhibits the activities of anti-HIV, anti-proliferative and antioxidant, the compound may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation. Uses: Anti-proliferative; antioxidant; anti-hiv. Group: Pharmaceutical. CAS No. 578-74-5. Pack Sizes: 20 mg. Product ID: NP1892. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cucurbitacin D | Source from rhizomes of Hemsleya amabilis Diels. It might be a new therapeutic option for the treatment of endometrial and ovarian cancers, also may be a potential therapeutic agent for β-hemoglobinopathies, including sickle cell anemia and β-thalassemia. And it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells. Uses: Antitumor, resistance to chemical carcinogens, protect liver. Group: Pharmaceutical. CAS No. 3877-86-9. Pack Sizes: 5 mg. Product ID: B0005-464521. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cyclosporin H | The minor analogues of the cyclosporin family have immunological activity because they do not bind to immunophilins. It is an inhibitor of phorbol ester that effectively promotes tumors on mouse skin, and effectively inhibits calcium/calmodulin-dependent phosphorylation of EF-2 in vitro. It is an effective and selective formyl peptide receptor antagonist and formyl peptide-induced superoxide formation inhibitor. Group: Pharmaceutical. CAS No. 83602-39-5. Pack Sizes: 10 mg. Product ID: BBF-05764. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cyclovirobuxine D | Cyclovirobuxine D is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis. Uses: Anti- oxidative/anticancer. Group: Pharmaceutical. CAS No. 860-79-7. Pack Sizes: 100 mg. Product ID: B2703-351077. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CZ415 | CZ415 is a highly selective potent mTOR inhibitor with little activity on other lipid and protein kinases with efficacy in a collagen induced arthritis model and exhibits excellent cell permeability. In the issue, Bergamini et al., who has identified CZ415, confirmed with its extraordinary selectivity, drug-like properties and proven efficacy in vivo, CZ415 represents an ideal molecule for the pharmacological investigation of mTOR pathophysiological role in vivo. Assessed in dose response format from HEK293T cells after treatment with CZ415: 1. inhibition of S6RP (downstream of mTORC1) phosphorylation in HEK293T: IC50 = 14.5 nM; 2. inhibition of Akt (mTORC2 substrate) phosphorylation in HEK293T: IC50 = 14.8 nM; 3. inhibition of IFNγ release in stimulated human whole blood: IC50 = 226 nM. Group: Pharmaceutical. CAS No. 1429639-50-8. Pack Sizes: 5 mg. Product ID: B0084-474821. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Damnacanthal | Damnacanthal is a natural compound isolated from the fruit of Morinda citrifolia Linn. Damnacanthal acts as a potent and selective inhibitor of p56lck tyrosine kinase. It inhibits p56lck autophosphorylation with IC50 of 17 nM. Group: Pharmaceutical. CAS No. 477-84-9. Pack Sizes: 5 mg. Product ID: NP0889. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| eFT-508 | eFT-508 is a selective inhibitor of MNK1/2 (IC50s = 2.4 nM and 1 nM respectively) inhibiting MNK1/2-mediated signaling and the phosphorylation of certain regulatory proteins. It acts against tumor. Group: Pharmaceutical. CAS No. 1849590-01-7. Pack Sizes: 100 mg. Product ID: B0084-008131. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Erlotinib O-Desmethyl Metabolite Isomer (M14) HCl | OSI-420 (CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells. Uses: For research used only. Group: Pharmaceutical. CAS No. 183320-51-6. Pack Sizes: 10 mg. Product ID: B0084-286627. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ETP-46321 | ETP-46321 is a potent and orally bioavailable PI3K α, δ inhibitor with potent biochemical and cellular activity and good pharmacokinetic properties (PK) after oral dosing. ETP-46321 PK/PD studies showed time dependent downregulation of AKT(Ser473) phosphorylation, which correlates with compound levels in tumor tissue and demonstrating to be efficacious in a GEMM mouse tumor model driven by a K-Ras(G12V) oncogenic mutation. Treatment with ETP-46321 resulted in significant tumor growth inhibition. Group: Pharmaceutical. CAS No. 1252594-99-2. Pack Sizes: 300 mg. Product ID: B0084-462342. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ezatiostat | Ezatiostat is a glutathione analog that acts as an inhibitor of glutathione S-transferase (GST) P1-1. TLK117, the active form of ezatiostat, inhibits GSTP1-1, resulting in phosphorylation of JNK, restoring JNK-mediated cellular proliferation and differentiation signaling pathways. Group: Pharmaceutical. CAS No. 168682-53-9. Pack Sizes: 25 mg. Product ID: BAT-010079. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| FIPI | FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. It rapidly blocks in vivo PA production with subnanomolar potency. It has good pharmacokinetic parameters in rats. It did not significantly inhibit p38 or ERK phosphorylation in bone marrow-derived macrophages stimulated with lipopolysaccharide. It prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. Group: Pharmaceutical. CAS No. 939055-18-2. Pack Sizes: 100 mg. Product ID: B2693-438324. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| FLLL32 | FLLL32, a novel curcumin analogue, is a potent STAT3 inhibitor. FLLL32 specifically reduced STAT3 phosphorylation at Tyr705 (pSTAT3) and induced apoptosis at micromolar amounts in human melanoma cell lines and primary melanoma cultures. Group: Pharmaceutical. CAS No. 1226895-15-3. Pack Sizes: 50 mg. Product ID: B0084-462347. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| FMK | FMK is a potent, highly specific and irreversible ribosomal s6 kinase (RSK) inhibitor that covalently modifies the C-terminal kinase domain of RSK. Its IC50 value is 15 nM. It could prevent the activation of the N-terminal kinase domain of RSK by the C-terminal kinase domain, but does not affect the activity of the N-terminal domain. It binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. It induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells. It is used to determine the role of RSK as a direct regulator of NHE1 phosphorylation and sarcolemmal NHE activity in this cell type, in response to 1-adrenergic stimulation. Uses: Fmk could prevent the activation of the n-terminal kinase domain of rsk by the c-terminal kinase domain, but does not affect the activity of the n-terminal domain. it is used to determine the role of rsk as a direct regulator of nhe1 phosphorylation and sarcolemmal nhe activity in this cell type, in response to 1-adrenergic stimulation. Group: Pharmaceutical. CAS No. 821794-92-7. Pack Sizes: 10 mg. Product ID: B0084-455721. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Fosaprepitant dimeglumine | Fosaprepitant is a selective NK-1 receptor antahonist. It is a water-soluble phosphoryl prodrug for Aprepitant. Group: Pharmaceutical. CAS No. 265121-04-8. Pack Sizes: 500 mg. Product ID: NP2602. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Fosbretabulin disodium | Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue. Group: Pharmaceutical. CAS No. 168555-66-6. Pack Sizes: 100 mg. Product ID: B0084-085514. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GDC-0077 | GDC-0077 is an orally available and selective PI3K inhibitor (IC50 = 0.038 + 0.003 nM) with > 300-fold selective over other Class I PI3K isoforms. GDC-0077 exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Group: Pharmaceutical. CAS No. 2060571-02-8. Pack Sizes: 100 mg. Product ID: B2693-007357. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GDC-0994 | GDC-0994, also known as RG7842, is an orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 1453848-26-4. Pack Sizes: 50 mg. Product ID: B2693-462528. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Gefitinib | Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Group: Pharmaceutical. CAS No. 184475-35-2. Pack Sizes: 5 g. Product ID: BBF-04570. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ginsenoside Rb1 | A major bioactive component of panax ginseng that promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. It has been reported to display immunostimulatory and anticancer effects. It has anti-aging effect, can be used in health products. Uses: Anti-oxidative damage,immunostimulatory,anticancer. Group: Pharmaceutical. CAS No. 41753-43-9. Pack Sizes: 100 mg. Product ID: NP6991. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Glaucocalyxin A | Glaucocalyxin A, which is extracted from the herbs of Rabdosia rubescens, inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GP? pathway. Uses: Antiplatelet/antithrombotic. Group: Pharmaceutical. CAS No. 79498-31-0. Pack Sizes: 10 mg. Product ID: NP1506. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Glutathione EP Impurity C | Oxiglutatione is a stabilized formulation of disodium glutathione disulfide (GSSG; oxidized glutathione) and cisplatin (1000:1) with potential chemoprotective and immunomodulating activities. Mimicking endogenous GSSG, Oxiglutatione acts as a competitive substrate for gamma-glutamyl-transpeptidase (GGT), which may result in the S-glutathionylation of proteins, predominantly actin, a redox stress on endoplasmic reticulum (ER), and ER stress-induced apoptosis. S-glutathionylation may be stimulated by reactive oxygen species (ROS) liberated by an oxiglutatione-induced increase in GGT activity. Oxiglutatione may also induce phosphorylation of proteins such as ERK and p38, two kinases that play critical regulatory roles in cell proliferation and apoptosis. The cisplatin component of this agent does not provide an effective therapeutic concentration of cisplatin in vivo. Group: Pharmaceutical. CAS No. 27025-41-8. Pack Sizes: 25 g. Product ID: B0084-064728. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Guanosine-5'-triphosphate trisodium salt | Guanosine-5'-triphosphate sodium salt could be used as a phosphoryl donor in signal transduction and protein synthesis. Group: Pharmaceutical. CAS No. 36051-31-7. Pack Sizes: 500 mg. Product ID: B2001-005564. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Hypaconitine | Hypaconitine, a neuromuscular blocker, is a diterpene alkaloid found in the root of Aconitum carmichaelii. It is the primary constituent responsible for the neuromuscular blocking action of aconite root. It could inhibit CaM expression and Cx43 (Ser368) phosphorylation. It has anti-inflammatory effect. Uses: A neuromuscular blocker could inhibit cam expression and cx43 (ser368) phosphorylation. it has anti-inflammatory effect. Group: Pharmaceutical. CAS No. 6900-87-4. Pack Sizes: 20 mg. Product ID: NP0562. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| IACS-010759 | IACS-010759 is an orally bioavailable inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targeting complex I of the electron transport chain (NADH ubiquinone oxidoreductase). Study showed that IACS-010759 induced AMPK activation leading to mTOR suppression which resulted in cell growth inhibition in AML cells. Group: Pharmaceutical. CAS No. 1570496-34-2. Pack Sizes: 10 mg. Product ID: B2693-291404. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| IMD 0354 | IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κβ pathway. Group: Pharmaceutical. CAS No. 978-62-1. Pack Sizes: 50 mg. Product ID: B2693-383149. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ISRIB | ISRIB is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Group: Pharmaceutical. CAS No. 1597403-47-8. Pack Sizes: 250 mg. Product ID: BAT-010737. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ISRIB (mix-Isomer) | ISRIB (mix-Isomer), is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Group: Pharmaceutical. CAS No. 548470-11-7. Pack Sizes: 25 mg. Product ID: BAT-010736. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| JNK-IN-8 | JNK-IN-8 inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively. Uses: Protein kinase inhibitors. Group: Pharmaceutical. CAS No. 1410880-22-6. Pack Sizes: 20 mg. Product ID: B0084-463416. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ku-0063794 | KU-0063794 is an inhibitor of both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks (phosphoinositide 3-kinases) at 1000-fold higher concentrations. KU-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC kinase not regulated by mTOR. It also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1). It does not affect Thr308 phosphorylation in fibroblasts lacking essential mTORC2 subunits. KU-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. KU-0063794 will be useful in delineating the physiological roles of mTOR and may have utility in treatment of cancers in which this pathway is inappropriately activated. Uses: Differentiation. Group: Pharmaceutical. CAS No. 938440-64-3. Pack Sizes: 100 mg. Product ID: B0084-100850. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| KU-60019 | KU-60019 is a potent and selective ATM inhibitor. KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells. Group: Pharmaceutical. CAS No. 925701-49-1. Pack Sizes: 25 mg. Product ID: B2693-286438. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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