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| Product | Description | |
|---|---|---|
| 4-Aminophenyl a-D-mannopyranoside 6-phosphate | 4-Aminophenyl a-D-mannopyranoside 6-phosphate is a chemical compound used in the synthesis of phosphoinositide. This product is also used in the study of phosphatidylinositol (PI) signaling pathways, and has been shown to inhibit phospholipase C activity. Additionally, it has been found to be involved in the regulation of insulin secretion. Group: Pharmaceutical. CAS No. 74160-60-4. Pack Sizes: 100 mg. Product ID: B1370-000873. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 740 Y-P (TFA) | 740 Y-P is a cell-permeable phosphopeptide activator of PI3K. It binds to the p85 N- and C-terminal SH2 domains of PI3K but not to GST or the N-terminal domain of phospholipase C (PLC) in an affinity purification assay. And it displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B1370-449751. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Darapladib | Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Group: Pharmaceutical. CAS No. 356057-34-6. Pack Sizes: 10 mg. Product ID: B0084-111850. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ethyl arachidonate | Arachidonic acid (AA) is an unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation. Uses: Arachidonic acid (aa) is an unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes. phospholipase a2 releases aa from the membrane phospholipids in response to inflammation. Group: Pharmaceutical. CAS No. 1808-26-0. Pack Sizes: 1 g. Product ID: B4059-069622. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| FIPI | FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. It rapidly blocks in vivo PA production with subnanomolar potency. It has good pharmacokinetic parameters in rats. It did not significantly inhibit p38 or ERK phosphorylation in bone marrow-derived macrophages stimulated with lipopolysaccharide. It prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. Group: Pharmaceutical. CAS No. 939055-18-2. Pack Sizes: 100 mg. Product ID: B2693-438324. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Glaucocalyxin A | Glaucocalyxin A, which is extracted from the herbs of Rabdosia rubescens, inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GP? pathway. Uses: Antiplatelet/antithrombotic. Group: Pharmaceutical. CAS No. 79498-31-0. Pack Sizes: 10 mg. Product ID: NP1506. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rilapladib | Rilapladib is the third genomics-derived small molecule drug as a lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor which is an enzyme associated with the formation of atherosclerotic plaques. Uses: 1-alkyl-2-acetylglycerophosphocholine esterase inhibitors. Group: Pharmaceutical. CAS No. 412950-08-4. Pack Sizes: 50 mg. Product ID: B1370-068407. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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