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| Product | Description | |
|---|---|---|
| 6R,12S-Tadalafil | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Group: Pharmaceutical. Alternative Names: Tadalafil EP Impurity A; (6R,12aS)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; (6R-cis)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a- hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione. CAS No. 171596-27-3. Pack Sizes: 25 mg. Product ID: B2694-263981. Molecular formula: C22H19N3O4. Mole weight: 389.41. Custom synthesis is available. Send your inquiries for more information. |  London |
| 6S,12R-Tadalafil | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Group: Pharmaceutical. Alternative Names: Tadalafil EP Impurity C; (6S ,12ar)-Tadalafil; (6S,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; (6S-cis)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione. CAS No. 171596-28-4. Pack Sizes: 10 mg. Product ID: B2694-263982. Molecular formula: C22H19N3O4. Mole weight: 389.41. Custom synthesis is available. Send your inquiries for more information. | London |
| 6S,12S-Tadalafil | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Group: Pharmaceutical. Alternative Names: ent-Tadalafil; Tadalafil USP Impurity B; (6S,12aS)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; L-Tadalafil; L-Tildenafil. CAS No. 629652-72-8. Pack Sizes: 25 mg. Product ID: B2694-263979. Molecular formula: C22H19N3O4. Mole weight: 389.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Amrinone | Amrinone is a selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. It is a simple, non-glycoside cardiotonic agent. It provides protection against ischemia-reperfusion injury in kidney, liver, and heart. It has the ability to stimulate calcium ion influx into the cardiac cell. It is used in the treatment of congestive heart failure. It increases cardiac contractility as a vasodilator. It acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme. It is a drug that may improve the prognosis in patients with congestive heart failure. It has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). It was developed by Sanofi and has been listed. Uses: Amrinone is a simple, non-glycoside cardiotonic agent. it provides protection against ischemia-reperfusion injury in kidney, liver, and heart. it is used in the treatment of congestive heart failure. it increases cardiac contractility as a vasodilator. Group: Pharmaceutical. Alternative Names: Inamrinone;Wincoram;Inocor;Cordemcura;Win-40680;Win40680;3-Amino-5-pyridin-4-yl-1H-pyridin-2-one. CAS No. 60719-84-8. Pack Sizes: 2.5 g. Product ID: B0084-072903. Molecular formula: C10H9N3O. Mole weight: 187.2. Custom synthesis is available. Send your inquiries for more information. | London |
| Apremilast | Apremilast is an orally available small molecule inhibitor of phosphodiesterase 4 (PDE4). Apremilast specifically inhibits PDE4 and inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells. Uses: Anti-inflammatory agents, non-steroidal; phosphodiesterase inhibitors. Group: Pharmaceutical. Alternative Names: (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione; (S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide; CC 10004; CC10004; CC-10004. CAS No. 608141-41-9. Pack Sizes: 5 g. Product ID: B0084-459333. Molecular formula: C22H24N2O7S. Mole weight: 460.5. Custom synthesis is available. Send your inquiries for more information. | London |
| (+/-)-Apremilast | (+/-)-Apremilast is the racemic form of Apremilast, an orally available small molecule inhibitor of phosphodiesterase 4 (PDE4). Group: Pharmaceutical. Alternative Names: Apremilast, (+/-)-; N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide; Acetamide, N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)-. CAS No. 253168-86-4. Pack Sizes: 100 mg. Product ID: B2694-006563. Molecular formula: C22H24N2O7S. Mole weight: 460.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Avanafil | A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction. Group: Pharmaceutical. Alternative Names: TA-1790; TA 1790; TA1790; Avanafil; trade name: Stendra; Spedra. CAS No. 330784-47-9. Pack Sizes: 1mg;1g;10g. Product ID: NP3542. Molecular formula: C23H26ClN7O3. Mole weight: 483.95064. Custom synthesis is available. Send your inquiries for more information. | London |
| Caffeine Impurity F | Paraxanthine is a metabolite of caffeine, and also acts as an inhibitor of phosphodiesterase 9 (PDE9) and an antagonist of adenosine receptors A1 and A2 (Kis = 35 and 22 μM, respectively in equine forebrain tissues). Group: Pharmaceutical. Alternative Names: 1,7-Dimethylxanthine; P-Xanthine; Xanthine, 1,7-dimethyl-; 3,7-Dihydro-1,7-dimethyl-1H-purine-2,6-dione. CAS No. 611-59-6. Pack Sizes: 200 mg. Product ID: B0084-129330. Molecular formula: C7H8N4O2. Mole weight: 180.17. Custom synthesis is available. Send your inquiries for more information. | London |
| Clenbuterol Impurity E | Clenbuterol Impurity E is an impurity of Clenbuterol and is used as a reagent in the synthesis of pyrazolopyridine derivatives as inhibitors of phosphodiesterase-4 (PDE-IV) and production of tumor necrosis factor-α (TNF-α). Group: Pharmaceutical. Alternative Names: 4-Amino-3,5-dichlorophenacylbromide; 1-(4-Amino-3,5-dichlorophenyl)-2-bromoethan-1-one. CAS No. 37148-47-3. Pack Sizes: 1 g. Product ID: B2694-469119. Molecular formula: C8H6BrCl2NO. Mole weight: 282.95. Custom synthesis is available. Send your inquiries for more information. | London |
| Doxofylline Impurity 1 | Doxofylline Impurity 1 is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Group: Pharmaceutical. Alternative Names: 1-(1,3-Dioxolan-2-ylmethyl)-N-methyl-4-(methylamino)-1H-imidazole-5-carboxamide. CAS No. 1429636-74-7. Pack Sizes: 100 mg. Product ID: B2694-470470. Molecular formula: C10H16N4O3. Mole weight: 240.26. Custom synthesis is available. Send your inquiries for more information. | London |
| Doxofylline Impurity 2 | Doxofylline Impurity 2 (Theophylline Impurity 2) is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Group: Pharmaceutical. Alternative Names: Theophylline Impurity 1; 1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxopurine-7-acetaldehyde; 7-(Formylmethyl)theophylline; 7-Theophyllineacetaldehyde. CAS No. 5614-53-9. Pack Sizes: 10 mg. Product ID: B2694-470471. Molecular formula: C9H10N4O3. Mole weight: 222.2. Custom synthesis is available. Send your inquiries for more information. | London |
| DPTIP | DPTIP is a potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). DPTIP is metabolically stable and brain penetrant, regulating astrocyte-peripheral immune communication following brain inflammation. Group: Pharmaceutical. Alternative Names: 2,6-Dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol. CAS No. 351353-48-5. Pack Sizes: 50 mg. Product ID: B1370-334115. Molecular formula: C21H18N2O3S. Mole weight: 378.45. Custom synthesis is available. Send your inquiries for more information. | London |
| Drotaverine | Drotaverine is an antispasmodic drug, which acts as a phosphodiesterase 4 inhibitor. Group: Pharmaceutical. Alternative Names: Drotaverin; (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline. CAS No. 14009-24-6. Pack Sizes: 1mg;1g;10g. Product ID: 14009-24-6. Molecular formula: C24H31NO4. Mole weight: 397.515. Custom synthesis is available. Send your inquiries for more information. | London |
| Drotaverine hydrochloride | The salt form of Drotaverine, an antispasmodic drug, acts as a phosphodiesterase 4 inhibitor. Group: Pharmaceutical. Alternative Names: (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline hydrochloride. CAS No. 985-12-6. Pack Sizes: 1mg;1g;10g. Product ID: 985-12-6. Molecular formula: C24H32ClNO4. Mole weight: 433.973. Custom synthesis is available. Send your inquiries for more information. | London |
| Ibudilast | Ibudilast is a nonselective inhibitor of cyclic nucleotide phosphodiesterase (PDE) which has been marketed for treating asthma. It crosses the blood-brain barrier, is well tolerated, is active on oral administration, reduces glial activation and attenuates pain symptoms in diverse rat models of neuropathic pain. In addition, it enhances acute morphine analgesia and attenuates morphine tolerance and withdrawal. Thus ibudilast may improve opioid efficacy and is a promising therapeutic candidate for neuropathic pain. Group: Pharmaceutical. Alternative Names: MN-166, MN166, MN 166, AV-411, AV 411, AV411, KC404; KC-404; KC 404; Ibudilast. CAS No. 50847-11-5. Pack Sizes: 5 g. Product ID: B0084-329045. Molecular formula: C14H18N2O. Mole weight: 230.31. Custom synthesis is available. Send your inquiries for more information. | London |
| Luteolin | Luteolin is an anti-inflammatory, antioxidant and free radical scavenger. Luteolin inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. It also inhibits TNF-α-induced COX-2 expression, and phosphodiesterase with with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM for PDE1-5 respectively. It inhibits proliferation of Lewis lung carcinoma cells in vivo. Luteolin is a natural compound found in the leaves of Dracocephalum ruyschiana L. It can be used in cosmetics material. Uses: Adcs cytotoxin. Group: Pharmaceutical. Alternative Names: 3',4',5,7-Tetrahydroxyflavone; Digitoflavone; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one; Flacitran. CAS No. 491-70-3. Pack Sizes: 5 g. Product ID: NP1855. Molecular formula: C15H10O6. Mole weight: 286.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetra-hydro-1H-pyrido[3,4-b]indole-3-carboxylate | One of the intermediates to synthethese Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatmen of erectile dysfunction. Group: Pharmaceutical. Alternative Names: (1R,3R)-Methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate; (1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester. CAS No. 171489-59-1. Pack Sizes: 1mg;1g;10g. Product ID: NP3313. Molecular formula: C22H19ClN2O5. Mole weight: 426.86. Custom synthesis is available. Send your inquiries for more information. | London |
| Methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate | Methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate is an impurity of Tadalafil, which is a phosphodiesterase type 5 (PDE5) inhibitor, primarily used to treat erectile dysfunction (ED) and symptoms of benign prostatic hyperplasia (BPH). Group: Pharmaceutical. Alternative Names: Tadalafil intermediate; 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-, methyl ester, hydrochloride (1:1), (1R,3R)-; 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-, methyl ester, monohydrochloride, (1R,3R)-; 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-, methyl ester, monohydrochloride, (1R-cis)-; Methyl (1R,3R)-1-(2H-1,3-benzodioxol-5-yl)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylate hydrochloride; (1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-Pyrido[3,4-B]indole-3-carboxylic acid methyl ester HCl; (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride. CAS No. 171752-68-4. Pack Sizes: 1mg;1g;10g. Product ID: NP3312. Molecular formula: C20H19ClN2O4. Mole weight: 386.83. Custom synthesis is available. Send your inquiries for more information. | London |
| Milrinone | Milrinone is a phosphodiesterase 3 (PDE3) inhibitor with vasodilator properties, used to increase the heart's contractility. It increases erythrocyte cAMP activity via inhibiting erythrocyte phosphodiesterase. Uses: Increase the heart's contractility. Group: Pharmaceutical. Alternative Names: Primacor; Corotrope; Corotrop; Milrinona. CAS No. 78415-72-2. Pack Sizes: 1 g. Product ID: B0084-291905. Molecular formula: C12H9N3O. Mole weight: 211.22. Custom synthesis is available. Send your inquiries for more information. | London |
| Mirodenafil Dihydrochloride | Mirodenafil dihydrochloride is a newly developed oral phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. Group: Pharmaceutical. Alternative Names: 5-Ethyl-3,5-dihydro-2-[5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]-2-propoxyphenyl]-7-propyl-4H-pyrrolo[3,2-d]pyrimidin-4-one Hydrochloride; 4-[[3-(5-Ethyl-4,5-dihydro-4-oxo-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-2-yl)-4-propoxyphenyl]sulfonyl]-1-piperazineethanol Dihydrochloride; Mirodenafil 2HCl; M-vix; SK 3530 dihydrochloride; SK3530 dihydrochloride; SK-3530 dihydrochloride. CAS No. 862189-96-6. Pack Sizes: 500 mg. Product ID: B0084-263050. Molecular formula: C26H39Cl2N5O5S. Mole weight: 604.59. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Desethyl Vardenafil-[d8] | N-Desethyl Vardenafil-[d8] is the labelled analogue of N-Desethyl Vardenafil, which is a metabolite of Vardenafil. Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for the treatment of erectile dysfunction. Group: Pharmaceutical. Alternative Names: N-Desethyl Vardenafil D8; 1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-piperazine-d8. CAS No. 1184985-26-9. Pack Sizes: 1mg;1g;10g. Product ID: BLP-006053. Molecular formula: C21H20D8N6O4S. Mole weight: 468.6. Custom synthesis is available. Send your inquiries for more information. | London |
| Osthol | Osthole is a coumarin which is isolated from Cnidium monnieri (L.) Cusson. Osthole is a calcium channel modulator via inhibiting phosphodiesterases. It also regulates the expression of TNF-α, NF-κB, TGF-β, cyclooxygenases, leukotrienes, nitric oxide, ERK, and JNK. Osthole is a natural compound used in cosmetics material. Uses: Anti-tumor; anti-cancer; may be used as bio-pesticides. Group: Pharmaceutical. Alternative Names: Osthol; 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one. CAS No. 484-12-8. Pack Sizes: 100 g. Product ID: NP1032. Molecular formula: C15H16O3. Mole weight: 244.29. Custom synthesis is available. Send your inquiries for more information. | London |
| Pimobendan | Pimobendan is both a calcium sensitizer and a selective inhibitor of phosphodiesterase III (PDE3) with positive inotropic and vasodilator effects. Uses: Phosphodiesterase inhibitors. Group: Pharmaceutical. Alternative Names: Alprostadil;UD-CG115; UD CG115; UD-CG 115; UD-CG-115; Pimobendan; pimobendane. Trade name: Vetmedin and Acardi. CAS No. 74150-27-9. Pack Sizes: 2 g. Product ID: B0084-303517. Molecular formula: C19H18N4O2. Mole weight: 334.37. Custom synthesis is available. Send your inquiries for more information. | London |
| Polygalasaponin XXXI | Polygalasaponin XXXI is a triterpenoid compound found in the herbs of Polygala japonica Houtt. In vivo, Polygalasaponin XXXI exhibits inhibitory effect on proliferation of mouse adapted influenza virus A/PR/8/34 and cyclic AMP phosphodiesterase. Group: Pharmaceutical. Alternative Names: Polygalasaponin XXXI|79103-90-5|Polygalasaponin XXXI;Onjisaponin F|AKOS037514965. CAS No. 79103-90-5. Pack Sizes: 5 mg. Product ID: B0005-053391. Molecular formula: C75H112O36. Mole weight: 1589.685. Custom synthesis is available. Send your inquiries for more information. | London |
| Tadalafil-[d3] | Tadalafil-[d3] is the labelled analogue of Tadalafil, which is an inhibitor of phosphodiesterase 5 and can be used to treat erectile dysfunction. Tadalafil is also a phosphodiesterase 5 (PDE5) inhibitor. Group: Pharmaceutical. Alternative Names: Tadalafil D3. CAS No. 960226-55-5. Pack Sizes: 10 mg. Product ID: BLP-012605. Molecular formula: C22H16D3N3O4. Mole weight: 392.42. Custom synthesis is available. Send your inquiries for more information. | London |
| Tadalafil EP Impurity I | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Group: Pharmaceutical. Alternative Names: Tadalafil Spiro-oxindole Impurity; (8a'R)-6'-(1,3-Benzodioxol-5-yl)-2'-methyl-2',3',8',8a'-tetrahydro-6'H-spiro[indole-3,7'-pyrrolo[1,2-a]pyrazine]-1',2,4'(1H)-trione. CAS No. 1795790-92-9. Pack Sizes: 10 mg. Product ID: B2694-482887. Molecular formula: C22H19N3O5. Mole weight: 405.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Tadalafil Impurity B | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Group: Pharmaceutical. Alternative Names: (6R,12aS)-6-(1,3-benzodioxal-5yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]-1,4-dione. CAS No. 951661-82-8. Pack Sizes: 25 mg. Product ID: B2694-482858. Molecular formula: C20H19N3O3. Mole weight: 349.39. Custom synthesis is available. Send your inquiries for more information. | London |
| Tadalafil Impurity D | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Group: Pharmaceutical. Alternative Names: (6bR)-12-(1,3-Benzodioxol-5-yl)-12a-hydroxy-8-methyl-6a,6b,8,9,12,12a-hexahydropyrazino[1,2:1,2]-pyrrolo[3,4-c]quinoline-6,7,10(5H)-trione. CAS No. 951661-81-7. Pack Sizes: 5 mg. Product ID: B2694-482857. Molecular formula: C22H20ClN3O4. Mole weight: 425.88. Custom synthesis is available. Send your inquiries for more information. | London |
| Vinpocetine | Vinpocetine is a Phosphodiesterase inhibitor and selective for PDE1. It also blocks voltage-gated Na+ channels. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: Eburnamenine-14-carboxylic acid, ethyl ester, (3α,16α)-; (+)-Apovincaminic acid ethyl ester; (+)-cis-Apovincaminic acid ethyl ester; (+)-Vinpocetine; Apovincaminic acid ethyl ester; AY 27255; Bravinton; Cavinton; Ceractin; cis-Apovincaminic acid ethyl ester; Ethyl (+)-apovincaminate; Ethyl (+)-cis-apovincaminate; Ethyl apovincaminate; RGH 4405; TCV 3B; Ultra-Vinca; Vinporal. CAS No. 42971-09-5. Pack Sizes: 500 mg. Product ID: B0046-464044. Molecular formula: C22H26N2O2. Mole weight: 350.45. Custom synthesis is available. Send your inquiries for more information. | London |
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