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| Product | Description | |
|---|---|---|
| 5-Hydroxymethyldeoxyuridylate | 5-Hydroxymethyldeoxyuridylate is a pivotal nucleotide in DNA bioresearch and repair, emerging as a substrate indispensable for diverse enzymes implicated in DNA methylation and demethylation cascades. Group: Pharmaceutical. Alternative Names: 5-hydroxymethyluridine-2'-deoxy-5'-phosphate; 5-hydroxymethyl-dUMP. CAS No. 5238-86-8. Pack Sizes: 10 mg. Product ID: B1370-376869. Molecular formula: C10H15N2O9P. Mole weight: 338.21. Custom synthesis is available. Send your inquiries for more information. |  London |
| AMPPD disodium salt | AMPPD is a chemiluminescent enzyme substrate applied in clinical diagnostics. Group: Pharmaceutical. Alternative Names: Lumigen PPD; 3-(4-Methoxyspiro[1,2-dioxetane-3,2'-tricyclo[3.3.1.1(3,7)]decan]-4-yl)phenol dihydrogen phosphate disodium salt. CAS No. 124951-96-8. Pack Sizes: 200 mg. Product ID: B0245-001110. Molecular formula: C18H21Na2O7P. Mole weight: 426.3. Custom synthesis is available. Send your inquiries for more information. | London |
| β-Nicotinamide Adenine Dinucleotide | NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It plays a role in the activity of several enzymes, such as poly(ADP)-ribose polymerases and cADP-ribose synthases. NAD+ is commonly used as an oxidizing agent. Nutritional supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: Adenosine 5'-(trihydrogen diphosphate), P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt; Nadide; Coenzyme I; Beta-NAD; Diphosphopyridine nucleotide; NAD+; Adenosine 5'-(trihydrogen diphosphate), P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium hydroxide, inner salt; Adenine-nicotinamide dinucleotide; CO-I; Codehydrase I; Codehydrogenase I; Cozymase I; DPN; Enzopride; NAD; Nicotinamide-adenine dinucleotide; NSC 20272; Oxidized diphosphopyridine nucleotide; β-Diphosphopyridine nucleotide; β-NAD; β-NAD+. CAS No. 53-84-9. Pack Sizes: 10 g. Product ID: B0084-094034. Molecular formula: C21H27N7O14P2. Mole weight: 663.43. Custom synthesis is available. Send your inquiries for more information. | London |
| D-Glucose-6-phosphate dipotassium salt trihydrate | D-Glucose-6-phosphate dipotassium salt trihydrate is a pivotal compound extensively employed in the biomedical research and pharmaceutical industry, unveiling noteworthy potential in investigating intricate metabolic disorders and glucose metabolism. This paramount product seamlessly acts as a substrate for a diverse array of enzymes, facilitating the meticulous identification and characterization of pertinent pathways germane to therapeutic drug development of afflictions such as diabetes and glycogen storage diseases. Group: Pharmaceutical. Alternative Names: D-Glucose 6-phosphate Dipotassium Salt Trihydrate; Potassium (2R,3R,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexyl phosphate trihydrate; AC8158; D-Glucose-6-phosphatedipotassiumsalttrihydrate; a-D-Glucose-6-phosphate dipotassium salt hydrate. CAS No. 207727-36-4. Pack Sizes: 250 mg. Product ID: B2705-101654. Molecular formula: C6H17K2O12P. Mole weight: 390.36. Custom synthesis is available. Send your inquiries for more information. | London |
| ITI214 | ITI214 is a highly selective PDE1 inhibitor (Ki = 58 pM) at picomolar concentration without disrupting other PDE family members and a panel of enzymes, receptors, transporters, and ion channels. Group: Pharmaceutical. Alternative Names: Lenrispodun phosphate; PDE1-IN-1 (phosphate); ITI 214; ITI-214. CAS No. 1642303-38-5. Pack Sizes: 100 mg. Product ID: B2693-474648. Molecular formula: C29H29FN7O5P. Mole weight: 605.56. Custom synthesis is available. Send your inquiries for more information. | London |
| Leucovorin Calcium | leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Group: Pharmaceutical. Alternative Names: IST5-002; IST5 002; IST5002; Benzyl-AMP; N6-Benzyladenosine-5'-phosphate; Folinic acid calcium salt; Calcium Folinate. CAS No. 1492-18-8. Pack Sizes: 5 g. Product ID: B2693-301409. Molecular formula: C20H21N7O7.Ca. Mole weight: 513.52. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Acetyl-α-D-glucosamine-1-phosphate disodium salt | N-Acetyl-α-D-glucosamine-1-phosphate disodium salt is an indispensable compound in the biomedical sector with applications extending to studying an array of diseases and conditions, including particular enzyme deficiencies and genetic disorders. Group: Pharmaceutical. Alternative Names: N-acetyl-D-glucosamine-1-phosphate disodium salt; Sodium 2-acetamido-2-deoxy-1-O-(hydroxyphosphinato)-α-D-glucopyranose; α-D-Glucopyranose, 2-(acetylamino)-2-deoxy-, 1-(dihydrogen phosphate), disodium salt. CAS No. 31281-59-1. Pack Sizes: 25 mg. Product ID: B1370-369865. Molecular formula: C8H14NNa2O9P. Mole weight: 345.15. Custom synthesis is available. Send your inquiries for more information. | London |
| OXi-4503 | OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated levels in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production. CA1 binds to tubulin at the same site as colchicine but with higher affinity. Group: Pharmaceutical. Alternative Names: OXi4503; OXi 4503; CA1P; tetrasodium [3-methoxy-2-phosphonatooxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate. CAS No. 288847-35-8. Pack Sizes: 100 mg. Product ID: B0084-353235. Molecular formula: C18H22O12P2. Mole weight: 492.31. Custom synthesis is available. Send your inquiries for more information. | London |
| PseudoUridine 5'-monophosphate Sodium salt | A metabolic process has been acknowledged for pseudoUridine, and it involves the pseudoUridine phosphorylation to generate pseudoUridine 5?-monophosphate (ΨMP) catalyzed by the enzyme pseudoUridine kinase and thereafter the C-C glycosidic bond cleavage to give uracil and ribose 5-phosphate which mediated by the pseudoUridine 5?-monophosphate glycosidase. Group: Pharmaceutical. Alternative Names: Pseudouridylic acid sodium salt; (1S)-1,4-anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-5-O-phosphono-D-ribitol sodium salt; pseudouridine 5'-phosphate sodium salt; 5-(5-O-phosphono-beta-D-ribofuranosyl)pyrimidine-2,4(1H,3H)-dione sodium salt; 5-b-D-Ribofuranosyluracil 5'-phosphate sodium salt; Uracil, 5-b-D-ribofuranosyl-, 5'-phosphate, sodium salt; pUMP Sodium Salt. Pack Sizes: 100 mg. Product ID: B1370-285301. Molecular formula: C9H13N2O9P.xNa. Mole weight: 324.18 (free acid). Custom synthesis is available. Send your inquiries for more information. | London |
| Vicine | Vicine is an alkaloid glycoside found mainly in fava beans. It is related to the loss of the enzyme glucose-6-phosphate dehydrogenase. Uses: Anti-arrhythmic. Group: Pharmaceutical. Alternative Names: 2,6-diamino-5-(beta-D-glucopyranosyloxy)-(1H)-pyrimidin-4-one; 2,6-Diamino-5-(β-D-glucopyranosyloxy)-4(1H)-pyrimidinone; 2,6-Diamino-5-(β-D-glucopyranosyloxy)pyrimidin-4-ol; Divicine β-D-glucopyranoside; Vicine[phytotoxin]; Vicioside; 2,6-Diamino-5-(beta-D-glucopyranosyloxy)-4(1H)-pyrimidinone. CAS No. 152-93-2. Pack Sizes: 20 mg. Product ID: B2703-464844. Molecular formula: C10H16N4O7. Mole weight: 304.26. Custom synthesis is available. Send your inquiries for more information. | London |
| D-Fructose 1-phosphate disodium salt | D-Fructose 1-phosphate disodium salt is a crucial component used in the biomedical industry playing a vital role in the research of metabolic disorders and genetic diseases associated with defects in fructose metabolism. This product acts as a substrate for the enzymatic reaction leading to the conversion of fructose-1-phosphate to fructose-6-phosphate, facilitating normal fructose metabolism. Group: Pharmaceutical. Alternative Names: D-Fructofuranose, 1-(dihydrogen phosphate), disodium salt. CAS No. 71662-09-4. Pack Sizes: 5 mg. Product ID: B1370-149824. Molecular formula: C6H11Na2O9P. Mole weight: 304.1. Custom synthesis is available. Send your inquiries for more information. | London |
| DL-α-Glycerophosphate | DL-α-Glycerophosphate is a renowned chemical compound with a remarkable attribute of DL-α-Glycerophosphate liying in its pivotal role as a substrate in enzymatic determinations of alkaline phosphatase activity. Unveiling its vast potential, DL-α-Glycerophosphate holds promise in the research of critical ailments, such as osteoporosand other grave bone-related disorders. Group: Pharmaceutical. Alternative Names: 1,2,3-Propanetriol, 1-(dihydrogen phosphate); Glycerol, 1-(dihydrogen phosphate); D,L-Glycerol phosphate; D,L-α-Glycerol-phosphate; DL-Glycerol 1-phosphate; DL-Glycerol 3-phosphate; DL-α-Glycerol phosphate; DL-α-Glycerophosphoric acid; DL-α-Glyceryl phosphate; Glycerol-1-phosphate; Glycerol-3-phosphate; Glycerophosphoric Acid (Racemic). CAS No. 57-03-4. Pack Sizes: 100 g. Product ID: B1370-027988. Molecular formula: C3H9O6P. Mole weight: 172.07. Custom synthesis is available. Send your inquiries for more information. | London |
| Fostriecin sodium salt | Fostriecin sodium salt is a protein phosphatase types 2A (PP2A) and 4 (PP4) inhibitor (IC50 = 1.5 nM and 3 nM, respectively). It also has an inhibitory effect on topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM). Fostriecin is found in Streptomyces pulveraceous. Uses: Enzyme inhibitors. Group: Pharmaceutical. Alternative Names: Fostriecin Sodium; Antibiotic CI 920 sodium salt; (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt. CAS No. 87860-39-7. Pack Sizes: 1 mg. Product ID: B1370-381555. Molecular formula: C19H26O9PNa. Mole weight: 452.37. Custom synthesis is available. Send your inquiries for more information. | London |
| KY-226 | KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that protects neurons from cerebral ischemic injury. It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice. Uses: Enzyme inhibitors. Group: Pharmaceutical. Alternative Names: 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide; BCP32729; EX-A3829. CAS No. 1621673-53-7. Pack Sizes: 25 mg. Product ID: B2693-010435. Molecular formula: C27H31NO3S2. Mole weight: 481.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Tricirbine | Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 μM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Group: Pharmaceutical. Alternative Names: VQD-002; VQD 002; VQD002; API-2; Akt Inhibitor V; Pentaazacentopthylene; Tricyclic nucleoside; 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine. CAS No. 35943-35-2. Pack Sizes: 100 mg. Product ID: B1370-090988. Molecular formula: C13H16N6O4. Mol | London |
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