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| Product | Description | |
|---|---|---|
| 1-(4-(5-methyl-2-oxopiperidin-1-yl)phenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one | An impurity of Apixaban, which is a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Group: Pharmaceutical. Alternative Names: Apixaban Impurity 33; 2(1H)-Pyridinone, 5,6-dihydro-1-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-3-(4-morpholinyl)-. CAS No. 1686149-78-9. Pack Sizes: 50 mg. Product ID: B1370-455515. Molecular formula: C21H27N3O3. Mole weight: 369.47. Custom synthesis is available. Send your inquiries for more information. |  London |
| 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide | 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide is an impurity of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Group: Pharmaceutical. Alternative Names: Apixaban Chloro Impurity; 1-(4-Chlorophenyl)-4,5,6,7-tetrahydro-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide. CAS No. 2029205-64-7. Pack Sizes: 5 mg. Product ID: B1370-377545. Molecular formula: C24H22ClN5O3. Mole weight: 463.92. Custom synthesis is available. Send your inquiries for more information. | London |
| 5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H)-pyridinone | An impurity of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Group: Pharmaceutical. Alternative Names: 2(1H)-Pyridinone, 5,6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-; 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one; 3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one. CAS No. 545445-44-1. Pack Sizes: 5 g. Product ID: B0001-455190. Molecular formula: C20H25N3O3. Mole weight: 355.43. Custom synthesis is available. Send your inquiries for more information. | London |
| 6-(4-((5-amino-5-oxopentyl)amino)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide | 6-(4-((5-amino-5-oxopentyl)amino)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide is a metabolite of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Group: Pharmaceutical. Alternative Names: 6-{4-[(5-Amino-5-oxopentyl)amino]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; Des(2-oxo-1-piperidinyl)6-(4-(5-Amino-5-oxopentyl))Apixaban. CAS No. 2187409-01-2. Pack Sizes: 5 mg. Product ID: B1370-377543. Molecular formula: C25H28N6O4. Mole weight: 476.53. Custom synthesis is available. Send your inquiries for more information. | London |
| Benzamide, N-[4-methyl-3-[[4-(6-methyl-3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]- | This product is a kinase inhibitor used in the treatment of certain types of cancer, including non-small cell lung cancer and pancreatic cancer. It works by inhibiting specific enzymes involved in cell growth and proliferation, ultimately leading to tumor regression. Group: Pharmaceutical. Alternative Names: N-[4-methyl-3-[[4-(6-methylpyridin-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide; CHEMBL1079113; 1032314-85-4; SCHEMBL11939618; BDBM50313640; ZINC49018631. CAS No. 1032314-85-4. Pack Sizes: 10 mg. Product ID: B2699-456548. Molecular formula: C30H33N7O. Mole weight: 507.63. Custom synthesis is available. Send your inquiries for more information. | London |
| Ethyl 1-(4-methoxyphenyl)-7a-morpholino-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate | An impurity of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Group: Pharmaceutical. CAS No. 1619934-76-7. Pack Sizes: 100 mg. Product ID: B2694-152256. Molecular formula: C31H37N5O6. Mole weight: 575.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Ethyl (4-((2-(Methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Group: Pharmaceutical. Alternative Names: PAPE-ethyl Carbamate; Sorafenib related compound 7. CAS No. 2206827-12-3. Pack Sizes: 100 mg. Product ID: B2694-479756. Molecular formula: C16H17N3O4. Mole weight: 315.32. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Methyl-1-(5-phenyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methanamine fumarate | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Group: Pharmaceutical. Alternative Names: Vonoprazan Impurity 31 Fumarate; Vonoprazan Impurity U8(Fumarate). CAS No. 928325-82-0. Pack Sizes: 50 mg. Product ID: B1370-449842. Molecular formula: C21H21N3O6S. Mole weight: 443.47. Custom synthesis is available. Send your inquiries for more information. | London |
| 5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione | 5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione is an impurity of Pioglitazone, a PPAR agonist that has antidiabetic activity in patients with type 2 diabetes mellitus. Group: Pharmaceutical. Alternative Names: 2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methylene]-; 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methylene]-2,4-thiazolidinedione; 5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzylidene]-1,3-thiazolidine-2,4-dione; 5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzylidene]thiazolidine-2,4-dione. CAS No. 144809-28-9. Pack Sizes: 100 mg. Product ID: NP3434. Molecular formula: C19H18N2O3S. Mole weight: 354.42. Custom synthesis is available. Send your inquiries for more information. | London |
| A12B4C3 | A12B4C3 is a potent and selective inhibitor of polynucleotide kinase/phosphatase (PNKP) (IC50 = 60 nM), a DNA repair enzyme. A12B4C3 is inactive to calcineurin, protein PP-1 or APTX. Group: Pharmaceutical. Alternative Names: A12B4C3; A-12-B-4-C-3; A 12 B 4 C 3; A12 B4 C3; A12-B4-C3; 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione. CAS No. 1005129-80-5. Pack Sizes: 1mg;1g;10g. Product ID: 1005129-80-5. Molecular formula: C30H38N4O5. Mole weight: 534.65. Custom synthesis is available. Send your inquiries for more information. | London |
| A-674563 | A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. Group: Pharmaceutical. Alternative Names: A674563; A 674563; Benzeneethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (αS)-; (αS)-α-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine; (S)-1-((5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine. CAS No. 552325-73-2. Pack Sizes: 10 mg. Product ID: B0084-307687. Molecular formula: C22H22N4O. Mole weight: 358.44. Custom synthesis is available. Send your inquiries for more information. | London |
| A-674563 dihydrochloride | A-674563, an Akt1 inhibitor with a Ki of 11 nM, is moderately potent against PKA and >30-fold selective for Akt1 over PKC. Group: Pharmaceutical. Alternative Names: A-674563 2HCl; Benzeneethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, hydrochloride (1:2), (αS)-; (αS)-α-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine dihydrochloride; (S)-1-((5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine hydrochloride; A 674563 dihydrochloride; A674563 dihydrochloride. CAS No. 2759293-92-8. Pack Sizes: 1mg;1g;10g. Product ID: 2759293-92-8. Molecular formula: C22H22N4O.2HCl. Mole weight: 431.36. Custom synthesis is available. Send your inquiries for more information. | London |
| A-674563 hydrochloride | A-674563 hydrochloride is a potent, orally available Akt1 inhibitor with Ki of 11 nM. Group: Pharmaceutical. Alternative Names: (S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine hydrochloride. CAS No. 2070009-66-2. Pack Sizes: 1mg;1g;10g. Product ID: 2070009-66-2. Molecular formula: C22H23ClN4O. Mole weight: 394.9. Custom synthesis is available. Send your inquiries for more information. | London |
| A 784168 | A 784168 is a potent and selective TRPV1 antagonist (IC50 = 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin) exhibiting no activity against a range of receptors such as TRPA1, GABA, opioid, and purinergic receptors. Group: Pharmaceutical. Alternative Names: A 784168; A784168; A-784168; 3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide; 1-[3-(trifluoromethyl)pyridin-2-yl]-N-[4-(trifluoromethylsulfonyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamide. CAS No. 824982-41-4. Pack Sizes: 1mg;1g;10g. Product ID: 824982-41-4. Molecular formula: C19H15F6N3O3S. Mole weight: 479.4. Custom synthesis is available. Send your inquiries for more information. | London |
| A81988 | A81988 is a potent, orally active angiotensin I1 antagonist with a long duration of action whose pharmacological profile has established it as an important tool for the investigation of a variety of A11 mediated pathological conditions. Uses: Angiotensin ii type 1 receptor blockers. Group: Pharmaceutical. Alternative Names: 2-[propyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]pyridine-3-carboxylic acid; 2-(N-propyl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)amino)pyridine-3-carboxylic acid; A 81988; A-81988; A81988; Abbott 81988; Abbott-81988. CAS No. 141887-34-5. Pack Sizes: 1mg;1g;10g. Product ID: 141887-34-5. Molecular formula: C23H22N6O2. Mole weight: 414.46. Custom synthesis is available. Send your inquiries for more information. | London |
| A 839977 | A-839977 is a novel and selective P2X7 antagonist. It blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors with IC50 values 20, 42 and 150 nM respectively. It also potently blocked agonist-evoked YO-PRO uptake and IL-1beta release from differentiated human THP-1 cells. It also produced robust antihyperalgesia in the CFA model of inflammatory pain in wild-type mice. It has been exhibited to reduce CFA-induced thermal hyperalgesia in a dose-dependent fashion with the ED50 value of 100μmol/kg. Group: Pharmaceutical. Alternative Names: 1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine. CAS No. 870061-27-1. Pack Sizes: 1mg;1g;10g. Product ID: 870061-27-1. Molecular formula: C19H14Cl2N6O. Mole weight: 413.26. Custom synthesis is available. Send your inquiries for more information. | London |
| ABBV-167 | ABBV-167 is a phosphate prodrug of venetoclax, a Bcl-2 inhibitor. Group: Pharmaceutical. Alternative Names: Benzamide, 4-(4-((2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)-2-((7-((phosphonooxy)methyl)-7H-pyrrolo(2,3-b)pyridin-5-yl)oxy)-; (5-{5-(4-{[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl}-1-piperazinyl)-2-[({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)carbamoyl]phenoxy}-7H-pyrrolo[2,3-b]pyridin-7-yl)methyl dihydrogen phosphate. CAS No. 1351456-78-4. Pack Sizes: 1mg;1g;10g. Product ID: 1351456-78-4. Molecular formula: C46H53ClN7O11PS. Mole weight: 978.45. Custom synthesis is available. Send your inquiries for more information. | London |
| ABBV-744 | ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers. Group: Pharmaceutical. Alternative Names: N-ethyl-4-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide. CAS No. 2138861-99-9. Pack Sizes: 1mg;1g;10g. Product ID: 2138861-99-9. Molecular formula: C28H30FN3O4. Mole weight: 491.55. Custom synthesis is available. Send your inquiries for more information. | London |
| Apixaban Acid | A metabolite of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Group: Pharmaceutical. Alternative Names: 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid; Apixaban Impurity 41. CAS No. 503614-92-4. Pack Sizes: 100 mg. Product ID: B2694-376320. Molecular formula: C25H24N4O5. Mole weight: 460.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Apixaban Dehydro Impurity | A metabolite of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Group: Pharmaceutical. Alternative Names: 4,5-Dehydro Apixaban; 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-6,7-dihydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6,7-Dihydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-Pyrazolo[3,4-c]pyridine-3-carboxamide. CAS No. 1074549-89-5. Pack Sizes: 10 mg. Product ID: B2694-466680. Molecular formula: C25H23N5O4. Mole weight: 457.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Asciminib | Asciminib, also known as ABL-001, is a potent and selective allosteric Bcr-Abl inhibitor. Asciminib inhibits Ba/F3 cell growth with an IC50 of 0.25 nM. Uses: Tyrosine kinase inhibitors. Group: Pharmaceutical. Alternative Names: ABL-001; ABL 001; ABL001; N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide. CAS No. 1492952-76-7. Pack Sizes: 10 mg. Product ID: B0084-007699. Molecular formula: C20H18ClF2N5O3. Mole weight: 449.843. Custom synthesis is available. Send your inquiries for more information. | London |
| Benidipine hydrochloride | Benidipine hydrochloride is the hydrochloride salt form of Benidipine, which is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension). Group: Pharmaceutical. Alternative Names: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, hydrochloride (1:1), (4R)-rel-; Coniel; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (4R)-rel-; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (R*,R*)-(±)-; (±)-Benidipine hydrochloride; KW 3049; KW-3049; KW3049; rac Benidipine Hydrochloride. CAS No. 91599-74-5. Pack Sizes: 500 mg. Product ID: B2693-079515. Molecular formula: C28H31N3O6.HCl. Mole weight: 542.02. Custom synthesis is available. Send your inquiries for more information. | London |
| Benzyl nicotinate | Benzyl nicotinate is a metabolite of Nicotine, which is a potent parasympathomimetic stimulant. Group: Pharmaceutical. Alternative Names: 3-pyridinecarboxylic acid phenylmethyl ester. CAS No. 94-44-0. Pack Sizes: 1 kg. Product ID: NP2761. Molecular formula: C13H11NO2. Mole weight: 213.23. Custom synthesis is available. Send your inquiries for more information. | London |
| Cetrorelix | Cetrorelix is a gonadotropin-releasing hormone antagonist that can be used in the treatment of prostate and breast cancers. Uses: Fertility agents. Group: Pharmaceutical. Alternative Names: Ac-D-2-Nal-4-chloro-D-Phe-β-(3-pyridyl)-D-Ala-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2; N-acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-D-citrullyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide; D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-; SB-075. CAS No. 120287-85-6. Pack Sizes: 25 mg. Product ID: BAT-015281. Molecular formula: C70H92ClN17O14. Mole weight: 1431.04. Custom synthesis is available. Send your inquiries for more information. | London |
| Cetrorelix diacetate | Cetrorelix is a gonadotropin-releasing hormone (GnRH) antagonist. Under the trade name Cetrotide, It is indicated for the inhibition of premature LH surges in women undergoing controlled ovarian stimulation. Group: Pharmaceutical. Alternative Names: D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-, diacetate (salt); Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2.CH3CO2H; N-acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-D-citrullyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide diacetate salt. CAS No. 130143-01-0. Pack Sizes: 50 mg. Product ID: BAT-010074. Molecular formula: C74H100ClN17O18. Mole weight: 1551.16. Custom synthesis is available. Send your inquiries for more information. | London |
| Cilofexor | Cilofexor is a farnesoid X receptor (FXR) agonist. Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay). Group: Pharmaceutical. Alternative Names: 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]-3-hydroxy-1-azetidinyl]-4-pyridinecarboxylic acid. CAS No. 1418274-28-8. Pack Sizes: 25 mg. Product ID: B2693-291596. Molecular formula: C28H22Cl3N3O5. Mole weight: 586.9. Custom synthesis is available. Send your inquiries for more information. | London |
| CTLA-4 inhibitor | CTLA-4 inhibitor is an inhibitor of CTLA-4, an immune checkpoint negatively regulating T cell function. CTLA-4 is thought to regulate T-cell proliferation early in an immune response, primarily in lymph nodes. Group: Pharmaceutical. Alternative Names: MDK24720; MDK 24720; MDK-24720; CTLA-4 inhibitor. 2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one; EX-A913. CAS No. 635324-72-0. Pack Sizes: 10 mg. Product ID: B0084-284810. Molecular formula: C21H13F4N5O. Mole weight: 427.363. Custom synthesis is available. Send your inquiries for more information. | London |
| Dabigatran Etexilate Impurity 2 | O-(2-Ethylbutyl) Dabigatran Ethyl Ester is an impurity of Dabigatran Ethyl Ester, a nonpeptide, direct thrombin inhibitor. Group: Pharmaceutical. Alternative Names: O-(2-Ethylbutyl) Dabigatran Ethyl Ester; N-[[2-[[[4-[[[(2-Ethylbutoxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-Alanine Ethyl Ester. CAS No. 1610758-20-7. Pack Sizes: 10 mg. Product ID: B2694-469643. Molecular formula: C34H41N7O5. Mole weight: 627.73. Custom synthesis is available. Send your inquiries for more information. | London |
| Dabigatran etexilate mesylate | Dabigatran etexilate mesylate is the orally active prodrug of dabigatran. It is a reversible and selective, direct thrombin inhibitor (DTI). Group: Pharmaceutical. Alternative Names: Ethyl 3-(((2-(((4-(((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-1h-benzimidazol-5-yl)carbonyl)(pyridin-2-yl)amino)propanoate, methanesulfonate; Dabigatran etexilate mesylate; BIBR 1048MS; BIBR1048MS; BIBR-1048MS; BIBR 1048; BIBR1048; BIBR-1048; band name: Pradaxa. CAS No. 872728-81-9. Pack Sizes: 2 g. Product ID: B0084-461975. Molecular formula: C35H45N7O8S. Mole weight: 723.84. Custom synthesis is available. Send your inquiries for more information. | London |
| Dabigatran Etexilate N-Oxide Inner Salt | Dabigatran Etexilate N-Oxide is a metabolite of Dabigatran Etexilate, an oral anticoagulant and direct thrombin inhibitor. Group: Pharmaceutical. Alternative Names: N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(1-oxido-2-pyridinyl)-β-Alanine Ethyl Ester. CAS No. 1381757-44-3. Pack Sizes: 5 mg. Product ID: B2694-469624. Molecular formula: C34H41N7O6. Mole weight: 643.73. Custom synthesis is available. Send your inquiries for more information. | London |
| Dabigatran Impurity E | O-(2-Heptyl) Dabigatran Ethyl Ester is an impurity of Dabigatran Ethyl Ester, a nonpeptide, direct thrombin inhibitor. Group: Pharmaceutical. Alternative Names: O-(2-Heptyl) Dabigatran Ethyl Ester; Ethyl 3-(2-(((4-(N-((Heptan-2-yloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate. CAS No. 1610758-21-8. Pack Sizes: 10 mg. Product ID: B2694-469631. Molecular formula: C35H43N7O5. Mole weight: 641.76. Custom synthesis is available. Send your inquiries for more information. | London |
| DCC-2618 | DCC-2618 inhibits normal and mutant KIT kinase at the nanomol level. The targets are wt c-KIT, c-KIT mutants, PDGFR alpha, PDGFR beta, KDR and cFMS. DCC-2618 inhibits mutant KIT in GIST patient cell line (GIST T1 pKIT western Ex11 deletion) at a IC 50 of 2 nM. Deciphera's technology has identified DCC-2618 as a molecule which can be developed as second line therapy for imatinib and sunitinib resistant GIST patients with the potential to progress to frontline GIST therapy. DCC-2618 has been designed to effectively inhibit the imatinib and sunitinib-sensitive KIT juxtamembrane domain mutants (JMD) as well as secondary resistant KIT kinase-domain mutants. DCC-2618 additionally targets PDGFR alpha oncogenic mutants. Group: Pharmaceutical. Alternative Names: DCC2618; DCC 2618; c-Kit-IN-1; PDGFR inhibitor 1; N-[2,5-Difluoro-4-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]phenyl]-N'-phenyl-1,1-cyclopropanedicarboxamide. CAS No. 1225278-16-9. Pack Sizes: 50 mg. Product ID: B0084-457687. Molecular formula: C26H21F2N5O3. Mole weight: 489.47. Custom synthesis is available. Send your inquiries for more information. | London |
| Degarelix acetate | Degarelix is a synthetic gonadotropin-releasing hormone receptor (GNRHR) antagonist. It decreases tumor volume of Dunning R3327H prostate tumor flank implants in rats when administered at a dose of 1 mg/kg per month. Formulations containing degarelix have been used in the treatment of advanced prostate cancer. Group: Pharmaceutical. Alternative Names: Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Phe(4-S-dihydroorotamido)-D-Phe(4-ureido)-Leu-Lys(iPr)-Pro-D-Ala-NH2.CH3CO2H; N-acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-4-((S)-dihydroorotamido)-L-phenylalanyl-4-ureido-D-phenylalanyl-L-leucyl-N6-isopropyl-L-lysyl-L-prolyl-D-alaninamide acetic acid; D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-4-[[[(4S)-hexahydro-2,6-dioxo-4-pyrimidinyl]carbonyl]amino]-L-phenylalanyl-4-[(aminocarbonyl)amino]-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-, acetate (1:1); FE 200486; Gonax. CAS No. 934016-19-0. Pack Sizes: 250 mg. Product ID: BAT-016344. Molecular formula: C82H103ClN18O16.C2H4O2. Mole weight: 1692.31. Custom synthesis is available. Send your inquiries for more information. | London |
| Des-(3-(Pyridin-2-ylamino)propanoate)Dabigatran Ethyl Ester | Des-(3-(Pyridin-2-ylamino)propanoate)Dabigatran Ethyl Ester is an impurity of Dabigatran. Dabigatran is a very potent anticoagulant, in which the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Group: Pharmaceutical. Alternative Names: Ethyl 2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-1H-benzo[d]imidazole-5-carboxylate. CAS No. 1408238-41-4. Pack Sizes: 100 mg. Product ID: B2694-377679. Molecular formula: C19H21N5O2. Mole weight: 351.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Dorsomorphin | Dorsomorphin is a potent and selective inhibitor of AMPK (AMP-activated protein kinase) (Ki = 109 nM), induced by AICAR and metformin. It also inhibits bone morphogenetic protein (BMP) receptors including BMPR-IA (ALK3) and BMPR-IB (ALK6). Dorsomorphin can induce myocardial differentiation in mouse embryonic stem cells (mESCs). Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine; Compound C; AMPK Inhibitor, Compound C; BML-275. CAS No. 866405-64-3. Pack Sizes: 10 mg. Product ID: B0084-462934. Molecular formula: C24H25N5O. Mole weight: 399.49. Custom synthesis is available. Send your inquiries for more information. | London |
| E-4031 | E-4031, a benzenesulfonamide derivative, could be used as a Class III antiarrhythmic agent due to its effect of blocking the ERG potassium channels. Uses: E-4031 could be used as a class iii antiarrhythmic agent due to its effect of blocking the erg potassium channels. Group: Pharmaceutical. Alternative Names: E-4031; E 4031; E4031; 113559-13-0;CHEMBL536480;E-4031dihydrochloride;E-4031;1-(2-(6-Methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidinedihydrochloride;N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamidedihydrochloride. CAS No. 113559-13-0. Pack Sizes: 25 mg. Product ID: B2693-338550. Molecular formula: C21H29Cl2N3O3S. Mole weight: 474.44. Custom synthesis is available. Send your inquiries for more information. | London |
| Entinostat | Entinostat is a histone deacetylase (HDAC) inhibitor displaying antiproliferative and antineoplastic effects. Entinostat induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), which slows cell growth, differentiation, and tumor development in vivo. Entinostat is potentially used as an antitumor drug in combination with other drugs like adriamycin, PARP inhibitors and Hsp90 inhibitors. Uses: Histone deacetylase inhibitors. Group: Pharmaceutical. Alternative Names: MS275; MS-275; MS 2275; SNDX275; SNDX-275; SNDX 275; Entinostat; pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate. CAS No. 209783-80-2. Pack Sizes: 500 mg. Product ID: B0084-062759. Molecular formula: C21H20N4O3. Mole weight: 376.416. Custom synthesis is available. Send your inquiries for more information. | London |
| FDI 6 | FDI 6 is an inhibitor of the Forkhead box protein M1 transcription factor (FOXM1) (IC50 value 22.5 μM) that suppresses FOXM1 binding to DNA. FDI6 displaces ?FOXM1 from genomic targets in MCF-7 breast cancer cells, and downregulates concomitant transcription. Group: Pharmaceutical. Alternative Names: FDI-6; FDI 6; FDI6; NCGC00099374; NCGC-00099374; NCGC 00099374; 3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid (4-fluoro-phenyl)-amide; 3-amino-N-(4-fluorophenyl)-6-(2-thienyl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide; 3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide; AC1NPA9B. CAS No. 313380-27-7. Pack Sizes: 50 mg. Product ID: B0084-054874. Molecular formula: C19H11F4N3OS2. Mole weight: 437.43. Custom synthesis is available. Send your inquiries for more information. | London |
| Ganirelix Acetate | Ganirelix acetate is a decapeptide GnRH antagonist. It acts by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of LH and FSH. It is primarily used in assisted reproduction to control ovulation. Group: Pharmaceutical. Alternative Names: Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-hArg(Et,Et)-Leu-hArg(Et,Et)-Pro-D-Ala-NH2.2CH3CO2H; Antagon; N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D-alaninamide diacetate; Orgalutran. CAS No. 129311-55-3. Pack Sizes: 5 mg. Product ID: BAT-006138. Molecular formula: C84H121ClN18O17. Mole weight: 1690.42. Custom synthesis is available. Send your inquiries for more information. | London |
| Ganirelix Impurity F | Ganirelix Impurity F is an impurity of Ganirelix Acetate. Group: Pharmaceutical. Alternative Names: AC-D-2-NAL-D-4-CLPHE-D-3-PAL; N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanine. CAS No. 129225-22-5. Pack Sizes: 5 mg. Product ID: B0998-255837. Molecular formula: C32H31ClN4O5. Mole weight: 587.08. Custom synthesis is available. Send your inquiries for more information. | London |
| GANT-61 | GANT 61 is a GLI antagonist that inhibits GLI1 activation of gene expression with an IC50 value of 5 μM. Group: Pharmaceutical. Alternative Names: GANT61; GANT-61; GANT 61; NSC 136476; NSC136476; NSC-136476; 2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline. CAS No. 500579-04-4. Pack Sizes: 100 mg. Product ID: B0084-272119. Molecular formula: C27H35N5. Mole weight: 429.612. Custom synthesis is available. Send your inquiries for more information. | London |
| GSK-1070916A | GSK-1070916A is an ATP-competitive inhibitor of the serine/threonine kinases Aurora B and C with potential antineoplastic activity. Aurora B/C kinase inhibitor GSK1070916A binds to and inhibits the activity of Aurora kinases B and C, which may result in inhibition of cellular division and a decrease in the proliferation of tumor cells that overexpress the Aurora kinases B and C. Aurora kinases play essential roles in mitotic checkpoint control during mitosis, and are overexpressed by a wide variety of cancer cell types. Group: Pharmaceutical. Alternative Names: GSK 1070916; GSK-1070916; GSK 1070916; GSK1070916A; GSK 1070916A; NMI-900; NMI 900; NMI900; N'-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethylurea. CAS No. 942918-07-2. Pack Sizes: 25 mg. Product ID: B1370-100932. Molecular formula: C30H33N7O. Mole weight: 507.63. Custom synthesis is available. Send your inquiries for more information. | London |
| HS-173 | HS-173 is a potent and selective PI3Kα inhibitor displaying anticancer activity. HS-173 was shown to induce apoptosis via arresting the cell cycle at the G2/M phase. It also decreases angiogenesis induced by VEGF. Group: Pharmaceutical. Alternative Names: Ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate; HS173; HS 173; HS-173. CAS No. 1276110-06-5. Pack Sizes: 100 mg. Product ID: B0084-462372. Molecular formula: C21H18N4O4S. Mole weight: 422.459. Custom synthesis is available. Send your inquiries for more information. | London |
| Hydroxy Pioglitazone-[d4] (M-IV) | Hydroxy Pioglitazone-[d4] (M-IV) is the labelled analogue of Hydroxy Pioglitazone (M-IV), which is a metabolite of Pioglitazone, a PPARγ agonist used as an anti-diabetic drug. Group: Pharmaceutical. Alternative Names: Hydroxy Pioglitazone-d4 (M-IV); 5-[[4-[2-[5-(1-Hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione-d4. CAS No. 1188263-49-1. Pack Sizes: 1 mg. Product ID: BLP-008210. Molecular formula: C19H16D4N2O4S. Mole weight: 376.46. Custom synthesis is available. Send your inquiries for more information. | London |
| Ibuprofen piconol | Ibuprofen piconol is an anti-inflammatory agent that can be synthesized from Ibuprofen. It acts as a cyclooxygenase inhibitor. Group: Pharmaceutical. Alternative Names: Pimeprofen; Staderm; Vesicum; pyridin-2-ylmethyl 2-[4-(2-methylpropyl)phenyl]propanoate. CAS No. 64622-45-3. Pack Sizes: 5 g. Product ID: B0046-448719. Molecular formula: C19H23NO2. Mole weight: 297.4. Custom synthesis is available. Send your inquiries for more information. | London |
| iCRT 14 | iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling. It is thought to directly influence the interaction between β-catenin and TCF4. It also induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. Group: Pharmaceutical. Alternative Names: iCRT14; iCRT-14; iCRT 14; Wnt inhibitor; CHEMBL3589010; STK155594; 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione. CAS No. 677331-12-3. Pack Sizes: 25 mg. Product ID: B0084-272145. Molecular formula: C21H17N3O2S. Mole weight: 375.44. Custom synthesis is available. Send your inquiries for more information. | London |
| Imatinib | Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with an IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. Imatinib is an oral chemotherapy agent used to treat cancers. Specifically, it is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+), certain types of gastrointestinal stromal tumors (GIST), hypereosinophilic syndrome (HES), chronic eosinophilic leukemia (CEL), systemic mastocytosis, and myelodysplastic syndrome. Group: Pharmaceutical. Alternative Names: CGP057148B; STI571; Gleevec; Glivec; N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide; 4-[(4-Methyl-1-piperazinyl)methyl]-N-(4-methyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}phenyl)benzamide. CAS No. 152459-95-5. Pack Sizes: 10 g. Product ID: BBF-05855. Molecular formula: C29H31N7O. Mole weight: 493.6. Custom synthesis is available. Send your inquiries for more information. | London |
| Imatinib-[d4] | Imatinib-[d4] is an isotopically labelled analogue of Imatinib. Imatinib is an inhibitor of multiple tyrosine kinases. It is a COVID-19-related research product. Group: Pharmaceutical. Alternative Names: N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide-2,3,5,6-d4; Imatinib D4. CAS No. 1134803-16-9. Pack Sizes: 5 mg. Product ID: BLP-005865. Molecular formula: C29H27D4N7O. Mole weight: 497.64. Custom synthesis is available. Send your inquiries for more information. | London |
| Imatinib EP Impurity D | An impurity of Imatinib, a tyrosine kinase inhibitor used as a chemotherapy drug for the treatment of leukemia and other kinds of cancer. Group: Pharmaceutical. Alternative Names: Des(methylpiperazinyl) Imatinib Dimer Piperazinium Chloride; 1-Methyl-1,4-bis[4-[(4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl)carbamoyl]benzyl]piperazin-1-ium chloride. CAS No. 1821122-73-9. Pack Sizes: 100 mg. Product ID: B2694-473167. Molecular formula: C53H51ClN12O2. Mole weight: 923.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Imatinib EP Impurity J | An impurity of Imatinib, a tyrosine kinase receptor inhibitor used for cancer therapy. Group: Pharmaceutical. Alternative Names: Imatinib (Piperidine)-N-oxide; 4-[(4-Methyl-4-oxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide; CGP 71422; CGP71422; CGP-71422. CAS No. 571186-91-9. Pack Sizes: 10 mg. Product ID: B2694-473158. Molecular formula: C29H31N7O2. Mole weight: 509.62. Custom synthesis is available. Send your inquiries for more information. | London |
| Imatinib Impurity C | an impurity of Imatinib (Gleevec). Group: Pharmaceutical. Alternative Names: Imatinib (Piperidine)-1-oxide; 4-[(4-Methyl-1-oxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide. CAS No. 938082-57-6. Pack Sizes: 10 mg. Product ID: B2694-473162. Molecular formula: C29H31N7O2. Mole weight: 509.62. Custom synthesis is available. Send your inquiries for more information. | London |
| Imatinib Impurity E | an impurity of Imatinib (Gleevec). Group: Pharmaceutical. Alternative Names: Des(methylpiperazinyl-N-methyl) Imatinib Dimer Impurity; 4,4'-(piperazine-1,4-diylbis(methylene))bis(N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide). CAS No. 1365802-18-1. Pack Sizes: 10 mg. Product ID: B2694-473163. Molecular formula: C52H48N12O2. Mole weight: 873.04. Custom synthesis is available. Send your inquiries for more information. | London |
| Imatinib Related Substance B | An impurity of Imatinib, a tyrosine kinase receptor inhibitor used for cancer therapy. Group: Pharmaceutical. Alternative Names: Imatinib (Piperidine)-N,N-dioxide; 4-[(4-Methyl-1,4-dioxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide. CAS No. 571186-93-1. Pack Sizes: 5 mg. Product ID: B2694-473161. Molecular formula: C29H31N7O3. Mole weight: 525.62. Custom synthesis is available. Send your inquiries for more information. | London |
| MCP110 | MCP110 is a Ras/Raf-1 interaction inhibitor. The Ras signaling pathway is activated either by direct mutation of Ras or its effector B-Raf. MCP110 was shown to inhibit proliferation of tumor cells. Group: Pharmaceutical. Alternative Names: MCP110; MCP-110; MCP 110; N-(4-(benzyloxy)-3-methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanamide. CAS No. 521310-51-0. Pack Sizes: 1 g. Product ID: B2693-074316. Molecular formula: C33H36N2O3. Mole weight: 508.662. Custom synthesis is available. Send your inquiries for more information. | London |
| Mivebresib | Mivebresib is a BET inhibitor with potential antineoplastic activity. It disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo. Mivebresib is also a MYC and the TMPRSS2-ETS fusion proteins inhibitor. Mivebresib can inhibit cell growth in susceptible tumors. Uses: Anti-tumor. Group: Pharmaceutical. Alternative Names: ABBV-075; ABBV 075; ABBV075; Mivebresib;N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide. CAS No. 1445993-26-9. Pack Sizes: 300 mg. Product ID: B0084-475449. Molecular formula: C22H19F2N3O4S. Mole weight: 459.47. Custom synthesis is available. Send your inquiries for more information. | London |
| MK-8353 | MK-8353 is an orally available ERK1/2 inhibitor. It exhibited antitumor activity in patients with BRAFV600-mutant melanoma. Group: Pharmaceutical. Alternative Names: (3S)-3-(methylthio)-1-[2-[4-[4-(1-methyl-1,2,4-triazol-3-yl)phenyl]-3,6-dihydro-2H-pyridin-1-yl]-2-oxoethyl]-N-[3-(6-propan-2-yloxy-3-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide. CAS No. 1184173-73-6. Pack Sizes: 50 mg. Product ID: B2693-291615. Molecular formula: C37H41N9O3S. Mole weight: 691.84. Custom synthesis is available. Send your inquiries for more information. | London |
| MSDC-0160 | MSDC-0160 reduces resistance in the insulin/IGF-1 signaling pathway and restores IGF-1-induced Akt and GSK-3 phosphorylation. Group: Pharmaceutical. Alternative Names: Mitoglitazone; CAY10415; 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione; Pioglitazone Ketone; 5-(4-(2-(5-ethylpyridin-2-yl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione; 5-{4-[2-(5-ethylpyridin-2-yl)-2-oxoethoxy]benzyl}-1,3-thiazolidine-2,4-dione. CAS No. 146062-49-9. Pack Sizes: 25 mg. Product ID: B0084-311834. Molecular formula: C19H18N2O4S. Mole weight: 370.42. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Desmethyl Imatinib | A metabolite of Imatinib, a tyrosine kinase receptor inhibitor used for cancer therapy. Group: Pharmaceutical. Alternative Names: N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide; N-Desmethyl Gleevec. CAS No. 404844-02-6. Pack Sizes: 10 mg. Product ID: B2694-473156. Molecular formula: C28H29N7O. Mole weight: 479.59. Custom synthesis is available. Send your inquiries for more information. | London |
| Neratinib | Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells. Group: Pharmaceutical. Alternative Names: 2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-; (2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide; (E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide; (E)-N-[4-[[3-Chloro-4-((pyridin-2-yl)meth. CAS No. 698387-09-6. Pack Sizes: 500 mg. Product ID: B0084-347125. Molecular formula: C30H29ClN6O3. Mole weight: 557.04. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Formyl Apixaban | N-Formyl Apixaban is an impurity of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Group: Pharmaceutical. Alternative Names: N-formyl-1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, N-formyl-4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-. CAS No. 1351611-14-7. Pack Sizes: 100 mg. Product ID: B2694-142759. Molecular formula: C26H25N5O5. Mole weight: 487.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Nilotinib EP Impurity H | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 40 nM. Group: Pharmaceutical. Alternative Names: Nilotinib Regio Isomer; 4-Methyl-N-(3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide. CAS No. 641571-15-5. Pack Sizes: 10 mg. Product ID: B1370-242094. Molecular formula: C28H22F3N7O. Mole weight: 529.53. Custom synthesis is available. Send your inquiries for more information. | London |
| Pioglitazone EP Impurity A | Pioglitazone EP Impurity A is an impurity of Pioglitazone, a PPAR agonist that has antidiabetic activity in patients with type 2 diabetes mellitus. Group: Pharmaceutical. Alternative Names: (5RS)-5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]-phenyl]methyl]-5-hydroxythiazolidine-2,4-dione; 2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-5-hydroxy-; Pioglitazone Impurity A; 5-Hydroxy Pioglitazone Impurity; Pioglitazone 5-Hydroxy Metabolite; 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-5-hydroxy-2,4-thiazolidinedione; 5-Hydroxy pioglitazone; Pioglitazone hydrochloride impurity A [EP]; Hydroxypioglitazone; 5-Hydroxypioglitazone; (±)-5-{4-[2-(5-Ethylpyridin-2-yl)ethoxy]benzyl}-5-hydroxythiazolidine-2,4-dione. CAS No. 625853-74-9. Pack Sizes: 10 mg. Product ID: B2694-262097. Molecular formula: C19H20N2O4S. Mole weight: 372.45. Custom synthesis is available. Send your inquiries for more information. | London |
| Pioglitazone hydrochloride | Pioglitazone hydrochloride, a thiazolidinedione antidiabetic drug, is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor with Kis of 1.7, 11.8 and 32.1 μM for CYP2C8, CYP3A4 and CYP2C9, respectively. It is an agonist of the peroxisome proliferator-activated receptor γ. Uses: Hypoglycemic agents. Group: Pharmaceutical. Alternative Names: 5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione Hydrochloride; AD-4833; Actos; U-72107A; 5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride; NSC 758876; 2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-, monohydrochloride. CAS No. 112529-15-4. Pack Sizes: 250 mg. Product ID: BBF-05868. Molecular formula: C19H20N2O3S.HCl. Mole weight: 392.9. Custom synthesis is available. Send your inquiries for more information. | London |
| Pranidipine | Pranidipine is a long acting calcium channel antagonist that can be used as a cardiovascular agent. Group: Pharmaceutical. Alternative Names: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl 5-[(2E)-3-phenyl-2-propen-1-yl] Ester; FRC 8411; OPC 13340. CAS No. 99522-79-9. Pack Sizes: 1 g. Product ID: B2693-080557. Molecular formula: C25H24N2O6. Mole weight: 448.473. Custom synthesis is available. Send your inquiries for more information. | London |
| Prasugrel EP Impurity A | Prasugrel EP Impurity A is an impurity of Prasugrel, which is a platelet inhibitor used to prevent formation of blood clots. Group: Pharmaceutical. Alternative Names: 5-[(1RS)-2-Cyclopropyl-2-oxo-1-phenylethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate; Ethanone, 2-[2-(acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-phenyl-; Desfluoro prasugrel; 2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-phenylethanone; 5-(2-Cyclopropyl-2-oxo-1-phenylethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate; Prasugrel Impurity I. CAS No. 1391194-45-8. Pack Sizes: 25 mg. Product ID: B0219-483209. Molecular formula: C20H21NO3S. Mole weight: 355.46. Custom synthesis is available. Send your inquiries for more information. | London |
| PSNCBAM-1 | PSNCBAM-1 is an allosteric, non-competitive antagonist of CB-1 (IC50= 45 and 209 nM) with hypophagic effects in vivo, potentially an anti-obesity agents. Group: Pharmaceutical. Alternative Names: PSNCBAM 1; PSNCBAM1; N-(4-Chlorophenyl)-N'-(3-(6-(1-pyrrolidinyl)-2-pyridinyl)phenyl)urea. CAS No. 877202-74-9. Pack Sizes: 100 mg. Product ID: B1370-170068. Molecular formula: C22H21ClN4O. Mole weight: 392.88. Custom synthesis is available. Send your inquiries for more information. | London |
| Pyrotinib | Pyrotinib, also known as SHR-1258, is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively. Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. Group: Pharmaceutical. Alternative Names: (R,E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide; Pyrotinib; SHR-1258; SHR1258; SHR 1258; Pyrotinib maleate. CAS No. 1269662-73-8. Pack Sizes: 1 mg. Product ID: B0084-267738. Molecular formula: C32H31ClN6O3. Mole weight: 582.21. Custom synthesis is available. Send your inquiries for more information. | London |
| Q203 | Q203, also known as IAP6, was active against the reference strain M. tuberculosis H37Rv at a minimum concentration required to inhibit the growth of 50% of organisms (MIC50) of 2.7 nM in culture broth medium and at a MIC50 of 0.28 nM inside macrophages. Group: Pharmaceutical. Alternative Names: Q203; Q 203; Q-203; 6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide; 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl) imidazo(1,2-a)pyridine-3-carboxamide. CAS No. 1334719-95-7. Pack Sizes: 100 mg. Product ID: B0084-007312. Molecular formula: C29H28ClF3N4O2. Mole weight: 557.01. Custom synthesis is available. Send your inquiries for more information. | London |
| Regorafenib | Regorafenib, also known as BAY 73-4506, is an orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling. Regorafenib is demonstrated to increase the overall survival of patients with metastatic colorectal cancer and has been approved by the US FDA on September 27, 2012. Uses: Antineoplastic agent. Group: Pharmaceutical. Alternative Names: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide; 4-[4-[N'-(4-Chloro-3-trifluoromethylphenyl)ureido]-3-fluorophenoxy]pyridine-2-carboxylic Acid Methylamide; Regorafenibum; Stivarga; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; BAY 73-4506; BAY 734506; BAY734506; BAY-734506. CAS No. 755037-03-7. Pack Sizes: 500 mg. Product ID: BBF-05856. Molecular formula: C21H15ClF4N4O3. Mole weight: 482.83. Custom synthesis is available. Send your inquiries for more information. | London |
| Regorafenib Impurity 6 | An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Group: Pharmaceutical. Alternative Names: Regorafenib Impurity 6; Regorafenib metabolite M6; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic acid; ZU2HG2Y956; UNII-ZU2HG2Y956; 2-Pyridinecarboxylic acid, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)-3-fluorophenoxy)-; 4-(4-((4-Chloro-3-(trifluoromethyl)phenyl)carbamoylamino)-3-fluoro-phenoxy)pyridine-2-carboxylic acid; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]pyridine-2-carboxylic acid; SCHEMBL4609009; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid. CAS No. 1187945-05-6. Pack Sizes: 50 mg. Product ID: B2694-483711. Molecular formula: C20H12ClF4N3O4. Mole weight: 469.78. Custom synthesis is available. Send your inquiries for more information. | London |
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