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| Product | Description | |
|---|---|---|
| 10-Acetyl-3,7-dihydroxyphenoxazine | 10-Acetyl-3,7-dihydroxyphenoxazine is a sensitive and stable substrate for horseradish peroxidase (HRP). It reacts with H2O2 to produce the fluorescent compound resorufin that can be used for detection of H2O2. Group: Pharmaceutical. CAS No. 119171-73-2. Pack Sizes: 1 g. Product ID: B0001-161736. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| (1S,3R)-RSL3 | (1S,3R)-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor with EC50 of 10 μM in cellular assay. It binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis. Group: Pharmaceutical. CAS No. 1219810-16-8. Pack Sizes: 100 mg. Product ID: B0084-474402. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ebselen | Ebselen, also known as SPI-1005, is an organoselenium compound with potential anti-oxidant, anti-inflammatory and cytoprotective activity. Upon oral administration of SPI-1005, this agent mimics the activity of glutathione peroxidase (GPx) and can utilize glutathione to reduce other unstable molecules, thus preventing the formation of reactive oxygen species (ROS) and reducing oxidative stress on the cell. In the cochlea, this agent may prevent drug-induced injury to the auditory hair cells thereby preventing hearing loss. GPx is the main antioxidant enzyme in the cochlea and protects the inner ear from loud sounds and biochemical damage. In addition, ebselen is able to inhibit the activity of many enzymes involved in inflammation. Group: Pharmaceutical. CAS No. 60940-34-3. Pack Sizes: 1 g. Product ID: B2693-072972. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Hypaphorine | Hypaphorine is an indole-3-acetic acid antagonist which specifically competes with indole-3-acetic acid in binding to the indole-3-acetic acid-binding site in plant peroxidases. Group: Pharmaceutical. CAS No. 487-58-1. Pack Sizes: 10 mg. Product ID: B2703-465879. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Lycopene | Lycopene, in the concentration used, is not toxic and also its health benefits in adipose tissue may play a role against obesity-related complications. Lycopene in tomato puree has decreased indicating an indirect effect on lycopene stability caused by high concentration of hydrogen peroxide and the activation of peroxidase enzymes leading to the reduction of ascorbic acid and its regenerative action towards lycopene. Besides, Lycopene protected β-carotene against isomerization during reactions with singlet oxygen and radicals. These findings can explain the pattern of carotenoid isomers analyzed in fruits and vegetables, where lycopene containing samples showed higher (all-E)/(9Z)-β-carotene ratios, and also in in vivo samples such as human blood plasma. Lycopene can be used as pigment in food processing, and is also used as raw material of antioxidant health food. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 502-65-8. Pack Sizes: 1 g. Product ID: B0005-464994. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PF-1355 | PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MPO without disrupting a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. PF-1355 was used to test the hypothesis that MPO activity is a critical mediator of disease activity in immune complex vasculitis mouse models, and to support the confidence in rationale for this mechanism as a therapeutic approach to treat related human condition such as alleviating tissue injury caused by Goodpasture syndrome and pulmonary vasculitis induced by immune complexes. Group: Pharmaceutical. CAS No. 1435467-38-1. Pack Sizes: 50 mg. Product ID: B0084-474818. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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