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| Product | Description | |
|---|---|---|
| AF 353 | AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. It is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. It also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3). It significantly reduces this parameter in both groups. It also reduces the inter-contractile interval in control but not in SCI rats. Group: Pharmaceutical. CAS No. 865305-30-2. Pack Sizes: 25 mg. Product ID: B2693-459983. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Apixaban Impurities | Apixaban Impurities hold paramount importance in pharmaceutical scrutiny and quality assurance during Apixaban production, an anticoagulant pivotal in venous thromboembolism prevention and stroke risk reduction in atrial fibrillation. Scrutinizing these impurities guarantees therapeutic safety, effectiveness, and adherence to regulatory standards in evolving Apixaban-based treatments. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Atranorin | Atranorin, which can be found in the herbs of Parmelia tinctorum Despr, has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical. Also, it will exert cytoprotective effects on cells under oxidative stress induced by H(2)O(2). It was found to be more efficient at equitoxic doses and correlated more strongly with an increased number of floating cells or a higher apoptotic index. It also exhibited significant anti-inflammatory activity in the acute model of inflammation (leukocyte migration to the peritoneal cavity), carrageenan- and arachidonic acid-induced hind paw edema in rats. Besides, Atranorin exhibited a dose-dependent antioxidant activity in vitro, as assessed by total radical-trapping antioxidant parameter and total antioxidant reactivity assays. Uses: Antinociceptive / antiinflammatory / antibacterial. Group: Pharmaceutical. CAS No. 479-20-9. Pack Sizes: 100 mg. Product ID: NP4582. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Demecarium bromide | Demecarium is a parasympathomimetic that acts as an acetylcholinesterase inhibitor. It is one of several topical (applied directly to the affected area) medications used to reduce elevated intraocular pressure (IOP) associated with primary glaucoma in cats, dogs, and other animals. Uses: Cholinesterase inhibitors; miotics. Group: Pharmaceutical. CAS No. 56-94-0. Pack Sizes: 500 mg. Product ID: B0084-071868. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Dexrazoxane Impurities | Dexrazoxane Impurities, integral to the scrutiny of synthetic by-products, hold paramount importance in ensuring drug purity and safety, especially within cardioprotective paradigms. These impurities play a critical role in the quality control landscape of dexrazoxane, instrumental in reducing anthracycline-induced cardiotoxicity in oncology patients, thereby fostering safer clinical methodologies. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Etelcalcetide hydrochloride | Etelcalcetide is a calcium-sensing receptor agonist as a D-amino peptide calcimimetic for the treatment of secondary hyperparathyroidism. It can bind to and activate the CaSR (calcium-sensing receptor) in the parathyroid gland as an allosteric activator, resulting in PTH reduction and suppression. Amgen Inc. announced its submission of a New Drug Application to the FDA for etelcalcetide in Aug 2015. Group: Pharmaceutical. CAS No. 1334237-71-6. Pack Sizes: 10 mg. Product ID: B0084-475311. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Iopamidol Impurities | Iopamidol Impurities are integral to the rigorous assessment of iopamidol's purity and safety profiles, a crucial iodine-based contrast medium utilized in radiographic imaging. The scrutiny of these impurities is paramount for refining imaging performance and reducing side effects, thereby augmenting diagnostic precision in cardiovascular and varied pathological evaluations. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Lacidipine Impurities | Lacidipine Impurities, crucial artifacts in pharmaceutical evaluations, manifest as influential byproducts or remnants from Lacidipine synthesis. Rigorous analysis is paramount for ensuring treatment purity and safety, anchoring drug efficacy and reducing adverse effects, thereby safeguarding therapeutic standards in antihypertensive interventions. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tizoxanide | Tizoxanide is the active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosporidium parvum. Tizoxanide is active against anaerobic bacteria, protozoan parasites, and viruses. It reduces the growth of the disease-causing parasites, L. mexicana and T. cruzi, in vitro (IC50s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC50s = 0.3-1 μM)3, and inhibits hepatitis B and hepatitis C virus replication (EC50s both = 0.15 μM). Uses: Anti-infective agents. Group: Pharmaceutical. CAS No. 173903-47-4. Pack Sizes: 100 mg. Product ID: B0084-264133. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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