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| Product | Description | |
|---|---|---|
| 6-Desacetyl-6-Bromo Palbociclib Hydrochloride | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Group: Pharmaceutical. Alternative Names: 6-bromo-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride. CAS No. 850918-83-1. Pack Sizes: 100 mg. Product ID: B1476-284929. Molecular formula: C22H27ClBrN7O. Mole weight: 520.86. Custom synthesis is available. Send your inquiries for more information. |  London |
| 6-Desacetyl Palbociclib Hydrochloride | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Group: Pharmaceutical. Alternative Names: 8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride. CAS No. 571189-66-7. Pack Sizes: 100 mg. Product ID: B1476-284928. Molecular formula: C22H28ClN7O. Mole weight: 441.96. Custom synthesis is available. Send your inquiries for more information. | London |
| Palbociclib N-oxide Hydrochloride | An impurity of Palbociclib which is a drug for the treatment of ER-positive and HER2-negative breast cancer. Group: Pharmaceutical. Alternative Names: PD-0332991 hydrochloride; 1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine 1-oxide Hydrochloride salt. Pack Sizes: 100 mg. Product ID: B1370-451980. Molecular formula: C24H30ClN7O3. Mole weight: 499.99. Custom synthesis is available. Send your inquiries for more information. | London |
| Pabociclib Impurity B Hydrochloride | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Group: Pharmaceutical. Alternative Names: tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate hydrochloride. CAS No. 1883672-48-7. Pack Sizes: 100 mg. Product ID: B1476-284924. Molecular formula: C29H38ClN7O4. Mole weight: 584.11. Custom synthesis is available. Send your inquiries for more information. | London |
| Palbociclib HCl | Palbociclib, also known as PD0332991, is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. PD-0332991 selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kinase), which may inhibit retinoblastoma (Rb) protein phosphorylation; inhibition of Rb phosphorylation prevents Rb-positive tumor cells from entering the S phase of the cell cycle (arrest in the G1 phase), resulting in suppression of DNA replication and decreased tumor cell proliferation. PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC50=0.011 μmol/L) and Cdk6 (IC50=0.016 μmol/L), having no activity against a panel of 36 additional protein kinases. Group: Pharmaceutical. Alternative Names: PD 0332991; PD 332991; PD0332991; PD-0332991; Palbociclib hydrochloride. CAS No. 827022-32-2. Pack Sizes: 1 g. Product ID: B2693-462758. Molecular formula: C24H29N7O2.HCl. Mole weight: 483.99. Custom synthesis is available. Send your inquiries for more information. | London |
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