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| Product | Description | |
|---|---|---|
| 3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazole | An impurity of Celecoxib, a cyclooxygenase 2 inhibitor. Group: Pharmaceutical. CAS No. 219986-64-8. Pack Sizes: 10 mg. Product ID: B2694-309476. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 4-Desmethyl-2-methyl Celecoxib | 4-Desmethyl-2-methyl Celecoxib is an analog of Celecoxib, a cyclooxygenase 2 inhibitor. Group: Pharmaceutical. CAS No. 170569-99-0. Pack Sizes: 100 mg. Product ID: B2694-468625. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5-Hydroxy-3',4',7-trimethoxyflavone | 7,3',4'-Tri-O-methylluteolin is a natural flavonoid found in the herbs of Callicarpa bodinieri Levl, it shows prominent inhibitory activity against soybean lipoxygenase. Group: Pharmaceutical. CAS No. 29080-58-8. Pack Sizes: 10 mg. Product ID: NP1805. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5-Methyl-3,4-diphenyl-4,5-dihydroisoxazol-5-ol | An intermediate for the preparation of Valdecoxib. Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of osteoarthritis, rheumatoid arthritis, etc. Valdecoxib exhibits a selectively inhibitory effect of cyclooxygenase-2. Uses: Intermediate for the preparation of valdecoxib. Group: Pharmaceutical. CAS No. 181696-73-1. Pack Sizes: 200 mg. Product ID: B2694-053919. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Shogaol | 6-Shogaol is a pungent constituent of ginger similar in chemical structure to gingerol. It has anti-inflammatory properties. lt was reported to have antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. lt effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-κB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis. lt inhibits the growth of human cancer cells and induces apoptosis in COLO 205 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). Uses: 6-shogaol exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. it has a very strong antitussive (anti-cough) effect. Group: Pharmaceutical. CAS No. 555-66-8. Pack Sizes: 50 mg. Product ID: NP5193. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Aceclofenac-[d2] | Labelled form of Aceclofenac. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. It works by blocking the action of a substance in the body called cyclo-oxygenase. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-003193. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Aceclofenac-[d4] | Labelled form of Aceclofenac. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. It works by blocking the action of a substance in the body called cyclo-oxygenase. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-003194. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Aceclofenac-[d7] | Labelled form of Aceclofenac. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. It works by blocking the action of a substance in the body called cyclo-oxygenase. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-003195. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetone 2,4-Dinitrophenylhydrazone-[13C3] | Isotope labelled Acetone 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic ketone found in mainstream cigarette smoke. Acetone 2,4-Dinitrophenylhydrazone showed inhibitory activity towards soybean lipoxygenase and renal prostaglandin synthetase. Group: Pharmaceutical. CAS No. 395075-27-1. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-003209. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetone 2,4-Dinitrophenylhydrazone-[d3] | Labelled Acetone 2,4-Dinitrophenylhydrazone. Acetone 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic ketone found in mainstream cigarette smoke. Acetone 2,4-Dinitrophenylhydrazone showed inhibitory activity towards soybean lipoxygenase and renal prostaglandin synthetase. Group: Pharmaceutical. CAS No. 259824-57-2. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-013535. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetophenone-[13C] | Acetophenone-[Methyl-13C] is an intermediate in synthesizing Ibuprofen-[13C6], a labelled Ibuprofen. It is a selective cyclooxygenase inhibitor (IC50=14.9uM). Group: Pharmaceutical. CAS No. 71777-36-1. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-009173. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetophenone-[13C6] | Acetophenone-[13C6] is an intermediate in synthesizing Ibuprofen-[13C]6, a labelled Ibuprofen. It is a selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. Group: Pharmaceutical. CAS No. 125770-94-7. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-000007. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetophenone-[α-13C] | Acetophenone-[α-13C] is an intermediate in synthesizing Ibuprofen-[13C6], a labelled Ibuprofen. It is a selective cyclooxygenase inhibitor (IC50=14.9uM). Group: Pharmaceutical. CAS No. 10383-88-7. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-010986. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetophenone-[α,β-13C2] | Acetophenone-[α,β-13C2] is an intermediate in synthesizing Ibuprofen-[13C6], a labelled Ibuprofen. It is a selective cyclooxygenase inhibitor (IC50=14.9uM). Group: Pharmaceutical. CAS No. 190314-15-9. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-010985. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetophenone-[d8] | Acetophenone-[d8] is an intermediate in synthesizing Ibuprofen-[13C6], a labelled Ibuprofen. It is a selective cyclooxygenase inhibitor (IC50=14.9uM). Group: Pharmaceutical. CAS No. 19547-00-3. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-010984. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetophenone-[methyl-d3] | Acetophenone-[methyl-d3] is an intermediate in synthesizing Ibuprofen-[13C6], a labelled Ibuprofen. It is a selective cyclooxygenase inhibitor (IC50=14.9uM). Group: Pharmaceutical. CAS No. 17537-31-4. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-010987. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetylcysteine-15N | Acetylcysteine-15N (N-Acetylcysteine-15N) is the 15N-labeled Acetylcysteine. Acetylcysteine is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor, a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell Apoptosis. Acetylcysteine also has anti-influenza virus activities. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Adapalene | Adapalene is more active than indomethacin, betamethasone valerate, tretinoin, isotretinoin or etretinate in inhibiting lipoxygease activity, but it has little activity against cyclo-oxygenase. Group: Pharmaceutical. CAS No. 106685-40-9. Pack Sizes: 500 mg. Product ID: B0046-463772. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Auranofin | Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA, as an inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Uses: Auranofin inhibits various leukocyte activation pathways at multiple sites. Group: Pharmaceutical. CAS No. 34031-32-8. Pack Sizes: 1 g. Product ID: B2693-397760. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bryonolic acid | Bryonolic acid isolated from the herbs of Sandoricum indicum. It induces a obviously increase in the expression of a phase 2 response enzyme and heme oxygenase 1 (HO-1) in a dose-dependent manner. Uses: Anti-allergic activity; anti-inflammatory and antioxidant activities. Group: Pharmaceutical. CAS No. 24480-45-3. Pack Sizes: 1 mg. Product ID: NP6506. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Caffeic acid | Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound. It is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LOX). Uses: Antioxidant activity; antineoplastic activity; anti-hiv activity; hepatotropic activity; choleretic activity. Group: Pharmaceutical. CAS No. 331-39-5. Pack Sizes: 1 kg. Product ID: NP5450. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cardanol monoene | Cardanol monoene is also known as anacardic acid (C15:1). It inhibits the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 with an IC50 of 6.8 mM. Cardanol monoene is also a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 56 μM in vitro. It halts the cell cycle at the S phase and inhibits proliferation dose- and time-dependently in M14 melanoma cells (IC50s = 23.15 and 12.30 μM after 24 and 48 hours of treatment, respectively). A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation. Group: Pharmaceutical. CAS No. 501-26-8. Pack Sizes: 5 mg. Product ID: B2693-292204. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Celecoxib | Celecoxib is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID) used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis. Uses: Cyclooxygenase 2 inhibitors. Group: Pharmaceutical. CAS No. 169590-42-5. Pack Sizes: 5 g. Product ID: B0084-451901. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Celecoxib EP Impurity A | A meta positional isomer of Celecoxib with selective inhibitory activity against human cyclooxygenase-2. Group: Pharmaceutical. CAS No. 170570-01-1. Pack Sizes: 100 mg. Product ID: B2694-468619. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Celecoxib EP Impurity B | An isomeric impurity of Celecoxib with selective inhibitory activity against human cyclooxygenase-2. Group: Pharmaceutical. CAS No. 331943-04-5. Pack Sizes: 100 mg. Product ID: B2694-468620. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Celecoxib Impurity 2 | An impurity of celecoxib, a cyclooxygenase 2 inhibitor. Group: Pharmaceutical. CAS No. 948293-46-7. Pack Sizes: 10 mg. Product ID: B2694-468624. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Clematomandshurica saponin B | Clematomandshurica saponin B is a triterpenoid saponin isolated from the roots and rhizomes of Clematis mandshurica with inhibitory effect against cyclooxygenase-2. Group: Pharmaceutical. CAS No. 916649-91-7. Pack Sizes: 5 mg. Product ID: B0005-053726. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Clobetasol Propionate | Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Uses: Anti-inflammatory, immunosuppressive and antimitotic agent. Group: Pharmaceutical. CAS No. 25122-46-7. Pack Sizes: 10 g. Product ID: B0084-300298. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Desoxo-narchinol A | Desoxo-narchinol A is a sesquiterpenoid isolated from Nardostachys jatamansi. Desoxo-narchinol A upregulates nuclear transcription factor erythroid-2-related factor 2/heme oxygenase-1 signaling and exhibits anti-neuroinflammatory effects. Group: Pharmaceutical. CAS No. 53859-06-6. Pack Sizes: 1 mg. Product ID: NP5924. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Diclofenac Potassium | Diclofenac potassium is a nonsteroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in certain conditions. It is a competitive inhibitor of cyclooxygenase (COX) that suppresses the production of prostaglandins. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade. Uses: Nsaid. Group: Pharmaceutical. CAS No. 15307-81-0. Pack Sizes: 20 g. Product ID: B0084-059596. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Disodium (R)-2-Hydroxyglutarate | Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM. In U-87MG cells, (R)-2-Hydroxyglutarate acts as a weak antagonist of α-KG to inhibit α-KG-dependent histone demethylases and increase dimethylation on both H3K9 and H3K79. Group: Pharmaceutical. CAS No. 103404-90-6. Pack Sizes: 100 mg. Product ID: BAT-008968. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (-)-Epiafzelechin | (-)-Epiafzelechin exhibits various modes of action in suppressing HSV-2 multiplication. Uses: Antioxidant; cyclooxygenase-1 inhibitor; anti-inflammatory. Group: Pharmaceutical. CAS No. 24808-04-6. Pack Sizes: 5 mg. Product ID: NP2037. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Epicatechin | (-)-Epicatechin is a 2R,3R stereoisomer of catechin and is a naturally occurring flavanol. It is a powerful antioxidant and could inhibit cyclooxygenase. L-Epicatechin is a natural compound found in the woods of Acacia catechu (L.F.) Willd, it can be used in cosmetics material. Uses: Anti-oxidant; anti-atherogenic. Group: Pharmaceutical. CAS No. 490-46-0. Pack Sizes: 5 g. Product ID: NP1874. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Etodolac Impurity L | An impurity of Etodolac. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B2694-471282. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GYY-4137 Morpholine salt | GYY-4137 Morpholine salt is a novel water-soluble and slow releasing Hydrogen sulfide(H2S) donor. It protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats. It inhibits the inflammatory response by suppressing the activation of nuclear factor-kappa B and mitogen-activated protein kinases in Coxsackie virus B3-infected rat cardiomyocytes. It exhibits potent anti-cancer activity. It exhibits vasodilator and antihypertensive activity in rats, in either the acute or chronic hypertension models. It does not influence vascular smooth muscle cell viability in culture. It also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation. Uses: Gyy-4137 morpholine salt inhibits the inflammatory response. it exhibits potent anti-cancer activity. it exhibits vasodilator and antihypertensive activity. Group: Pharmaceutical. CAS No. 106740-09-4. Pack Sizes: 100 mg. Product ID: B2693-272139. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Harpagoside | Harpagoside, isolated from the Harpagophytum procumbens (Devil's Claw) root or Crophularia ningpoensis Hemsl (Figwort), inhibited lipopolysaccharide-induced mRNA levels. Harpagoside also inhibited protein expression of cyclooxygenase-2 and inducible nitric oxide in HepG2 cells, which involves suppression of NF-kappaB activation, thereby inhibiting downstream inflammation and subsequent pain events. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 19210-12-9. Pack Sizes: 50 mg. Product ID: NP3892. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ibuprofen piconol | Ibuprofen piconol is an anti-inflammatory agent that can be synthesized from Ibuprofen. It acts as a cyclooxygenase inhibitor. Group: Pharmaceutical. CAS No. 64622-45-3. Pack Sizes: 5 g. Product ID: B0046-448719. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Iguratimod | Iguratimod is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor. Uses: Anti-inflammation agent. Group: Pharmaceutical. CAS No. 123663-49-0. Pack Sizes: 250 mg. Product ID: B0084-056331. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Irigenin | Irigenin is a natural compound isolated from the rhizomes of Belamcanda chinensis (L.) DC. Irigenin prevents metastatic capacity of lung cancer cells by selectively blocking Extra Domain A. Irigenin has anti-inflammatory effects that can inhibit the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins and mRNAs without an appreciable cytotoxic effect. Group: Pharmaceutical. CAS No. 548-76-5. Pack Sizes: 20 mg. Product ID: NP2498. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mofezolac | Mofezolac is a cyclooxygenase-1 selective inhibitor. Uses: Cyclooxygenase inhibitors. Group: Pharmaceutical. CAS No. 78967-07-4. Pack Sizes: 10 g. Product ID: B2693-008944. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mussaenoside | Mussaenoside is a natural iridoid found in the herbs of Melampyrum roseum Maxim, it can inhibit the release of pro-inflammatory cytokines induced by LPS, the production of nitric oxide (NO) and prostaglandin E2, and the expression of inducible NO synthase and cyclooxygenase-2 induced by lipopolysaccharide (LPS) in the RAW264.7 murine macrophage cell line. Mussaenoside also exhibits the activity of anti-inflammatory. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 64421-27-8. Pack Sizes: 1 mg. Product ID: NP3859. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)acetamide | An impurity of Valdecoxib. Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of osteoarthritis, rheumatoid arthritis, etc. Valdecoxib exhibits a selectively inhibitory effect of cyclooxygenase-2. Group: Pharmaceutical. CAS No. 198471-06-6. Pack Sizes: 20 mg. Product ID: B2694-484462. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| NLG-919 | NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Group: Pharmaceutical. CAS No. 1402836-58-1. Pack Sizes: 50 mg. Product ID: B0084-462741. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Osthol | Osthole is a coumarin which is isolated from Cnidium monnieri (L.) Cusson. Osthole is a calcium channel modulator via inhibiting phosphodiesterases. It also regulates the expression of TNF-α, NF-κB, TGF-β, cyclooxygenases, leukotrienes, nitric oxide, ERK, and JNK. Osthole is a natural compound used in cosmetics material. Uses: Anti-tumor; anti-cancer; may be used as bio-pesticides. Group: Pharmaceutical. CAS No. 484-12-8. Pack Sizes: 100 g. Product ID: NP1032. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Procyanidin C1 | Procyanidin C1 is extracted from the fruits of Vitis vinifera L. It is a B type proanthocyanidin and found in grape. It belongs to a polyphenol flavonoid epicatechin trimer. It can decrease cytokine production of mast cells and Fc epsilon RI-mediated degranulation in vitro dose-dependently. It inhibits ROS generation in stimulated mast cells and the tyrosine phosphorylation of Syk and linker for activation of T cells. It may be used for the treatment of cardiovascular diseases and may be useful as a lead compound to develop inhibitors of cancer metastasis and other diseases related to EMT. It has HIV-related, antioxidant and anti-inflammatory effects. It also inhibits the activity of 15-lipoxygenase and α-glucosidase. It could scavenge 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radicals. Group: Pharmaceutical. CAS No. 37064-30-5. Pack Sizes: 10 mg. Product ID: NP1983. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rebamipide | Rebamipide has been shown to enhance mucosal defense by scavenging free radicals, and temporarily activating genes encoding cyclooxygenase-2. Uses: Enzyme inhibitors. Group: Pharmaceutical. CAS No. 90098-04-7. Pack Sizes: 20 g. Product ID: B0084-100251. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Resveratrol | Resveratrol is a phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity), mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity), and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose-and time-dependent manner. Resveratrol is a natural compound used in cosmetic materials. It is widely used in anti-aging and wrinkle removal, whitening and whitening spots, antibacterial and anti-inflammatory, oil control and acne, anti-allergy and analgesia, scar repair, hair care and other products, and it is compatible with lotion cream formula, gel formula and water formula. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 501-36-0. Pack Sizes: 20 g. Product ID: BBF-03781. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| RTA-408 | RTA-408 is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity. Upon administration, RTA 408 activates the cytoprotective transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH). Nrf2, a leucine zipper transcription factor, plays a key role in the maintenance of redox balance and cytoprotection against oxidative stress. Group: Pharmaceutical. CAS No. 1474034-05-3. Pack Sizes: 20 mg. Product ID: B0084-462776. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Seneciphylline | Seneciphylline, a natural pyrrolizidine alkaloid isolated from the herbs of Senecio scandens, may cause reduction of cytochrome P-450 and related monooxygenase activities. Seneciphylline is a pyrrolizidine alkaloid with the potential to affect hepatic drug metabolizing enzymes in rat cells. In vitro, seneciphylline has no effection on hepatic drug metabolizing enzymes, but has seneciphyllineslight activity of reducing aminopyrine demethylase. Group: Pharmaceutical. CAS No. 480-81-9. Pack Sizes: 10 mg. Product ID: NP0002. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SKF-86002 | SKF-86002 is a p38 MAP kinase inhibitor, the IC50 is 0.1 - 1 μM. It potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes, the IC50 is1 μM. It also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO). In vitro: SKF-86002 inhibited prostaglandin H2 synthase activity, the IC50 is 120 mM as well as prostanoid production by rat basophilic leukemia cells, the IC50 is mM and its sonicate ( the IC50 is 100 mM and human monocytes (the IC50 is 1 mM. It inhibited the generation of dihydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid by a high speed supernatant fraction of RBL-1 cells (the IC50 is 10 mM). It blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP. Uses: Skf-86002 could potently inhibit lps-induced il-1 and tnf-α production in human monocytes. it acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. Group: Pharmaceutical. CAS No. 72873-74-6. Pack Sizes: 300 mg. Product ID: B0084-195907. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Trachelosiaside | Trachelosiaside is isolated from the leaves of Trachelospermum lucidum (D. Don) Schum. Trachelosiaside shows moderate activity against lipoxygenase. Group: Pharmaceutical. CAS No. 106647-12-5. Pack Sizes: 1 mg. Product ID: NP4131. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Valdecoxib Impurity E | An impurity of Valdecoxib. Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of osteoarthritis, rheumatoid arthritis, etc. Valdecoxib exhibits a selectively inhibitory effect of cyclooxygenase-2. Group: Pharmaceutical. CAS No. 1373038-63-1. Pack Sizes: 5 mg. Product ID: B2694-484468. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Valdecoxib Impurity I | An impurity of Valdecoxib. Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of osteoarthritis, rheumatoid arthritis, etc. Valdecoxib exhibits a selectively inhibitory effect of cyclooxygenase-2. Group: Pharmaceutical. CAS No. 1373038-59-5. Pack Sizes: 5 mg. Product ID: B2694-484471. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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