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| Product | Description | |
|---|---|---|
| N-(2-hydroxyethyl)-5-methyl-1,2,4-oxadiazole-3-carboxamide | An impurity of Metronidazole. Metronidazole is an antibacterial in the treatment of rosacea. Antiprotozoal (trichomonas). A potential human carcinogen. Group: Pharmaceutical. Alternative Names: 1,2,4-Oxadiazole-3-carboxamide, N-(2-hydroxyethyl)-5-methyl-; Metronidazole Impurity 08. CAS No. 110578-73-9. Pack Sizes: 10 mg. Product ID: B1370-377329. Molecular formula: C6H9N3O3. Mole weight: 171.16. Custom synthesis is available. Send your inquiries for more information. |  London |
| Epacadostat | Epacadostat, also known as INCB024360 or INCB24360, is a potent and selective IDO1 inhibitor with IC50 of 71.8 nM±17.5 nM, with potential immunomodulating and antineoplastic activities. It has been shown to promote T and natural killer-cell growth, to increase IFN-γ production, and to reduce conversion to regulatory T (Treg)-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells. Group: Pharmaceutical. Alternative Names: IDO inhibitor 1; 1,2,5-Oxadiazole-3-carboximidamide, 4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-, [C(Z)]-; [C(Z)]-4-[[2-[(Aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide; ICBN 24360; ICBN-24360; ICBN24360; INCB 024360; INCB024360; INCB-024360. CAS No. 1204669-58-8. Pack Sizes: 100 mg. Product ID: B0084-465275. Molecular formula: C11H13BrFN7O4S. Mole weight: 438.23. Custom synthesis is available. Send your inquiries for more information. | London |
| IACS-010759 | IACS-010759 is an orally bioavailable inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targeting complex I of the electron transport chain (NADH ubiquinone oxidoreductase). Study showed that IACS-010759 induced AMPK activation leading to mTOR suppression which resulted in cell growth inhibition in AML cells. Group: Pharmaceutical. Alternative Names: 5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole. CAS No. 1570496-34-2. Pack Sizes: 10 mg. Product ID: B2693-291404. Molecular formula: C25H25F3N6O4S. Mole weight: 562.57. Custom synthesis is available. Send your inquiries for more information. | London |
| MK-4101 | MK-4101 is a potent and selective SMO Inhibitor of the Hedgehog Pathway with anti-tumor activity. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1 MK-4101 also induced deregulation of cell cycle and block of DNA replication in tumors. Group: Pharmaceutical. Alternative Names: 5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole; MK-4101; MK 4101; MK4101. CAS No. 935273-79-3. Pack Sizes: 300 mg. Product ID: B0084-007827. Molecular formula: C24H24F5N5O. Mole weight: 493.48. Custom synthesis is available. Send your inquiries for more information. | London |
| Pleconaril | Pleconaril is a capsid function inhibitor which targets a conserved hydrophobic pocket of a major viral capsid protein called VP-1. Pleconaril inhibits attachment and virus uncoating. Uses: Picornavirus replication inhibitor. antiviral. Group: Pharmaceutical. Alternative Names: SR-263843; SR-63843; VP-63843; Win-63843; SR263843; SR63843; VP63843; Win63843; SR 263843; SR 63843; VP 63843; Win 63843; Pleconaril, Picovir. 3-[3,5-dimethyl-4-[3-(3-methyl-1,2-oxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole3-(3,5-dimethyl-4((3-(3-methyl-5-isoxazolyl)propyl)phenyl)-5-trifluoromethyl)-1,2,4-oxadiazolePicovirpleconaril. CAS No. 153168-05-9. Pack Sizes: 25 mg. Product ID: B0084-059600. Molecular formula: C18H18F3N3O3. Mole weight: 381.35. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Amino-2-(5-(5-(3-chloro-4-propoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol | AKP-11 is a novel agonist of sphingosine-1-phosphate receptor (S1PR) subtype 1 with the potential to treat multiple sclerosis (MS). Group: Pharmaceutical. Alternative Names: SCHEMBL177513; ACN-051239; AKP-11; ACN 051239; AKP 11; ACN051239; AKP11. CAS No. 1220973-37-4. Pack Sizes: 10 mg. Product ID: B0084-008121. Molecular formula: C22H22ClN3O5. Mole weight: 443.884. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Defluoro Raltegravir | An impurity of Raltegravir. Raltegravir is an integrase inhibitor as an antiretroviral drug. It can be used for the treatment of HIV infection. Group: Pharmaceutical. Alternative Names: 1,6-Dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-N-(phenylmethyl)-4-pyrimidinecarboxamide. CAS No. 1193687-87-4. Pack Sizes: 2.5 mg. Product ID: B2694-483628. Molecular formula: C20H22N6O5. Mole weight: 426.44. Custom synthesis is available. Send your inquiries for more information. | London |
| Amenamevir | Amenamevir is a DNA helicase-primase inhibitor. It has anti-HSV activity against herpes simplex keratitis. In Mar 2016, Mahuro completed a phase III trial in Herpes simplex virus infections in Japan. Uses: Herpes simplex virus infections; herpes zoster. Group: Pharmaceutical. Alternative Names: UNII-94X46KW4AE; ASP2151; N-(2,6-dimethylphenyl)-N-[2-[4-(1,2,4-oxadiazol-3-yl)anilino]-2-oxoethyl]-1,1-dioxothiane-4-carboxamide. CAS No. 841301-32-4. Pack Sizes: 10 mg. Product ID: B0084-459784. Molecular formula: C24H26N4O5S. Mole weight: 482.55. Custom synthesis is available. Send your inquiries for more information. | London |
| Avagacestat | BMS-708163 is a potent and orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP (IC50 = 0.30 nM) to Aβ40 than signaling through Notch (IC50s = 58 nM). Uses: Gamma secretase inhibitors and modulators. Group: Pharmaceutical. Alternative Names: Avagacestat; BMS 708163; (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide. CAS No. 1146699-66-2. Pack Sizes: 50 mg. Product ID: B0084-286394. Molecular formula: C20H17ClF4N4O4S. Mole weight: 520.89. Custom synthesis is available. Send your inquiries for more information. | London |
| Azilsartan-[d5] | Azilsartan-[d5] is the labelled analogue of Azilsartan, which is an angiotensin II type 1 receptor antagonist and could be used against hypertension and inflammation. Group: Pharmaceutical. Alternative Names: Azilsartan D5; 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-(ethoxy-d5)-1H-benzimidazole-7-carboxylic Acid; 2-(Ethoxy-d5)-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic Acid; TAK 536-d5; Azilsartan O-Ethyl-d5. CAS No. 1346599-45-8. Pack Sizes: 5 mg. Product ID: BLP-011801. Molecular formula: C25H15D5N4O5. Mole weight: 461.48. Custom synthesis is available. Send your inquiries for more information. | London |
| BAM 15 | BAM 15 is a novel mitochondrial protonophore uncoupler that uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). BAM 15 cannot depolarize the plasma membrane, and protects mice from acute renal ischemic-reperfusion injury. BAM 15 has the potential to treat obesity, Parkinson's disease, and aging. Group: Pharmaceutical. Alternative Names: BAM15; BAM-15; N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine; N-[6-(2-Fluoroanilino)[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl]-N-(2-fluorophenyl)amine. CAS No. 210302-17-3. Pack Sizes: 100 mg. Product ID: B1370-119162. Molecular formula: C16H10F2N6O. Mole weight: 340.29. Custom synthesis is available. Send your inquiries for more information. | London |
| Freselestat | Freselestat is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM) with >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Freselestat can be used as treatment for neutrophil-predominant inflammatory lung diseases. Group: Pharmaceutical. Alternative Names: 2-(5-amino-6-oxo-2-phenylpyrimidin-1-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl]acetamide; ONO6818; ONO 6818; ONO-6818. CAS No. 208848-19-5. Pack Sizes: 10 mg. Product ID: B0084-101783. Molecular formula: C23H28N6O4. Mole weight: 452.51. Custom synthesis is available. Send your inquiries for more information. | London |
| GSK-2018682 | GSK-2018682 is a potent and selective agonist of sphingosine-1-phosphate receptor (S1PR) subtype 1 that has the potential to treat multiple sclerosis (MS). Group: Pharmaceutical. Alternative Names: GSK2018682; GSK 2018682; GSK-2018682. UNII-NJL503AIJA; NJL503AIJA; 4-(4-(5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl)-1H-indol-1-yl)butanoic acid. CAS No. 1034688-30-6. Pack Sizes: 10 mg. Product ID: B0084-008117. Molecular formula: C22H21ClN4O4. Mole weight: 440.884. Custom synthesis is available. Send your inquiries for more information. | London |
| Ozanimod | Ozanimod is a medication used for the treatment of multiple sclerosis (MS) and inflammatory bowel disease (IBD), specifically ulcerative colitis. Ozanimod is a selective sphingosine 1-phosphate (S1P) receptor modulator. It binds to S1P receptors on lymphocytes (a type of white blood cell), thereby inhibiting their egress from lymph nodes. This action reduces the number of circulating lymphocytes that can cause inflammation in the central nervous system (in the case of MS) or the intestines (in the case of ulcerative colitis). Ozanimod is indicated for the treatment of relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. It is also approved for the treatment of moderate to severe ulcerative colitis in adults who have not responded adequately to conventional therapies. Group: Pharmaceutical. Alternative Names: Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-; 5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile; 5-[3-[1-(S)-(2-Hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-isopropoxybenzonitrile; RPC 1063; RPC-1063; RPC1063; Zeposia. CAS No. 1306760-87-1. Pack Sizes: 50 mg. Product ID: B0084-470834. Molecular formula: C23H24N4O3. Mole weight: 404.47. Custom synthesis is available. | London |
| TMP269 | TMP269 is a highly potent, selective and cell-permeable class IIa HDAC inhibitor with IC50 values of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. Group: Pharmaceutical. Alternative Names: TMP269; TMP 269; TMP-269; N-((4-(4-Phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide. CAS No. 1314890-29-3. Pack Sizes: 25 mg. Product ID: B0084-462603. Molecular formula: C25H21F3N4O3S. Mole weight: 514.523. Custom synthesis is available. Send your inquiries for more information. | London |
| Verucerfont | Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000?nM for CRF1, CRF2, and CRF-BP, respectively. Verucerfont supresses the CRH-1 receptor to decrease ACTH release following chronic stress. Group: Pharmaceutical. Alternative Names: GSK561679; GSK 561679; GSK-561679; GSK561679A; NBI-77860; NBI 77860; NBI77860; 3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-N-[(1S)-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]pyrazolo[1,5-a]pyrimidin-7-amine. CAS No. 885220-61-1. Pack Sizes: 1 mg. Product ID: B0084-460213. Molecular formula: C22H26N6O2. Mole weight: 406.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Zibotentan | Zibotentan is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). Group: Pharmaceutical. Alternative Names: ZD4054; ZD-4054; ZD 4054; N-(3-methoxy-5-methylpyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3-sulfonamide. CAS No. 186497-07-4. Pack Sizes: 20 mg. Product ID: B0084-418686. Molecular formula: C19H16N6O4S. Mole weight: 424.44. Custom synthesis is available. Send your inquiries for more information. | London |
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