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| Product | Description | |
|---|---|---|
| Oleandrin | Oleandrin, also known as PBI-05204, is a lipid soluble cardiac glycoside with potential antineoplastic activity. Upon administration, oleandrin specifically binds to and inhibits the alpha3 subunit of the Na/K-ATPase pump in human cancer cells. This may inhibit the phosphorylation of Akt, upregulate MAPK, inhibit NF-kb activation and inhibit FGF-2 export and may downregulate mTOR thereby inhibiting p70S6K and S6 protein expression. All of this may lead to an induction of apoptosis. As cancer cells with relatively higher expression of the alpha3 subunit and with limited expression of the alpha1 subunit more sensitive to oleandrin, one may predict the tumor response to treatment with lipid-soluble cardiac glycosides such as oleandrin based on the tumors Na/K-ATPase pump protein subunit expression. Overexpression of the alpha3 subunit in tumor cells correlates with tumor proliferation. Uses: Anti-proliferative. Group: Pharmaceutical. CAS No. 465-16-7. Pack Sizes: 10 mg. Product ID: NP6109. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Oleandrin Impurities | Oleandrin Impurities, fundamental to biomedical investigations, enable meticulous analysis and purity scrutiny of cardiac glycosides used in heart failure treatment regimes. These impurities are pivotal for assessing drug metabolism and safety parameters, thus propelling the evolution and quality validation of cardioprotective agents and their respective formulations. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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